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Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
Knowledge about exposure to cannabidiol (CBD) in breastfed infants can provide an improved understanding of potential risk...
Multivariate Exact Discrepancy: A New Tool for PK/PD Model Evaluation
Multivariate Exact Discrepancy: A New Tool for PK/PD Model Evaluation
Pharmacokinetic models are evaluated using three types of metrics: those based on estimating the typical pharmacokinetic p...
Imeglimin: A Clinical Pharmacology Review
Imeglimin: A Clinical Pharmacology Review
Imeglimin (PXL008, EMD-387008, Twymeeg®) is a first-in-class novel oral hypoglycemic agent, launched in Japan, for th...
Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes
Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes
This study aimed to assess the pharmacokinetics of henagliflozin in dialysis patients with diabetes. In this prospective, ...
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1
Side effects of irinotecan treatment can be dose limiting and may impair quality of life. In this study, we investigated t...
Assessing QTc Effects of Vericiguat Using Two Different Concentration-QTc Modeling Approaches
Assessing QTc Effects of Vericiguat Using Two Different Concentration-QTc Modeling Approaches
Vericiguat is a soluble guanylate cyclase stimulator indicated to reduce the risk of cardiovascular death and hospitalizat...
Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
Vitamin D insufficiency is common in several pediatric diseases including obesity and asthma. Little data exist describing...
Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents
Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents
HIV treatment options remain limited in children. Dolutegravir is a potent and well-tolerated, once-daily HIV-1 integrase ...
Enigma of Intramuscular Triamcinolone Acetonide (Kenalog®) Efficacy
Enigma of Intramuscular Triamcinolone Acetonide (Kenalog®) Efficacy
Triamcinolone acetonide is a glucocorticosteroid used in standard clinical practice for its anti-inflammatory properties. ...
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Although kinase inhibitors (KI) frequently portray large interpatient variability, a ‘one size fits all’ regim...
Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review
Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review
The life expectancy of people living with HIV (PLWHIV) has significantly improved in recent decades, mostly due to antiret...
Correction: A Review of Population Pharmacokinetic Analyses of Linezolid
Correction: A Review of Population Pharmacokinetic Analyses of Linezolid
Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Travesía da Choupana, 15706, Santiag...
Population Pharmacokinetic Analysis of Dorzagliatin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus
Population Pharmacokinetic Analysis of Dorzagliatin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus
Dorzagliatin is a first-in-class small molecule glucokinase activator (GKA) that improves pancreatic insulin secretion beh...
CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults
CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults
Voriconazole is an important broad-spectrum anti-fungal drug with nonlinear pharmacokinetics. The aim of this single centr...
Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument
Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument
With the progress of therapeutic drug monitoring (TDM) technology and the development of evidence-based medicine, many gui...
Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor designed to overcome mechanisms of resistance ass...
Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide
Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide
Darolutamide is a next-generation androgen receptor signaling inhibitor (ARSI) currently approved for the treatment of non...
Relationship Between Cetuximab Target-Mediated Pharmacokinetics and Progression-Free Survival in Metastatic Colorectal Cancer Patients
Relationship Between Cetuximab Target-Mediated Pharmacokinetics and Progression-Free Survival in Metastatic Colorectal Cancer Patients
Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal immunoglobulin (Ig)G1 antibody, has been approved fo...
Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement
Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement
Abiraterone is a first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1), and its pharmacokinetic (PK) profile is susce...