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Exercise to Prevent and Manage Frailty and Fragility Fractures
Exercise to Prevent and Manage Frailty and Fragility Fractures
This review identifies exercise-based recommendations to prevent and manage frailty and fragility fractures from current c...
Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus
Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus
Chromosome region 7q31.31, also known as the CPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim...
SP7: from Bone Development to Skeletal Disease
SP7: from Bone Development to Skeletal Disease
The purpose of this review is to summarize the different roles of the transcription factor SP7 in regulating bone formatio...
Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop
Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop
Herein, we report on the proceedings of the workshop entitled “Post-Genome analysis for musculoskeletal biology̶...
Osteoimmunology in Periodontitis and Orthodontic Tooth Movement
Osteoimmunology in Periodontitis and Orthodontic Tooth Movement
To review the role of the immune cells and their interaction with cells found in gingiva, periodontal ligament, a...
Craniofacial Fibrous Dysplasia: Clinical and Therapeutic Implications
Craniofacial Fibrous Dysplasia: Clinical and Therapeutic Implications
This study aims to review diagnosis, potential complications, and clinical management in craniofacial fibrous dysplasia. F...
Impact of Cinacalcet and Etelcalcetide on Bone Mineral and Cardiovascular Disease in Dialysis Patients
Impact of Cinacalcet and Etelcalcetide on Bone Mineral and Cardiovascular Disease in Dialysis Patients
With chronic kidney disease (CKD) progression, secondary hyperparathyroidism (sHPT) and mineral and bone metabolism diseas...
The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression
The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression
The purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal...
Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes
Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes
There is a growing appreciation within the scientific community that cells exhibit regional variation. Whether the variati...
Using Finite Element Modeling in Bone Mechanoadaptation
Using Finite Element Modeling in Bone Mechanoadaptation
Bone adapts structure and material properties in response to its mechanical environment, a process called mechanoadpatatio...
Copy Number Variation and Osteoporosis
Copy Number Variation and Osteoporosis
The purpose of this review is to summarize recent findings on copy number variations and susceptibility to osteoporosis. O...
Genetics of Intervertebral Disc Degeneration
Genetics of Intervertebral Disc Degeneration
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early o...
Denosumab Discontinuation
Denosumab Discontinuation
To review the pathophysiology, the clinical consequences as well as way of mitigating the effects of denosumab discontinua...
Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging
Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging
Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles tha...
Energy Balance and Bone Health: a Nutrient Availability Perspective
Energy Balance and Bone Health: a Nutrient Availability Perspective
Obesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone...
Osteoporosis and Bone Marrow Adipose Tissue
Osteoporosis and Bone Marrow Adipose Tissue
This review focuses on the recent findings regarding bone marrow adipose tissue (BMAT) concerning bone health. We summariz...
Clinical Assessments of Fracture Healing and Basic Science Correlates: Is There Room for Convergence?
Clinical Assessments of Fracture Healing and Basic Science Correlates: Is There Room for Convergence?
The purpose of this review is to summarize the clinical and basic science methods used to assess fracture healing and prop...
Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?
Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?
Osteocytes directly modify the bone surrounding the expansive lacunar-canalicular system (LCS) through both resorption and...
Disorganization and Musculoskeletal Diseases: Novel Insights into the Enigma of Unexplained Bone Abnormalities and Fragility Fractures
Disorganization and Musculoskeletal Diseases: Novel Insights into the Enigma of Unexplained Bone Abnormalities and Fragility Fractures
Describe the potential contribution of disorganized tissue to the pathogenesis of bone abnormalities and fractures. Especi...
Multicentric Carpotarsal Osteolysis: a Contemporary Perspective on the Unique Skeletal Phenotype
Multicentric Carpotarsal Osteolysis: a Contemporary Perspective on the Unique Skeletal Phenotype
Multicentric carpotarsal osteolysis (MCTO) is an ultra-rare disorder characterized by osteolysis of the carpal and tarsal ...
The Gut-Bone Axis in Diabetes
The Gut-Bone Axis in Diabetes
To describe recent advances in the understanding of how gut-derived hormones regulate bone homeostasis in humans with emph...
Opportunistic Screening Techniques for Analysis of CT Scans
Opportunistic Screening Techniques for Analysis of CT Scans
Opportunistic screening is a combination of techniques to identify subjects of high risk for osteoporotic fracture using r...
The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease
The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease
Bone quality and strength are diminished with age and disease but can be improved by clinical intervention. Energetic path...
Bone Tissue Responsiveness To Mechanical Loading—Possible Long-Term Implications of Swimming on Bone Health and Bone Development
Bone Tissue Responsiveness To Mechanical Loading—Possible Long-Term Implications of Swimming on Bone Health and Bone Development
To revisit the bone tissue mechanotransduction mechanisms behind the bone tissue response to mechanical loading and, withi...
Rethinking the Genetic Etiology of Nonsyndromic Tooth Agenesis
Rethinking the Genetic Etiology of Nonsyndromic Tooth Agenesis
Genetic studies in humans and animal models have improved our understanding of the role of numerous genes in the etiology ...
Fragility Fractures of the Pelvis: Current Practices and Future Directions
Fragility Fractures of the Pelvis: Current Practices and Future Directions
To summarise the current evidence and clinical practices for patients with fragility fractures of the pelvis (FFP). FFPs a...
Glycemic Control and Bone in Diabetes
Glycemic Control and Bone in Diabetes
This review summarizes recent developments on the effects of glycemic control and diabetes on bone health. We discuss the ...
Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation
Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation
Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a nu...
CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple
CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple
The purpose of the review is to summarize the expression and function of CSF1R and its ligands in bone homeostasis and con...
Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography
Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography
Diabetes mellitus is defined by elevated blood glucose levels caused by changes in glucose metabolism and, according to it...
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