SCI时时刷

search
The nexus between RNA-binding proteins and their effectors
The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA molecule, from its production to it...
Viral protection from viruses
Viral protection from viruses
A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with ...
Assigning phenotypes to essential human genes
A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes...
Locking in a synthetic genetic code
Locking in a synthetic genetic code
A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genet...
Prime editing for precise and highly versatile genome manipulation
Prime editing for precise and highly versatile genome manipulation
Programmable gene-editing tools have transformed the life sciences and have shown potential for the treatment of genetic d...
Spatial epigenomics in single cells
Spatial epigenomics in single cells
A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone...
Probing the dynamic RNA structurome and its functions
Probing the dynamic RNA structurome and its functions
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA molecules are thought to be cen...
A TAD refined for gene regulation
A TAD refined for gene regulation
A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the r...
Dynamic alternative DNA structures in biology and disease
Dynamic alternative DNA structures in biology and disease
Repetitive elements in the human genome, once considered ‘junk DNA’, are now known to adopt more than a dozen ...
Genetic determinism, essentialism and reductionism: semantic clarity for contested science
Genetic determinism, essentialism and reductionism: semantic clarity for contested science
Research linking genetic differences with human social and behavioural phenotypes has long been controversial. Frequently,...
RADARs and READRs for programmable RNA sensing
RADARs and READRs for programmable RNA sensing
Two new papers report programmable systems that leverage ADAR adenosine deaminases for recording transcript abundance.
The mutation rate as an evolving trait
Guojie Zhang discusses a seminal paper by Alfred H. Sturtevant, in which he concluded based on his observations in fruitfl...
Biological roles of adenine methylation in RNA
Biological roles of adenine methylation in RNA
N6-Methyladenosine (m6A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs a...
Linking disease-associated genetic variants to cell types and processes
Linking disease-associated genetic variants to cell types and processes
Jagadeesh, Dey et al. report the development of ‘sc-linker’, an open-source framework that integrates scRNA-se...
Biomarker benchmarking
Biomarker benchmarking
A paper in Cancer Cell reports genetic ancestry-associated differences in clinical outcomes when using tumour mutational b...
Towards gut-friendly grains
A paper in Nature Communications describes a framework for identifying seed traits in food crops that have health-promotin...
Target-directed microRNA degradation in Drosophila
A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for norma...
DNA methylation and cell fate in mouse embryos
A study in Genome Biology provides new insight into the role of DNA methylation and demethylation in regulating cell fate ...
The gene variant that helped put Latinxs in the 1000 genomes project
In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that w...
Microbiome epidemiology and association studies in human health
Microbiome epidemiology and association studies in human health
Studies of the human microbiome share both technical and conceptual similarities with genome-wide association studies and ...
Obtaining genetics insights from deep learning via explainable artificial intelligence
Obtaining genetics insights from deep learning via explainable artificial intelligence
Artificial intelligence (AI) models based on deep learning now represent the state of the art for making functional predic...
New insights into genome folding by loop extrusion from inducible degron technologies
New insights into genome folding by loop extrusion from inducible degron technologies
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically wire distant loci together for gen...
Genetics of human telomere biology disorders
Genetics of human telomere biology disorders
Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that prevent the activation of DNA da...
Promoting a new view of mitochondrial genome regulation
Promoting a new view of mitochondrial genome regulation
A paper in Molecular Cell reports the characterization of a second functional light strand promoter (LSP2) in the mitochon...
Mapping vertebrate brain evolution
Mapping vertebrate brain evolution
Four papers in Science use single-cell, single-nucleus and spatial transcriptomic profiling of reptilian and amphibian bra...
The spatial organization of transcriptional control
The spatial organization of transcriptional control
In animals, the sequences for controlling gene expression do not concentrate just at the transcription start site of genes...
Mapping dosage
Mapping dosage
A new study in Cell has characterized genome-wide dosage sensitivity for 54 human disorders, providing insight into the ca...
The origin of animals and fungi
The origin of animals and fungi
By studying the closest extant unicellular relatives of animals and fungi, a study in Nature contrasts the evolutionary tr...
Decoding noncoding variation in dementia
Decoding noncoding variation in dementia
Cooper et al. report in Science the use of massively parallel reporter assays and CRISPR-based validation to characterize ...
Genetics of circadian rhythms and sleep in human health and disease
Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human health. Their disruption is associated ...