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miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19
miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19
MicroRNAs (miRNAs) are gene regulators essential for cell homeostasis, their alteration is related to a pathological state...
Recanalization is more important than procedure time on outcome of thrombectomy in acute vertebrobasilar artery occlusion
Recanalization is more important than procedure time on outcome of thrombectomy in acute vertebrobasilar artery occlusion
Longer procedure time (PT) predicts worse prognosis after endovascular treatment (EVT) in acute vertebrobasilar artery occ...
Management of thrombocytopenia and anticoagulant therapy in patients with hematological malignancy on chemotherapy: a binational prospective study (TAT study)
Management of thrombocytopenia and anticoagulant therapy in patients with hematological malignancy on chemotherapy: a binational prospective study (TAT study)
Anticoagulant use in patients with hematological malignancies treated on intensive chemotherapy represents a management ch...
Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence
Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence
Aspergillus fumigatus, the primary etiological agent of invasive aspergillosis, causes over 1.8 million deaths annually. T...
Multi-cascade signal amplification and structure modulation strategy for highly sensitive and selective detection of cysteine using bovine serum albumin-stabilized gold nanoflowers as signal mediator
Cysteine (Cys), as one of the most important biological thiol molecules, is a crucial structural and functional component ...
Effect of polysaccharides and saponins from Polygonatum kingianum against uranium-induced renal injury in rats
Uranium possesses numerous utilitarian applications, particularly within the energy sector. The most prevalent application...
Exploring cellulose-derived esters/curcumin materials: Synthesis, characterization, and biological assay in zebrafish model
Polymer scaffolds for tissue engineering with three-dimensional structures can offer a favorable environment for cell grow...
Curcumin@ graphene oxide/chitosan/arginine hydrogel: A novel approach to treat Candida periprosthetic joint infections
Prosthetic joint infection (PJI) is a significant complication following arthroplasty, occurring in 1 % to 2 % of procedur...
Mechanistic insights into starch behavior and starch-protein interactions in whole grain oat flour: Structural and functional modifications by steam explosion treatment
Whole grain oats have garnered global attention due to their exceptional nutritional profile and health benefits, which in...
Chitooligosaccharide enhances plant resistance to P. nicotianae via sugar homeostasis and microorganism assembly
Black shank disease (BSD), caused by Phytophthora nicotianae, is a critical and destructive soil-borne disease affecting t...
High strength kami-ito yarns from microbial cellulose biofilms
The textile industry is driven to reduce its environmental impact, particularly regarding the production of polyester and ...
A renewable thermochromic phase change material encapsulated within a wood-based cellulose/sodium methylsilicate framework
Thermochromic phase change materials (TCs) exhibit reversible color changes within specific temperature ranges and absorb ...
Expandable konjac fiber modulates appetite and chyme digestion in vivo by stomach-intestine-brain axis
The body's sensory, physiological, and metabolic networks delicately manipulate food intake to maintain energy homeostasis...
Carboxybetaine modified chitosan as viscosupplementation for osteoarthritis therapy
Over the past few decades, osteoarthritis (OA) has experienced a global surge in morbidity, characterized by symptoms such...
Design and development of drug delivery nanocarriers based on liquid-liquid phase separation, improved stability, cell-penetration and anti-cancer effect
Cancer is a major societal, public health, and economic problem in the 21st century, responsible for 16.8 % and 22.8 % fro...
High-solids gel properties of acid-hydrolyzed waxy maize starch are determined by the molecular-weight distribution
To make starch suitable for food and non-food applications, it is typically modified using chemical, enzymatic, and physic...
Rational design of DAHP synthase and prephenate dehydrogenase for metabolic engineering of Bacillus amyloliquefaciens to produce L-tyrosine
L-tyrosine is an indispensable amino acid for human nutrition [[1], [2], [3]]. It has widespread applications in various f...
IRE1α-mediated UPR activation in gastrointestinal cancers: adaptive mechanisms and therapeutic potential
Gastrointestinal cancer (GC) is one of the most prevalent digestive malignancies, marked by high mortality, late detection...
Corrigendum to “Benchmarking R&D success rates of leading pharmaceutical companies: an empirical analysis of FDA approvals (2006–2022)” [Drug Discov. Today 30(2) (2025) 104291]
Available online 15 March 2025, 104326Author links open overlay panelAlexander Schuhmacher 1 2, Markus Hinder 3 6, Elazar ...
2024 in Review: FDA Approval of New Medicines
Michael S Kinch is Chief Innovation Officer Stony Brook University (SBU), where he researches the sources of innovation in...
Enhancing clinical trial outcome prediction with artificial intelligence: a systematic review
The development of modern molecular biology disciplines, such as genomics, proteomics, and bioinformatics, has brought gre...
Medicare austerity reforms and patient out-of-pocket costs: The experience from Australian cancer patients
Volume 155, May 2025, 105296Author links open overlay panel, , , Highlights•We investigate costs following policy changes ...
Phylogenetic Insights of a Human-Derived optrA-Positive Staphylococcus aureus Isolated from a Person with Chronic Diarrhea in China
Available online 15 March 2025, 107493Author links open overlay panel, , , , , , Section snippetsEthical ApprovaEthical pe...
In vitro and in vivo assessment of diosmetin-loaded lactoferrin-modified liposomes for brain delivery in intracerebral hemorrhage therapy
In vitro and in vivo assessment of diosmetin-loaded lactoferrin-modified liposomes for brain delivery in intracerebral hemorrhage therapy
Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high morbidity, mortality, and disability rates, ...
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Since cell dying in heart failure (HF) may vary based on the aetiology, we examined the main forms of regulated necrosis, ...
The opioid epidemic in rural communities: Can telehealth increase access to medications for opioid use disorder and offset barriers to care?
Volume 271, 1 June 2025, 112628Author links open overlay panel, , , , , Highlights•Rural consortia reduced the number of c...
Polypharmacology: new drugs in 2023–2024
Polypharmacology: new drugs in 2023–2024
Polypharmacology is an emerging approach to drug design and development that involves the use of multi-target-directed lig...
A cohort of highly activated CD99− CD72+ B cells promoting autoimmune progression in juvenile systemic lupus erythematosus
Inhibiting the deposition of self-antigen-antibody complexes in various tissues is crucial for the health and survival of ...
Exploring the revolutionary potential of MXene nanoparticles in breast Cancer therapy: A review of applications and future prospects
Breast cancer (BC) is the most prevalent malignant tumor found in females and one of the most common cancers overall. It a...
MALAT1 promotes microglia activation and neuronal apoptosis through via the miR-124-3p/ SGK1 axis mediating experimental autoimmune encephalomyelitis disease progression in mice
Multiple sclerosis (MS) is a debilitating chronic condition marked by demyelination in the central nervous system. The dis...
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