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Mechanism and regulation of kinesin motors
Mechanism and regulation of kinesin motors
Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental roles in intracellular transport, ...
The discovery of oncogene-induced senescence
The discovery of oncogene-induced senescence
Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness increases susceptibility to dis...
Mechanisms and regulation of substrate degradation by the 26S proteasome
Mechanisms and regulation of substrate degradation by the 26S proteasome
The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a ...
Sorting membrane proteins by size in the Golgi
Sorting membrane proteins by size in the Golgi
De Caestecker and Macara find that the sorting of membrane proteins in the Golgi relies on a size filter that enables corr...
Following the electric current
Following the electric current
Elias Barriga discusses a seminal 2006 paper from Zhao et al., which was the first study to integrate electrotaxis signals...
Proteoforms: a tale of two (initiation) sites
Proteoforms: a tale of two (initiation) sites
mRNAs with alternative in-frame translation initiation sites can yield proteoforms with distinct localization and functions.
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation
In sexually reproducing organisms, life begins with the fusion of transcriptionally silent gametes, the oocyte and sperm. ...
The role and regulation of integrins in cell migration and invasion
The role and regulation of integrins in cell migration and invasion
Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell&...
Author Correction: The role of the haematopoietic stem cell niche in development and ageing
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking
Authors and AffiliationsDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel A...
Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels
Authors and AffiliationsDepartment of Molecular Biology, Princeton University, Princeton, NJ, USAJian HuangInstitute of Bi...
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Mechanical force is an essential physical element that contributes to the formation and function of life. The discovery of...
The role of the haematopoietic stem cell niche in development and ageing
The role of the haematopoietic stem cell niche in development and ageing
Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic stem and progenitor cells (HSPCs) tha...
CLASPing and squeezing during cell migration
CLASPing and squeezing during cell migration
This study finds that microtubules act as a mechanostat during cell migration, becoming mechanically reinforced in respons...
Dynamics of DNA replication speeds in single cells
In this Tools of the Trade article, Jeroen van den Berg (van Oudenaarden lab) presents a new method based on pulse-labelli...
Mechanisms of assembly and remodelling of the extracellular matrix
Mechanisms of assembly and remodelling of the extracellular matrix
The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms the scaffold that surrounds and ...
Epigenetic gene regulation in plants and its potential applications in crop improvement
Epigenetic gene regulation in plants and its potential applications in crop improvement
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has crucial functions in plant growth,...
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene expression dynamics in healthy ...
Far from the cytoplasmic crowd
Far from the cytoplasmic crowd
Stresses induce de-crowding and fluidization of the cytoplasm, which promotes the formation of biomolecular condensates.
Structural biology and molecular pharmacology of voltage-gated ion channels
Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively permeate ions across the cell membra...
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged org...
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration
In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and pl...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
Long-lived proteomes in healthy ovaries
Long-lived proteomes in healthy ovaries
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby su...
Virus–host warfare by PROTACs
Virus–host warfare by PROTACs
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, ...
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