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Poor response of HER2-positive mucinous carcinomas of breast to neoadjuvant HER2-targeted therapy: A study of four cases
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Can the integration of new rules into a clinical decision support system reduce the incidence of acute kidney injury and hyperkalemia among hospitalized older adults: a protocol for a stepped-wedge, cluster-randomized trial (DETECT-IP)
Can the integration of new rules into a clinical decision support system reduce the incidence of acute kidney injury and hyperkalemia among hospitalized older adults: a protocol for a stepped-wedge, cluster-randomized trial (DETECT-IP)
Clinical decision support systems (CDSSs) enable the automated, real-time detection of situations associated with a risk o...
Permissive weight bearing versus restrictive weight bearing in surgically treated trauma patients with displaced intra-articular calcaneal fractures (the PIONEER study): study protocol for a multicenter randomized controlled trial
Permissive weight bearing versus restrictive weight bearing in surgically treated trauma patients with displaced intra-articular calcaneal fractures (the PIONEER study): study protocol for a multicenter randomized controlled trial
Following successful treatment, displaced intra-articular calcaneal fractures (DIACFs) necessitate an extensive rehabilita...
Improving measures of context in process evaluations: development and use of the Context Tracker tool
Improving measures of context in process evaluations: development and use of the Context Tracker tool
Process evaluations are increasingly integrated into randomised controlled trials (RCTs) of complex interventions to docum...
Mixed reality-assisted versus landmark-guided spinal puncture in elderly patients: protocol for a stratified randomized controlled trial
Mixed reality-assisted versus landmark-guided spinal puncture in elderly patients: protocol for a stratified randomized controlled trial
Performing spinal anesthesia in elderly patients with spine degeneration is challenging for novice practitioners. This str...
Testing the informativeness of Y-STR and mitochondrial DNA control region markers in an attempt to predict ancestry of World War II victims from Slovenian mass grave
Testing the informativeness of Y-STR and mitochondrial DNA control region markers in an attempt to predict ancestry of World War II victims from Slovenian mass grave
Identification of human remains is a challenge in forensic genetics without relatives or personal items available. In Slov...
Computer tomography-based radiomics combined with machine learning for predicting the time since onset of epidural hematoma
Computer tomography-based radiomics combined with machine learning for predicting the time since onset of epidural hematoma
Estimation of the age of epidural hematoma (EDH) is a challenge in clinical forensic medicine, and this issue has yet to b...
Superficial ALK-rearranged myxoid spindle cell neoplasms: Clinicopathologic and molecular analysis of two cases and a review of the literature
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Effects of ultrasound-guided external oblique intercostal plane block on the postoperative analgesia after open liver surgery: study protocol for a randomised controlled trial
Effects of ultrasound-guided external oblique intercostal plane block on the postoperative analgesia after open liver surgery: study protocol for a randomised controlled trial
Open liver surgery remains a primary surgical approach for complex liver resections and liver transplantation. However, th...
Accuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom
Accuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom
Healthcare systems data (HCSD) could improve the efficiency of clinical trials, but their accuracy and validity are uncert...
Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial
Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial
Despite significant progress in orthopaedic surgery, the prevalence of periprosthetic joint infections (PJIs) remains pers...
Evaluating effects of community-based social healing model on Ubuntu, mental health and psychosocial functioning in post-genocide Rwanda: protocol for cluster randomized control trial
Evaluating effects of community-based social healing model on Ubuntu, mental health and psychosocial functioning in post-genocide Rwanda: protocol for cluster randomized control trial
The community-based social healing (CBSH) model, developed by Ubuntu Centre for Peace, aims to support individuals with tr...
T-cells are significantly reduced in the luminal gastrointestinal tract of patients with “complete” 22q11.2 deletion syndrome (DiGeorge syndrome): Utilization of chromogenic multiplex immunohistochemistry to define cellular populations
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PIT-1/SF-1 co-expression in pituitary neuroendocrine tumors (PitNETs) with comprehensive review of the literature: How should we best characterize these neoplasms?
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TRPS1 expression in cytologic specimens of salivary duct carcinoma and other salivary gland tumors
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FOXP3 expression in duodenal mucosa: Unique role in pathogenesis and differential diagnosis of celiac disease
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PD-L1 (22C3) expression and prognostic implications in esophageal squamous cell carcinoma
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Effects on tricuspid regurgitation by different techniques for passing permanent pacemaker leads through the tricuspid valve: a randomized, open-label, superiority clinical trial study protocol
Effects on tricuspid regurgitation by different techniques for passing permanent pacemaker leads through the tricuspid valve: a randomized, open-label, superiority clinical trial study protocol
In recent years, lead-induced tricuspid regurgitation (LITR) has attracted increasing attention. At present, there are two...
