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2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS)
2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS)
Quantification of the morphology of osteocyte lacunae has become a powerful tool to investigate bone metabolism, pathologi...
Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development
Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development
Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important modulator of the adult...
Efferocytosis and Bone Dynamics
Efferocytosis and Bone Dynamics
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and...
Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints
Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints
Recently, photon-counting computed tomography (PCCT) has been introduced in clinical research and diagnostics. This review...
Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss
Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss
Beyond aging, senescent cells accumulate during multiple pathological conditions, including chemotherapy, radiation, gluco...
Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging
Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging
In this review, we discuss the most recent scientific advances on the reciprocal regulatory interactions between the skele...
Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
To illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeleta...
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential
This review aims to provide a theoretical basis and insights for quercetin’s clinical application in the prevention ...
Osteoimmunology of Fracture Healing
Osteoimmunology of Fracture Healing
The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone f...
Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function
Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function
This review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses...
Diagnosing Osteoporosis in Diabetes—A Systematic Review on BMD and Fractures
Diagnosing Osteoporosis in Diabetes—A Systematic Review on BMD and Fractures
Recently, the American Diabetes Association updated the 2024 guidelines for Standards of Care in Diabetes and recommend th...
Osteocytes and Paget’s Disease of Bone
Osteocytes and Paget’s Disease of Bone
To describe the contributions of osteocytes to the lesions in Paget’s disease, which are characterized by locally ov...
Correction: Practical Compass of Single-Cell RNA-Seq Analysis
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-Ku, Toky...
Neutrophils in Inflammatory Bone Diseases
Neutrophils in Inflammatory Bone Diseases
In this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to...
Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health
Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health
The present review will highlight recent reports supporting the relevance of extracellular vesicles to the musculoskeletal...
Fat as a Friend or Foe of the Bone
Fat as a Friend or Foe of the Bone
The objective of this review is to summarize the literature on the prevalence and diagnosis of obesity and its metabolic p...
Interfacial Tissue Regeneration with Bone
Interfacial Tissue Regeneration with Bone
Interfacial tissue exists throughout the body at cartilage-to-bone (osteochondral interface) and tendon-to-bone (enthesis)...
From the Mind to the Spine: The Intersecting World of Alzheimer’s and Osteoporosis
From the Mind to the Spine: The Intersecting World of Alzheimer’s and Osteoporosis
This comprehensive review delves into the intricate interplay between Alzheimer’s disease (AD) and osteoporosis, two...
Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing
Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing
Fractures are a prominent form of traumatic injury and shall continue to be for the foreseeable future. While the inflamma...
Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health
Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health
This review examines the linked pathophysiology of Alzheimer’s disease/related dementia (AD/ADRD) and bone disorders...
Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics
Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics
Musculoskeletal imaging serves a critical role in clinical care and orthopaedic research. Image-based modeling is also gai...
SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence
SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence
SARS-CoV-2 infection, the culprit of the COVID-19 pandemic, has been associated with significant long-term effects on vari...
Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair
Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair
The traditionally understated role of neural regulation in fracture healing is gaining prominence, as recent findings unde...
Role of the Neurologic System in Fracture Healing: An Extensive Review
Role of the Neurologic System in Fracture Healing: An Extensive Review
Despite advances in orthopedics, there remains a need for therapeutics to hasten fracture healing. However, little focus i...
Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis
Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis
This comprehensive review discusses the complex relationship between Alzheimer’s disease (AD) and osteoporosis, two ...
COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions
COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions
SARS-CoV-2 drove the catastrophic global phenomenon of the COVID-19 pandemic resulting in a multitude of systemic health i...
Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer’s Disease and Bone
Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer’s Disease and Bone
This Comment represents three review articles on the relationship between Alzheimer’s disease, osteoporosis, and fra...
The Use of Artificial Intelligence in Writing Scientific Review Articles
The Use of Artificial Intelligence in Writing Scientific Review Articles
With the recent explosion in the use of artificial intelligence (AI) and specifically ChatGPT, we sought to determine whet...
In Vivo Assessment of Bone Quality Without X-rays
In Vivo Assessment of Bone Quality Without X-rays
This review summarizes recent advances in the assessment of bone quality using non-X-ray techniques. Quantitative ultrasou...
The Utility of AI in Writing a Scientific Review Article on the Impacts of COVID-19 on Musculoskeletal Health
The Utility of AI in Writing a Scientific Review Article on the Impacts of COVID-19 on Musculoskeletal Health
There were two primary purposes to our reviews. First, to provide an update to the scientific community about the impacts ...
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