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Ring Finger Protein 215 Negatively Regulates Type I IFN Production via Blocking NF-{kappa}B p65 Activation [INNATE IMMUNITY AND INFLAMMATION]
Ring Finger Protein 215 Negatively Regulates Type I IFN Production via Blocking NF-{kappa}B p65 Activation [INNATE IMMUNITY AND INFLAMMATION]
Key PointsRNF215 is upregulated by viral infection in human macrophages.RNF215 inhibits the production of IFN-β via blocki...
Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination [CLINICAL AND HUMAN IMMUNOLOGY]
Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination [CLINICAL AND HUMAN IMMUNOLOGY]
Key PointsCMV-seropositive older adults have more EMRA and terminally differentiated T cells.CMV seropositivity does not p...
TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a [INNATE IMMUNITY AND INFLAMMATION]
TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a [INNATE IMMUNITY AND INFLAMMATION]
Key PointsTRIM21 regulates virus-induced pyroptosis.ISG12a is required for TRIM21-mediated pyroptosis.TRIM21 promotes ISG1...
B Cells Drive MHC Class I-Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity [AUTOIMMUNITY]
B Cells Drive MHC Class I-Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity [AUTOIMMUNITY]
Key PointsCD4 T cells cause spontaneous EAE using an MHC class I–restricted MBP-specific TCR.Spontaneous disease is depend...
Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice [INFECTIOUS DISEASE AND HOST RESPONSE]
Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice [INFECTIOUS DISEASE AND HOST RESPONSE]
AbstractAspergillus fumigatus is an important opportunistic fungal pathogen and causes invasive pulmonary aspergillosis in...
{gamma}{delta} TCRs Function as Innate-like Receptors in the Bovine {gamma}{delta} T Cell Response against Leptospira [ANTIGEN RECOGNITION AND RESPONSES]
{gamma}{delta} TCRs Function as Innate-like Receptors in the Bovine {gamma}{delta} T Cell Response against Leptospira [ANTIGEN RECOGNITION AND RESPONSES]
Key PointsThis is the first description, to our knowledge, of bovine γδ TCR repertoires using the NGS approach.In the bovi...
E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency [IMMUNOTHERAPY AND VACCINES]
E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency [IMMUNOTHERAPY AND VACCINES]
Key PointsWT and TLR4-SNP mice respond comparably to T-dependent and -independent Ags alone.TLR4-SNP mice exhibit reduced ...
The Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions [BRIEF REVIEWS]
The Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions [BRIEF REVIEWS]
AbstractThe fruit fly Drosophila melanogaster Toll signaling pathway has an evolutionarily conserved role in controlling i...
Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors [CUTTING EDGE]
Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors [CUTTING EDGE]
Key PointsMonocytes have impaired antifungal effector function in neutropenic mice.STAT1 expression on CCR2+ monocytes is ...
Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8+ T Cells in the Face of Pre-Existing Humoral Immunity [CUTTING EDGE]
Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8+ T Cells in the Face of Pre-Existing Humoral Immunity [CUTTING EDGE]
Key PointsInfluenza-reactive Abs block CD8+ T cell responses to an LAIV.High-dose LAIV immunization overcomes Ab-mediated ...
Histamine-Releasing Factor Is a Novel Alarmin Induced by House Dust Mite Allergen, Cytokines, and Cell Death [ALLERGY AND OTHER HYPERSENSITIVITIES]
Histamine-Releasing Factor Is a Novel Alarmin Induced by House Dust Mite Allergen, Cytokines, and Cell Death [ALLERGY AND OTHER HYPERSENSITIVITIES]
Key PointsHRF secretion is enhanced by cytokines, HDM allergens, ATP, and adenosine.Several HDM allergens enhance HRF secr...
{beta}-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells [ALLERGY AND OTHER HYPERSENSITIVITIES]
{beta}-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells [ALLERGY AND OTHER HYPERSENSITIVITIES]
Key Pointsβ-Glucosylceramides increased development of CD11b+CD11c+ dendritic cells via PKC.Tocopherol isoforms modified t...
Transcriptional Profiling of Phagocytic Leukocytes and Microglia Reveals a Critical Role for Reactive Oxygen Species in Biofilm Containment during Staphylococcus aureus Craniotomy Infection [INFECTIOUS DISEASE AND HOST RESPONSE]
Transcriptional Profiling of Phagocytic Leukocytes and Microglia Reveals a Critical Role for Reactive Oxygen Species in Biofilm Containment during Staphylococcus aureus Craniotomy Infection [INFECTIOUS DISEASE AND HOST RESPONSE]
Key PointsTissue microenvironment influences microglial and leukocyte phagocytosis.Phagocytic versus nonphagocytic cells e...
Mechanisms of Corticosteroid Resistance in Type 17 Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]
Mechanisms of Corticosteroid Resistance in Type 17 Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]
Key PointsBlood LCN2 and SAA levels may be associated with a type 17 asthma subtype.LCN2 and SAAs are steroid-resistant IL...
An AhR-Caspase Axis Mediated Antiviral Apoptosis in an Arthropod [INNATE IMMUNITY AND INFLAMMATION]
An AhR-Caspase Axis Mediated Antiviral Apoptosis in an Arthropod [INNATE IMMUNITY AND INFLAMMATION]
Key PointsA homolog of the AhR family named LvAhR was cloned and identified from L. vannamei.Caspases are novel target gen...
