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The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells
The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells
One promising strategy to alleviate aging symptoms is the treatment with senolytics that is compounds which selectively el...
Serum β-secretase 1 (sBACE1) activity in subjective cognitive decline: an exploratory study
Serum β-secretase 1 (sBACE1) activity in subjective cognitive decline: an exploratory study
β-Secretase-1 (BACE1) plays a key role in the regulation of cerebral amyloid-β homeostasis, being involved in am...
Circulating biomarkers associated with walking performance in elderly subjects: exploring miRNAs, metabolic and inflammatory biomarkers
Circulating biomarkers associated with walking performance in elderly subjects: exploring miRNAs, metabolic and inflammatory biomarkers
Aging phenotype is characterized by musculoskeletal impairment that leads to diminished mobility and physical function. Th...
Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals
Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals
With advancements in veterinary care and the growing recognition of pets as integral member of the family, the lifespans o...
Accelerated epigenetic ageing after burn injury
Accelerated epigenetic ageing after burn injury
Individuals who suffer a major burn injury are at higher risk of developing a range of age-associated diseases prematurely...
The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway
The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway
D-β-hydroxybutyrate, BHB, has been previously proposed as an anti-senescent agent in vitro and in vivo in several tis...
The bright and dark side of blue-enriched light on sleep and activity in older adults
The bright and dark side of blue-enriched light on sleep and activity in older adults
Low indoor light in urban housing can disrupt health and wellbeing, especially in older adults who experience reduced ligh...
Aβ42 biomarker linked to insula, striatum, thalamus and claustrum in dementia with Lewy bodies
Aβ42 biomarker linked to insula, striatum, thalamus and claustrum in dementia with Lewy bodies
The differential mechanisms between proteinopathies and neurodegeneration in Alzheimer’s disease (AD) and dementia w...
Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol
Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol
Ageing is the primary driver of age-associated chronic diseases and conditions. Asian populations have traditionally been ...
Association between inflammatory biomarkers and the cognitive response to a multidomain intervention: secondary longitudinal analyses from the MAPT study
Association between inflammatory biomarkers and the cognitive response to a multidomain intervention: secondary longitudinal analyses from the MAPT study
The aim of this study is to evaluate the association of systemic inflammation measured by plasma biomarkers with the chang...
5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept
5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept
Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and d...
Healthy aging changes in conventional frequency bands of neuroelectric brain activity reconstructed from resting-state MEG
Healthy aging changes in conventional frequency bands of neuroelectric brain activity reconstructed from resting-state MEG
Age-related dependencies of electric and spectral powers in conventional frequency bands were studied by the newly propose...
Light buckets and laser beams: mechanisms and applications of photobiomodulation (PBM) therapy
Light buckets and laser beams: mechanisms and applications of photobiomodulation (PBM) therapy
Photobiomodulation (PBM) therapy, a non-thermal light therapy using nonionizing light sources, has shown therapeutic poten...
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related c...
DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging
DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging
Biological age estimation from DNA methylation and determination of relevant biomarkers is an active research problem whic...
Analysis of sex-specific disease patterns associated with human lifespan
Analysis of sex-specific disease patterns associated with human lifespan
Disability and multimorbidity increase with aging and constitute a challenge for the health system. However, different ind...
Age-specific effects of a sustained cognitive activity on perceived cognitive fatigue as well as single- and dual-task treadmill walking performance
Age-specific effects of a sustained cognitive activity on perceived cognitive fatigue as well as single- and dual-task treadmill walking performance
During their daily lives humans are often confronted with sustained cognitive activities (SCA) leading to state fatigue, a...
Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
Flaxseed, a rich source of omega-3 polyunsaturated fatty acid alpha-linolenic acid (ALA), lignans, and soluble fiber, has ...
Lung endothelial cell senescence impairs barrier function and promotes neutrophil adhesion and migration
Lung endothelial cell senescence impairs barrier function and promotes neutrophil adhesion and migration
Cellular senescence contributes to inflammation and organ dysfunction during aging. While this process is generally charac...
The impact of co-housing on murine aging studies
The impact of co-housing on murine aging studies
Analysis of preclinical lifespan studies often assume that outcome data from co-housed animals are independent. In practic...
Enhancing emergency care for older persons: the role and impact of the electronic Frailty Index
Enhancing emergency care for older persons: the role and impact of the electronic Frailty Index
As the elderly population expands, enhancing emergency department (ED) care by assessing frailty becomes increasingly vita...
Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis
Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis
Rheumatoid arthritis (RA) is an age-related chronic inflammatory disease which may include accelerated biological ageing p...
The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis
The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis
Age-related cognitive impairment and dementia pose a significant global health, social, and economic challenge. While Alzh...
Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults
Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults
Unintentional weight loss in older populations is linked to greater mortality and morbidity risks. This study aims to unde...
Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65–85 years) individuals
Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65–85 years) individuals
Declines in physical and cognitive function are common in older adults. The circulating enzyme glycosylphosphatidylinosito...
Impact of adherence to the Mediterranean diet on stroke risk
Impact of adherence to the Mediterranean diet on stroke risk
Stroke is a leading cause of morbidity and mortality worldwide, and dietary patterns have emerged as a significant modifia...
Prognostic impact of glucagon-like peptide-1 receptor (GLP1R) expression on cancer survival and its implications for GLP-1R agonist therapy: an integrative analysis across multiple tumor types
Prognostic impact of glucagon-like peptide-1 receptor (GLP1R) expression on cancer survival and its implications for GLP-1R agonist therapy: an integrative analysis across multiple tumor types
Glucagon-like peptide-1 receptor (GLP-1R) agonists, such as exenatide (Byetta, Bydureon), liraglutide (Victoza, Saxenda), ...
Differential striatal dopamine binding in Parkinson’s Disease with and without REM sleep behavior disorder: A Tc-99 m TRODAT-1 SPECT study
Differential striatal dopamine binding in Parkinson’s Disease with and without REM sleep behavior disorder: A Tc-99 m TRODAT-1 SPECT study
Rapid eye movement (REM) sleep behavior disorder (RBD) is an early and significant prodromal marker for Parkinson’s ...
Digital cognitive training for functionality in mild cognitive impairment: a randomized controlled clinical trial
Digital cognitive training for functionality in mild cognitive impairment: a randomized controlled clinical trial
Digital cognitive training may improve cognition in people with mild cognitive impairment (MCI); however, the effect on fu...
Disentangling the effect of sex from brain size on brain organization and cognitive functioning
Disentangling the effect of sex from brain size on brain organization and cognitive functioning
Neuroanatomical sex differences estimated in neuroimaging studies are confounded by total intracranial volume (TIV) as a m...
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