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Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
The purpose of this study was to review the pharmacokinetic profile of gentamicin among neonates with hypoxic ischemic enc...
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable ...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, w...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Immunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplan...
Preventing Recurrence of Crohn’s Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence
Preventing Recurrence of Crohn’s Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence
Ileocaecal resection (ICR) is frequent in paediatric patients with Crohn’s disease (pCD). Despite rates of reoperati...
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
The efficacy and safety of propranolol for retinopathy of prematurity (ROP) remain under debate. This network meta-analysi...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
Opioid therapy is the mainstay for managing pain in pediatric oncology. This narrative review describes the current litera...
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined ...
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable m...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab ozogamicin (BESPONSA™) is a CD22-targeted monoclonal antibody drug conjugate (ADC) developed by Pfizer fo...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, ...
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspep...
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
The widespread use of drugs for unapproved purposes remains common in children, primarily attributable to practical, ethic...
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
In adults, sodium-glucose cotransporter type 2 inhibitors have revolutionised the treatment of type 2 diabetes mellitus, h...
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disorder that primarily affects the joints in children. Notabl...
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
To date, evidence has been lacking regarding bevacizumab pharmacokinetics in the cerebrospinal fluid (CSF). This study ass...
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Necrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight ...
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
Neuromuscular blocking agents are routinely used in laparoscopic surgery to optimize operative conditions. We compared the...
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (...
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