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PD-1/PD-L1 Inhibitors Increase Pathological Complete Response in Locally Advanced Gastric Cancer: A Meta-analysis and Trial Sequential Analysis
PD-1/PD-L1 Inhibitors Increase Pathological Complete Response in Locally Advanced Gastric Cancer: A Meta-analysis and Trial Sequential Analysis
Gastric cancer (GC) remains a leading cause of morbidity and mortality worldwide. The current standard of care involves ne...
Identification of Metabolic Characteristic–Pancreatic Ductal Adenocarcinoma Associations Using Mendelian Randomization and Metabolomics
Identification of Metabolic Characteristic–Pancreatic Ductal Adenocarcinoma Associations Using Mendelian Randomization and Metabolomics
Metabolic reprogramming is increasingly recognized as a crucial factor influencing the development, progression, and progn...
Preoperative Carcinoembryonic Antigen as a Predictor of 5-Year Survival in Rectal Cancer: Proposing a New Prognostic Cutoff
Preoperative Carcinoembryonic Antigen as a Predictor of 5-Year Survival in Rectal Cancer: Proposing a New Prognostic Cutoff
Carcinoembryonic antigen (CEA) is an important prognostic factor for rectal cancer. This study aims to introduce a novel c...
Prevalence and Risk Factors of Acute Kidney Injury After Colorectal Cancer Surgery
Prevalence and Risk Factors of Acute Kidney Injury After Colorectal Cancer Surgery
Acute kidney injury is a sentinel event affecting colorectal cancer patients either as a consequence of surgery or systemi...
The Current Role of Circulating Tumor DNA in the Management of Pancreatic Cancer
The Current Role of Circulating Tumor DNA in the Management of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer-related death by 2030. Early...
Curative-Intended Management of Synchronous Esophageal and Rectal Cancer—A Systematic Literature Review
Curative-Intended Management of Synchronous Esophageal and Rectal Cancer—A Systematic Literature Review
Synchronous esophageal (EC) and rectal carcinoma (RC) is a rare and challenging condition, particularly in curative-intend...
Pancreatic Ductal Adenocarcinoma with Medullary Features and a Complete Pathological Response After Neoadjuvant FOLFIRINOX: A Case Report and Literature Review
Pancreatic Ductal Adenocarcinoma with Medullary Features and a Complete Pathological Response After Neoadjuvant FOLFIRINOX: A Case Report and Literature Review
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor response to chemotherapy. High-frequency mic...
Nivolumab Combined with Chemotherapy in FGFR2 and PD-L1 Co-Expressing Metastatic Gastric Cancer: A Prospective Phase 2 NIVOFGFR2 Study
Nivolumab Combined with Chemotherapy in FGFR2 and PD-L1 Co-Expressing Metastatic Gastric Cancer: A Prospective Phase 2 NIVOFGFR2 Study
Immunotherapy is increasingly significant in treating metastatic gastric cancer. This prospective phase 2 study investigat...
Development of a Prognostic Nomogram for Overall Survival in Gastric Cancer Patients Who Underwent Adjuvant Chemoradiotherapy
Development of a Prognostic Nomogram for Overall Survival in Gastric Cancer Patients Who Underwent Adjuvant Chemoradiotherapy
The aim of this study was to identify prognostic factors influencing overall survival (OS) in patients with gastric cancer...
Advances in Novel Targeted Therapies for Pancreatic Adenocarcinoma
Advances in Novel Targeted Therapies for Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited therapeutic options and poor progno...
Preoperative CT-Scan Angiography Reconstruction Before Right Colectomy with Complete Mesocolon Excision: A Systematic Review and Meta-analysis
Preoperative CT-Scan Angiography Reconstruction Before Right Colectomy with Complete Mesocolon Excision: A Systematic Review and Meta-analysis
Complete mesocolon excision (CME) and central vascular ligation for right colonic cancers have been developed to improve o...
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Regorafenib in the Treatment of Metastatic Colorectal Cancer
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Regorafenib in the Treatment of Metastatic Colorectal Cancer
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite advances in treatment, metastati...
Gender, Race, and Regional Disparities in Leading Authorships of Gastroenterology and Hepatology Randomized Controlled Trials
Gender, Race, and Regional Disparities in Leading Authorships of Gastroenterology and Hepatology Randomized Controlled Trials
To investigate gender, racial, ethnic, and regional disparities in first and senior authorship positions in gastroenterolo...
Clinical Outcomes and Prognosis of Esophageal Squamous Cell Carcinoma Presenting with Obstruction
Clinical Outcomes and Prognosis of Esophageal Squamous Cell Carcinoma Presenting with Obstruction
The prognosis of esophageal squamous cell carcinoma (ESCC) with obstruction is unclear. This study aimed to analyze clinic...
Demographics, Prognostic Factors, and Survival Outcomes in Hepatic Angiosarcoma: A Retrospective Analysis
Demographics, Prognostic Factors, and Survival Outcomes in Hepatic Angiosarcoma: A Retrospective Analysis
Hepatic angiosarcoma (HA) is a rare malignant vascular neoplasm. Currently, there are no standardized protocols for treati...
