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A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
Opioid therapy is the mainstay for managing pain in pediatric oncology. This narrative review describes the current litera...
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined ...
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable m...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab ozogamicin (BESPONSA™) is a CD22-targeted monoclonal antibody drug conjugate (ADC) developed by Pfizer fo...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, ...
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspep...
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
The widespread use of drugs for unapproved purposes remains common in children, primarily attributable to practical, ethic...
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
In adults, sodium-glucose cotransporter type 2 inhibitors have revolutionised the treatment of type 2 diabetes mellitus, h...
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disorder that primarily affects the joints in children. Notabl...
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
To date, evidence has been lacking regarding bevacizumab pharmacokinetics in the cerebrospinal fluid (CSF). This study ass...
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Necrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight ...
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Neuromuscular blocking agents are routinely used in laparoscopic surgery to optimize operative conditions. We compared the...
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (...
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Systemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders assoc...
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Juvenile psoriatic arthritis (JPsA) is a heterogeneous type of non-systemic chronic inflammatory arthritis affecting child...
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
The management of vascular malformations is complex and challenging. This study aimed to explore efficacy, plasma trough c...
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Funding No funding was received for the preparation of this letter....
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Concerns exist regarding the rising use of methylphenidate. A double-blind, placebo-controlled methylphenidate titration (...
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Patients with atopic dermatitis (AD), particularly infants and young children, are at greater risk of developing skin infe...
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Prescribing is a high-risk task within the pediatric medication-use process and requires defenses to prevent errors. Such ...
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study
Voriconazole pharmacokinetics are highly variable in pediatric patients, and the optimal dosage has yet to be det...
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Pediatric prucalopride studies for treatment of gastrointestinal (GI) disorders have reported mixed results. We aimed to a...
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Anti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma,...
Managing Lupus Nephritis in Children and Adolescents
Managing Lupus Nephritis in Children and Adolescents
Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidn...
Incidence of Antimicrobial-Associated Acute Kidney Injury in Children: A Structured Review
Incidence of Antimicrobial-Associated Acute Kidney Injury in Children: A Structured Review
Acute kidney injury (AKI) is a commonly reported adverse effect of administration of antimicrobials. While AKI can be asso...
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