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Plant pattern recognition receptors: from evolutionary insight to engineering
Plant pattern recognition receptors: from evolutionary insight to engineering
The plant immune system relies on germline-encoded pattern recognition receptors (PRRs) that sense foreign and plant-deriv...
Exploring biodiversity through museomics
Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic...
Genetic conflict and its resolution between the sexes
Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic sa...
The design and engineering of synthetic genomes
The design and engineering of synthetic genomes
Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome...
Slide-tags enables spatial single-nucleus sequencing
Slide-tags enables spatial single-nucleus sequencing
In this Tools of the Trade article, Andrew Russell describes Slide-tags, a method for scalable, spatially resolved single-...
Cohesin and CTCF emerge as building blocks of 3D genome structure
In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the gen...
Causal inference for epigenetic ageing
Causal inference for epigenetic ageing
In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelia...
The phenotypic consequences of enhancer evolution
In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes und...
Context-specific regulatory variants in precision medicine and agriculture
Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene e...
How the waxing and waning of a mutation determines HIV treatment success
In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with the...
Functional specificity in biomolecular condensates revealed by genetic complementation
Functional specificity in biomolecular condensates revealed by genetic complementation
Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities...
A brief history of metabolic gradient theory
In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20t...
Ethical governance for genomic data science in the cloud
Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomi...
Systemic cell–cell communication in cancer
In this Journal Club article, Edroaldo Lummertz da Rocha discusses two papers that provided important insights into how tu...
Single-cell expression profiling has its roots in in situ techniques
In this Journal Club, Shila Ghazanfar highlights a seminal paper by Levsky et al. that paved the way for contemporary sing...
Genome-wide association testing beyond SNPs
Genome-wide association testing beyond SNPs
Decades of genetic association testing in human cohorts have provided important insights into the genetic architecture and...
A call to action to scale up research and clinical genomic data sharing
A call to action to scale up research and clinical genomic data sharing
Genomic data from millions of individuals have been generated worldwide to drive discovery and clinical impact in precisio...
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
Since the discovery of RNA splicing and its role in gene expression, researchers have sought a set of rules, an algorithm ...
Endogenous retroviruses: unveiling new targets for cancer immunotherapy
In this Journal Club, Shengbao Suo highlights two publications that underscore the importance of genetic regulation of end...
Inference and applications of ancestral recombination graphs
Inference and applications of ancestral recombination graphs
Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships between individuals represented in ...
Selection on structural variation in the amylase locus
Selection on structural variation in the amylase locus
Bolognini et al. report evidence of positive selection for human amylase gene duplications associated with the agricultura...
The evolution of DNA sequencing with microfluidics
The adoption of microfluidics was fundamental to the development of cost-effective, high-throughput DNA sequencing. As the...
Why geneticists should care about male infertility
The widespread use of medically assisted reproduction fosters the false impression that the underlying causes of male infe...
Gene synthesis from a non-coding RNA
Gene synthesis from a non-coding RNA
A study in Science investigating bacterial defence mechanisms against phages reports a novel mode of gene regulation throu...
Genome-scale models in human metabologenomics
Genome-scale models in human metabologenomics
Metabologenomics integrates metabolomics with other omics data types to comprehensively study the genetic and environmenta...
Identifying off-target effects of genome editing with Tracking-seq
Identifying off-target effects of genome editing with Tracking-seq
In this Tools of the Trade article, Ming Zhu describes Tracking-seq, a versatile method for detecting off-target effects o...
Reshaping Waddington’s developmental landscape
Yimiao Qu and Kyle Loh discuss a 2004 paper by Xie et al., who demonstrated that B cells can be reprogrammed into macropha...
Tumbling bacteria and non-genetic individuality
In this Journal Club, Alejo Rodriguez-Fratelli discusses a paper by Spudich and Koshland Jr that characterized non-genetic...
Progress in toxicogenomics to protect human health
Progress in toxicogenomics to protect human health
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and epigenomic modifications, to un...
The complex non-genetic inheritance of complex traits
Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a ...
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