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Evaluation of culture methods and chemical reagent combinations on CRISPR/Cas9 gene editing systems by lipofection in pig zygotes
Evaluation of culture methods and chemical reagent combinations on CRISPR/Cas9 gene editing systems by lipofection in pig zygotes
The delivery of CRISPR/Cas ribonucleoprotein (RNP) complexes is gaining attention owing to its high cleavage efficiency an...
Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue
Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue
Hair follicle stem cells (HFSCs) are adult stem cells located in the outer root sheath of the follicle bulge with high neu...
The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells
The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells
Gastrulation is the first major differentiation process in animal embryos. However, the dynamics of human gastrulation rem...
Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells
Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells
Skeletal muscle's regenerative ability is vital for maintaining muscle function, but chronic diseases like Duchenne mu...
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment
It is necessary to explore new targets for the treatment of colon adenocarcinoma (COAD) according to the tumor microenviro...
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling
Cancer stem cells (CSCs), which are critical targets for cancer therapy as they are involved in drug resistance to antican...
3,3′-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice
3,3′-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice
Psoriasis is a paradigmatic condition characterised by a heightened autoimmune response and chronic inflammation. However,...
Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study
Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study
The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when t...
Rutin alleviates Sjogren’s syndrome via CaR/NLRP3/NF-κB signal pathway
Rutin alleviates Sjogren’s syndrome via CaR/NLRP3/NF-κB signal pathway
Sjogren’s syndrome (SS) is an autoimmune disease. Its mechanism and treatment methods are unclear. The purpose of th...
Role of the Ror family receptors in Wnt5a signaling
Role of the Ror family receptors in Wnt5a signaling
Ror-family receptors, Ror1 and Ror2, are type I transmembrane proteins that possess an extracellular cysteine-rich domain,...
A comparative study on targeted gene expression in zebrafish and its gill cell line exposed to chlorpyrifos
A comparative study on targeted gene expression in zebrafish and its gill cell line exposed to chlorpyrifos
Chlorpyrifos (CPF) is an organophosphorus-based insecticide, which is known to pose a serious risk to aquatic animals. How...
High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy
High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy
Chimeric antigen receptors (CARs) offer a promising new approach for targeting B cell malignancies through the immune syst...
Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3
Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3
It has been reported that the effective inhibition of vascular endothelial growth factor (VEGF) can prevent the progressio...
Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK
Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK
Oxidative stress and apoptosis play crucial roles in myocardial ischemia‒reperfusion injury (MIRI). In this study, w...
The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function
The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function
Muscular dystrophy in the NH-413 chicken is caused by a missense mutation in the WWP1 gene. WWP1 is a HECT-type E3 ubiquit...
Eco-friendly green synthesis of N‑pyrazole amino chitosan using PEG-400 as an anticancer agent against gastric cancer cells via inhibiting EGFR
Eco-friendly green synthesis of N‑pyrazole amino chitosan using PEG-400 as an anticancer agent against gastric cancer cells via inhibiting EGFR
The present study was conducted to develop a green process that provides access to the development of Schiff base derivati...
Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models
Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models
Astrocytes play key roles regulating brain homeostasis and accumulating evidence has suggested that glia are the first cel...
PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation
PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation
Peroxiredoxin 6 (PRDX6) is a protective biomarker associated with ferroptosis in heart failure (HF). This study investigat...
Influence of the storage conditions of embryo culture media on mouse development
Influence of the storage conditions of embryo culture media on mouse development
The culture of preimplantation embryos in vitro is an important method for human and mouse reproductive technology. This s...
In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
The epidermis is largely composed of keratinocytes (KCs), and the proliferation and differentiation of KCs from the stratu...
The molecular mechanisms underlying the regeneration process in the earthworm, Perionyx excavatus exhibit indications of apoptosis-induced compensatory proliferation (AICP)
The molecular mechanisms underlying the regeneration process in the earthworm, Perionyx excavatus exhibit indications of apoptosis-induced compensatory proliferation (AICP)
Regeneration is a multifaceted biological phenomenon that necessitates the intricate orchestration of apoptosis, stem cell...
Ocu-miR-10a-5p promotes the chondrogenic differentiation of rabbit BMSCs by targeting BTRC-mediated Wnt/β-catenin signaling pathway
Ocu-miR-10a-5p promotes the chondrogenic differentiation of rabbit BMSCs by targeting BTRC-mediated Wnt/β-catenin signaling pathway
MicroRNAs (miRNAs) play an important role in articular cartilage damage in osteoarthritis (OA). However, the biological ro...
Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes
Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes
Programmed cell death-1 (PD-1) is an immunoinhibitory receptor required to suppress inappropriate immune responses such as...
Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose
Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose
Previous studies have implicated targeting Pim-1 proto-oncogene, serine/threonine kinase (PIM1) as a preventive measure ag...
Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway
Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway
The study aimed to investigate the effect of ginsenoside Rg1 on intervertebral disc degeneration (IVDD) in rats and IL-1&#...
CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway
Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the und...
Human embryonic stem cells maintain their stemness in three-dimensional microenvironment
Human embryonic stem cells maintain their stemness in three-dimensional microenvironment
Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ, Oyen ML (2019) ...
Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis
Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis
Adiponectin has previously been investigated for exerting its protective effect against myocardial injury through anti-apo...
Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy
Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy
It has been demonstrated that angiopoietin-like protein 4 (ANGPTL4) plays an important regulatory role in lipid metabolism...
Preclinical assessments of safety and tumorigenicity of very high doses of allogeneic human umbilical cord mesenchymal stem cells
Preclinical assessments of safety and tumorigenicity of very high doses of allogeneic human umbilical cord mesenchymal stem cells
Human umbilical cord-mesenchymal stem cells (hUC-MSCs) have been widely investigated as a new therapeutic agent to treat i...
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