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Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults
Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults
Cognitive training using a visual speed-of-processing task, called the Useful Field of View (UFOV) task, reduced dementia ...
Metabolic dysfunction and the development of physical frailty: an aging war of attrition
Metabolic dysfunction and the development of physical frailty: an aging war of attrition
The World Health Organization recently declared 2021–2030 the decade of healthy aging. Such emphasis on healthy agin...
Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to alter...
Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats
Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats
Cerebral small vessel diseases (CSVD) are neurological disorders associated with microvessels, manifested pathologically a...
Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure
Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure
Sensing temperature is vitally important to adapt our body to environmental changes. Local warm detection is required to i...
Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Machine learning models are increasingly being used to estimate “brain age” from neuroimaging data. The gap be...
Association of birthweight and risk of incident dementia: a prospective cohort study
Association of birthweight and risk of incident dementia: a prospective cohort study
Given the epidemiological studies investigating the relationship between birthweight and dementia are limited. Our study a...
Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing pro...
Exclusion of older patients from randomized clinical trials in Parkinson’s disease
Exclusion of older patients from randomized clinical trials in Parkinson’s disease
Prevalence of Parkinson’s disease (PD) increases with age. The purpose of this study was to evaluate the eligibility...
Resistance exercise effects on hippocampus subfield volumes and biomarkers of neuroplasticity and neuroinflammation in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial
Resistance exercise effects on hippocampus subfield volumes and biomarkers of neuroplasticity and neuroinflammation in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial
Physical exercise is suggested to promote hippocampal neuroplasticity by increasing circulating neurotrophic and anti-infl...
Exploring the potential of combining transcranial magnetic stimulation and electroencephalography to investigate mild cognitive impairment and Alzheimer’s disease: a systematic review
Exploring the potential of combining transcranial magnetic stimulation and electroencephalography to investigate mild cognitive impairment and Alzheimer’s disease: a systematic review
Transcranial magnetic stimulation (TMS) and electroencephalography (EEG) are non-invasive techniques used for neuromodulat...
The structural–functional-connectivity coupling of the aging brain
The structural–functional-connectivity coupling of the aging brain
Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all...
Short-term fasting of a single amino acid extends lifespan
Short-term fasting of a single amino acid extends lifespan
Diet and health are strongly linked, though the strict changes in diet required to improve health outcomes are usually dif...
Cross-frequency modulation of postural fluctuations and scalp EEG in older adults: error amplification feedback for rapid balance adjustments
Cross-frequency modulation of postural fluctuations and scalp EEG in older adults: error amplification feedback for rapid balance adjustments
Virtual error amplification (VEA) in visual feedback enhances attentive control over postural stability, although the neur...
Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim
Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim
Healthy Longevity Medicine aims to optimize health by targeting aging processes across the lifespan. Addressing accelerate...
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan predictio...
Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Diabetes mellitus type 2 (T2D) is associated with accelerated biological aging and the increased risk of onset of other ag...
Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis
Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis
A growing body of research suggested that there was a link between poor periodontal health and systemic diseases, particul...
Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride time asymmetry and increased gait entropy
Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride time asymmetry and increased gait entropy
Cerebral microhemorrhages (CMHs) are of paramount importance as they not only signify underlying vascular pathology but al...
Neurological diagnostic tests for patients with and without delirium: a prospective observational study
Neurological diagnostic tests for patients with and without delirium: a prospective observational study
Since most of the precipitating factors of delirium are not due to neurological disorders, neurological diagnostic tests (...
Guideline for designing microbiome studies in neoplastic diseases
Guideline for designing microbiome studies in neoplastic diseases
Oncobiosis has emerged as a key contributor to the development, and modulator of the treatment efficacy of cancer. Hereby,...
Correction to: Using non‑invasive behavioral and physiological data to measure biological age in wild baboons
Correction to: Using non‑invasive behavioral and physiological data to measure biological age in wild baboons
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USAChelsea J. Weibel, Mauna R. Dasari, David ...
The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans
The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans
Large central arterial stiffness is a risk factor for cerebrovascular damage and subsequent progression of neurodegenerati...
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Neuroinflammation, triggered by aberrantly activated microglia, is widely recognized as a key contributor to the initiatio...
Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age
Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age
Little is known about the possibility of reversing age-related biological changes when they have already occurred. To expl...
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variatio...
The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets
The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets
Beyond their activity in hemostasis and thrombosis, recent advances attribute platelets a pro-youthful role capable to att...
The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach
The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach
Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral sm...
Rho-kinase inhibition reduces systolic blood pressure and forearm vascular resistance in healthy older adults: a double-blind, randomized, placebo-controlled pilot study
Rho-kinase inhibition reduces systolic blood pressure and forearm vascular resistance in healthy older adults: a double-blind, randomized, placebo-controlled pilot study
Rho-kinase has been implicated in the development of hypertension in preclinical studies and may contribute to age-related...
Differentiation in theta and gamma activation in weight-shifting learning between people with parkinson’s disease of different anxiety severities
Differentiation in theta and gamma activation in weight-shifting learning between people with parkinson’s disease of different anxiety severities
Anxiety and postural control deficits may be related in people with Parkinson’s disease (PwPD). However, the associa...
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