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Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice
Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice
Frailty is an age-related condition characterized by a multisystem functional decline, increased vulnerability to stressor...
Efficient representations of binarized health deficit data: the frailty index and beyond
Efficient representations of binarized health deficit data: the frailty index and beyond
We investigated efficient representations of binarized health deficit data using the 2001–2002 National Health and N...
Strength gains after 12 weeks of resistance training correlate with neurochemical markers of brain health in older adults: a randomized control 1H-MRS study
Strength gains after 12 weeks of resistance training correlate with neurochemical markers of brain health in older adults: a randomized control 1H-MRS study
Physical exercise is considered a potent countermeasure against various age-associated physiological deterioration process...
CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
Locus of control (LOC) describes whether an individual thinks that they themselves (internal LOC) or external factors (ext...
Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
Age represents a major risk factor in heart failure (HF). However, the mechanisms linking ageing and HF are not clear. We ...
The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition
The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition
Hyperventilation (HV) is a voluntary activity that causes changes in the neuronal firing characteristics noticeable in the...
A new set of estimated cardiorespiratory fitness equations are associated with cognitive performance in older adults
A new set of estimated cardiorespiratory fitness equations are associated with cognitive performance in older adults
This study aimed to develop new equations to estimate cardiorespiratory fitness specifically for older adults and, secondl...
Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics
Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics
Ovarian injury caused by chemotherapy can lead to early menopause, infertility, and even premature senility in female canc...
Baseline and usual cardiorespiratory fitness and the risk of chronic kidney disease: A prospective study and meta-analysis of published observational cohort studies
Baseline and usual cardiorespiratory fitness and the risk of chronic kidney disease: A prospective study and meta-analysis of published observational cohort studies
Chronic kidney disease (CKD) is a global public health burden but is largely preventable. Few studies have reported an ass...
T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults
T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults
In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common co...
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner
Evidence for hypothalamic regulation of energy homeostasis and thermoregulation in brown adipose tissue (BAT) during aging...
Testing the evidence that lifespan-extending compound interventions are conserved across laboratory animal model species
Testing the evidence that lifespan-extending compound interventions are conserved across laboratory animal model species
A growing number of pharmaceutical and small molecule interventions are reported to extend the lifespan of laboratory anim...
Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
Although physiological data suggest that neuromuscular junction (NMJ) dysfunction is a principal mechanism underpinning sa...
GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer’s disease
GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer’s disease
Increased interest in the aging and Alzheimer’s disease (AD)-related impairments in autophagy in the brain raise imp...
Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults
Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults
Based on the premise that physical activity/exercise impacts hippocampal structure and function, we investigated if hippoc...
The aging of the immune system and its implications for transplantation
The aging of the immune system and its implications for transplantation
By the last third of life, most mammals, including humans, exhibit a decline in immune cell numbers, immune organ structur...
Understanding changes in mental health symptoms from young-old to old-old adults by sex using multiple-group latent transition analysis
Understanding changes in mental health symptoms from young-old to old-old adults by sex using multiple-group latent transition analysis
Older adults are classified into three homogeneous groups: young-old (age 65–74), old-old (age 75–84), and old...
Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection
Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection
Older adults have diminished immune responses that increase susceptibility to infectious diseases, such as influenza (flu)...
Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease
Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease
In the present study, we investigated the effects of urolithin A (UA), a metabolite generated from ellagic acid via its me...
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence
Slowing aging can reduce the risk of chronic diseases. In particular, eliminating senescent cells is a promising approach ...
Approximate entropy analysis across electroencephalographic rhythmic frequency bands during physiological aging of human brain
Approximate entropy analysis across electroencephalographic rhythmic frequency bands during physiological aging of human brain
Aging is the inevitable biological process that results in a progressive structural and functional decline associated with...
Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice
Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice
Deletion of pregnancy-associated plasma protein-A (PAPP-A), a protease that cleaves some but not all IGF1 binding proteins...
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial
Functional brain connectivity (FBC), or areas that are anatomically separate but temporally synchronized in their activati...
Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men
Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men
Hippocampal blood–brain barrier (BBB) permeability may increase in normal healthy ageing and contribute to neurodege...
Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids
Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids
Non-alcoholic fatty liver disease (NAFLD), encompassing fatty liver and its progression into nonalcoholic steatohepatitis ...
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies
The most severe alterations in Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome Coronav...
Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice
Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice
Adapting to stress, including cold environmental temperature (eT), is crucial for the survival of mammals, especially smal...
The effect of a digital health coaching and health education protocol on cognition in adults at-risk for Alzheimer’s
The effect of a digital health coaching and health education protocol on cognition in adults at-risk for Alzheimer’s
Several modifiable lifestyle factors have been linked to cognitive ability and the risk of developing Alzheimer’s di...
Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening
Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening
Hypertrophic carotid geometric phenotypes (h-CGP) are predictors of incident cardiovascular disease (CVD). While arterial ...
The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases
The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases
The World Health Organization estimates that by the year 2040, neurodegenerative diseases will be the second leading cause...
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