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Improving mental health in chronic care in general practice: study protocol for a cluster-randomised controlled trial of the Healthy Mind intervention
Improving mental health in chronic care in general practice: study protocol for a cluster-randomised controlled trial of the Healthy Mind intervention
Mental health issues are common among patients with chronic physical conditions, affecting approximately one in five patie...
Evaluation of KIAA1549::BRAF fusions and clinicopathological insights of pilocytic astrocytomas
Evaluation of KIAA1549::BRAF fusions and clinicopathological insights of pilocytic astrocytomas
Pilocytic astrocytoma (PAs) account for about 20 % of all childhood primary brain tumors and is the most common glioma in ...
How reliable is pre-sleeve endoscopy to characterize pathological features?
How reliable is pre-sleeve endoscopy to characterize pathological features?
Volume 72, October 2024, 152319Author links open overlay panel, , , , Highlights•Negative predictive value of preoperative...
The clinical value of mNGS of bronchoalveolar lavage fluid versus traditional microbiological tests for pathogen identification and prognosis of severe pneumonia (NT-BALF):study protocol for a prospective multi-center randomized clinical trial
The clinical value of mNGS of bronchoalveolar lavage fluid versus traditional microbiological tests for pathogen identification and prognosis of severe pneumonia (NT-BALF):study protocol for a prospective multi-center randomized clinical trial
Early, rapid, and accurate pathogen diagnosis can help clinicians select targeted treatment options, thus improving progno...
Efficacy of Wearable low-intensity pulsed Ultrasound treatment in the Movement disorder in Parkinson’s disease (the SWUMP trial): protocol for a single-site, double-blind, randomized controlled trial
Efficacy of Wearable low-intensity pulsed Ultrasound treatment in the Movement disorder in Parkinson’s disease (the SWUMP trial): protocol for a single-site, double-blind, randomized controlled trial
Parkinson’s disease (PD) is a progressive, neurodegenerative illness marked by the loss of dopaminergic neurons, cau...
Photocoagulation or sham laser in addition to conventional anti-VEGF therapy in macular edema associated with TelCaps due to diabetic macular edema or retinal vein occlusion (TalaDME): a study protocol for a multicentric, French, two-group, non-commercial, active-control, observer-masked, non-inferiority, randomized controlled clinical trial
Photocoagulation or sham laser in addition to conventional anti-VEGF therapy in macular edema associated with TelCaps due to diabetic macular edema or retinal vein occlusion (TalaDME): a study protocol for a multicentric, French, two-group, non-commercial, active-control, observer-masked, non-inferiority, randomized controlled clinical trial
Macular edema (ME) results from hyperpermeability of retinal vessels, leading to chronic extravasation of plasma component...
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
Children with sensitization against foods have to be orally food-challenged before eating these foods for the first time. ...
Analysis of CSF3R mutations in atypical chronic myeloid leukemia and other myeloid malignancies
Analysis of CSF3R mutations in atypical chronic myeloid leukemia and other myeloid malignancies
Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) are two rare myeloid malignancies that ar...
Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms
Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms
Primary ovarian mucinous neoplasms (POMNs) represent a spectrum of disease ranging from benign mucinous cystadenomas to mu...
Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}
Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}
The World Health Organization recommends universal iron supplementation for children aged 6–23 months in countries w...
Amendments in surgical pathology reports: An 8-year institutional experience
Amendments in surgical pathology reports: An 8-year institutional experience
Surgical pathology is a complex and manual process that is prone to various defects (errors) in tissue analysis and report...
Depth of invasion analysis to predict acral melanoma outcomes
Depth of invasion analysis to predict acral melanoma outcomes
Cutaneous melanoma constitutes only 1 % of cutaneous tumor cases; nevertheless, it is among the deadliest forms of skin ca...
Theta-burst rTMS in schizophrenia to ameliorate negative and cognitive symptoms: study protocol for a double-blind, sham-controlled, randomized clinical trial
Theta-burst rTMS in schizophrenia to ameliorate negative and cognitive symptoms: study protocol for a double-blind, sham-controlled, randomized clinical trial
Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes t...
LapEmerge trial: study protocol for a laparoscopic approach for emergency colon resection—a multicenter, open label, randomized controlled trial
LapEmerge trial: study protocol for a laparoscopic approach for emergency colon resection—a multicenter, open label, randomized controlled trial
Due to faster recovery and lower morbidity rates, laparoscopy has become the gold standard in elective colorectal surgery ...
