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Pioneer factors — key regulators of chromatin and gene expression
Pioneer factors are a group of transcription factors with important roles in gene regulation during development. Their uni...
Illuminating the human yolk sac through single-cell omics
Illuminating the human yolk sac through single-cell omics
A paper in Science reports a time-resolved multiomic atlas of the human yolk sac, expanding knowledge of this poorly resol...
RNA modifications in physiology and disease: towards clinical applications
RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge, hydrophobic surface and bas...
Imprinted genes and the manipulation of parenting in mammals
Imprinted genes and the manipulation of parenting in mammals
Genomic imprinting refers to the parent-of-origin expression of genes, which originates from epigenetic events in the mamm...
Unequal global implementation of genomic newborn screening
Studies of genomic newborn screening are highly skewed towards populations in high-income countries. The evidence generate...
Transposable elements: McClintock’s legacy revisited
Transposable elements: McClintock’s legacy revisited
In 1983, Barbara McClintock was awarded the Nobel Prize in Physiology or Medicine for her discovery of transposable elemen...
More than a decade of genetic research on the Denisovans
More than a decade of genetic research on the Denisovans
Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and Late Pleistocene, were first iden...
Predicting the effects of multigene perturbations
Roohani et al. have developed a deep learning tool called GEARS that predicts the effects of multigene perturbations.
Mary Lyon and the birth of X-inactivation research
Marnie Blewitt highlights the visionary 1961 paper by Mary Lyon in which she proposed that dosage compensation in female m...
Computational methods for analysing multiscale 3D genome organization
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome mapping and imaging technologies has enabled the characterization of the spatial organizat...
Harnessing deep learning for population genetic inference
Harnessing deep learning for population genetic inference
In population genetics, the emergence of large-scale genomic data for various species and populations has provided new opp...
In vivo editing of blood stem cells
In vivo editing of blood stem cells
Breda et al. developed a method for gene editing bone marrow cells in vivo, circumventing the need for toxic conditioning ...
Enhancing sustainable development through plant genetics
In April 2023, scholars and experts met members of the US Congress for the Aspen Institute Congressional Program conferenc...
Principles and methods for transferring polygenic risk scores across global populations
Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a val...
Explaining the male bias in cancers
Explaining the male bias in cancers
Two studies published in Nature investigate the genetic mechanisms of sex bias in cancers and implicate Y chromosome genes...
Not all co-repressors are equal
Not all co-repressors are equal
Jacobs et al. report in Science that different co-repressors repress the transcriptional activity of different subsets of ...
Predictive evidence of the relevance of epigenetics to PTSD
Leon Mutesa highlights a 2009 article by Yehuda and Bierer that considered the relevance of epigenetic mechanisms to post-...
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in eukaryotic transcription regulation, and...
Alu sequences promote long-distance relationships
Alu sequences promote long-distance relationships
Liang et al. report in Nature that complementary Alu sequences allow an enhancer to find its cognate promoter over long di...
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01
A study in Nature reports a strong association between asymptomatic SARS-CoV-2 infections and the HLA-B*15:01 allele and r...
Spatial mapping of translation in single cells
Spatial mapping of translation in single cells
Zeng et al. introduce RIBOmap, a three-dimensional in situ imaging technique that enables the mapping of mRNAs undergoing ...
Genetics of human brain development
Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain lar...
The chromosome hoarding syndrome of (some) ferns and lycophytes
Fay-Wei Li recalls a 1966 paper by Klekowski and Baker, who built on their observation that homosporous pteridophytes have...
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans
Next-generation sequencing technology has rapidly accelerated the discovery of genetic variants of interest in individuals...
A focus on single-cell omics
Cellular heterogeneity lies at the heart of biological complexity and plays a critical role in development, homeostasis an...
Maverick — top gun of horizontal gene transfer
Maverick — top gun of horizontal gene transfer
A study in Science identifies Mavericks, a class of ancient, virus-like transposable elements, as a vector for horizontal ...
A diverse and inclusive human pangenome
A diverse and inclusive human pangenome
In five new studies, the Human Pangenome Reference Consortium reports the generation and initial characterization of a dra...
Steering and controlling evolution — from bioengineering to fighting pathogens
Steering and controlling evolution — from bioengineering to fighting pathogens
Control interventions steer the evolution of molecules, viruses, microorganisms or other cells towards a desired outcome. ...
Genomic newborn screening for rare diseases
Genomic newborn screening for rare diseases
Rare diseases are a leading cause of infant mortality and lifelong disability. To improve outcomes, timely diagnosis and e...
Incongruence in the phylogenomics era
Incongruence in the phylogenomics era
Genome-scale data and the development of novel statistical phylogenetic approaches have greatly aided the reconstruction o...
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