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Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and ...
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodal...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidenc...
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Chronic subdural hematoma (cSDH) is one of the most prevalent neurosurgical diseases, especially in the elderly. Yet, its ...
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
Age-related deterioration of condylar cartilage is an etiological factor in temporomandibular joint-osteoarthritis (TMJ-OA...
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradi...
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, wh...
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the ...
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
The extent to which the neural systems underlying semantic processes degrade with advanced age remains unresolved, which m...
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
The incidence of aortic valve stenosis (AoS) increases with age, and once diagnosed, symptomatic severe AoS has a yearly m...
Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study
Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study
Cardiovascular endurance and muscular fitness seem to impact specific cognitive components in older females. However, it r...
Frailty, age, and treatment effect of surgical coronary revascularization in ischemic cardiomyopathy: a post hoc analysis of the STICHES trial
Frailty, age, and treatment effect of surgical coronary revascularization in ischemic cardiomyopathy: a post hoc analysis of the STICHES trial
Frailty is common among older patients with heart failure (HF). The efficacy of coronary artery bypass grafting (CABG) on ...
Alzheimer’s disease and other memory disorders in the age of AI: reflection and perspectives on the 120th anniversary of the birth of Dr. John von Neumann
Alzheimer’s disease and other memory disorders in the age of AI: reflection and perspectives on the 120th anniversary of the birth of Dr. John von Neumann
Two themes are coming to the forefront in this decade: Cognitive impairment of an aging population and the quantum leap in...
Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice
Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice
Our study investigates gene expression in adipose tissue of Ames dwarf (df/df) mice, whose deficiency in growth hormone is...
Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank
Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank
A potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored t...
Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging
Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging
Background: Glycated haemoglobin (HbA1c) is a well-established biomarker for diabetes diagnosis and management and is link...
DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress
DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress
Aging of hematopoietic stem cells (HSCs) is implicated in various aging phenotypes, including immune dysfunction, anemia, ...
Uncovering mediational pathways behind racial and socioeconomic disparities in brain volumes: insights from the UK Biobank study
Uncovering mediational pathways behind racial and socioeconomic disparities in brain volumes: insights from the UK Biobank study
Mediation pathways explaining racial/ethnic and socioeconomic (SES) disparities in structural MRI markers of brain health ...
Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset
Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset
This study investigates whether older adults diagnosed with the apathy, gait impairment, and executive dysfunction (AGED) ...
Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss
Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss
Age-related macular degeneration (AMD) is a leading cause of blindness in elderly populations, yet the molecular events th...
Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25–57% elevation in risk
Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25–57% elevation in risk
The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk f...
Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging
Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging
The mechanistic target of rapamycin complex 1 (mTORC1) has a major impact on aging by regulation of proteostasis. It is we...
Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
Functional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a pr...
Impaired brain ability of older adults to transit and persist to latent states with well-organized structures at wakeful rest
Impaired brain ability of older adults to transit and persist to latent states with well-organized structures at wakeful rest
The intrinsic brain functional network organization continuously changes with aging. By integrating spatial and temporal i...
Aging enhances pro-atrogenic gene expression and skeletal muscle loss following respiratory syncytial virus infection
Aging enhances pro-atrogenic gene expression and skeletal muscle loss following respiratory syncytial virus infection
Aging and many age-related health conditions are associated with skeletal muscle loss. Furthermore, older adults are more ...
A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs
A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs
Predicting aging trajectories through biomarkers of biological aging can guide interventions that optimize healthy lifespa...
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