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Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
The pathogenesis of recurrent pregnancy loss (RPL) is unclear. RPL may have an association with disruption of immune toler...
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Antinuclear antibodies (ANA) are the most common biomarkers observed in autoimmune diseases. Cytoplasmic staining patterns...
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Gouty arthritis (GA) is an inflammatory disorder characterized by deposition of monosodium urate (MSU) crystal in joints. ...
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its in...
Belimumab 10 years later: how drug positioning has changed
Belimumab 10 years later: how drug positioning has changed
We analysed the change in the positioning of belimumab (BLM) in systemic lupus erythematosus (SLE) treatment in the first ...
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis
It is known that 1,7-dihydroxy-3,4-dimethoxyxanthone (XAN), derived from Securidaca inappendiculata Hassk., exhibits anti-...
Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity
Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity
Pomalidomide, a third-generation oral immunomodulatory drug, exhibits efficacy in patients with relapsed multiple myeloma ...
Integrating machine learning and multi-omics analysis to develop an asparagine metabolism immunity index for improving clinical outcome and drug sensitivity in lung adenocarcinoma
Integrating machine learning and multi-omics analysis to develop an asparagine metabolism immunity index for improving clinical outcome and drug sensitivity in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is a malignancy affecting the respiratory system. Most patients are diagnosed with advanced or ...
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India
Hereditary angioedema (HAE) is a rare genetic disorder. The pattern of HAE is different in children as compared to adults....
Post-translational modification in the pathogenesis of vitiligo
Post-translational modification in the pathogenesis of vitiligo
Vitiligo is a chronic dermatological condition marked by the loss of skin pigmentation. Its complex etiology involves mult...
Patent blue V dye anaphylaxis: should basophil activation test play a role in the diagnosis?
Patent blue V dye anaphylaxis: should basophil activation test play a role in the diagnosis?
Garvey LH, Ebo DG, Mertes PM, et al. An EAACI position paper on the investigation of perioperative immediate hypersensitiv...
A rare cause of immune dysregulation, prolidase deficiency: a case report and review of the literature
A rare cause of immune dysregulation, prolidase deficiency: a case report and review of the literature
We report a pediatric patient with prolidase deficiency, caused by a mutation in the PEPD gene, which encodes the enzyme p...
ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?
ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?
Vaccines are an identified cause of autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In this researc...
DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability
DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability
Asthma is featured by persistent airway inflammation. Long noncoding RNAs (lncRNAs) are reported to play critical roles in...
Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy
Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy
This study aims to explore the relationship between serum soluble interleukin-2 receptor alpha (sIL-2Rα) lev...
Tumour-associated macrophages in diffuse large B-cell lymphoma: the prognostic and therapeutic impact in a South African centre with high HIV seroprevalence
Tumour-associated macrophages in diffuse large B-cell lymphoma: the prognostic and therapeutic impact in a South African centre with high HIV seroprevalence
Diffuse large B-cell lymphoma (DLBCL) is a common malignancy among people living with HIV. Macrophage enrichment of the tu...
The dysregulation of mitochondrial homeostasis–related genes could be involved in the decrease of mtDNA copy number in systemic lupus erythematosus patients
The dysregulation of mitochondrial homeostasis–related genes could be involved in the decrease of mtDNA copy number in systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is a chronic multifactorial autoimmune disease. It is now widely demonstrated that oxid...
NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy
NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy
The complex relationship between natural killer (NK) cells and dendritic cells (DCs) within the tumor microenvironment sig...
Changes in immune subsets during chemotherapy as prognosis biomarkers for multiple myeloma patients by longitudinal monitoring
Changes in immune subsets during chemotherapy as prognosis biomarkers for multiple myeloma patients by longitudinal monitoring
Multiple myeloma (MM) is a malignancy of plasma cells accompanied by immune dysfunction. This study aimed to provide a com...
MYOCD and SRF-mediated MLCK transcription prevents polymorphonuclear neutrophils from ferroptosis in sepsis-related acute lung injury
MYOCD and SRF-mediated MLCK transcription prevents polymorphonuclear neutrophils from ferroptosis in sepsis-related acute lung injury
Persistent activation of polymorphonuclear neutrophils (PMNs) plays a crucial role in the development of sepsis-related ac...
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation
Amphotericin B, a polyene macrolide antifungal agent, still plays an important role in the management of serious systemic ...
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity
In the recent EULAR recommendations, ultrasound examination is now recommended as a first-line imaging test in all patient...
Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature
Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature
Good syndrome (GS), a rare acquired immunodeficiency disorder characterized by thymoma and hypogammaglobulinemia, predispo...
EBV + B cell-derived exosomes promote EBV-associated T/NK-cell lymphoproliferative disease immune evasion by STAT3/IL-10/PD-L1 pathway
EBV + B cell-derived exosomes promote EBV-associated T/NK-cell lymphoproliferative disease immune evasion by STAT3/IL-10/PD-L1 pathway
EBV-associated T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are characterized by the clonal proliferation of EBV...
In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties
In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties
Conventional therapeutic agents are no longer adequate against leishmaniasis. This complex condition continues to have a h...
New mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency
New mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency
Major Histocompatibility Complex Class II Deficiency is a rare primary immunodeficiency disease with autosomal recessive i...
Artificial intelligence applications for immunology laboratory: image analysis and classification study of IIF photos
Artificial intelligence applications for immunology laboratory: image analysis and classification study of IIF photos
Artificial intelligence (AI) is increasingly being used in medicine to enhance the speed and accuracy of disease diagnosis...
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer
Single-cell RNA sequencing (scRNA-seq) has contributed to understanding cellular heterogeneity and immune profiling in can...
cGAS-STING pathway in systemic lupus erythematosus: biological implications and therapeutic opportunities
cGAS-STING pathway in systemic lupus erythematosus: biological implications and therapeutic opportunities
The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway has been identified as a...
Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway
Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway
The cause of food allergy (FA) is still a mystery. Telomerases are involved in the regulation of immune responses. This st...
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