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Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice
Septic arthritis (SA) caused by Staphylococcus aureus is a severe inflammatory joint disease, characterized by synovitis a...
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in lung adenocarcinoma
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in lung adenocarcinoma
The presence of tertiary lymphoid structures (TLSs) has been correlated with improved prognosis and clinical outcomes in r...
A central role of stimulator of interferon genes’ adaptor protein in defensive immune response
A central role of stimulator of interferon genes’ adaptor protein in defensive immune response
Cytotoxic DNAs, methylation, histones and histones binding proteins are speculated to induce DNA sensors. Under stressed c...
Irisin-mediated KEAP1 degradation alleviates oxidative stress and ameliorates pancreatitis
Irisin-mediated KEAP1 degradation alleviates oxidative stress and ameliorates pancreatitis
Oxidative stress (OS) injury is pivotal in acute pancreatitis (AP) pathogenesis, contributing to inflammatory cascades. Ir...
Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy
Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy
Recently, a strategy involving the engineering of chemokine receptors on immune cells was developed to optimize adoptive c...
Association between TLR 2 (rs3804099), TLR4 (rs4986790), and TLR 9 (rs187084) polymorphism and leukemia risk: a systematic review and meta-analysis
Association between TLR 2 (rs3804099), TLR4 (rs4986790), and TLR 9 (rs187084) polymorphism and leukemia risk: a systematic review and meta-analysis
Toll-like receptors (TLRs) are crucial components of innate immunity. A specific form of genetic variation in TLR genes ma...
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
The ABCC subfamily contains thirteen members. Nine of these transporters are called multidrug resistance proteins (MRPs). ...
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1
Baicalein, one of the major active flavonoids found in Scutellaria baicalensis, has been revealed to exhibit potent anti-i...
The effects of bone marrow humoral components of B-cell acute lymphoblastic leukemia patients on natural killer cell suppression
The effects of bone marrow humoral components of B-cell acute lymphoblastic leukemia patients on natural killer cell suppression
B-cell acute lymphoblastic leukemia (B-ALL) is the most common form of cancer diagnosed in children. While the majority of...
Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity
Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity
In tropical countries, malaria transmission is the major health issue. To eradicate malaria, health communities depend on ...
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy ...
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
This study assessed trends in age-standardized incidence (ASIR), prevalence (ASPR), and mortality rates (ASMR) per 100,000...
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantl...
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Congenital neutropenia (CoN) is a heterogeneous group of inborn errors of immunity (IEI) characterized by recurrent infect...
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding ...
QuantiFERON SARS-CoV-2 assay for the evaluation of cellular immunity after immunization with mRNA SARS-CoV-2 vaccines: a systematic review and meta-analysis
QuantiFERON SARS-CoV-2 assay for the evaluation of cellular immunity after immunization with mRNA SARS-CoV-2 vaccines: a systematic review and meta-analysis
A systematic review and meta-analysis were performed to evaluate the virus-specific T-cell response after COVID-19 mRNA va...
Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia
Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia
This study aims to characterize the majority of immune cell subsets in peripheral blood mononuclear cells in children with...
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Helicobacter pylori (Hp) has been postulated as an infectious trigger of psoriatic disease, namely psoriasis (Ps) and psor...
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This...
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
Currently, COVID-19 is still striking after 4 years of prevalence, with millions of cases and thousands of fatali...
Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3
Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3
We determined expression of PDL-1 mRNA in the papillary and anaplastic thyroid cancer cell lines BC-PAP and Cal-62 by real...
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
Dendritic cells (DCs) are essential for promoting T lymphocyte responses since they are specialist antigen-presenting cell...
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
The inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to re...
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
After stroke, there is a high incidence of acute lung injury and impairment of intestinal barrier function. In this resear...
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
Macrophages, the most abundant cells that participate in tumour progression, are the subject of a number of anticancer the...
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has con...
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
Lung adenocarcinoma (LUAD) is the common form of lung cancer and is prone to distant metastasis. IGF2BP2, an m6A modificat...
Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages
Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages
Leech therapy has been utilized in modern and traditional medicine. Leech saliva contains versatile peptides and molecules...
USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome
USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome
Sjögren Syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of exocr...
Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations
Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that acts on both innate and adaptive immunity, fo...
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