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Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis
Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis
Isoniazid is a first-line antituberculosis agent with high variability, which would profit from individualized dosing. Con...
Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties
Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties
Saliva is a patient-friendly matrix for therapeutic drug monitoring (TDM) but is infrequently used in routine care. This i...
Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort
Evaluating the Clinical Impact and Feasibility of Therapeutic Drug Monitoring of Pazopanib in a Real-World Soft-Tissue Sarcoma Cohort
Pazopanib is registered for metastatic renal cell carcinoma and soft-tissue sarcoma (STS). Its variable pharmacokinetic (P...
Clinical Pharmacokinetics and Pharmacodynamics of Letermovir in Allogenic Hematopoietic Cell Transplantation
Clinical Pharmacokinetics and Pharmacodynamics of Letermovir in Allogenic Hematopoietic Cell Transplantation
Letermovir is a newly developed antiviral agent used for the prophylaxis of human cytomegalovirus infections in patients u...
The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study
The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study
Trifluridine/tipiracil, registered for the treatment of patients with metastatic gastric and colorectal cancer, is a subst...
Penetration of Antibiotics into Subcutaneous and Intramuscular Interstitial Fluid: A Meta-Analysis of Microdialysis Studies in Adults
Penetration of Antibiotics into Subcutaneous and Intramuscular Interstitial Fluid: A Meta-Analysis of Microdialysis Studies in Adults
The interstitial fluid of tissues is the effect site for antibiotics targeting extracellular pathogens. Microdialysis stud...
Characterizing Enoxaparin’s Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population
Characterizing Enoxaparin’s Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population
Pediatric dosing of enoxaparin was derived based on extrapolation of the adult therapeutic range to children. However, a l...
Clinical Pharmacokinetic and Pharmacodynamic Profile of Vericiguat
Clinical Pharmacokinetic and Pharmacodynamic Profile of Vericiguat
Vericiguat is an oral soluble guanylate cyclase stimulator and enhances the cyclic guanosine monophosphate pathway indepen...
Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug interactions (DDIs) can com...
Population Pharmacokinetics of Cabozantinib in Metastatic Renal Cell Carcinoma Patients: Towards Drug Expenses Saving Regimens
Population Pharmacokinetics of Cabozantinib in Metastatic Renal Cell Carcinoma Patients: Towards Drug Expenses Saving Regimens
Cabozantinib is one of the preferred treatment options in the latest metastatic renal cell carcinoma (mRCC) guidelines. Ca...
Pharmacogenetic Testing or Therapeutic Drug Monitoring: A Quantitative Framework
Pharmacogenetic Testing or Therapeutic Drug Monitoring: A Quantitative Framework
Pharmacogenetic profiling and therapeutic drug monitoring (TDM) have both been proposed to manage inter-individual variabi...
Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk
Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk
Human milk is a remarkable biofluid that provides essential nutrients and immune protection to newborns. Breastfeeding wom...
The Effect of Various Degrees of Renal or Hepatic Impairment on the Pharmacokinetic Properties of Once-Weekly Insulin Icodec
The Effect of Various Degrees of Renal or Hepatic Impairment on the Pharmacokinetic Properties of Once-Weekly Insulin Icodec
Icodec is a once-weekly insulin being developed to provide basal insulin coverage in diabetes mellitus. This stud...
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
The establishment of optimal dosing regimens for intravenous (IV) lidocaine in the perioperative setting, aiming to balanc...
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model
Vosoritide is a recently approved therapy for achondroplasia, the most common form of disproportionate short stature, that...
Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Milrinone is an inotrope and vasodilator used for prophylaxis or treatment of low cardiac output syndrome after weaning fr...
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
Although little information is available on the pharmacokinetics (PK) of monoclonal antibodies (mAbs) during pregnancy, mu...