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Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
Knowledge about exposure to cannabidiol (CBD) in breastfed infants can provide an improved understanding of potential risk...
Multivariate Exact Discrepancy: A New Tool for PK/PD Model Evaluation
Multivariate Exact Discrepancy: A New Tool for PK/PD Model Evaluation
Pharmacokinetic models are evaluated using three types of metrics: those based on estimating the typical pharmacokinetic p...
Imeglimin: A Clinical Pharmacology Review
Imeglimin: A Clinical Pharmacology Review
Imeglimin (PXL008, EMD-387008, Twymeeg®) is a first-in-class novel oral hypoglycemic agent, launched in Japan, for th...
Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes
Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes
This study aimed to assess the pharmacokinetics of henagliflozin in dialysis patients with diabetes. In this prospective, ...
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1
Side effects of irinotecan treatment can be dose limiting and may impair quality of life. In this study, we investigated t...
Assessing QTc Effects of Vericiguat Using Two Different Concentration-QTc Modeling Approaches
Assessing QTc Effects of Vericiguat Using Two Different Concentration-QTc Modeling Approaches
Vericiguat is a soluble guanylate cyclase stimulator indicated to reduce the risk of cardiovascular death and hospitalizat...
Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
Vitamin D insufficiency is common in several pediatric diseases including obesity and asthma. Little data exist describing...
Pharmacokinetics and Pharmacodynamics of Patisiran in Patients with hATTR Amyloidosis and with Polyneuropathy After Liver Transplantation
Pharmacokinetics and Pharmacodynamics of Patisiran in Patients with hATTR Amyloidosis and with Polyneuropathy After Liver Transplantation
Variants of the transthyretin (TTR) gene cause hereditary transthyretin-mediated (hATTR) amyloidosis, or ATTRv amyloidosis...
Population Pharmacokinetic Analysis of Follicle-Stimulating Hormone During Ovarian Stimulation: Relation with Weight, Prolactin and Gene Polymorphism in THADA and ADIPOQ
Population Pharmacokinetic Analysis of Follicle-Stimulating Hormone During Ovarian Stimulation: Relation with Weight, Prolactin and Gene Polymorphism in THADA and ADIPOQ
Personalisation strategies of ovarian stimulation for in vitro fertilisation (IVF)/ intracytoplasmic sperm injection (ICSI...
Mirikizumab Pharmacokinetics in Patients with Moderately to Severely Active Ulcerative Colitis: Results from Phase III LUCENT Studies
Mirikizumab Pharmacokinetics in Patients with Moderately to Severely Active Ulcerative Colitis: Results from Phase III LUCENT Studies
Mirikizumab is a humanized anti-interleukin-23-p19 monoclonal antibody being developed for ulcerative colitis and Crohn...
Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data
Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data
Model-informed precision dosing (MIPD) frequently uses nonlinear mixed-effects (NLME) models to predict and optimize thera...
Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents
Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents
HIV treatment options remain limited in children. Dolutegravir is a potent and well-tolerated, once-daily HIV-1 integrase ...
Enigma of Intramuscular Triamcinolone Acetonide (Kenalog®) Efficacy
Enigma of Intramuscular Triamcinolone Acetonide (Kenalog®) Efficacy
Triamcinolone acetonide is a glucocorticosteroid used in standard clinical practice for its anti-inflammatory properties. ...
Population Pharmacokinetic Analysis Supports Initiation Treatment and Bridging from Sublingual Buprenorphine to Subcutaneous Administration of a Buprenorphine Depot (CAM2038) in the Treatment of Opioid Use Disorder
Population Pharmacokinetic Analysis Supports Initiation Treatment and Bridging from Sublingual Buprenorphine to Subcutaneous Administration of a Buprenorphine Depot (CAM2038) in the Treatment of Opioid Use Disorder
In treating opioid use disorder (OUD), subcutaneous (SC) extended-release buprenorphine (BPN) depots, e.g., CAM20...
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Although kinase inhibitors (KI) frequently portray large interpatient variability, a ‘one size fits all’ regim...
Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review
Pharmacokinetics of Antiretroviral Drugs in Older People Living with HIV: A Systematic Review
The life expectancy of people living with HIV (PLWHIV) has significantly improved in recent decades, mostly due to antiret...
Correction: A Review of Population Pharmacokinetic Analyses of Linezolid
Correction: A Review of Population Pharmacokinetic Analyses of Linezolid
Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Travesía da Choupana, 15706, Santiag...
Population Pharmacokinetic Analysis of Dorzagliatin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus
Population Pharmacokinetic Analysis of Dorzagliatin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus
Dorzagliatin is a first-in-class small molecule glucokinase activator (GKA) that improves pancreatic insulin secretion beh...
Correction to: Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment
Correction to: Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment
Janssen R&D, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, USAPeter ZannikosJanssen R&D, 6050 Paseo Carreta...
CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults
CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults
Voriconazole is an important broad-spectrum anti-fungal drug with nonlinear pharmacokinetics. The aim of this single centr...
Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument
Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument
With the progress of therapeutic drug monitoring (TDM) technology and the development of evidence-based medicine, many gui...
Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor designed to overcome mechanisms of resistance ass...
Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling
Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling
Mycophenolic acid (MPA) is an immunosuppressant commonly prescribed in pediatric kidney transplantation to prevent graft r...
Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide
Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide
Darolutamide is a next-generation androgen receptor signaling inhibitor (ARSI) currently approved for the treatment of non...
Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
SPI-62 is a small-molecule 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor exhibiting complicated nonlinear...
Relationship Between Cetuximab Target-Mediated Pharmacokinetics and Progression-Free Survival in Metastatic Colorectal Cancer Patients
Relationship Between Cetuximab Target-Mediated Pharmacokinetics and Progression-Free Survival in Metastatic Colorectal Cancer Patients
Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal immunoglobulin (Ig)G1 antibody, has been approved fo...
Population Pharmacokinetic Model of Intravenous Busulfan in Hematopoietic Cell Transplantation: Systematic Review and Comparative Simulations
Population Pharmacokinetic Model of Intravenous Busulfan in Hematopoietic Cell Transplantation: Systematic Review and Comparative Simulations
Busulfan is commonly used in the chemotherapy prior to hematopoietic cell transplantation (HCT). Busulfan has a narrow the...
Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment
Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment
Nasal esketamine is indicated for the treatment of adults with treatment-resistant depression and depressive symptoms in a...
Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement
Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement
Abiraterone is a first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1), and its pharmacokinetic (PK) profile is susce...
Correction to: Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects
Correction to: Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
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