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Gene therapy for deafness: we can do more
Challenges in the development of treatments for hereditary hearing loss include the exploration of the underlying patholog...
Genomic landscape of cancer in racially and ethnically diverse populations
Genomic landscape of cancer in racially and ethnically diverse populations
Cancer incidence and mortality rates can vary widely among different racial and ethnic groups, attributed to a complex int...
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus
A fertilized egg is initially transcriptionally silent and relies on maternally provided factors to initiate development. ...
The lives of cells, recorded
The lives of cells, recorded
A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own ge...
Biobanking with genetics shapes precision medicine and global health
Biobanking with genetics shapes precision medicine and global health
Precision medicine provides patients with access to personally tailored treatments based on individual-level data. However...
Plant pattern recognition receptors: from evolutionary insight to engineering
Plant pattern recognition receptors: from evolutionary insight to engineering
The plant immune system relies on germline-encoded pattern recognition receptors (PRRs) that sense foreign and plant-deriv...
Exploring biodiversity through museomics
Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic...
Genetic conflict and its resolution between the sexes
Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic sa...
The design and engineering of synthetic genomes
The design and engineering of synthetic genomes
Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome...
Slide-tags enables spatial single-nucleus sequencing
Slide-tags enables spatial single-nucleus sequencing
In this Tools of the Trade article, Andrew Russell describes Slide-tags, a method for scalable, spatially resolved single-...
Cohesin and CTCF emerge as building blocks of 3D genome structure
In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the gen...
Causal inference for epigenetic ageing
Causal inference for epigenetic ageing
In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelia...
The phenotypic consequences of enhancer evolution
In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes und...
Context-specific regulatory variants in precision medicine and agriculture
Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene e...
How the waxing and waning of a mutation determines HIV treatment success
In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with the...
Functional specificity in biomolecular condensates revealed by genetic complementation
Functional specificity in biomolecular condensates revealed by genetic complementation
Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities...
A brief history of metabolic gradient theory
In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20t...
Ethical governance for genomic data science in the cloud
Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomi...
Systemic cell–cell communication in cancer
In this Journal Club article, Edroaldo Lummertz da Rocha discusses two papers that provided important insights into how tu...
Single-cell expression profiling has its roots in in situ techniques
In this Journal Club, Shila Ghazanfar highlights a seminal paper by Levsky et al. that paved the way for contemporary sing...
Genome-wide association testing beyond SNPs
Genome-wide association testing beyond SNPs
Decades of genetic association testing in human cohorts have provided important insights into the genetic architecture and...
A call to action to scale up research and clinical genomic data sharing
A call to action to scale up research and clinical genomic data sharing
Genomic data from millions of individuals have been generated worldwide to drive discovery and clinical impact in precisio...
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
Since the discovery of RNA splicing and its role in gene expression, researchers have sought a set of rules, an algorithm ...
Endogenous retroviruses: unveiling new targets for cancer immunotherapy
In this Journal Club, Shengbao Suo highlights two publications that underscore the importance of genetic regulation of end...
Inference and applications of ancestral recombination graphs
Inference and applications of ancestral recombination graphs
Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships between individuals represented in ...
Selection on structural variation in the amylase locus
Selection on structural variation in the amylase locus
Bolognini et al. report evidence of positive selection for human amylase gene duplications associated with the agricultura...
The evolution of DNA sequencing with microfluidics
The adoption of microfluidics was fundamental to the development of cost-effective, high-throughput DNA sequencing. As the...
Why geneticists should care about male infertility
The widespread use of medically assisted reproduction fosters the false impression that the underlying causes of male infe...
Gene synthesis from a non-coding RNA
Gene synthesis from a non-coding RNA
A study in Science investigating bacterial defence mechanisms against phages reports a novel mode of gene regulation throu...
Genome-scale models in human metabologenomics
Genome-scale models in human metabologenomics
Metabologenomics integrates metabolomics with other omics data types to comprehensively study the genetic and environmenta...
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