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Novel diazepine-carbamate derivatives as dual-acting butyrylcholinesterase inhibitors and antioxidants for Alzheimer’s disease
Novel diazepine-carbamate derivatives as dual-acting butyrylcholinesterase inhibitors and antioxidants for Alzheimer’s disease
Cholinergic neuron damage and oxidative stress are prominent hypotheses explaining the pathogenesis of Alzheimer’s d...
Peptide-Tetrahydroisoquinoline (THIQ) Conjugated Derivatives as Dual-Targeting Therapeutics: Superior VEGFR-2 Inhibition and Antioxidant Activity against Renal Cell Carcinoma
Peptide-Tetrahydroisoquinoline (THIQ) Conjugated Derivatives as Dual-Targeting Therapeutics: Superior VEGFR-2 Inhibition and Antioxidant Activity against Renal Cell Carcinoma
Renal cell carcinoma (RCC) represents a therapeutic challenge due to aberrant angiogenesis and oxidative stress pathways, ...
Monocyte-derived macrophages support alveolar regeneration via oncostatin M post-H1N1 infection during the recovery phase
Monocyte-derived macrophages support alveolar regeneration via oncostatin M post-H1N1 infection during the recovery phase
Severe influenza virus infection often triggers acute lung injury, and the efficacy of respiratory functional recovery cri...
Cannabis use disorder risks among Medicaid enrollees with comorbid psychiatric illnesses: 2012–2021
The prevalence of cannabis use disorder (CUD) has steadily risen among the U.S. population since the 2010s, especially amo...
Longitudinal trajectories of binge and heavy drinking pattern among World Trade Center Health Registry enrollees, 2006–2021: A dual trajectory modeling approach
Volume 276, 1 November 2025, 112912Author links open overlay panel, , , , Highlights•9/11-exposed population had higher bi...
The 10 Commandments for Successful Trapeziometacarpal Total Joint Arthroplasty
Available online 9 October 2025, 102290Author links open overlay panelAbstractTrapeziometacarpal total joint replacement w...
The sensory comfort — a neglected priority in hand rehabilitation
Available online 10 October 2025, 102272Author links open overlay panelAnne-Lise Garel a, Louis Tremblais a, Julien Mellad...
Muenster orthosis: clinical benefits and indications
Available online 10 October 2025, 102273Author links open overlay panelSylvain Celerier a, Ruben Dukan b, Frédéric Degez c...
Association of Monocyte-to-Lymphocyte Ratio with Coronary Endothelial Dysfunction and Cardiovascular Events in Patients with Angina and Nonobstructive Coronary Artery Disease
Coronary artery disease (CAD) remains the leading cause of global mortality despite advancements in prevention, diagnosis,...
Green technology for glycemic control: developing rice starch-red rice bran polyphenol complexes through ultrasonication and freeze–thaw treatment
Zero–waste utilization is increasingly recognized as essential for sustainable food systems, with a strong focus on repurp...
Microwave-assisted diol DES system enables efficient biomass fractionation and lignin grafting stabilization from peanut shells via a lignin-first strategy
Lignocellulosic biomass represents an abundant, renewable, and carbon-neutral resource, serving as a crucial feedstock for...
Modifying a loop region in ene-reductase to boost catalytic activity
In recent years, the role of loop dynamics in enzyme properties and functions has garnered much attention [1]. As the most...
Sustainable vegetable tanning: Ultrasound-assisted tannin extraction of oak bark and analytical approaches to collagen–tannin interactions
The global leather industry faces an urgent environmental and health crisis due to widespread chrome tanning, which accoun...
Integrative multi-omics analysis and experimental validation reveal centromere protein W as a potential therapeutic target and predictive biomarker in renal clear cell carcinoma
Renal cell carcinoma (RCC) is a genitourinary malignancy that poses a significant threat to global health. It is primarily...
Diagnostic Features and Prescription Rules of Influenza-Like Illnesses in Traditional Chinese Medicine: A Data Mining Approach
Diagnostic Features and Prescription Rules of Influenza-Like Illnesses in Traditional Chinese Medicine: A Data Mining Approach
Data mining techniques that analyze ILI-related Traditional Chinese prescriptions, & describe diagnostic features, pre...
