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CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
In adults, sodium-glucose cotransporter type 2 inhibitors have revolutionised the treatment of type 2 diabetes mellitus, h...
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disorder that primarily affects the joints in children. Notabl...
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
To date, evidence has been lacking regarding bevacizumab pharmacokinetics in the cerebrospinal fluid (CSF). This study ass...
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Necrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight ...
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Neuromuscular blocking agents are routinely used in laparoscopic surgery to optimize operative conditions. We compared the...
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (...
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Systemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders assoc...
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Juvenile psoriatic arthritis (JPsA) is a heterogeneous type of non-systemic chronic inflammatory arthritis affecting child...
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
The management of vascular malformations is complex and challenging. This study aimed to explore efficacy, plasma trough c...
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Funding No funding was received for the preparation of this letter....
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Concerns exist regarding the rising use of methylphenidate. A double-blind, placebo-controlled methylphenidate titration (...
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Patients with atopic dermatitis (AD), particularly infants and young children, are at greater risk of developing skin infe...
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Prescribing is a high-risk task within the pediatric medication-use process and requires defenses to prevent errors. Such ...
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study
Voriconazole pharmacokinetics are highly variable in pediatric patients, and the optimal dosage has yet to be det...
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Pediatric prucalopride studies for treatment of gastrointestinal (GI) disorders have reported mixed results. We aimed to a...
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Anti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma,...
Managing Lupus Nephritis in Children and Adolescents
Managing Lupus Nephritis in Children and Adolescents
Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidn...
Incidence of Antimicrobial-Associated Acute Kidney Injury in Children: A Structured Review
Incidence of Antimicrobial-Associated Acute Kidney Injury in Children: A Structured Review
Acute kidney injury (AKI) is a commonly reported adverse effect of administration of antimicrobials. While AKI can be asso...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and is...
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0.7% ...
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Patent ductus arteriosus (PDA) in preterm infants is associated with increased morbidities and mortality. Prophylactic tre...
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a pr...
Emerging Treatments for Childhood Interstitial Lung Disease
Emerging Treatments for Childhood Interstitial Lung Disease
Childhood interstitial lung disease (chILD) is a large and heterogeneous group of disorders characterized by diffuse lung ...
Correction to: Viloxazine: Pediatric First Approval
Correction to: Viloxazine: Pediatric First Approval
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children. In recent years, pediatric psor...
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
U.S. Food and Drug Administration. Accelerated approval. 2023. https://www.fda.gov/patients/fast-track-breakthrough-therap...
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Pfizer is developing a bivalent respiratory syncytial virus (RSV) prefusion F subunit vaccine (RSVpreF; ABRYSVO™) fo...
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is an emerging and potentially life...
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