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A peer-volunteer led active ageing programme to prevent decline in physical function in older people at risk of mobility disability (Active, Connected, Engaged [ACE]): study protocol for a randomised controlled trial
A peer-volunteer led active ageing programme to prevent decline in physical function in older people at risk of mobility disability (Active, Connected, Engaged [ACE]): study protocol for a randomised controlled trial
The Active Connected Engaged [ACE] study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial...
Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
This manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate t...
(Un)Reliable detection of menstrual blood in forensic casework — evaluation of the Seratec® PMB test with mock samples
(Un)Reliable detection of menstrual blood in forensic casework — evaluation of the Seratec® PMB test with mock samples
The identification of the type of body fluid in crime scene evidence may be crucial, so that the efforts are high to reduc...
The effects of Olmesartan/amlodipine administered in the Morning or At Night on nocturnal blood pressure reduction in Chinese patients with mild-moderate essential hypertension (OMAN Trial): study protocol for a prospective, multicenter, randomized, open-label clinical trial {1}
The effects of Olmesartan/amlodipine administered in the Morning or At Night on nocturnal blood pressure reduction in Chinese patients with mild-moderate essential hypertension (OMAN Trial): study protocol for a prospective, multicenter, randomized, open-label clinical trial {1}
Hypertension increases the risk of cardiovascular disease. Uncontrolled nocturnal blood pressure is prevalent in patients ...
The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper’s knee) in athletes—study protocol for a double-blind randomized controlled trial
The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper’s knee) in athletes—study protocol for a double-blind randomized controlled trial
Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is...
Supporting physical activity for mobility in older adults with mobility limitations (SuPA Mobility): study protocol for a randomized controlled trial
Supporting physical activity for mobility in older adults with mobility limitations (SuPA Mobility): study protocol for a randomized controlled trial
Limited mobility in older adults consistently predicts both morbidity and mortality. As individuals age, the rates of mobi...
Hearing intervention for decreasing risk of developing dementia in elders with mild cognitive impairment: study protocol of a multicenter randomized controlled trial for Chinese Hearing Solution for Improvement of Cognition in Elders (CHOICE)
Hearing intervention for decreasing risk of developing dementia in elders with mild cognitive impairment: study protocol of a multicenter randomized controlled trial for Chinese Hearing Solution for Improvement of Cognition in Elders (CHOICE)
Age-related hearing loss (ARHL) signifies the bilateral, symmetrical, sensorineural hearing loss that commonly occurs in e...
Reducing Stress after Trauma (ReSeT): study protocol for a randomized, controlled trial of an online psychoeducational program and video therapy sessions for children hospitalized after trauma
Reducing Stress after Trauma (ReSeT): study protocol for a randomized, controlled trial of an online psychoeducational program and video therapy sessions for children hospitalized after trauma
Post-traumatic stress symptoms develop in a quarter to half of injured children affecting their longer-term psychologic an...
Morphology of immune-mediated hepatitis: A comparison between immune checkpoint inhibitor therapy and combined immune checkpoint inhibitor/anti-angiogenic therapy
Morphology of immune-mediated hepatitis: A comparison between immune checkpoint inhibitor therapy and combined immune checkpoint inhibitor/anti-angiogenic therapy
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that can block inhibitors of T-cell activation and function ...
Perceived dyspnea and experience of hospitalized patients with acute decompensated heart failure undergoing an early MObilization protocol with immersive Virtual rEality: MOVE study protocol for a parallel superiority randomized clinical trial
Perceived dyspnea and experience of hospitalized patients with acute decompensated heart failure undergoing an early MObilization protocol with immersive Virtual rEality: MOVE study protocol for a parallel superiority randomized clinical trial
Immersive virtual reality (VR) is an innovative strategy for inpatient rehabilitation programs. Using immersive VR in earl...
Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial)
Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial)
Pulsed radiofrequency (PRF) treatment on the dorsal root ganglion (DRG) has been proposed as a good option for the treatme...
Attitudes and barriers to participation in window-of-opportunity trials reported by White and Asian/Asian British ethnicity patients who have undergone treatment for endometrial cancer
Attitudes and barriers to participation in window-of-opportunity trials reported by White and Asian/Asian British ethnicity patients who have undergone treatment for endometrial cancer
Window-of-opportunity trials (WOT) are a study design that have been used to investigate drug activity in endometrial canc...
Awareness with paralysis and symptoms of post-traumatic stress disorder among mechanically ventilated emergency department survivors (ED-AWARENESS-2 Trial): study protocol for a pragmatic, multicenter, stepped wedge cluster randomized trial
Awareness with paralysis and symptoms of post-traumatic stress disorder among mechanically ventilated emergency department survivors (ED-AWARENESS-2 Trial): study protocol for a pragmatic, multicenter, stepped wedge cluster randomized trial
Awareness with paralysis (AWP) is memory recall during neuromuscular blockade (NMB) and can cause significant psychologica...
Effects of the “ICU Support” team meeting concept on patient-centered and staff-centered outcomes: study protocol for a randomized controlled multicenter study
Effects of the “ICU Support” team meeting concept on patient-centered and staff-centered outcomes: study protocol for a randomized controlled multicenter study
Providing optimal care for critically ill patients is an extremely important but also highly demanding task, both emotiona...
Pediatric HIV+ Kaposi sarcoma exhibits clinical, virological, and molecular features different from the adult disease
Clinical MedicineAIDS/HIVOncology Open Access | 10.1172/jci.insight.167854 Carolina Caro-Vegas,...
Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy
Research ArticleCardiology Open Access | 10.1172/jci.insight.157956 Al-Hassan J. Dajani,1 M...
Failure to breathe persists without air hunger or alarm following amygdala seizures
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.172423 Gail I.S. Harmata,1,2,3,4...
Biallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors
Research ArticleGeneticsOncology Open Access | 10.1172/jci.insight.170079 Ghada M. H. Abdel-Sal...
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Cell isolation. PBMCs from adult blood were isolated by Ficoll-Histopaque (MilliporeSigma) gradient centrifugation and cr...
Effects of dulaglutide on alcohol consumption during smoking cessation
The main finding of the present study is that participants treated for smoking cessation drink significantly less alcohol...
Anti–NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice
Research ArticleBone biology Open Access | 10.1172/jci.insight.171962 Kenji Takami,1,2 Kazu...
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/jci.insight.165709 Alfonso Galder...
Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3
D2.1 dormancy is immune independent. The D2 series of cells, consisting of D2A1, D2.OR, and D2.1 cell lines that arose fr...
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma
Cytotoxicity and induction of stable global hyperacetylation in patient-derived GSCs treated with QST. QST (JNJ-26481585)...
N6-methyladenosine–mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling
ADAMTS9-AS2 is differentially expressed in neuroblastoma and is positively correlated with differentiation. We used high-...
Cell-based screen identifies porphyrins as FGFR3 activity inhibitors with therapeutic potential for achondroplasia and cancer
A cell-based receptor/adaptor translocation assay to specifically monitor FGFR3 activity. Plant extracts have long been r...
Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.172845 Cláudia Gomes,1 ...
Smooth muscle–derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner
Research ArticleStem cellsVascular biology Open Access | 10.1172/jci.insight.174639 Allison M. ...
Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease
Increased synaptosomal Aβ42 in patients with aMCI. To determine whether brain Aβ load differentiates preclinical AD from ...
Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.172510 Brock Kingstad-Bakk...
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