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Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group of disorders, ranging fr...
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
The long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVI...
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
Massive evidence shows that intestinal tryptophan metabolites affected by intestinal flora can modulate the progression of...
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity an...
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with a risk associated with hormonal and repr...
Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization
Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have rep...
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice
In modern medical practice, where polyethylene glycol is widely used as a component of various drugs, such as vaccines, ch...
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment
Passerini L, Barzaghi F, Curto R, Sartirana C, Barera G, Tucci F, Albarello L, Mariani A, Testoni PA, Bazzigaluppi E, Bosi...
Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target
Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target
Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination and damage to the central nervous sy...
Mass cytometry revealed the circulating immune cell landscape across different Suzuki stages of Moyamoya disease
Mass cytometry revealed the circulating immune cell landscape across different Suzuki stages of Moyamoya disease
Moyamoya disease (MMD) is a cerebrovascular disorder marked by progressive arterial narrowing, categorized into six stages...
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection
To increase the effectiveness of methicillin-resistant Staphylococcus aureus vaccines (MRSA), a new generation of immune s...
Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying mechanisms linking DM and TB re...
Acute stress transiently activates macrophages and chemokines in cervical lymph nodes
Acute stress transiently activates macrophages and chemokines in cervical lymph nodes
Acute restraint stress (RS) is routinely used to study the effects of psychological and/or physiological stress. We evalua...
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro
Allergic diseases affect nearly 30% of people worldwide. There is a wide range of allergen sources, such as animal dander,...
Study of pathogenic T-helper cell subsets in Asian Indian patients with Takayasu arteritis
Study of pathogenic T-helper cell subsets in Asian Indian patients with Takayasu arteritis
The relapses and refractory disease are a challenge in the management of patients with Takayasu arteritis (TAK). ...
Blood and CSF anti-neuronal antibodies testing in psychotic syndromes: a retrospective analysis from a tertiary psychiatric hospital
Blood and CSF anti-neuronal antibodies testing in psychotic syndromes: a retrospective analysis from a tertiary psychiatric hospital
A Consensus of Psychoimmunology Experts (Pollak et al., 2019) established a set of red flags and proposed diagnostic crite...
Evidence of concerning decline of COVID-19 vaccination in older persons
Evidence of concerning decline of COVID-19 vaccination in older persons
Lippi G, Plebani M. COVID-19: the global health emergency is over for the WHO, but not yet for laboratory medicine. J Lab ...
Rituximab alleviates pediatric systemic lupus erythematosus associated refractory immune thrombocytopenia: a case-based review
Rituximab alleviates pediatric systemic lupus erythematosus associated refractory immune thrombocytopenia: a case-based review
A complication of pediatric systemic lupus erythematosus (pSLE) is immune thrombocytopenia (ITP). Although corticosteroids...
The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
B7-H3 is a member of the B7 superfamily and a putative inhibitory immune checkpoint molecule. Several early-phase clinical...
Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection
Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection
Although the functions of programmed death-1 (PD-1) on αβ T cells have been extensively reported, a role for PD-...
DNA methylation profiling of labial salivary gland tissues revealed hypomethylation of B-cell-related genes in primary Sjögren’s syndrome
DNA methylation profiling of labial salivary gland tissues revealed hypomethylation of B-cell-related genes in primary Sjögren’s syndrome
The objective of this epigenetic study was to investigate the cellular proportions based on DNA methylation signatures and...
Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase
Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase
Recombination-activating gene 1 (RAG1) is a vital player in V(D)J recombination, a fundamental process in primary B cell a...
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant
Papa R, Caorsi R, Volpi S, Gattorno M. New monogenic autoinflammatory diseases: 2021 year in review. Immunol Lett. 2022;24...
Response to: regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection
Response to: regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection
In response to Chen et al.’s comments on our paper regarding the significance of anti-COVID-IgA antibody response in...
Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs
Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs
In rheumatoid arthritis (RA), immune homeostasis is maintained by T regulatory cells (Tregs) that in an inflammatory milie...
The combination of IDO and AHR blockers reduces the migration and clonogenicity of breast cancer cells
The combination of IDO and AHR blockers reduces the migration and clonogenicity of breast cancer cells
The indoleamine-2,3-dioxygenase (IDO) enzyme causes immunosuppressive consequences in the tumor microenvironment (TME). In...
Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study
Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study
Diagnosis of renal fibrosis can only be verified by kidney biopsy, but biomarkers for non-invasive evaluation remain unsat...
COVID-19 in Systemic Lupus Erythematosus patients treated with belimumab: a retrospective clinical study
COVID-19 in Systemic Lupus Erythematosus patients treated with belimumab: a retrospective clinical study
Routine use of immunosuppressive agents in systemic lupus erythematosus (SLE) patients infected with severe acute respirat...
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research
Publisher's noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional a...
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps
Activated neutrophils release neutrophil extracellular traps (NETs) composed of chromatin filaments containing bactericida...
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