Brief communication: demographic disparities and modes of transmission of HIV in Mizoram, Northeast India
Brief communication: demographic disparities and modes of transmission of HIV in Mizoram, Northeast India
This study examines the prevalence of Human immunodeficiency virus (HIV) in Mizoram, Northeast India, with a focus on age-...
Exploring barriers to PMTCT: perceptions of HIV-positive pregnant women in western Kenya
Exploring barriers to PMTCT: perceptions of HIV-positive pregnant women in western Kenya
Kenya is among the six high-burden HIV/AIDS countries in Africa, with approximately 1.3 million people living with HIV as ...
Correction: Age-specific associations between Perand polyfluoroalkyl substances exposure and metabolic syndrome: a cross-sectional study
Correction: Age-specific associations between Perand polyfluoroalkyl substances exposure and metabolic syndrome: a cross-sectional study
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Age at diabetes diagnosis and fracture risk in women: a cohort study from the Australian Longitudinal Study on Women’s Health
Age at diabetes diagnosis and fracture risk in women: a cohort study from the Australian Longitudinal Study on Women’s Health
Diabetes increases fracture risk, but whether this risk varies by age at diagnosis is unclear. In a large cohort of Austra...
ROMosozumab early experience in female patients with severe osteoporosis in an Italian real-world setting, the ROMEO study
ROMosozumab early experience in female patients with severe osteoporosis in an Italian real-world setting, the ROMEO study
The impact of romosozumab on the bone mineral density surrogate threshold effect (BMD-STE) in postmenopausal women with se...
Bridging the knowledge gap in rare bone disorders: insights from the APCO Asia-Pacific Rare Bone Disorders Engagement (ASPIRE) survey
Bridging the knowledge gap in rare bone disorders: insights from the APCO Asia-Pacific Rare Bone Disorders Engagement (ASPIRE) survey
This first-of-its-kind survey reveals deep gaps in awareness, diagnostic confidence, and access to resources for rare bone...
Arsenic trioxide enhances the inhibitory effect of lenvatinib on hepatocellular carcinoma through HMOX1-mediated ferroptosis
Globally, hepatocellular carcinoma (HCC) is the fifth most common neoplasm and the third leading cause of cancer-related m...
Phellodendrine alleviates acute pancreatitis by inhibiting p38 MAPK-p47phox pathway-mediated neutrophil extracellular traps formation and ROS production
Acute pancreatitis (AP) represents a predominant cause of hospitalization related to digestive system disorders, marked by...
Panobinostat suppresses cGAS-STING pathway activation and ameliorates DSS-induced colitis in mice
Inflammatory bowel disease (IBD) represents a chronic, nonspecific inflammatory condition of the gastrointestinal tract wi...
2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide alleviates idiopathic pulmonary fibrosis through activation of LGALS3-mediated AGE-RAGE signaling pathway
Idiopathic pulmonary fibrosis (IPF), representing one of the most aggressive types of pulmonary fibrosis (PF), is characte...
Non-lethal sonodynamic therapy-engineered foam cell exosomes reprograms endothelial immunometabolic crosstalk to stabilize atherosclerotic plaques
Cardiovascular diseases (CVDs) remain the primary contributor to global mortality [1]. Atherosclerosis (AS), the most prev...
Pathogenesis of osteoarthritis and treatment with traditional Chinese medicine: New perspectives on platelet aggregation
Osteoarthritis (OA) is a common joint disease affecting more than 500 million people worldwide, with a prevalence rate of ...
Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation
Postoperative Cognitive Dysfunction (POCD), a condition also encompassed by the broader term ‘Postoperative Neurocognitive...
Gut microbiota as a central mediator in hydrogen gas–induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon characterized by persistent mucosal infla...
GPRC5A+ myCAFs promote ESCC progression via TGF-β-induced fibroblast activation and ANXA1-mediated M2 macrophage polarization
Esophageal cancer is one of the most aggressive malignancies globally, with a poor clinical prognosis. According to the la...
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