SCI时时刷

search
+
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Helicobacter pylori (Hp) has been postulated as an infectious trigger of psoriatic disease, namely psoriasis (Ps) and psor...
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This...
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
Currently, COVID-19 is still striking after 4 years of prevalence, with millions of cases and thousands of fatali...
Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3
Regulation of PDL-1 expression in thyroid carcinoma cells by tumor cell derived cytokines activating STAT3
We determined expression of PDL-1 mRNA in the papillary and anaplastic thyroid cancer cell lines BC-PAP and Cal-62 by real...
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
Dendritic cells (DCs) are essential for promoting T lymphocyte responses since they are specialist antigen-presenting cell...
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
The inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to re...
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
After stroke, there is a high incidence of acute lung injury and impairment of intestinal barrier function. In this resear...
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
Macrophages, the most abundant cells that participate in tumour progression, are the subject of a number of anticancer the...
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has con...
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
Lung adenocarcinoma (LUAD) is the common form of lung cancer and is prone to distant metastasis. IGF2BP2, an m6A modificat...
Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages
Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages
Leech therapy has been utilized in modern and traditional medicine. Leech saliva contains versatile peptides and molecules...
USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome
USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome
Sjögren Syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of exocr...
Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations
Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that acts on both innate and adaptive immunity, fo...
Arginine vasopressin (AVP) treatment increases the expression of inhibitory immune checkpoint molecules in monocyte-derived dendritic cells
Arginine vasopressin (AVP) treatment increases the expression of inhibitory immune checkpoint molecules in monocyte-derived dendritic cells
Arginine vasopressin (AVP) has disparate impacts on immune responses by divergent receptors on cells including DCs. This s...
Clinical and molecular profile of 20 patients with DOCK8 deficiency—a single-center experience from Southern India
Clinical and molecular profile of 20 patients with DOCK8 deficiency—a single-center experience from Southern India
DOCK8 deficiency is the most common cause of autosomal recessive hyper-IgE syndrome (AR-HIES). The clinical spectrum is wi...
OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2
OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2
Osteoarthritis (OA) is a chronic degenerative joint disease that imposes a substantial economic burden on patients and soc...
Leptin/LPS-treated dendritic cells reduce the expression of genes involved in tumor tissue metastasis and angiogenesis in an animal model of breast cancer
Leptin/LPS-treated dendritic cells reduce the expression of genes involved in tumor tissue metastasis and angiogenesis in an animal model of breast cancer
Leptin, an immune-regulating protein, enhances the maturation of dendritic cells (DCs). We previously demonstrated that le...
Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation
Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation
Neutrophil proteinase 3 (PR3), cathepsin G, elastase, and neutrophil serine protease 4 constitute the neutrophil serine pr...
The function of CD8 + T cells in the absence of MHC-I in target cells: what to learn from the deficiency of MHC-I expression in humans
The function of CD8 + T cells in the absence of MHC-I in target cells: what to learn from the deficiency of MHC-I expression in humans
Gao Y, Arkwright PD, Carter R, Cazaly A, Harrison RJ, Mant A, Cant AJ, Gadola S, Elliott TJ, Khakoo SI, Williams AP. Bone ...
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6
The study aimed to investigate the regulatory role of Regnase-1 in ankylosing spondylitis (AS) inflammation. We collected ...
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
The pathogenesis of recurrent pregnancy loss (RPL) is unclear. RPL may have an association with disruption of immune toler...
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Antinuclear antibodies (ANA) are the most common biomarkers observed in autoimmune diseases. Cytoplasmic staining patterns...
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Gouty arthritis (GA) is an inflammatory disorder characterized by deposition of monosodium urate (MSU) crystal in joints. ...
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its in...
Belimumab 10 years later: how drug positioning has changed
Belimumab 10 years later: how drug positioning has changed
We analysed the change in the positioning of belimumab (BLM) in systemic lupus erythematosus (SLE) treatment in the first ...
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis
It is known that 1,7-dihydroxy-3,4-dimethoxyxanthone (XAN), derived from Securidaca inappendiculata Hassk., exhibits anti-...
Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity
Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity
Pomalidomide, a third-generation oral immunomodulatory drug, exhibits efficacy in patients with relapsed multiple myeloma ...
Integrating machine learning and multi-omics analysis to develop an asparagine metabolism immunity index for improving clinical outcome and drug sensitivity in lung adenocarcinoma
Integrating machine learning and multi-omics analysis to develop an asparagine metabolism immunity index for improving clinical outcome and drug sensitivity in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is a malignancy affecting the respiratory system. Most patients are diagnosed with advanced or ...
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India
Hereditary angioedema (HAE) is a rare genetic disorder. The pattern of HAE is different in children as compared to adults....
Post-translational modification in the pathogenesis of vitiligo
Post-translational modification in the pathogenesis of vitiligo
Vitiligo is a chronic dermatological condition marked by the loss of skin pigmentation. Its complex etiology involves mult...
阅读更多
format_indent_increase