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Correction: Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine [CORRECTIONS]
Correction: Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine [CORRECTIONS]
Sinkora, M., J. Sinkorova, and K. Stepanova. 2017. Ig light chain precedes heavy chain gene rearrangement during developme...
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]
Key PointsLnc57Rik can be induced by tumor-associated factors.Lnc57Rik promotes the immunosuppressive function of MDSCs.Ln...
Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing [IMMUNE SYSTEM DEVELOPMENT]
Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing [IMMUNE SYSTEM DEVELOPMENT]
Key PointsTregs develop via distinct agonist and postagonist stages.CD25+ TregP agonist cells are a main source of IL2 nee...
Unique Cell Subpopulations and Disease Progression Markers in Canines with Atopic Dermatitis [SYSTEMS IMMUNOLOGY]
Unique Cell Subpopulations and Disease Progression Markers in Canines with Atopic Dermatitis [SYSTEMS IMMUNOLOGY]
AbstractAtopic dermatitis (AD) is a common pruritic inflammatory skin disease with unclear molecular and cellular contribu...
STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells [IMMUNE REGULATION]
STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells [IMMUNE REGULATION]
Key PointsRNA-seq profiling delineates cDC1 responses to extracellular stimuli.Poly(I:C) activates autocrine IFN-I signali...
Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis [INNATE IMMUNITY AND INFLAMMATION]
Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis [INNATE IMMUNITY AND INFLAMMATION]
Key PointsLigature-induced periodontitis activates complement in a microbiota-dependent manner.Complement C3 deficiency in...
The Heart of the Machine: Construction of T Cell Identity, Made Accessible [PILLARS OF IMMUNOLOGY]
The Heart of the Machine: Construction of T Cell Identity, Made Accessible [PILLARS OF IMMUNOLOGY]
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Cutting Edge: The Expression of Transcription Inhibitor GFI1 Is Induced by Retinoic Acid to Rein in Th9 Polarization [CUTTING EDGE]
Cutting Edge: The Expression of Transcription Inhibitor GFI1 Is Induced by Retinoic Acid to Rein in Th9 Polarization [CUTTING EDGE]
Visual AbstractAbstractIL-9, produced mainly by specialized T cells, mast cells, and group 2 innate lymphoid cells, regula...
CBLB Deficiency in Human CD4+ T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms [AUTOIMMUNITY]
CBLB Deficiency in Human CD4+ T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms [AUTOIMMUNITY]
Visual AbstractAbstractCbl-b is a negative regulator of T cell activation, and in murine models, a lack of Cblb results in...
MCP-Induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance [INNATE IMMUNITY AND INFLAMMATION]
MCP-Induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance [INNATE IMMUNITY AND INFLAMMATION]
Key PointsMyeloid MCPIP1 controls the endotoxin tolerance.MCPIP1 ensures the tolerance to LPS via restriction of the NF-κB...
Migrating Type 2 Dendritic Cells Prime Mucosal Th17 Cells Specific to Small Intestinal Commensal Bacteria [MUCOSAL IMMUNOLOGY]
Migrating Type 2 Dendritic Cells Prime Mucosal Th17 Cells Specific to Small Intestinal Commensal Bacteria [MUCOSAL IMMUNOLOGY]
Key PointsThe gut Th17 response is type 2 DC driven.IL-6 is required for Th17 differentiation but does not act directly on...
A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation [IMMUNE SYSTEM DEVELOPMENT]
A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation [IMMUNE SYSTEM DEVELOPMENT]
AbstractIn response to an intracellular infectious agent, the immune system produces a specific cellular response as well ...
CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways [IMMUNE REGULATION]
CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways [IMMUNE REGULATION]
Key PointsCD8+ TEMRA cells respond better to IL-15 than do CD8+ TEM cells.CD5 negatively regulates IL-15–induced prolifera...
TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages [INNATE IMMUNITY AND INFLAMMATION]
TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages [INNATE IMMUNITY AND INFLAMMATION]
Key PointsFasL-treated macrophages display proteolytic cleavage of the gasdermin family.TAK1 functions as a negative regul...
Systemic Activation of Neutrophils by Immune Complexes Is Critical to IgA Vasculitis [CLINICAL AND HUMAN IMMUNOLOGY]
Systemic Activation of Neutrophils by Immune Complexes Is Critical to IgA Vasculitis [CLINICAL AND HUMAN IMMUNOLOGY]
Key PointsPerivascular deposition of IgA is not the only major trigger in IgA vasculitis.Perivascular deposition needs to ...
RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response [IMMUNE REGULATION]
RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response [IMMUNE REGULATION]
Key PointsADAR1 p150 but not the p110 isoform controls the GC response.ADAR1 regulates the GC response partially through t...