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Lithospermic acid targeting heat shock protein 90 attenuates LPS-induced inflammatory response via NF-кB signalling pathway in BV2 microglial cells
Lithospermic acid targeting heat shock protein 90 attenuates LPS-induced inflammatory response via NF-кB signalling pathway in BV2 microglial cells
Microglia function as a vital constituent in the maintenance of brain homeostasis. Aberrant microglial activation, however...
A case of atypical infantile de novo antiphospholipid syndrome presenting with neonatal ischemic stroke without any triggering risk factors as a “second hit” and review of the literature
A case of atypical infantile de novo antiphospholipid syndrome presenting with neonatal ischemic stroke without any triggering risk factors as a “second hit” and review of the literature
Infantile antiphospholipid syndrome (APS) is a rare condition arising from either transplacental transfer of antiphospholi...
Risk factors for predicting medium-giant coronary artery aneurysms in Kawasaki disease
Risk factors for predicting medium-giant coronary artery aneurysms in Kawasaki disease
The objective of this study is to determine whether the data of blood profiles before and after therapy can be useful for ...
Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis
Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis
Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. Metformin has pleiotropic effects...
Immunization with recombinant HPV16-E7d in fusion with Flagellin as a cancer vaccine: Effect of antigen-adjuvant orientation on the immune response pattern
Immunization with recombinant HPV16-E7d in fusion with Flagellin as a cancer vaccine: Effect of antigen-adjuvant orientation on the immune response pattern
Human papillomavirus (HPV) is the leading cause of cervical cancer worldwide. The pathogenesis of HPV is mainly dependent ...
PANoptosis-related genes in the prognosis and immune landscape of hepatocellular carcinoma
PANoptosis-related genes in the prognosis and immune landscape of hepatocellular carcinoma
In hepatocellular carcinoma (HCC) individuals, the influence of numerous variables on the HCC prognosis has gained widespr...
Killed whole-cell Staphylococcus aureus formulation in Montanide ISA266 and Alum adjuvants: different vaccine formulations varied in the vaccine’s potency and efficacy
Killed whole-cell Staphylococcus aureus formulation in Montanide ISA266 and Alum adjuvants: different vaccine formulations varied in the vaccine’s potency and efficacy
Immunotherapy can be a sensible alternative because invasive Staphylococcus aureus infection mortality, morbidity, and cos...
The role of NF-κB pathway and its regulation of inflammatory cytokines in scleral remodeling of form-deprivation mice model
The role of NF-κB pathway and its regulation of inflammatory cytokines in scleral remodeling of form-deprivation mice model
Myopia has become a worldwide public health problem. In this study, we constructed a form deprivation (FD) myopia mouse mo...
Integrative bioinformatics and experimental analyses identify U2SURP as a novel lactylation-related prognostic signature in esophageal carcinoma
Integrative bioinformatics and experimental analyses identify U2SURP as a novel lactylation-related prognostic signature in esophageal carcinoma
The lactylation modification has been implicated in several cancer types; however, the role of lactylation modification-re...
Identifying potential signatures of immune cells in hepatocellular carcinoma using integrative bioinformatics approaches and machine-learning strategies
Identifying potential signatures of immune cells in hepatocellular carcinoma using integrative bioinformatics approaches and machine-learning strategies
Hepatocellular carcinoma (HCC) is a malignant tumor regulated by the immune system. Immunotherapy using checkpoint inhibit...
Amphibian cellular immune response to chytridiomycosis at metamorphic climax
Amphibian cellular immune response to chytridiomycosis at metamorphic climax
The fungal disease chytridiomycosis (caused by Batrachochytrium dendrobatidis [Bd]) is a primary contributor to amphibian ...
The ability of CD4dimCD8+ T cells to distinguish between Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis and pediatric infectious mononucleosis
The ability of CD4dimCD8+ T cells to distinguish between Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis and pediatric infectious mononucleosis
Epstein–Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (EBV-HLH) and infectious mononucleosis (IM) are ...
α2-adrenoblockers modulatory effect on the noise-mediated several biochemical and morpho-immuno-histochemical changes in the rat’s blood plasma and tissues
α2-adrenoblockers modulatory effect on the noise-mediated several biochemical and morpho-immuno-histochemical changes in the rat’s blood plasma and tissues
Experimental studies of chronic noise exposure in modern urban life testified about oxidative stress due to the correspond...
Current utilization trend of immortalized mast cell lines in allergy research: a systematic review
Current utilization trend of immortalized mast cell lines in allergy research: a systematic review
Today, in the modern world, allergic diseases, also described as atopic allergies, are classified as a type of multifactor...
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice
Septic arthritis (SA) caused by Staphylococcus aureus is a severe inflammatory joint disease, characterized by synovitis a...
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in lung adenocarcinoma
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in lung adenocarcinoma
The presence of tertiary lymphoid structures (TLSs) has been correlated with improved prognosis and clinical outcomes in r...
A central role of stimulator of interferon genes’ adaptor protein in defensive immune response
A central role of stimulator of interferon genes’ adaptor protein in defensive immune response
Cytotoxic DNAs, methylation, histones and histones binding proteins are speculated to induce DNA sensors. Under stressed c...
Irisin-mediated KEAP1 degradation alleviates oxidative stress and ameliorates pancreatitis
Irisin-mediated KEAP1 degradation alleviates oxidative stress and ameliorates pancreatitis
Oxidative stress (OS) injury is pivotal in acute pancreatitis (AP) pathogenesis, contributing to inflammatory cascades. Ir...
Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy
Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy
Recently, a strategy involving the engineering of chemokine receptors on immune cells was developed to optimize adoptive c...
Association between TLR 2 (rs3804099), TLR4 (rs4986790), and TLR 9 (rs187084) polymorphism and leukemia risk: a systematic review and meta-analysis
Association between TLR 2 (rs3804099), TLR4 (rs4986790), and TLR 9 (rs187084) polymorphism and leukemia risk: a systematic review and meta-analysis
Toll-like receptors (TLRs) are crucial components of innate immunity. A specific form of genetic variation in TLR genes ma...
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
The ABCC subfamily contains thirteen members. Nine of these transporters are called multidrug resistance proteins (MRPs). ...
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1
Baicalein, one of the major active flavonoids found in Scutellaria baicalensis, has been revealed to exhibit potent anti-i...
The effects of bone marrow humoral components of B-cell acute lymphoblastic leukemia patients on natural killer cell suppression
The effects of bone marrow humoral components of B-cell acute lymphoblastic leukemia patients on natural killer cell suppression
B-cell acute lymphoblastic leukemia (B-ALL) is the most common form of cancer diagnosed in children. While the majority of...
Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity
Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity
In tropical countries, malaria transmission is the major health issue. To eradicate malaria, health communities depend on ...
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy ...
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
This study assessed trends in age-standardized incidence (ASIR), prevalence (ASPR), and mortality rates (ASMR) per 100,000...
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantl...
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Congenital neutropenia (CoN) is a heterogeneous group of inborn errors of immunity (IEI) characterized by recurrent infect...
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding ...
QuantiFERON SARS-CoV-2 assay for the evaluation of cellular immunity after immunization with mRNA SARS-CoV-2 vaccines: a systematic review and meta-analysis
QuantiFERON SARS-CoV-2 assay for the evaluation of cellular immunity after immunization with mRNA SARS-CoV-2 vaccines: a systematic review and meta-analysis
A systematic review and meta-analysis were performed to evaluate the virus-specific T-cell response after COVID-19 mRNA va...
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