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The senescence-associated secretory phenotype and its physiological and pathological implications
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibito...
Is endocytosis by caveolae dependent on dynamin?
Is endocytosis by caveolae dependent on dynamin?
The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular...
Relaying gasdermin D to the membrane
Relaying gasdermin D to the membrane
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosi...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...
Modelling tauopathies
Modelling tauopathies
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
A novel photosystem assembly line worker
A novel photosystem assembly line worker
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. de...
Seeing transcription in real time
Seeing transcription in real time
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenou...
Opportunities and challenges in design and optimization of protein function
Opportunities and challenges in design and optimization of protein function
The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely...
How ancient RNA survives and what we can learn from it
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this...
Single-cell live volume measurements using the fluorescence exclusion method
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion met...
Cellular and molecular mechanisms of skin wound healing
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different tissues and cell lineages. It r...
Co-transcriptional gene regulation in eukaryotes and prokaryotes
Co-transcriptional gene regulation in eukaryotes and prokaryotes
Many steps of RNA processing occur during transcription by RNA polymerases. Co-transcriptional activities are deemed commo...
Localized translation in the embryo
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the im...
A code within the genetic code
A code within the genetic code
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and m...
Protein N-terminal acetylation is entering the degradation end game
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation re...
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enable...
A SOX9 switch from regeneration to fibrosis
A SOX9 switch from regeneration to fibrosis
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the ...
Keeping a low cGAS profile in the nucleus
Keeping a low cGAS profile in the nucleus
Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.
Cellular and molecular control of vertebrate somitogenesis
Cellular and molecular control of vertebrate somitogenesis
Segmentation is a fundamental feature of the vertebrate body plan. This metameric organization is first implemented by som...
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that ca...
Intrinsic calibration and deformation mapping for expansion microscopy using GelMap
In this Tools of the Trade article, Hugo Damstra and Josiah Passmore (Kapitein Lab) describe GelMap, which introduces a fl...
Live-cell imaging powered by computation
Live-cell imaging powered by computation
The proliferation of microscopy methods for live-cell imaging offers many new possibilities for users but can also be chal...
Emerging mechanistic understanding of cilia function in cellular signalling
Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in huma...
The cell biology of ferroptosis
The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. Here, we ...
A catalytic function for mammalian Argonautes
A catalytic function for mammalian Argonautes
Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi...
Mechanisms and functions of protein S-acylation
Mechanisms and functions of protein S-acylation
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulat...
Condensates burst the bridge for transcription
Condensates burst the bridge for transcription
A recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.
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