Intravenous versus oral iron supplementation for iron deficiency anemia in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy: a study protocol for a randomized controlled trial
Intravenous versus oral iron supplementation for iron deficiency anemia in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy: a study protocol for a randomized controlled trial
Numerous studies have been conducted to manage anemia in surgical patients through iron supplementation as an alternative ...
How should trial teams make decisions about the proportions and diversity of the ethnic groups in their trial?
How should trial teams make decisions about the proportions and diversity of the ethnic groups in their trial?
The benefits of randomised trials are not shared equally, and people from ethnic minority groups are a key constituency un...
Anorexia nervosa-specific home treatment in children and adolescents and their families (the HoT study): a study protocol of a randomized, controlled, multicenter, open-label, parallel group superiority trial
Anorexia nervosa-specific home treatment in children and adolescents and their families (the HoT study): a study protocol of a randomized, controlled, multicenter, open-label, parallel group superiority trial
New treatment approaches are urgently needed to improve the prognosis of children and adolescents with anorexia nervosa (A...
Induction of Cure in Early Arthritis (I CEA): study protocol for an investigator-initiated randomized single-blind clinical trial with open-label extension to compare three treatment strategies in patients with newly diagnosed undifferentiated arthritis
Induction of Cure in Early Arthritis (I CEA): study protocol for an investigator-initiated randomized single-blind clinical trial with open-label extension to compare three treatment strategies in patients with newly diagnosed undifferentiated arthritis
Undifferentiated arthritis (UA) is a term used to describe patients with inflammatory arthritis that has not diff...
A survey to determine the zone of equipoise for the Proximal FEmur Resection or Internal Fixation fOR Metastases (PERFORM) randomized controlled trial
A survey to determine the zone of equipoise for the Proximal FEmur Resection or Internal Fixation fOR Metastases (PERFORM) randomized controlled trial
The objective of this study was to establish a zone of clinical equipoise for the Proximal FEmur Resection or Internal Fix...
Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial
Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial
Chronic kidney disease (CKD) is a pervasive disease of the current century that usually affects the adult population, espe...
Thrombopoietin mimetic reduces mouse lung inflammation and fibrosis after radiation by attenuating activated endothelial phenotypes
TPOm reduces lung injury, barrier dysfunction, and inflammation in mice after WTI. At 2 weeks after WTI in C57BL/6J mice,...
Diagnostic immunohistochemistry use in Belgian laboratories
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The cerebral and cognitive changes after intermittent theta burst stimulation (iTBS) treatment for depression: study protocol for a randomized double-blind sham-controlled trial
The cerebral and cognitive changes after intermittent theta burst stimulation (iTBS) treatment for depression: study protocol for a randomized double-blind sham-controlled trial
The therapeutic use of intermittent theta burst stimulation (iTBS) delivered to the left dorsolateral prefrontal cortex (L...
PRO-P: evaluating the effect of electronic patient-reported outcome measures monitoring compared with standard care in prostate cancer patients undergoing surgery—study protocol for a randomized controlled trial
PRO-P: evaluating the effect of electronic patient-reported outcome measures monitoring compared with standard care in prostate cancer patients undergoing surgery—study protocol for a randomized controlled trial
With over 65,000 new cases per year in Germany, prostate cancer (PC) is the most common cancer in men in Germany. Localize...
Protocol for a randomized comparative effectiveness trial comparing a very low-carbohydrate diet to DASH diet for polycystic ovary syndrome: the SUPER (Supporting Understanding of PCOS Education and Research) trial
Protocol for a randomized comparative effectiveness trial comparing a very low-carbohydrate diet to DASH diet for polycystic ovary syndrome: the SUPER (Supporting Understanding of PCOS Education and Research) trial
Polycystic ovary syndrome (PCOS), the most common endocrine disorder for women of reproductive age, is associated with inc...
A new trial monitoring plan (TMP) template for clinical trials: output from a Delphi process
A new trial monitoring plan (TMP) template for clinical trials: output from a Delphi process
Monitoring is a crucial part of trial conduct and ensures that participants’ data is fairly represented, and future ...
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