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The majority of severe COVID-19 patients develop anti-cardiac autoantibodies
The majority of severe COVID-19 patients develop anti-cardiac autoantibodies
Severe cases of COVID-19 are characterized by an inflammatory burst, which is accompanied by multiorgan failure. The elder...
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus
Recent monkeypox (MPX) outbreaks are major ones in non-endemic countries. The present study analyzed molecular phylogeneti...
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
Delayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer&...
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study
Aging has often been characterized by progressive cognitive decline in memory and especially executive function. Yet some ...
Is “cellular senescence” a misnomer?
Is “cellular senescence” a misnomer?
One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells...
How size and genetic diversity shape lifespan across breeds of purebred dogs
How size and genetic diversity shape lifespan across breeds of purebred dogs
While the lifespan advantage of small body size and mixed breed status has been documented repeatedly, evidence for an eff...
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Ageing limits growth capacity of skeletal muscle (e.g. in response to resistance exercise), but the role of satellite cell...
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging
Cellular senescence is characterized by cell cycle arrest and the senescence-associated secretory phenotype (SASP) and can...
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?
Machine learning methods have been applied to estimate measures of brain aging from neuroimages. However, only rarely have...
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies en...
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile
Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and n...
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% incre...
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study
The paper aimed to compare how factors previously identified as predictive factors for cognitive decline and dementia rela...
Microbiota mitochondria disorders as hubs for early age-related macular degeneration
Microbiota mitochondria disorders as hubs for early age-related macular degeneration
Age-related macular degeneration (AMD) is a progressive neurodegenerative disease affecting the central area (macula lutea...
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome
Age-related vascular alterations promote the pathogenesis of vascular cognitive impairment (VCI). Cardiovascular risk fact...
Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata
Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata
Mitochondrial dysfunction and oxidative damage have long been suggested as critically important mechanisms underlying the ...
A metabolomic signature of the APOE2 allele
A metabolomic signature of the APOE2 allele
With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein ...
Vitamin D3 promotes longevity in Caenorhabditis elegans
Vitamin D3 promotes longevity in Caenorhabditis elegans
Vitamin D deficiency is associated with a variety of age-related diseases and is becoming increasingly more prevalent in t...
Old plasma dilution reduces human biological age: a clinical study
Old plasma dilution reduces human biological age: a clinical study
This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct meas...
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study
Telomeres shorten with age and shorter leukocyte telomere length (LTL) has been associated with various age-related diseas...
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through wh...
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task
Declines in processing speed performance occur in aging and are a critical marker of functional independence in older adul...
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age
Exercise training can induce adaptive changes to tendon tissue both structurally and mechanically; however, the underlying...
DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes
DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes
DNA methylation (DNAm) patterns across the genome changes during aging and development of complex diseases including type ...
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain
Age-associated cognitive decline is common among otherwise healthy elderly people, even in the absence of Alzheimer’...