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Nuclear receptors — studying genes to understand hormones
In this Journal Club, Jessica Tollkuhn discusses how a paper describing genome-wide application of chromatin immunoprecipi...
BANKSY: scalable cell typing and domain segmentation for spatial omics
BANKSY: scalable cell typing and domain segmentation for spatial omics
In this Tools of the Trade article, Vipul Singhal and Nigel Chou describe BANKSY, a machine learning tool that harnesses g...
Dysregulation of epigenetically induced cancers
Dysregulation of epigenetically induced cancers
A study in Nature finds that transient perturbation of the Polycomb complex and target epigenome can irreversibly induce c...
Miller spreads and the power of observation
Mustafa Mir reflects on a 1976 paper by McKnight and Miller, in which they developed a technique to directly visualize gen...
Genetics of glycosylation in mammalian development and disease
Genetics of glycosylation in mammalian development and disease
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyse...
Tandem repeat variation of human centromeres
Tandem repeat variation of human centromeres
Logsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative ana...
The emerging role of tandem repeats in complex traits
The emerging role of tandem repeats in complex traits
Tandem repeats are a large source of genetic variation but are challenging to analyse and have been missing from most geno...
Rapid pathogen surveillance: field-ready sequencing solutions
In this Journal Club, Kirstyn Brunker highlights two papers published in 2017 that showcase how the emergence of portable ...
Prime editing sensors enable multiplexed genome editing
Prime editing sensors enable multiplexed genome editing
In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency an...
The hidden world of transient enhancers
Renée Beekman discusses the possibilities for research into transient enhancers by highlighting a recent paper by Ver...
What tubulin can teach us about gene regulation
In this Journal Club article, Olivia Rissland describes how a 1987 paper by Don Cleveland and colleagues provided insight ...
Targeted genome-modification tools and their advanced applications in crop breeding
Targeted genome-modification tools and their advanced applications in crop breeding
Crop improvement by genome editing involves the targeted alteration of genes to improve plant traits, such as stress toler...
Genome assembly in the telomere-to-telomere era
Genome assembly in the telomere-to-telomere era
Genome sequences largely determine the biology and encode the history of an organism, and de novo assembly — the pro...
Nuclear mRNA decay: regulatory networks that control gene expression
Nuclear mRNA decay: regulatory networks that control gene expression
Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adapta...
Natural antisense transcripts as versatile regulators of gene expression
Natural antisense transcripts as versatile regulators of gene expression
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that have central roles in cell and developm...
Understanding human uniqueness in the pre-genomic era
In this Journal Club article, Jenny Tung reflects on a 1975 paper from King and Wilson that emphasized the importance of g...
A developmental exit from totipotency
A developmental exit from totipotency
A paper in Nature Genetics identifies a mechanism involving the transcription factor DUXBL that controls the development o...
SIMPLE-seq to decode DNA methylation dynamics in single cells
SIMPLE-seq to decode DNA methylation dynamics in single cells
In this Tools of the Trade article, Dongsheng Bai and Chenxu Zhu describe SIMPLE-seq, a scalable single-cell sequencing me...
Human embryonic genetic mosaicism and its effects on development and disease
Human embryonic genetic mosaicism and its effects on development and disease
Nearly every mammalian cell division is accompanied by a mutational event that becomes fixed in a daughter cell. When carr...
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions betwe...
Genetic variation across and within individuals
Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germl...
AIRE targets poised promoters enriched for Z-DNA
AIRE targets poised promoters enriched for Z-DNA
A paper in Nature reports a ‘Z-DNA-anchored’ model for the target specificity of the transcription factor AIRE...
Building a catalogue of short tandem repeats in diverse populations
Reflecting on the importance of short tandem repeats (STRs) in population genetics, Ning Xie highlights a 2023 publication...
Global genomic diversity for All of Us
Global genomic diversity for All of Us
A publication in Nature reports the data release of around 245,000 clinical-grade whole-genome sequences as part of the NI...
The evolution of modifier genes
In this Journal Club, Yoav Ram recalls how he reconciled results from his own research with the reduction principle throug...
Dynamics of ER stress-induced gene regulation in plants
Dynamics of ER stress-induced gene regulation in plants
Endoplasmic reticulum (ER) stress is a potentially lethal condition that is induced by the abnormal accumulation of unfold...
The regulatory landscape of chromatin accessibility
The regulatory landscape of chromatin accessibility
A study in Nature Genetics identifies many regulators of genome-wide chromatin accessibility and then reports the mechanis...
Competition between sites of meiotic recombination in snakes
Competition between sites of meiotic recombination in snakes
A study in Science reports that corn snakes use both PRDM9 and promoter-like features to direct meiotic recombination, ind...
Short tandem repeats — how microsatellites became the currency of forensic genetics
Short tandem repeats (STRs), also known as microsatellites, are the primary markers of forensic genetics for developing in...
Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications
Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications
Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays of 1–6 base pair sequence ...