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Evolutionary relationships of adenylation domains in fungi
Non-ribosomal peptide synthetases (NRPSs) and NRPS-like enzymes are abundant in microbes as they are involved in the produ...
Deep-sea sediment metagenome from Bay of Bengal reveals distinct microbial diversity and functional significance
Bay of Bengal (BoB) has immense significance with respect to ecological diversity and natural resources. Studies on microb...
Hydrogen improves exercise endurance in rats by promoting mitochondrial biogenesis
BackgroundPrevious studies have shown that hydrogen water has antioxidant and anti-inflammatory effects on exercise-induce...
Small RNAs target native and cross-kingdom transcripts on both sides of the wheat stripe rust interaction
The wheat stripe rust fungus (Puccinia striiformis f.sp. tritici) threatens global wheat production. Small RNAs (sRNAs) mo...
Causal association between heart failure and bone mineral density: Insights from a two-sample bidirectional Mendelian randomization study
In recent times, the association between HF and BMD has attracted enormous interest in the scientific community. However, ...
De novo genome assembly of the bioluminescent mushroom Omphalotus guepiniiformis reveals an Omphalotus-specific lineage of the luciferase gene block
Omphalotus guepiniiformis, a bioluminescent mushroom species, is a source of the potentially valuable anticancer chemical....
Transcriptome of pituitary function changes in rat model of high altitude cerebral edema
High altitude cerebral edema (HACE) is a serious subtype of acute mountain sickness (AMS). Studies have suggested that inc...
Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility
The assembled genome and annotation were deposited in the Genome Warehouse of the National Genomics Data Center (https://n...
An integrated transcriptomic and metabolomic analysis for changes in rose plant induced by rose powdery mildew and exogenous salicylic acid
We explored the transcriptomic and metabolomic changes in Rosa chinensis after the infection with Podosphaera pannosa and ...
Integrated metabolite profiling and transcriptome analysis reveal candidate genes involved in the formation of yellow Nelumbo nucifera
As a worldwide major ornamental flower and a edible plant, lotus (Nelumbo nucifera) is also used as medicine and tea bever...
Phylogenomics and gene selection in Aspergillus welwitschiae: Possible implications in the pathogenicity in Agave sisalana
Aspergillus welwitschiae causes bole rot disease in sisal (Agave sisalana and related species) which affects the productio...
A ∼ 4.1 kb deletion in IRX1 gene upstream is completely associated with rumplessness in Piao chicken
Piao chicken, a Chinese indigenous rumpless chicken breed, lacks pygostyle, caudal vertebra, uropygial gland and tail feat...
SRP54 mediates circadian rhythm-related, temperature-dependent gene expression in Drosophila
Recent studies have shown that alternative splicing (AS) plays an important role in regulating circadian rhythm. However, ...
Informing plasmid compatibility with bacterial hosts using protein-protein interaction data
The compatibility of plasmids with new host cells is significant given their role in spreading antimicrobial resistance (A...
Identification and characterization of unique and common lncRNAs and mRNAs in the pituitary, ovary, and uterus of Hu sheep with different prolificacy
LncRNAs are regarded as regulators in various animal reproductive physiological processes. However, the regulation of lncR...
A392V and R945X mutations cause orofacial clefts via impairing PTCH1 function
The Hedgehog (HH) signaling plays key roles in embryogenesis and organogenesis, and its dysfunction causes a variety of hu...
Associations of genome-wide cell-free DNA fragmentation profiles with blood biochemical and hematological parameters in healthy individuals
Cell-free DNA (cfDNA), as a non-invasive approach, has been introduced in a wide range of applications, including cancer d...
Effect of prior drought and heat stress on Camellia sinensis transcriptome changes to Ectropis oblique (Lepidoptera: Geometridae) resistance
Tea plants are continuously confronted with a wide range of biotic and abiotic stressors in the field, which can occur con...
An improved, chromosome-level genome of the giant panda (Ailuropoda melanoleuca)
BackgroundThe iconic giant panda (Ailuropoda melanoleuca), as both a flagship and umbrella species endemic to China, is a ...
Methylation microarray-based detection of clinical copy-number aberrations in CLL benchmarked to standard FISH analysis
Copy-number aberrations (CNAs) are assessed using FISH analysis in diagnostics of chronic lymphocytic leukemia (CLL), but ...
The dynamics of lncRNAs transcription in interspecific F1 allotriploid hybrids between Brassica species
Interspecific hybridization is the intrinsic forces behind genome evolution. Long non-coding RNAs (lncRNAs) are important ...
The impact of Piscirickettsia salmonis infection on genome-wide DNA methylation profile in Atlantic Salmon
Salmon rickettsial septicaemia (SRS), caused by the bacteria Piscirickettsia salmonis (P. salmonis), is responsible for si...
Detection and monitoring of HBV-related hepatocellular carcinoma from plasma cfDNA fragmentation profiles
Most hepatocellular carcinomas (HCCs) are associated with hepatitis B virus infection (HBV) in China. Early detection of H...
Detection, monitoring, and carcinogenesis study of HBV-related HCCs from plasma cfDNA fragmentation profiles
Most hepatocellular carcinomas (HCCs) are associated with hepatitis B virus infection (HBV) in China. Early detection of H...
m6A transferase METTL3 regulates endothelial-mesenchymal transition in diabetic retinopathy via lncRNA SNHG7/KHSRP/MKL1 axis
Diabetic retinopathy is one of the microvascular complications in diabetic patients and the leading cause of blindness wor...
NanoCross: A pipeline that detecting recombinant crossover using ONT sequencing data
Meiotic recombination is crucial for eukaryotes but varies among taxonomic scales (between individuals, groups, species, e...