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Revealing gene function with statistical inference at single-cell resolution
Revealing gene function with statistical inference at single-cell resolution
Single-cell and spatial molecular profiling assays have shown large gains in sensitivity, resolution and throughput. Apply...
Decoding the language of chromatin modifications with MARCS
Decoding the language of chromatin modifications with MARCS
In this Tools of the Trade article, Andrey Tvardovskiy and Saulius Lukauskas introduce the web resource MARCS, which offer...
Publisher Correction: How germ granules promote germ cell fate
Authors and AffiliationsWhitehead Institute for Biomedical Research, Cambridge, MA, USAMelissa C. Pamula & Ruth Lehman...
Decoding protein–RNA interactions using CLIP-based methodologies
Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expr...
Programmable DNA rearrangements using bridge RNAs
Programmable DNA rearrangements using bridge RNAs
Two studies in Nature reveal the mechanistic and structural properties of a family of mobile genetic elements that can be ...
Evolution and regulation of animal sex chromosomes
Evolution and regulation of animal sex chromosomes
Animal sex chromosomes typically carry the upstream sex-determining gene that triggers testis or ovary development and, in...
Methods and applications of genome-wide profiling of DNA damage and rare mutations
Methods and applications of genome-wide profiling of DNA damage and rare mutations
DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemi...
Sequencing-based analysis of microbiomes
Sequencing-based analysis of microbiomes
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they have varied functional roles th...
Charting the evolutionary history of malaria
Charting the evolutionary history of malaria
A study in Nature charts the history of malaria in the Americas from ancient Plasmodium parasite genomes.
A digital marker for coronary artery disease
A digital marker for coronary artery disease
Petrazzini et al. leverage exome sequencing data and a novel machine learning-based marker to identify rare and ultra-rare...
BRCA1 and friends 30 years on
With the benefit of hindsight, recognition of the cancer susceptibility gene BRCA1 and its later cloning were defining mom...
DNA packaging by molecular motors: from bacteriophage to human chromosomes
DNA packaging by molecular motors: from bacteriophage to human chromosomes
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the ...
How germ granules promote germ cell fate
How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their a...
Tandem repeats in the long-read sequencing era
Tandem repeats are ubiquitous in the human genome and hold crucial information about our genetic diversity, evolution and ...
Next-generation data filtering in the genomics era
Next-generation data filtering in the genomics era
Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology, evolution and human health. How...
From Mendel’s laws to non-Mendelian inheritance
In this Journal Club article, Laura Ross discusses several seminal papers that describe the discovery of germline-specific...
Mini-colons unlock tumour development outside the body
Mini-colons unlock tumour development outside the body
In this Tools of the Trade article, Francisco Lorenzo-Martín and Matthias Lutolf present mini-colons as a new ex vivo...
SCENT defines non-coding disease mechanisms using single-cell multi-omics
SCENT defines non-coding disease mechanisms using single-cell multi-omics
In this Tools of the Trade article, Saori Sakaue describes SCENT, a tool to generate cell-type-specific enhancer–gen...
Gene–environment interactions in human health
Gene–environment interactions in human health
Gene–environment interactions (G × E), the interplay of genetic variation with environmental factor...
Nuclear receptors — studying genes to understand hormones
In this Journal Club, Jessica Tollkuhn discusses how a paper describing genome-wide application of chromatin immunoprecipi...
BANKSY: scalable cell typing and domain segmentation for spatial omics
BANKSY: scalable cell typing and domain segmentation for spatial omics
In this Tools of the Trade article, Vipul Singhal and Nigel Chou describe BANKSY, a machine learning tool that harnesses g...
Dysregulation of epigenetically induced cancers
Dysregulation of epigenetically induced cancers
A study in Nature finds that transient perturbation of the Polycomb complex and target epigenome can irreversibly induce c...
Miller spreads and the power of observation
Mustafa Mir reflects on a 1976 paper by McKnight and Miller, in which they developed a technique to directly visualize gen...
Genetics of glycosylation in mammalian development and disease
Genetics of glycosylation in mammalian development and disease
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyse...
Tandem repeat variation of human centromeres
Tandem repeat variation of human centromeres
Logsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative ana...
The emerging role of tandem repeats in complex traits
The emerging role of tandem repeats in complex traits
Tandem repeats are a large source of genetic variation but are challenging to analyse and have been missing from most geno...
Rapid pathogen surveillance: field-ready sequencing solutions
In this Journal Club, Kirstyn Brunker highlights two papers published in 2017 that showcase how the emergence of portable ...
Prime editing sensors enable multiplexed genome editing
Prime editing sensors enable multiplexed genome editing
In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency an...
The hidden world of transient enhancers
Renée Beekman discusses the possibilities for research into transient enhancers by highlighting a recent paper by Ver...
What tubulin can teach us about gene regulation
In this Journal Club article, Olivia Rissland describes how a 1987 paper by Don Cleveland and colleagues provided insight ...
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