SCI时时刷

search
+
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senescent cell number increases with age in different tissues, leading to greater senescent cell load, proinflammatory str...
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 ...
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
The aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation...
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Older adults with cognitive impairment (CI) are twice as likely to fall compared to the general older adult population. Tr...
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated w...
Fear extinction is impaired in aged rats
Fear extinction is impaired in aged rats
Normal aging is accompanied by broad loss of cognitive function in humans and rodents, including declines in cognitive fle...
Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study
Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study
Spousal bereavement is associated with health declines and increased mortality risk, but its specific impact on physical a...
Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease
Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease
As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer’s disease (AD). Pr...
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role ...
The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT
The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT
Geriatric rehabilitation inpatients have high levels of sedentary behaviour (SB) and low levels of physical activity (PA)....
Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes
Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes
Yoga-based clinical research has shown considerable promise in varied ageing-related health outcomes in older adults. Howe...
DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease
DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease
Epidemiological studies report an elevated risk of Parkinson's disease (PD) in patients with type 2 diabetes mellitus ...
The behavioural effect of short-term cognitive and physical intervention therapies in old dogs
The behavioural effect of short-term cognitive and physical intervention therapies in old dogs
Efforts to counteract age-related decline have resulted in the emergence of various interventions. However, everyday benef...
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable...
Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation
Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation
Atherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial fu...
Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women
Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women
Postmenopausal osteoporosis is a public health problem leading to an increased risk of fractures, negatively impacting wom...
Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats
Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats
Engagement in cognitive activity in adulthood is one of the factors that enable successful cognitive aging, both in humans...
The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults
The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults
It is unknown how the DNA repair enzyme OGG1 relates to healthy aging in humans, in particular to inflammaging, that is as...
Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity
Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity
MultiMorbidity (MM), defined as the co-occurrence of two or more chronic conditions, is associated with poorer health outc...
Castration reduces mortality and increases resilience in male mice: what is next?
Castration reduces mortality and increases resilience in male mice: what is next?
This commentary concerns our recent report that prepubertal castration rescued the shorter lifespan of males, using the fi...
Effect of calorie restriction on redox status during chemically induced estropause in female mice
Effect of calorie restriction on redox status during chemically induced estropause in female mice
In females, there is a continuous decline of the ovarian reserve with age, which results in menopause in women or estropau...
Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorh...
Extreme-aged patients (≥ 85 years) experience similar outcomes as younger geriatric patients following chronic subdural hematoma evacuation: a matched cohort study
Extreme-aged patients (≥ 85 years) experience similar outcomes as younger geriatric patients following chronic subdural hematoma evacuation: a matched cohort study
Subdural hematoma (SDH) evacuation represents one of the most frequently performed neurosurgical procedures. Several repor...
Surgical management of spinal pathologies in the octogenarian: a narrative review
Surgical management of spinal pathologies in the octogenarian: a narrative review
Optimal management paradigms of spinal pathologies in the octogenarian population are controversial given the higher incid...
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponenti...
Purpose in life and slow walking speed: cross-sectional and longitudinal associations
Purpose in life and slow walking speed: cross-sectional and longitudinal associations
The present research examines the association between purpose in life – a component of well-being defined as the fee...
Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, “futile” fatty acid cycling, and FADH2 oxidation
Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, “futile” fatty acid cycling, and FADH2 oxidation
Inhibition of mitochondrial complex I (NADH dehydrogenase) is the primary mechanism of the antidiabetic drug metformin and...
Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer
Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer
Bladder cancer (BCa) incidence is tightly linked to aging. Older patients with BCa present with higher grade tumors and ha...
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
To examine whether physical activity can mitigate the mortality risk associated with disability in activities of daily liv...
The influence of APOE status on rate of cognitive decline
The influence of APOE status on rate of cognitive decline
Apolipoprotein (APOE) ɛ4 positivity and subjective cognitive decline (SCD) both increase risk of Alzheimer&#...
阅读更多
format_indent_increase