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Author Correction: Mechanisms controlling cellular and systemic iron homeostasis
Authors and AffiliationsGerman Cancer Research Center (DKFZ), Division of Virus-associated Carcinogenesis (F170), Heidelbe...
Harnessing the deep learning power of foundation models in single-cell omics
Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require furt...
Identification of RNA structures and their roles in RNA functions
Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has greatly facilitated our ability ...
Author Correction: Fundamentals of redox regulation in biology
Authors and AffiliationsInstitute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University...
Assembly and fission of tubular carriers mediating protein sorting in endosomes
Assembly and fission of tubular carriers mediating protein sorting in endosomes
Endosomes are central protein-sorting stations at the crossroads of numerous membrane trafficking pathways in all eukaryot...
Regulation of cellular and systemic sphingolipid homeostasis
Regulation of cellular and systemic sphingolipid homeostasis
One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from...
Monitoring subcellular protein localization at scale in live cells
In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protei...
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP
This study uncovered a link between PI5P, PI5P4Ks and the Hippo pathway, whereby PI5P reinforces the inhibition of YAP, th...
A histone code controls positional identity in limb regeneration
A histone code controls positional identity in limb regeneration
Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves a...
SenNet recommendations for detecting senescent cells in different tissues
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological proces...
Splicing regulation through biomolecular condensates and membraneless organelles
Splicing regulation through biomolecular condensates and membraneless organelles
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs), can form through weak multivalent interm...
Solving the Wnt nuclear puzzle
Solving the Wnt nuclear puzzle
Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear &#...
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Author notesThese authors contributed equally: Fereshteh Sadat Younesi, Andrew E. Miller.Authors and AffiliationsKeenan Re...
Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing
Author notesThese authors contributed equally: Lukas Villiger, Julia Joung.These authors jointly supervised this work: Oma...
Integrator and U1 snRNPs steer Pol II in the right direction
Integrator and U1 snRNPs steer Pol II in the right direction
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
Epithelial–mesenchymal transition in tissue repair and degeneration
Epithelial–mesenchymal transition in tissue repair and degeneration
Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; du...
Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation refers to the use of small molecules to induce the selective degradation of proteins. In its ...
Fundamentals of redox regulation in biology
Fundamentals of redox regulation in biology
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and...
Is amyloid-β a friend or foe?
Is amyloid-β a friend or foe?
Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to unders...
Translation feedback control in the brain
Translation feedback control in the brain
Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiati...
The senescence-associated secretory phenotype and its physiological and pathological implications
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibito...
Is endocytosis by caveolae dependent on dynamin?
Is endocytosis by caveolae dependent on dynamin?
The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular...
Relaying gasdermin D to the membrane
Relaying gasdermin D to the membrane
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosi...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...
Modelling tauopathies
Modelling tauopathies
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
A novel photosystem assembly line worker
A novel photosystem assembly line worker
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. de...
Seeing transcription in real time
Seeing transcription in real time
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenou...
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