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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
The ability of animal cells to sense, adhere to and remodel their local extracellular matrix (ECM) is central to control o...
The forks guardian
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is important for replication-fork reversal under replication str...
Cell competition in development, homeostasis and cancer
Cell competition in development, homeostasis and cancer
Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue ...
Persisting through apoptosis
Kalkavan et al. show how drug-tolerant persister cells evade apoptosis by release of sublethal cytochrome c and activation...
Decoding the Ca2+ signal for salt tolerance
Decoding the Ca2+ signal for salt tolerance
Steinhorst et al. show how calcium signal induced by salt stress is ‘decoded’ by plant roots to provide system...
The emerging mechanisms and functions of microautophagy
The emerging mechanisms and functions of microautophagy
‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged org...
Emerging roles and functional mechanisms of PIWI-interacting RNAs
Emerging roles and functional mechanisms of PIWI-interacting RNAs
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the ...
Mechanisms and roles of podosomes and invadopodia
Mechanisms and roles of podosomes and invadopodia
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in bot...
Mechanism of pathogen-induced cap-independent translation in plants
Mechanism of pathogen-induced cap-independent translation in plants
Translation reprogramming in plants in response to innate-immunity induction relies on a novel cap-independent translation...
Regulation of membrane protein structure and function by their lipid nano-environment
Regulation of membrane protein structure and function by their lipid nano-environment
Transmembrane proteins comprise ~30% of the mammalian proteome, mediating metabolism, signalling, transport and many other...
Aneuploidy in mammalian oocytes and the impact of maternal ageing
Aneuploidy in mammalian oocytes and the impact of maternal ageing
During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo...
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles
A long-standing paradigm in molecular biology assumes a direct relationship between increases in mRNA levels and the abund...
A-to-I editing prevents self-RNA sensing
Leilei Chen describes the discovery that adenosine-to-inosine editing by ADAR1 marks endogenous double-stranded RNA as sel...
To fuse or to divide, that was the question
Elizabeth Chen looks back on the work by Beatrice Mintz and Wilber Baker (1967) that settled the debate on the origin of m...
Re-evaluate evaluation letters — set scientists free!
Re-evaluate evaluation letters — set scientists free!
Academia’s dependence on evaluation letters is toxic. Scientists know that bad letters might derail their career or ...
Regulation, functions and transmission of bivalent chromatin during mammalian development
Regulation, functions and transmission of bivalent chromatin during mammalian development
Cells differentiate and progress through development guided by a dynamic chromatin landscape that mediates gene expression...
Resilience through selective translation
Julia Bailey-Serres highlights early work on the molecular mechanisms of plant stress responses, indicating that selective...
Viruses show the way
Chiara Zurzolo brings to attention the pioneering work that established virus-infected cells as a model to study cell pola...
‘Poisoning’ of the transcriptome by ultraconserved elements
Leclair and Anczuków describe how high-throughput screens uncovered the connection between poison exons and cancer.
Cellular role of TETs in early embryos
Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocatio...
Biochemical and mechanical regulation of actin dynamics
Biochemical and mechanical regulation of actin dynamics
Polymerization of actin filaments against membranes produces force for numerous cellular processes, such as migration, mor...
Generation of nanoscopic membrane curvature for membrane trafficking
Generation of nanoscopic membrane curvature for membrane trafficking
Curved membranes are key features of intracellular organelles, and their generation involves dynamic protein complexes. He...
Ethylene — the lifeguard hormone
Rashmi Sasidharan highlights the work by Musgrave et al. (1972) demonstrating that ethylene drives shoot elongation in pla...
Mitochondrial ROS drive cell cycle progression
Kirova et al. demonstrate that reactive oxygen species signals are integrated into cell cycle control through a direct int...
Ageing and rejuvenation of tissue stem cells and their niches
Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem cell function is critical for ...
Multicellular self-organization
Luciano Marcon discusses the revolutionary work by Alan Turing proposing that embryogenesis could be entirely a self-organ...
YAP/TAZ get a STING in the tail
Sladitschek-Martens show that reduced activity of key cellular mechanosensors, transcription co-activators YAP/TAZ, is an ...
Mechanisms of mitochondrial respiratory adaptation
Mechanisms of mitochondrial respiratory adaptation
Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness ...
The RNA world ‘hypothesis’
Hiroshide Saito discusses two seminal papers that provided foundational evidence for the hypothesis that RNA with both gen...
Unravelling oocyte ultrastructure
Elvan Böke recounts the pioneering work of Arthur T. Hertig on the ultrastructure of human oocytes.