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In Memoriam C. David Allis: Chromatin unlocked
The lab of C. David Allis was among the pioneers of developing histone-PTM-specific antibodies to unlock the mysteries of ...
Principles and dynamics of spindle assembly checkpoint signalling
Principles and dynamics of spindle assembly checkpoint signalling
The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tiss...
Mechanisms underlying spindle assembly and robustness
Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division. Following more than a century of s...
The birth of stable introns
Stable introns were serendipitously discovered just over a decade ago.
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that supports normal tissue turnove...
Cellular and molecular mechanisms of Hedgehog signalling
Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning, postembryonic tissue regeneration, and c...
C-degron mimicry confers E3 ligase selectivity
C-degron mimicry confers E3 ligase selectivity
Scott et al. describe a mechanism based on C-degron mimicry by which an E3 ubiquitin ligase discriminates bona fide substr...
Single-cell lipidomics reveals the organizing principle of cell fate decision
In this Tools of the Trade article, Laura Capolupo (at D’Angelo lab) describes the approach to study cell-to-cell he...
Cytosol-to-nucleus journey of a novel histone PTM
Cytosol-to-nucleus journey of a novel histone PTM
Tyrosine sulfation is a novel histone post-translational modification, which facilitates transcription.
Anoikis resistance through blebs
Weems et al. show that sustained membrane blebbing promotes pro-survival signalling in extracellular matrix-detached cells.
Permeable dye-based fluorescent speckle microscopy for human cells
In this Tools of the Trade article, Patrik Risteski (at Tolić lab) describes high-throughput fluorescent speckle micr...
BCL-2 proteins in senescence: beyond a simple target for senolysis?
BCL-2 and related proteins are major regulators of apoptosis that have emerged as promising targets for the elimination se...
Autophagy and autophagy-related pathways in cancer
Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viab...
Cell–extracellular matrix mechanotransduction in 3D
Cell–extracellular matrix mechanotransduction in 3D
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours, including differentiation, migr...
The birth of evo-devo
Discovery of the wide conservation of the homeodomain provided revolutionary insight into gene function and ushered in the...
DNA modifications walk a fine line between epigenetics and mutagenesis
In the study of DNA modifications, the disciplines of epigenetics and of DNA damage and repair have evolved separately. Th...
From shortening telomeres to replicative crisis
From shortening telomeres to replicative crisis
Nassour et al. demonstrate that the innate immunity sensor Z-DNA binding protein 1 (ZBP1) is an important mediator of immu...
Restoration of embryonic gene expression patterns in tissue regeneration and disease
Embryonic gene expression programmes are reactivated in response to various types of tissue damage in adult organs to prov...
Who did what: changing how science papers are written to detail author contributions
We suggest an alternative approach to ascribing authorship in scientific papers. We argue that it should be known who thou...
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
All organisms possess molecular mechanisms that govern DNA repair and associated DNA damage response (DDR) processes. Owin...
Context-specific regulation of extracellular vesicle biogenesis and cargo selection
Context-specific regulation of extracellular vesicle biogenesis and cargo selection
To coordinate, adapt and respond to biological signals, cells convey specific messages to other cells. An important aspect...
Science Twitter — navigating change in science communication
Science Twitter — navigating change in science communication
Twitter has become an increasingly influential tool in science communication. With the ongoing changes in management, the ...
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome. Since then, organisms have dedicate...
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships
On the basis of his personal experience, Alexios-Fotios Mentis urges mentor-seekers to consider emotional ‘matchR...
Chilling paternal chloroplasts
Chilling paternal chloroplasts
Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genet...
Younger endogenous retroviruses make us older
Younger endogenous retroviruses make us older
The increased expression of certain human endogenous retroviruses induces the cGAS–STING pathway and drives cell sen...
Voices of the new generation: normalizing career choices outside academia
Voices of the new generation: normalizing career choices outside academia
Although you might not see many academics publicly criticizing non-academic career choices, there is still a clear bias ag...
Instruction of epigenetic states from DNA sequences
Yonatan Stelzer highlights a landmark work from the lab of Howard Cedar that addresses how genome-wide DNA methylation pat...
Metabolites as signalling molecules
Metabolites as signalling molecules
Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becomin...
Nuclear pore complexes as clocks of zygotic genome activation
Nuclear pore complexes as clocks of zygotic genome activation
Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear impor...
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