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Clinical Pharmacokinetics and Pharmacodynamics of Rucaparib
Clinical Pharmacokinetics and Pharmacodynamics of Rucaparib
Rucaparib is an oral small-molecule poly(ADP-ribose) polymerase inhibitor indicated for patients with recurrent ovarian ca...
Correction to: Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling
Correction to: Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling
The article titled “Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Model...
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative Review
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative Review
The search for clinically effective antivirals against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is...
Clinical Pharmacokinetic Monitoring of Free Valproic Acid Levels: A Systematic Review
Clinical Pharmacokinetic Monitoring of Free Valproic Acid Levels: A Systematic Review
Current guidelines recommend therapeutic drug monitoring as a critical component of valproic acid (VPA) therapy. Due to hi...
Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates
Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates
Previously, we developed a pharmacokinetic-pharmacodynamic model of allopurinol, oxypurinol, and biomarkers, hypoxanthine,...
Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
Daptomycin has been recommended in the treatment of bone and joint infection. Previous work showed that the approved dosag...
Correction to: An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients
Correction to: An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients
This is a corrigendum to Clin Pharmacokinet. 2022 Apr 4 An Integral Pharmacokinetic Analysis of Piperacillin and Tazobacta...
Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling
Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling
The combination of polymyxins, meropenem, and sulbactam demonstrated efficacy against multi-drug-resistant bacillus Acinet...
Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers
Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers
Tucatinib is approved for treatment of human epidermal growth factor receptor 2-positive metastatic breast cancer. Underst...
Up to 100 g of Intravenous Vitamin C Appears to be Safe and Elicits No Adverse Effects but Needs Further Evaluation in High-Risk Groups
Up to 100 g of Intravenous Vitamin C Appears to be Safe and Elicits No Adverse Effects but Needs Further Evaluation in High-Risk Groups
Chen P, Reed G, Jiang J, et al. Pharmacokinetic evaluation of intravenous vitamin C: a classic pharmacokinetic study. Clin...
Pharmacological Basis for Abrogating Myocardial Reperfusion Injury Through a Multi-Target Combined Antioxidant Therapy
Pharmacological Basis for Abrogating Myocardial Reperfusion Injury Through a Multi-Target Combined Antioxidant Therapy
The main goal of the treatment for acute myocardial infarction is to achieve reperfusion of the affected myocardial tissue...
Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction
Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction
Numerous drugs have the potential to be affected by cytochrome P450 (CYP) 2B6-mediated drug–drug interactions (DDIs)...
Establishing the Pharmacokinetics of Genetic Vaccines is Essential for Maximising their Safety and Efficacy
Establishing the Pharmacokinetics of Genetic Vaccines is Essential for Maximising their Safety and Efficacy
In a typical course of drug development, thorough pharmacokinetic (PK) studies are essential for the determination of drug...
Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain–Barré Syndrome
Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain–Barré Syndrome
Intravenous immunoglobulin (IVIg) at a standard dosage is the treatment of choice for Guillain–Barré syndrome. ...
Clinical Pharmacokinetics and Pharmacodynamics of Fostamatinib and Its Active Moiety R406
Clinical Pharmacokinetics and Pharmacodynamics of Fostamatinib and Its Active Moiety R406
Fostamatinib is the first approved spleen tyrosine kinase inhibitor for chronic immune thrombocytopenia. This review summa...
Clinical Pharmacokinetics of Metoprolol: A Systematic Review
Clinical Pharmacokinetics of Metoprolol: A Systematic Review
Metoprolol is recommended for therapeutic use in multiple cardiovascular conditions, thyroid crisis, and circumscribed cho...
Clinical Pharmacokinetics and Pharmacodynamics of Cefepime
Clinical Pharmacokinetics and Pharmacodynamics of Cefepime
Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-positive and Gram-negative pathoge...