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Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review
Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review
Abstract Curcuma longa and its constituents, mainly curcumin, showed various of pharmacological effects in previous studie...
NXNL1 negatively regulates osteoblast differentiation via GDF15‐induced PP2A Cα dependent manner in MC3T3‐E1 cells
NXNL1 negatively regulates osteoblast differentiation via GDF15‐induced PP2A Cα dependent manner in MC3T3‐E1 cells
Abstract Controlling the level of intracellular reactive oxygen species (ROS) is important for the survival and differenti...
Dioscin: A review on pharmacological properties and therapeutic values
Dioscin: A review on pharmacological properties and therapeutic values
Abstract Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical bene...
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway
Abstract Bisphenol A (BPA) has caused serious pathologies in varying organs of humans and animals, especially reproductive...
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application
Abstract We aimed to investigate the target and signal pathway of Smilacis Glabrae Rhixoma (SGR) in the treatment of myast...
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model
Abstract Although the concomitance of nonalcoholic fatty liver disease (NAFLD) and viral hepatitis is soaring, there is no...
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein
Abstract Increasing evidence suggests that hypothyroidism aggravates atherosclerosis. Macrophage apoptosis plays a signifi...
Ginger and its constituents: Role in treatment of inflammatory bowel disease
Ginger and its constituents: Role in treatment of inflammatory bowel disease
Abstract Inflammatory bowel diseases (IBD), with obscure etiology, are rising and are of worldwide concern. Of the various...
LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer
LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer
Abstract Long noncoding RNAs (lncRNAs) appear as vital regulators and biomarkers in many human cancers. LOC100507144 is a ...
Issue Highlights
Issue Highlights
BioFactors is an international journal aimed at identifying and increasing our understanding of the precise biochemical ef...
Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation
Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation
Abstract Intensive care unit patients and chronic airway inflammatory disease are characterized by chronic systemic hypoxi...
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation
Abstract Growth hormone (GH) exhibited the important biological activities in the mesenchymal stem cell (MSCs). However, t...
Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma
Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma
Abstract Melatonin (Mel.), also known as the magic hormone, is a nocturnally secreted hormone orchestrates the clearance o...
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro
Abstract The most widespread and challenging aggressive malignant tumor in the brain is glioblastoma multiforme (GBM). GBM...
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK‐3β/β‐catenin pathway
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK‐3β/β‐catenin pathway
Abstract Kinesin family member 18B (KIF18B) is a new tumor-associated protein that contributes to the carcinogenesis of mu...
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers
Abstract Endoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis of asthma. The present study aimed to ...
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis
Abstract Although the specific expression of long noncoding RNA (lncRNA) in mastitis tissue has been reported, few studies...
Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497
Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497
Abstract Noncoding RNAs (ncRNAs) such as microRNAs (miRNAs), long noncoding RNAs (lncRNA), and circular RNAs are closely r...
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)
Abstract Teucrium polium has been used in traditional medicine as antifungal, antipyretic, antispasmodic, and antibacteria...
Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice
Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice
Abstract Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that represents a link between diet-i...
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat
Abstract This study investigated the effects of omega-3 oils (OM) and/or vitamin D3 (VD) against metabolic dysfunction-ass...
Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus
Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus
Abstract Peripheral artery disease (PAD) is an atherosclerotic disorder affecting arteries of the lower limbs, the major r...
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE study
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE study
Abstract Inflammation is a component of the pathogenesis of atherosclerosis and is associated with an increased risk of at...
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer
Abstract Anticancer drugs are not purely effective because of their toxicity, side effects, high cost, inaccessibility, an...
Celastrol attenuates high‐fructose diet‐induced inflammation and insulin resistance via inhibition of 11β‐hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues
Celastrol attenuates high‐fructose diet‐induced inflammation and insulin resistance via inhibition of 11β‐hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues
Abstract High fructose consumption has been linked to low-grade inflammation and insulin resistance that results in increa...
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes
Abstract Alcohol abuse reduces hepatic vitamin A (retinoids), reductions that are associated with progression of alcohol l...
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action
Abstract Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disrupt...
Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction
Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction
Abstract Mulberry (Morus australis Poir.) leaves have long been consumed in the form of tea or tincture especially in Asia...
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1
Abstract The emerging role of FERM domain-containing protein 6 (FRMD6) in cancer progression has been revealed in several ...
Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components
Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components
Abstract Gut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of t...
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