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SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
SARS-CoV-2 down-regulates ACE2 by inducing clathrin- and AP2-dependent endocytosis, leading to its degradation in the lyso...
A virus changed my life
A virus changed my life
The E. E. Just Award commemorates the great African-American cell biologist Dr. Ernest Everett Just, who was a successful ...
Preprint Highlight: ALIBY: ALFA nanobody-based toolkit for imaging and biochemistry in yeast
Preprint Highlight: ALIBY: ALFA nanobody-based toolkit for imaging and biochemistry in yeast
Many commonly used protein epitope tags are optimized for one or a few biological applications. The recently developed ALF...
Preprint Highlight: Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks
Preprint Highlight: Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks
Tissue folding requires proper coordination between constricting cells and their neighbors that are not undergoing cell sh...
Getting where you want to go
Getting where you want to go
In 1956, referring to the emerging application of electron microscopy to the study of eukaryotic cells, Keith R. Porter wr...
Preprint Highlight: ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue
Preprint Highlight: ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue
During development, cells operate in a complex geometrical environment. Geometry can inform morphogenesis by patterning me...
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis
The fission yeast polycystin channel Pkd2 is required for the expansion of cell volume during cell growth and cytokinesis....
Coatomer in the universe of cellular complexity
Coatomer in the universe of cellular complexity
Eukaryotic cells possess considerable internal complexity, differentiating them from prokaryotes. Eukaryogenesis, an evolu...
Reflections on mentorship as an early career researcher
Reflections on mentorship as an early career researcher
It is my great honor to receive the 2022 Günter Blobel Early Career Award from the American Society for Cell Biology. Refl...
Preprint Highlight: Actin-driven protrusions generate rapid long-range membrane tension propagation in cells
Preprint Highlight: Actin-driven protrusions generate rapid long-range membrane tension propagation in cells
The distribution of long-range membrane tension across a cell is controversial. Previous studies find either that cell mem...
Inclusivity in cell biology: cultural identity and the power of authenticity
Inclusivity in cell biology: cultural identity and the power of authenticity
I am deeply honored to be the recipient of the 2022 ASCB Public Service Award. In addition to my research on the cytoskele...
Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament
Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament
The fine regulation of actin polymerization is essential to control cell motility, architecture and to perform essential c...
MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles
MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles
Faithful chromosome segregation requires the assembly of a bipolar spindle, consisting of two antiparallel microtubule (MT...
Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles
Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles
Dynein inactivates the spindle assembly checkpoint (SAC) by transporting checkpoint proteins away from kinetochores toward...
Suppression of chromosome instability by targeting a DNA helicase in budding yeast
Suppression of chromosome instability by targeting a DNA helicase in budding yeast
Chromosome instability (CIN) is an important driver of cancer initiation, progression, drug resistance, and aging. As such...
Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells
Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells
Trophoblast giant cells (TGCs) undergo endocycles resulting in polyploidy but their centriole state is unknown. We find th...
Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei
Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei
Chromosomes in micronuclei are fragmented into small pieces, sometimes catastrophically. Such severely damaged chromosomes...
Preprint Highlight: A role for phase separation to prevent R-loops during transcription
Preprint Highlight: A role for phase separation to prevent R-loops during transcription
The RNA-binding protein FUS (FUSed in sarcoma) regulates transcription by binding to polymerases and undergoing phase sepa...
Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation
Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation
Membrane remodeling mediated by heteropolymeric filaments composed of ESCRT-III subunits is an essential process that occu...
Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality
Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality
Matrix stiffness and dimensionality were shown to be major determinants of cell behavior. However, a workflow for examinin...
SARS-CoV-2 downregulates ACE2 through lysosomal degradation
SARS-CoV-2 downregulates ACE2 through lysosomal degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S) glycoprotein to bind to the angiotensi...
Imp2p forms actin-dependent clusters and imparts stiffness to the contractile ring
Imp2p forms actin-dependent clusters and imparts stiffness to the contractile ring
The contractile ring must anchor to the plasma membrane and cell wall to transmit its tension. F-BAR domain containing pro...
Basal bodies bend in response to ciliary forces
Basal bodies bend in response to ciliary forces
Motile cilia beat with an asymmetric waveform consisting of a power stroke that generates a propulsive force and a recover...