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Complete assembly, annotation of virulence genes and CRISPR editing of the genome of Leishmania amazonensis PH8 strain
Available online 30 May 2023, 110661Author links open overlay panel, , , , , , , , , , Highlights•The L. amazonensis PH8 s...
Testing the generalizability of cfDNA fragmentomic features across different studies for cancer early detection
cfDNA fragmentomic features have been used in cancer detection models; however, the generalizability of the models needs t...
Transcriptional profiling of exosomes derived from plasma of canine with mammary tumor by RNA-seq analysis
Canine mammary tumor (CMT) are the second most common tumor in dogs. Exosomes can act as biomarkers for the early diagnosi...
Mechanisms of ferroptosis with immune infiltration and inflammatory response in rotator cuff injury
The processes driving ferroptosis and rotator cuff (RC) inflammation are yet unknown. The mechanism of ferroptosis and inf...
Whole genome sequence analysis and in-vitro probiotic characterization of Bacillus velezensis FCW2 MCC4686 from spontaneously fermented coconut water
In this study, the probiotic potential of B. velezensis FCW2, isolated from naturally fermented coconut water, was investi...
Chromatin accessibility in gill tissue identifies candidate genes and loci associated with aquaculture relevant traits in tilapia
Volume 115, Issue 4, July 2023, 110633Author links open overlay panel, , , , , , Highlights•85% of all Nile tilapia genes ...
Sex different effect of antibiotic and probiotic treatment on intestinal microbiota composition in chemically induced liver injury rats
Differences in the gut microbiota and metabolic processes between males and females may explain differences in the risk of...
Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer
ResultsExosomes containing PD-L1 siRNA and CTLA-4 siRNA repressed malignant features of CRC cells and restrained tumor gro...
Correlation between immunotherapy biomarker PD-L1 expression and genetic alteration in patients with non-small cell lung cancer
Programmed death-ligand 1 (PD-L1) has been widely used in immunotherapy evaluation of patients with non-small cell lung ca...
Global dissection of R2R3-MYB in Pogostemon cablin uncovers a species-specific R2R3-MYB clade
KeywordsR2R3-MYBPatchouliGenome-wide identificationGene family characterizationFunction predictionSynteny analysisAbbrevia...
Hsa_circ_0002019 promotes cell proliferation, migration, and invasion by regulating TNFAIP6/NF-κB signaling in gastric cancer
BackgroundGastric cancer (GC) is a common cancer with a high incidence and mortality rate. Herein, the role of hsa_circ_00...
Transcriptome wide functional analysis of HBx expressing human hepatocytes stimulated with endothelial cell cross-talk
The datasets analysed during the current study are publicly available in the Gene Expression Omnibus (GEO) repository, htt...
Comparative basal transcriptome profiles of the olfactory rosette and gills of Atlantic salmon (Salmo salar) unveil shared and distinct immunological features
The molecular repertoire of the mucosa-associated lymphoid tissue (MALT) in the olfactory rosette in most teleost fish is ...
Emergence and evolution of drug-resistant Mycobacterium tuberculosis in eastern China: A six-year prospective study
Understanding the emergence and evolution of drug resistance can inform public health intervention to combat tuberculosis ...
Interleukin-35 expression promotes hepatocellular carcinogenesis by inducing γδ T-cell exhaustion
Interleukin (IL)-35, a new member of the IL-12 family, exerts immunosuppressive effects in the hepatic microenvironment. I...
STAT5A modulates gastric cancer progression via upregulation of CD44
ObjectiveSignal transduction and transcriptional activator 5A (STAT5A), which has been reported to be frequently phosphory...
Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism
KeywordsCRKLPan-cancerMelanomaImmunotherapeutic responsePyroptosisData availabilityThe original contributions presented in...
Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts
Orofacial clefts (OFCs) are the most common congenital craniofacial disorders and cause serious problems with the appearan...
SCARA5 in bone marrow stromal cell-derived exosomes inhibits colorectal cancer progression by inactivating the PI3K/Akt pathway
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer worldwide. Bone marrow stromal cells (BMSCs) play a...
Whole genome sequence analysis and in-vitro probiotic characterization of Bacillus velezensis FCW2 from spontaneously fermented coconut water
In this study, the probiotic potential of B. velezensis FCW2, isolated from naturally fermented coconut water, was investi...
Deciphering the biodesulfurization pathway employing marine mangrove Bacillus aryabhattai strain NM1-A2 according to whole genome sequencing and transcriptome analyses
In the biogeochemical cycle, sulfur oxidation plays a vital role and is typically referred to as the elemental sulfur or r...
A systematic genome-wide analysis and screening of the NAC family genes related to wood formation in Cinnamomum camphora
KeywordsCinnamomum camphoraNAC transcription factorsCollinearity analysisPhylogenetic treeGene expressionAbbreviationsCcNA...
Intestinal epigenotype of Atlantic salmon (Salmo salar) associates with tenacibaculosis and gut microbiota composition
Author links open overlay panel, , , , , , , , Highlights•DNA methylation associated with tenacibaculosis and microbiota i...
A self-developed AIM-InDel panel designed for degraded DNA analysis: Forensic application characterization and genetic landscape investigation in the Han Chinese population
KeywordsAncestry inferenceDegraded DNACapillary electrophoresisSelf-developed panelForensic geneticsData availabilityThe d...
Longitudinal large-scale changes in maternal circulating microRNAs associated with gestation-related compartments, fetal sex, and growth during and post-pregnancy
Circulating microRNAs (c-miRNAs) during pregnancy could provide information regarding the functional status of the mother ...
Establishment and validation of lncRNA-related prognostic signatures in cholangiocarcinoma
The datasets generated and/or analyzed during the current study are available on TCGA (https://portal.gdc.cancer.gov/) and...
Identification of two cassava receptor-like cytoplasmic kinase genes related to disease resistance via genome-wide and functional analysis
KeywordsCassavaRLCK gene familyDisease resistanceCassava bacterial blightVirus-induced gene silencingAbbreviationsRLCKRece...
Investigation of changes in DNA methylation associated with alterations in gene expression resulting in differences between lean and obese adipogenesis
Available online 14 April 2023, 110623Author links open overlay panel, , Highlights•Alterations in DNA methylation that ne...
Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury
The raw sequencing data after filtering in the form of FASTQ sequencing files and processed data showing normalized expres...
A chromosome-scale genome assembly of Malus domestica, a multi-stress resistant apple variety
Hanfu apple is the main cultivar grown in the cool areas of Northeast, Northwest, and North China. Here, we proposed a chr...
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