Does presence of complex translocations involving BCR::ABL1 in chronic myeloid leukemia affect the response rate to tyrosine kinase inhibitors? A systematic review of the literature
Does presence of complex translocations involving BCR::ABL1 in chronic myeloid leukemia affect the response rate to tyrosine kinase inhibitors? A systematic review of the literature
Chronic myeloid leukemia (CML) patients have a classical cytogenetic abnormality formed by a reciprocal translocation betw...
Educational nutritional intervention to prevent loss of health-related quality of life among older adults after a surgical treatment: design of a randomised controlled trial
Educational nutritional intervention to prevent loss of health-related quality of life among older adults after a surgical treatment: design of a randomised controlled trial
Disease-related malnutrition after a hospital stay has major consequences for older adults, the healthcare system and soci...
The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents (the EARLY study): a study protocol for a randomized controlled trial
The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents (the EARLY study): a study protocol for a randomized controlled trial
Although clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating ev...
Designing greener participant-centred trials: an analysis of ‘carbon relevant’ factors within items that influence participants’ decisions about trial recruitment and retention
Designing greener participant-centred trials: an analysis of ‘carbon relevant’ factors within items that influence participants’ decisions about trial recruitment and retention
Included study characteristicsThe first of the evidence sources included a review of participant-reported influences on re...
Study protocol for a randomized controlled trial of the Parent–Child Assistance Program: a case management and home visiting program for people using substances during pregnancy
Study protocol for a randomized controlled trial of the Parent–Child Assistance Program: a case management and home visiting program for people using substances during pregnancy
Perinatal substance use can have significant adverse effects on maternal and child health and family stability. Few interv...
A methodological review of randomised n-of-1 trials
A methodological review of randomised n-of-1 trials
n-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patie...
P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas
P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas
Head and neck host a milieu for multifactorial carcinogens, including tobacco smoking, alcohol consumption and viral infec...
Probiotic supplementation and risk of necrotizing enterocolitis and mortality among extremely preterm infants—the Probiotics in Extreme Prematurity in Scandinavia (PEPS) trial: study protocol for a multicenter, double-blinded, placebo-controlled, and registry-based randomized controlled trial
Probiotic supplementation and risk of necrotizing enterocolitis and mortality among extremely preterm infants—the Probiotics in Extreme Prematurity in Scandinavia (PEPS) trial: study protocol for a multicenter, double-blinded, placebo-controlled, and registry-based randomized controlled trial
Extremely preterm infants, defined as those born before 28 weeks’ gestational age, are a very vulnerable patient gro...
Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation
Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation
UK national clinical guidance recommends that men with prostate cancer on androgen deprivation therapy are offered twice w...
The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries
The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries
Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur i...
Remote or in-clinic? The effect of service delivery mode on hearing aid output: study protocol for a double-blinded, randomised trial in adults with mild to moderate sensorineural hearing loss
Remote or in-clinic? The effect of service delivery mode on hearing aid output: study protocol for a double-blinded, randomised trial in adults with mild to moderate sensorineural hearing loss
Teleaudiology can potentially improve access to hearing healthcare services. Remote hearing aid fittings offer a new mode ...
How inclusive were UK-based randomised controlled trials of COVID-19 vaccines? A systematic review investigating enrolment of Black adults and adult ethnic minorities
How inclusive were UK-based randomised controlled trials of COVID-19 vaccines? A systematic review investigating enrolment of Black adults and adult ethnic minorities
To establish if Black adults and adult ethnic minorities, defined as any group except White British, were represented in U...
INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens
INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens
Pancreatic serous cystadenoma (SCA) is a rare exocrine neoplasm of the pancreas with benign behavior. Histologically, it c...
Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series
Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series
Salivary gland tumors pose a diagnostic challenge to their diverse morphology and a vast range of biological behavior [1]....
Vitamin D as an intervention for improving quadriceps muscle strength in patients after anterior cruciate ligament reconstruction: study protocol for a randomized double-blinded, placebo-controlled clinical trial
Vitamin D as an intervention for improving quadriceps muscle strength in patients after anterior cruciate ligament reconstruction: study protocol for a randomized double-blinded, placebo-controlled clinical trial
The goal of anterior cruciate ligament reconstruction (ACLR) is to restore the preinjury level of knee function to return ...
Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients—a randomized rater-blinded trial
Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients—a randomized rater-blinded trial
Brain-derived neurotrophic factor (BDNF) is essential for antidepressant treatment of major depressive disorder (MDD). Our...
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