SCI时时刷

search
+
Layering epigenomic and transcriptomic space
Layering epigenomic and transcriptomic space
Zhang et al. describe two technologies for the spatially resolved co-mapping of epigenome and transcriptome at near single...
Corrupted USB1 fails to process microRNAs required for blood development
Corrupted USB1 fails to process microRNAs required for blood development
A new study in Science identifies a role for USB1 in deadenylating microRNAs to regulate blood development.
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age
Two studies analysing ancient hunter-gatherer genomes report detailed insights into the history and interactions of West E...
Methods and applications for single-cell and spatial multi-omics
Methods and applications for single-cell and spatial multi-omics
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming o...
Engineering transgenerational epigenetic inheritance in mammals
Engineering transgenerational epigenetic inheritance in mammals
A new study in Cell uses epigenome engineering to confer transgenerational inheritance of DNA methylation states and metab...
Sex and age affect circadian gene expression
Sex and age affect circadian gene expression
A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explai...
Simultaneous sequencing of genome and epigenome
Simultaneous sequencing of genome and epigenome
A study in Nature Biotechnology reports a whole-genome sequencing methodology that combines genome and epigenome sequencin...
Mendelian inheritance revisited: dominance and recessiveness in medical genetics
Mendelian inheritance revisited: dominance and recessiveness in medical genetics
Understanding the consequences of genotype for phenotype (which ranges from molecule-level effects to whole-organism trait...
Understanding soft sweeps: a signature of rapid adaptation
Nandita Garud recalls two seminal papers by Hermisson and Pennings that provide a framework for understanding when adaptat...
The FinnGen study: disease insights from a ‘bottlenecked’ population
The FinnGen study: disease insights from a ‘bottlenecked’ population
A collection of articles in Nature describe insights into disease-associated genetic variants obtained from the geneticall...
Regulatory promoter architectures in the hands of thermodynamic modelling
Julio Collado-Vides recalls two 2005 publications that provide a conceptual framework based on a statistical thermodynamic...
Chromatin organization in red triangles
This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture me...
How Hi-C ignited the era of 3D genome biology
Magda Bienko highlights a landmark paper by Lieberman-Aiden et al., which in 2009 reported the development of high-through...
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled humans to colonize diverse habita...
Exon junction complex modulates m6A distribution
Exon junction complex modulates m6A distribution
Two studies have revealed that the characteristic distribution of N6-methyladenosine (m6A) — an RNA modification kno...
Molecular mechanisms of environmental exposures and human disease
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to environmental exposures and pollu...
Pharmacogenomics: current status and future perspectives
Pharmacogenomics: current status and future perspectives
Inter-individual variability in drug response, be it efficacy or safety, is common and likely to become an increasing prob...
Optical filament recording of cellular events
Optical filament recording of cellular events
Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals...
Stem cell-derived organoid models: defying the Hayflick limit
In this Journal club, Meritxell Huch recalls a dogma postulated by Hayflick in 1961, that the capacity for propagating pri...
Navigating the pitfalls of mapping DNA and RNA modifications
Navigating the pitfalls of mapping DNA and RNA modifications
Chemical modifications to nucleic acids occur across the kingdoms of life and carry important regulatory information. Reli...
Mapping the minutiae of the human methylome
Mapping the minutiae of the human methylome
A study in Nature reports comprehensive, genome-wide mapping of the human methylome that provides mechanistic insights int...
Advances of aneuploidy research in the maternal germline
Sérgio Pena discusses a 2019 study by Gruhn et al., which showed that meiotic chromosome segregation errors originati...
Down memory lane — unravelling the puzzle of gene regulation
Selene Fernandez-Valverde recalls a seminal publication by Jacob and Monod to showcase how thoughtful reasoning and extrap...
Prioritizing the detection of rare pathogenic variants in population screening
Population genomic screening to detect carriers of rare monogenic variants for medically actionable conditions&am...
Autophagy genes in biology and disease
Autophagy genes in biology and disease
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in ...
High-throughput biochemistry in RNA sequence space: predicting structure and function
High-throughput biochemistry in RNA sequence space: predicting structure and function
RNAs are central to fundamental biological processes in all known organisms. The set of possible intramolecular interactio...
Current advances in primate genomics: novel approaches for understanding evolution and disease
Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution and disease. However, genetic diver...
New cuts for CRISPR effectors
New cuts for CRISPR effectors
Two new studies in Science characterize a CRISPR-associated nuclease–protease system that can be leveraged as a prog...
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene express...
CHIPping away at the genetic aetiology of clonal haematopoiesis
CHIPping away at the genetic aetiology of clonal haematopoiesis
A study in Nature reports the identification of new germline variants associated with particular subtypes of clonal haemat...
阅读更多
format_indent_increase