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IFN-signaling gene expression as a diagnostic biomarker for monogenic interferonopathies
Research ArticleInflammationNeuroscience Open Access | 10.1172/jci.insight.178456 Laura A. Adan...
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma
Research ArticleTherapeutics Open Access | 10.1172/jci.insight.169647 Santhoshkumar Sundaramoor...
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV
Research ArticleAIDS/HIV Open Access | 10.1172/jci.insight.174168 Jennifer Simpson,1 Carly ...
Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas
Research ArticleImmunologyOncology Open Access | 10.1172/jci.insight.178767 Chang Su,1,2 Co...
Myocardial infarction causes sex-dependent dysfunction in vagal sensory glutamatergic neurotransmission that is mitigated by 17β-estradiol
BRS testing in mice after MI. The arterial baroreflex is critical for the regulation of BP and HR. Rises in BP led to act...
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis
Sex as a biological variable. For human participants, sex was not considered as a biological variable. Male mice were use...
Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs
Individual versus combined TNF-α and IL-17 differentially modulate CFTR modulator–evoked anion secretion. Transepithelial...
A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models
Research ArticleTherapeutics Open Access | 10.1172/jci.insight.177003 Paul R. Stabach,1 Dom...
Three-dimensional imaging of upper tract urothelial carcinoma improves diagnostic yield and accuracy
Research ArticleOncology Open Access | 10.1172/jci.insight.175751 Keishiro Fukumoto,1,2 Kan...
Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation
Loss of MPO attenuates acute DSS colitis severity. As an initial series of experiments to define the contribution of MPO ...
Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice
Cinaciguat prevents dexamethasone-induced inhibition of osteoblast proliferation, survival, and differentiation. Based on...
Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGF-β
scRNA-Seq analysis reveals AG immune response to physiological stressors. Macrophages are remarkably diverse immune cells...
Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.176329 Ying Li,1 Yuchen Deng...
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
Research ArticleOncologyTherapeutics Open Access | 10.1172/jci.insight.177857 Jiaxin Yin,1 ...
DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function
Linaclotide stimulates bicarbonate secretion in mouse and human duodenum. To determine linaclotide’s ability to stimulate...
FDXR variants cause adrenal insufficiency and atypical sexual development
Research ArticleEndocrinologyGenetics Open Access | 10.1172/jci.insight.179071 Emanuele Pignatt...
Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity
Detection of naive-like CD4+ T cells after YFV vaccination. We had previously performed a longitudinal study of YFV-speci...
PM2.5 triggers tau aggregation in a mouse model of tauopathy
Sex as a biological variable. Our study examined male and female animals, and similar findings were reported for both sex...
Detection of human papillomavirus (HPV) in malignant melanoma
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ChatGPT and pathology residents in histopathologic description and diagnosis of common diseases: Comment
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Performance and limitations of customized ChatGPT in histopathologic diagnosis
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Forensic age estimation of adolescents using computed tomography of the clavicles
Forensic age estimation of adolescents using computed tomography of the clavicles
In forensic age estimation, CT imaging of the clavicles is used to determine an age over completed 21 years. If o...
Comparative analysis of PD-L1 expression and tumor-infiltrating lymphocytes in metaplastic breast carcinoma and gynecologic carcinosarcoma: A single-institution retrospective study
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Hope Groups: a protocol for a cluster randomized controlled trial of psychosocial, mental health, and parenting support groups for Ukrainian caregivers during war and conflict
Hope Groups: a protocol for a cluster randomized controlled trial of psychosocial, mental health, and parenting support groups for Ukrainian caregivers during war and conflict
In 2021, more than two-thirds of the world’s children lived in a conflict-affected country. In 2022, 13 million Ukra...
Bringing optimised COVID-19 vaccine schedules to immunocompromised populations (BOOST-IC): study protocol for an adaptive randomised controlled clinical trial
Bringing optimised COVID-19 vaccine schedules to immunocompromised populations (BOOST-IC): study protocol for an adaptive randomised controlled clinical trial
Immunocompromised hosts (ICH) experience more breakthrough infections and worse clinical outcomes following infection with...
Personality vulnerabilities and adverse event reporting in phase 1 clinical studies
Personality vulnerabilities and adverse event reporting in phase 1 clinical studies
Phase 1 clinical trials involve rigorous safety monitoring to identify any adverse effects of investigational treatments. ...
Forensic age estimation by MRI of the knee – comparison of two classifications for ossification stages in a German population
Forensic age estimation by MRI of the knee – comparison of two classifications for ossification stages in a German population
In forensic age estimation e.g. for judicial proceedings surpassed age thresholds can be legally relevant. To examine age ...
Single-camera photogrammetry using a mobile phone for low-cost documentation of corpses
Single-camera photogrammetry using a mobile phone for low-cost documentation of corpses
Photogrammetry is a technique for studying and defining objects’ shape, dimension, and position in a three-dimension...
Integrated Assessment of GFAP and UCH-L1 for their utility in severity assessment and outcome prediction in Traumatic Brain Injury
Integrated Assessment of GFAP and UCH-L1 for their utility in severity assessment and outcome prediction in Traumatic Brain Injury
This study aimed to explore the potential of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 ...
Forensic species identification: practical guide for animal and plant DNA analysis
Forensic species identification: practical guide for animal and plant DNA analysis
The importance of non-human DNA in the forensic field has increased greatly in recent years, together with the type of app...
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