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Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk
Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk
Human milk is a remarkable biofluid that provides essential nutrients and immune protection to newborns. Breastfeeding wom...
The Effect of Various Degrees of Renal or Hepatic Impairment on the Pharmacokinetic Properties of Once-Weekly Insulin Icodec
The Effect of Various Degrees of Renal or Hepatic Impairment on the Pharmacokinetic Properties of Once-Weekly Insulin Icodec
Icodec is a once-weekly insulin being developed to provide basal insulin coverage in diabetes mellitus. This stud...
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
The establishment of optimal dosing regimens for intravenous (IV) lidocaine in the perioperative setting, aiming to balanc...
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model
Vosoritide is a recently approved therapy for achondroplasia, the most common form of disproportionate short stature, that...
Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Milrinone is an inotrope and vasodilator used for prophylaxis or treatment of low cardiac output syndrome after weaning fr...
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
Although little information is available on the pharmacokinetics (PK) of monoclonal antibodies (mAbs) during pregnancy, mu...
Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature
Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature
Drug dosing should ideally be based on the drug concentrations at the target site, which, for most drugs, corresponds to t...
Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole
Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole
Posaconazole is a pharmacotherapeutic pillar for prophylaxis and treatment of invasive fungal diseases. Dose individualiza...
Population Pharmacodynamic Dose–Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate
Population Pharmacodynamic Dose–Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate
Sodium zirconium cyclosilicate (SZC) is an approved oral treatment for hyperkalemia that selectively binds potass...
Performance of Eight Infliximab Population Pharmacokinetic Models in a Cohort of Dutch Children with Inflammatory Bowel Disease
Performance of Eight Infliximab Population Pharmacokinetic Models in a Cohort of Dutch Children with Inflammatory Bowel Disease
Efficacy of infliximab in children with inflammatory bowel disease can be enhanced when serum concentrations are measured ...
Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning
Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning
Ganciclovir (GCV) and valganciclovir (VGCV) show large interindividual pharmacokinetic variability, particularly in childr...
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respirato...
Toward Genetic Testing of Rivaroxaban? Insights from a Systematic Review on the Role of Genetic Polymorphism in Rivaroxaban Therapy
Toward Genetic Testing of Rivaroxaban? Insights from a Systematic Review on the Role of Genetic Polymorphism in Rivaroxaban Therapy
Investigations into the rivaroxaban response from the perspective of genetic variation have been relatively recent and wid...
Dosing of Convalescent Plasma and Hyperimmune Anti-SARS-CoV-2 Immunoglobulins: A Phase I/II Dose-Finding Study
Dosing of Convalescent Plasma and Hyperimmune Anti-SARS-CoV-2 Immunoglobulins: A Phase I/II Dose-Finding Study
During the COVID-19 pandemic, trials on convalescent plasma (ConvP) were performed without preceding dose-finding studies....
Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates
Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates
Pharmacokinetic models can inform drug dosing of vancomycin in neonates to optimize therapy. However, the model selected n...
A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects
A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects
l-Glutamine is a treatment for children and adults with sickle cell disease. A comprehensive evaluation of the pharmacokin...
Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy
Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy
A major breakthrough in cystic fibrosis (CF) therapy was achievedAQ1 with CFTR modulators. The lumacaftor/ivacaftor combin...
Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Moderate-to-Severe Psoriasis
Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Moderate-to-Severe Psoriasis
Psoriasis is a common inflammatory immune disorder due to chronic activation of the adaptive and innate immune responses. ...
Maternal Ezetimibe Concentrations Measured in Breast Milk and Its Use in Breastfeeding Infant Exposure Predictions
Maternal Ezetimibe Concentrations Measured in Breast Milk and Its Use in Breastfeeding Infant Exposure Predictions
Lactating mothers taking ezetimibe, an antihyperlipidemic agent, may be hesitant to breastfeed despite the known benefit o...