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Understanding mechanisms of antioxidant action in health and disease
Understanding mechanisms of antioxidant action in health and disease
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in the development of certain human...
FOXO transcription factors as mediators of stress adaptation
FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mamm...
The discovery of simple repeats that cause complex disorders
Two papers published in 1991 established a new class of human genetic disorders, caused by expansion of simple DNA repeats.
Smelling your way to longevity
The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.
Transcription factors crossing the cell membrane
Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochia...
Alternative to lysosomal degradation: mitochondrial removal via EVs
Alternative to lysosomal degradation: mitochondrial removal via EVs
Liang et al. show that mitochondria can be expelled from cells via extracellular vesicles as a route of quality control th...
Mechanisms and pathology of protein misfolding and aggregation
Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how pro...
The double-edged sword of bivalency
Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this ...
STINGing through the membrane to channel protons
To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a ...
The neuronal epigenome is special
Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with post...
The translation m(o)TOR that propels regeneration
The translation m(o)TOR that propels regeneration
In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial fo...
Control of stem cell renewal and fate by YAP and TAZ
Control of stem cell renewal and fate by YAP and TAZ
Complex physiological processes control whether stem cells self-renew, differentiate or remain quiescent. Two decades of r...
Genetic wrinkles in time
Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR c...
Publisher Correction: Reading, writing and erasing mRNA methylation
Publisher Correction: Reading, writing and erasing mRNA methylation
In the version of this article initially published, there were errors in the pseudouridine (Ψ) structure displayed in the ...
Unbiased mapping of protein trafficking with TransitID
In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows ...
RNF26 and vimentin orchestrate ER stress recovery
Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinucl...
Has translation in the nucleus found its purpose?
Translation in the nucleus is a long-standing controversial issue with unclear physiological importance. Recent studies sh...
Context-dependent TGFβ family signalling in cell fate regulation
Context-dependent TGFβ family signalling in cell fate regulation
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved cytokines whose sig...
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death
Cell death and inflammation are closely linked arms of the innate immune response to combat infection and tissue malfuncti...
Structural and functional complexity of HSP90 in cellular homeostasis and disease
Structural and functional complexity of HSP90 in cellular homeostasis and disease
Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function...
Mechanisms of substrate processing during ER-associated protein degradation
Mechanisms of substrate processing during ER-associated protein degradation
Maintaining proteome integrity is essential for long-term viability of all organisms and is overseen by intrinsic quality ...
Harnessing fluorescent probes to unveil dynamic membrane mechanics
In this Tools of the Trade article, Roffay and Mercier (from the Roux lab) describe the development of fluorescent Flipper...
Biology and therapeutic targeting of vascular endothelial growth factor A
Biology and therapeutic targeting of vascular endothelial growth factor A
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological process in which several famil...
May the force be with microtubules
Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules ow...
RNA binding — a useful third wheel in transcription
RNA binding — a useful third wheel in transcription
Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and develop...
Cellular functions of eukaryotic RNA helicases and their links to human diseases
Cellular functions of eukaryotic RNA helicases and their links to human diseases
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or remodel RNA, RNA–protein co...
Myosin VI assists in fork protection
Shi et al. show the role of myosin VI in the protection of stalled replication forks during replication stress.
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as either promoters or inhibitors o...
How embryos sort themselves out
Diana Pinheiro recounts two seminal papers describing how cell surface tension dictates how cells sort into different tiss...