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Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study
Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study
This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in p...
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of...
Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment
Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment
Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease primarily affecting very pre...
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis with onset before 18 years of age. It is characteri...
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achie...
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited...
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
We aimed to determine the piperacillin disposition and optimize the dosing regimens for infants and children with pneumoni...
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and inclu...
Apremilast: First Pediatric Approval
Apremilast: First Pediatric Approval
Apremilast (Otezla®) is an inhibitor of phosphodiesterase-4 (PDE-4) being developed by Amgen. It is approved in multi...
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passi...
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
The purpose of this study was to review the pharmacokinetic profile of gentamicin among neonates with hypoxic ischemic enc...
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable ...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, w...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Immunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplan...
Preventing Recurrence of Crohn’s Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence
Preventing Recurrence of Crohn’s Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence
Ileocaecal resection (ICR) is frequent in paediatric patients with Crohn’s disease (pCD). Despite rates of reoperati...
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
The efficacy and safety of propranolol for retinopathy of prematurity (ROP) remain under debate. This network meta-analysi...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
Opioid therapy is the mainstay for managing pain in pediatric oncology. This narrative review describes the current litera...
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined ...
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable m...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab ozogamicin (BESPONSA™) is a CD22-targeted monoclonal antibody drug conjugate (ADC) developed by Pfizer fo...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
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