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Association of the interaction between daily step counts and frailty with disability in older adults
Association of the interaction between daily step counts and frailty with disability in older adults
The differences in the association of objectively measured physical activity with disability between frail and non-frail o...
Linking metabolic syndrome, cerebral small vessel disease, and cognitive health: insights from a subclinical population study using TriNetX
Linking metabolic syndrome, cerebral small vessel disease, and cognitive health: insights from a subclinical population study using TriNetX
Metabolic syndrome (MetS) has been linked to accelerated cognitive decline and Alzheimer’s disease and related demen...
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
The alarmingly high prevalence of obesity in older adults coupled with the negative health effects of chronic inflammation...
Plasma extracellular vesicles carry immune system-related peptides that predict human longevity
Plasma extracellular vesicles carry immune system-related peptides that predict human longevity
Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to ...
Biomarkers of cellular senescence and major health outcomes in older adults
Biomarkers of cellular senescence and major health outcomes in older adults
The geroscience hypothesis proposes that underlying biological processes, such as the accumulation of senescent cells, hav...
A complex systems approach to mosaic loss of the Y chromosome
A complex systems approach to mosaic loss of the Y chromosome
Mosaic loss of Y chromosome (mLOY) is an acquired condition wherein a sizeable proportion of an organ’s cells have l...
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
Digital technology interventions (DTIs) are seen as promising interventions to prevent or delay cognitive decline in older...
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive ...
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine ant...
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation ...
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
The present study explored for the first time the blood-based proteomic signature that could potentially distinguish older...
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Age-associated loss of muscle mass and function and subsequent mobility decline define poor health outcomes, reduced quali...
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
Cognitive aging is described as the age-related decline in areas such as memory, executive function, reasoning, and proces...
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty is considered a clinical entity associated with a high risk for adverse health outcomes. However, its cl...
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Frailty is a complex condition characterized by a decline in multiple physiological systems, compromising an individual...
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
The prevalence of hypertension increases with age and is the leading modifiable risk factor for cognitive impairment and d...
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frai...
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diver...
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and ...
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodal...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidenc...
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Chronic subdural hematoma (cSDH) is one of the most prevalent neurosurgical diseases, especially in the elderly. Yet, its ...
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
Age-related deterioration of condylar cartilage is an etiological factor in temporomandibular joint-osteoarthritis (TMJ-OA...
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradi...
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, wh...
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the ...
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