Monocyte/Macrophage Heterogeneity during Skin Wound Healing in Mice [INNATE IMMUNITY AND INFLAMMATION]
Monocyte/Macrophage Heterogeneity during Skin Wound Healing in Mice [INNATE IMMUNITY AND INFLAMMATION]
Key PointsMos/Mϕs exhibit complex and dynamic heterogeneity during skin wound healing.Mos/Mϕs transit from proinflammatory...
Correction: Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness [CORRECTIONS]
Correction: Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness [CORRECTIONS]
Jiang, W., J. Le, P.-y. Wang, X. Cheng, M. Smelkinson, W. Dong, C. Yang, Y. Chu, P. M. Hwang, R. S. Munford, and M. Lu. 20...
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Key PointsHigh surface expression of IgM protects against apoptosis in human GC B cells.CD79A/B depletion resulted in loss...
IL-7 Receptor Drives Early T Lineage Progenitor Expansion [IMMUNE SYSTEM DEVELOPMENT]
IL-7 Receptor Drives Early T Lineage Progenitor Expansion [IMMUNE SYSTEM DEVELOPMENT]
Key PointsIL-7R–deficient ETPs have defects in cell cycle and survival.The most immature Flt3+ ETPs are enriched in IL-7R–...
Therapeutic Opportunities for Immunoreceptor-Engineered T Cell Therapy for Modulation of Alloimmunity [TRANSLATING IMMUNOLOGY]
Therapeutic Opportunities for Immunoreceptor-Engineered T Cell Therapy for Modulation of Alloimmunity [TRANSLATING IMMUNOLOGY]
AbstractAchieving immunosuppression-free immune tolerance to an allograft is one of the central goals of transplantation. ...
Correction: Maternal Monocytes Respond to Cell-Free Fetal DNA and Initiate Key Processes of Human Parturition [CORRECTIONS]
Correction: Maternal Monocytes Respond to Cell-Free Fetal DNA and Initiate Key Processes of Human Parturition [CORRECTIONS]
Kazemi, N.Y., B. Fedyshyn, S. Sutor, Y. Fedyshyn, S. Markovic, and E.A.L. Enninga. 2022. Maternal monocytes respond to cel...
Sharks Provide Evidence for a Highly Complex TNFSF Repertoire in the Jawed Vertebrate Ancestor [IMMUNOGENETICS]
Sharks Provide Evidence for a Highly Complex TNFSF Repertoire in the Jawed Vertebrate Ancestor [IMMUNOGENETICS]
Key PointsShark genomes harbor more TNFSF genes than any other vertebrate examined to date.Most human TNFSFs had already d...
Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-{alpha} during Acute and Chronic Lung Allograft Rejection [TRANSPLANTATION]
Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-{alpha} during Acute and Chronic Lung Allograft Rejection [TRANSPLANTATION]
Key PointsFBXO3/FBXL2 balance is significantly increased during lung allograft rejection.TNF-α negatively regulates FBXL2 ...
Pre-Germinal Center Interactions with T Cells Are Natural Checkpoints to Limit Autoimmune B Cell Responses [IMMUNE REGULATION]
Pre-Germinal Center Interactions with T Cells Are Natural Checkpoints to Limit Autoimmune B Cell Responses [IMMUNE REGULATION]
Key PointsInteractions between myelin Ag-specific T and B cells are of low quality.Autoimmune B cells express low levels o...
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells [MUCOSAL IMMUNOLOGY]
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells [MUCOSAL IMMUNOLOGY]
AbstractLung tissue-resident memory T cells are crucial mediators of cellular immunity against respiratory viruses; howeve...
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality [BRIEF REVIEWS]
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality [BRIEF REVIEWS]
AbstractInnate immunity is the first response to protect against pathogens and cellular insults. Pattern recognition recep...
Calpains Released from Necrotic Tumor Cells Enhance Antigen Cross-Presentation to Activate CD8+ T Cells In Vitro [ANTIGEN RECOGNITION AND RESPONSES]
Calpains Released from Necrotic Tumor Cells Enhance Antigen Cross-Presentation to Activate CD8+ T Cells In Vitro [ANTIGEN RECOGNITION AND RESPONSES]
Key PointsSevere heat shock enhances the immunogenicity of necrotic tumor cells.Severe heat shock promotes cross-presentat...
Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors [ANTIGEN RECOGNITION AND RESPONSES]
Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors [ANTIGEN RECOGNITION AND RESPONSES]
Key PointsA pair of public TCRs was identified from White and Japanese patients with HIV.The public TCRs can recognize bot...
Polarization and {beta}-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues [CLINICAL AND HUMAN IMMUNOLOGY]
Polarization and {beta}-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues [CLINICAL AND HUMAN IMMUNOLOGY]
Key PointsEnhanced tryptophan catabolism with blocked NAD+ and UTP synthesis was seen in M1-Mϕs.WGPs increased glucose uti...
Enhanced IFN Sensing by Aggressive Chronic Lymphocytic Leukemia Cells [CLINICAL AND HUMAN IMMUNOLOGY]
Enhanced IFN Sensing by Aggressive Chronic Lymphocytic Leukemia Cells [CLINICAL AND HUMAN IMMUNOLOGY]
Visual AbstractAbstractType I IFN is made by cells in response to stress. Cancer cells exist in a state of stress, but the...
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