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Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release
Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release
In recent years, exploring natural compounds with functional properties to ameliorate aging-associated cognitive decline h...
Brain age prediction across the human lifespan using multimodal MRI data
Brain age prediction across the human lifespan using multimodal MRI data
Measuring differences between an individual’s age and biological age with biological information from the brain have...
Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
Comparing biomarker profiles measured at similar ages, but earlier in life, among exceptionally long-lived individuals and...
Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs
Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs
The twofold life expectancy difference between dog breeds predicts differential behavioral and cognitive aging patterns be...
Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging
Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging
The blood–brain barrier (BBB) undergoes functional changes with aging which may contribute to cognitive decline. A n...
Salidroside promotes healthy longevity by interfering with HSP90 activity
Salidroside promotes healthy longevity by interfering with HSP90 activity
Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medication...
Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefo...
Associations between psychological resilience and epigenetic clocks in the health and retirement study
Associations between psychological resilience and epigenetic clocks in the health and retirement study
The aim of this study was to evaluate the associations between psychological resilience and epigenetic clocks assessed by ...
Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism
Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism
Understanding the mechanisms of geroprotective interventions is central to aging research. We compare four promin...
Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline
Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline
Older adults often have difficulty in making decisions under uncertainty, increasing the risk of financial exploitation. H...
FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer’s disease
FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer’s disease
Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is characterized by the accumulation of ...
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardio...
Physiological phenotypes have optimal values relevant to healthy aging: sweet spots deduced from the Canadian Longitudinal Study on Aging
Physiological phenotypes have optimal values relevant to healthy aging: sweet spots deduced from the Canadian Longitudinal Study on Aging
Previous observations on a group of exceptionally healthy “Super-Seniors” showed a lower variance of multiple ...
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
ApoE4 as a risk factor for dementia with Lewy bodies (DLB) is still an issue. We sought to determine the involvement of Ap...
Proteomic changes induced by longevity-promoting interventions in mice
Proteomic changes induced by longevity-promoting interventions in mice
Using mouse models and high-throughput proteomics, we conducted an in-depth analysis of the proteome changes induced in re...
Comparing the associations between muscle strength, walking speed, and mortality in community-dwelling older adults of two birth cohorts born 28 years apart
Comparing the associations between muscle strength, walking speed, and mortality in community-dwelling older adults of two birth cohorts born 28 years apart
Reduced age-specific mortality and increased muscle strength and walking speed of current older adults may have altered th...
Distinct subsets of anti-pulmonary autoantibodies correlate with disease severity and survival in severe COVID-19 patients
Distinct subsets of anti-pulmonary autoantibodies correlate with disease severity and survival in severe COVID-19 patients
Autoantibodies targeting the lung tissue were identified in severe COVID-19 patients in this retrospective study. Fifty-th...
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes
Accumulation of senescent cells accelerates aging and age-related diseases, whereas preventing this accumulation extends t...
Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain
Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain
Whole brain irradiation (WBI), a commonly employed therapy for multiple brain metastases and as a prophylactic measure aft...
Metabolic biomarkers using nuclear magnetic resonance metabolomics assay for the prediction of aging-related disease risk and mortality: a prospective, longitudinal, observational, cohort study based on the UK Biobank
Metabolic biomarkers using nuclear magnetic resonance metabolomics assay for the prediction of aging-related disease risk and mortality: a prospective, longitudinal, observational, cohort study based on the UK Biobank
The identification of metabolic biomarkers for aging-related diseases and mortality is of significant interest in the fiel...
Endocytosis and Alzheimer’s disease
Endocytosis and Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The p...
Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults
Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults
Intrinsic capacity (IC), the composite of physical and mental capacities, declines with age at different rates and pattern...
Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty
Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty
Methylmalonic acid (MMA), a by-product of propionate metabolism, is known to increase with age. This study investigates th...
Sex-dependent associations of plasma high-density lipoprotein cholesterol and mortality risk in healthy older men and women: two prospective cohort studies
Sex-dependent associations of plasma high-density lipoprotein cholesterol and mortality risk in healthy older men and women: two prospective cohort studies
The relationship between high plasma high-density lipoprotein cholesterol (HDL-C) and cause and mortality are not well est...
Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of 18F-FDG-PET
Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of 18F-FDG-PET
Amyloid-β (Aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (CU) to dem...
Signs of aging in midlife: physical function and sex differences in microbiota
Signs of aging in midlife: physical function and sex differences in microbiota
Microbiota composition has been linked to physical activity, health measures, and biological age, but a shared profile has...
Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome
Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome
A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase...
Assessment of cerebral autoregulatory function and inter-hemispheric blood flow in older adults with internal carotid artery stenosis using transcranial Doppler sonography-based measurement of transient hyperemic response after carotid artery compression
Assessment of cerebral autoregulatory function and inter-hemispheric blood flow in older adults with internal carotid artery stenosis using transcranial Doppler sonography-based measurement of transient hyperemic response after carotid artery compression
Unhealthy vascular aging promotes atherogenesis, which may lead to significant internal carotid artery stenosis (CAS) in 5...
DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease
DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence...
Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker of human ageing and a risk factor for...
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