Delayed Surgery after Neoadjuvant Short-course Radiation for Rectal Cancer Improves Pathologic Outcomes without Impacting Survival: A National Cancer Database Analysis
Delayed Surgery after Neoadjuvant Short-course Radiation for Rectal Cancer Improves Pathologic Outcomes without Impacting Survival: A National Cancer Database Analysis
Interval to surgery following short course radiotherapy (SCRT) for rectal cancer is not standardized. This study investiga...
The Association Between Patient-Reported Outcomes and Surgical Attrition During Neoadjuvant Therapy for Gastrointestinal Malignancies
The Association Between Patient-Reported Outcomes and Surgical Attrition During Neoadjuvant Therapy for Gastrointestinal Malignancies
Neoadjuvant therapy (NT) is increasingly used for gastrointestinal (GI) and hepatopancreatobiliary (HPB) cancers. Risk fac...
Predictors of Understaging with EUS and PET-CECT in Early Esophageal Carcinoma
Predictors of Understaging with EUS and PET-CECT in Early Esophageal Carcinoma
The clinicoradiological staging for esophageal cancer is fraught with variable accuracy, potentially depriving patients wh...
A Phase 2 study of Savolitinib in Patients with MET Amplified Metastatic Colorectal Cancer
A Phase 2 study of Savolitinib in Patients with MET Amplified Metastatic Colorectal Cancer
MET amplification (amp) is a driver of acquired resistance to epidermal growth factor receptor (EGFR) antibodies in patien...
Anti-EGFR Rechallenge in Metastatic Colorectal Cancer and the Role of ctDNA: A Systematic Review and Meta-analysis
Anti-EGFR Rechallenge in Metastatic Colorectal Cancer and the Role of ctDNA: A Systematic Review and Meta-analysis
Metastatic colorectal cancer (mCRC) remains a significant clinical challenge. While anti-EGFR inhibitors have improved sur...
Immunohistochemical Expression of ROR2 in Gastrointestinal Stromal Tumor
Immunohistochemical Expression of ROR2 in Gastrointestinal Stromal Tumor
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors affecting the digestive tract, comprising ap...
Factors Influencing Immunotherapy Utilization in Stage IV Pancreatic Cancer: Impact of Race and Socioeconomics in the U.S
Factors Influencing Immunotherapy Utilization in Stage IV Pancreatic Cancer: Impact of Race and Socioeconomics in the U.S
Pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer with a poor prognosis, is expected to become the second de...
Prognostic Effect of the PNI and LSR in Patients with Esophageal Squamous Cell Carcinoma Patients Receiving Radiotherapy
Prognostic Effect of the PNI and LSR in Patients with Esophageal Squamous Cell Carcinoma Patients Receiving Radiotherapy
The prognostic nutritional index (PNI) has been used to assess the immunonutritional status of cancer patients and can pre...
Recruitment and Retention Strategies for Historically Marginalized Populations in Colorectal Cancer Trials: A Cross-Sectional Analysis Using Systematic Review Methods
Recruitment and Retention Strategies for Historically Marginalized Populations in Colorectal Cancer Trials: A Cross-Sectional Analysis Using Systematic Review Methods
Colorectal cancer (CRC), a leading cause of cancer mortality, disproportionately impacts historically marginalized populat...
Initial Application of Fluorescence Imaging for Intraoperative Localization of Small Neuroendocrine Tumors in the Pancreas: Case Report and Review of the Literature
Initial Application of Fluorescence Imaging for Intraoperative Localization of Small Neuroendocrine Tumors in the Pancreas: Case Report and Review of the Literature
Indocyanine green is commonly used for laparoscopic hepatectomy but remains uncommon in pancreatic surgery. Given the incr...
Third- or Further-Line Treatment in Patients with MSS Type Metastatic Colorectal Cancer
Third- or Further-Line Treatment in Patients with MSS Type Metastatic Colorectal Cancer
The survival benefit from later-line treatment for patients with metastatic colorectal cancer (mCRC) remains disappointing...
The Effect of Vitamin D Supplementation on Quality of Life in Stage II–III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial
The Effect of Vitamin D Supplementation on Quality of Life in Stage II–III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial
Colorectal cancer is the third most common cancer with the second highest mortality worldwide in 2020. Adjuvant chemothera...
Unexpected Multiple Gastrointestinal Cancers in a Patient with Chronic Eosinophilia: A Case Report
Unexpected Multiple Gastrointestinal Cancers in a Patient with Chronic Eosinophilia: A Case Report
While the relationship between eosinophilia and tumors has been extensively studied, eosinophilia is primarily observed cl...
The Extent of Tumor in the Peritoneum and Liver Influences Outcomes After Surgery for Synchronous Liver and Peritoneal Colorectal Metastases: A Cohort Study
The Extent of Tumor in the Peritoneum and Liver Influences Outcomes After Surgery for Synchronous Liver and Peritoneal Colorectal Metastases: A Cohort Study
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRSH) or liver resection have led to increased surviv...
Expression of Salivary miRNAs, Clinical, and Demographic Features in the Early Detection of Gastric Cancer: A Statistical and Machine Learning Analysis
Expression of Salivary miRNAs, Clinical, and Demographic Features in the Early Detection of Gastric Cancer: A Statistical and Machine Learning Analysis
Gastric cancer ranks as one of the top five deadliest cancers worldwide and is often diagnosed at late stages. Analysis of...
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