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Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
This manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate t...
(Un)Reliable detection of menstrual blood in forensic casework — evaluation of the Seratec® PMB test with mock samples
(Un)Reliable detection of menstrual blood in forensic casework — evaluation of the Seratec® PMB test with mock samples
The identification of the type of body fluid in crime scene evidence may be crucial, so that the efforts are high to reduc...
Supporting physical activity for mobility in older adults with mobility limitations (SuPA Mobility): study protocol for a randomized controlled trial
Supporting physical activity for mobility in older adults with mobility limitations (SuPA Mobility): study protocol for a randomized controlled trial
Limited mobility in older adults consistently predicts both morbidity and mortality. As individuals age, the rates of mobi...
Failure to breathe persists without air hunger or alarm following amygdala seizures
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.172423 Gail I.S. Harmata,1,2,3,4...
Biallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors
Research ArticleGeneticsOncology Open Access | 10.1172/jci.insight.170079 Ghada M. H. Abdel-Sal...
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Cell isolation. PBMCs from adult blood were isolated by Ficoll-Histopaque (MilliporeSigma) gradient centrifugation and cr...
Effects of dulaglutide on alcohol consumption during smoking cessation
The main finding of the present study is that participants treated for smoking cessation drink significantly less alcohol...
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/jci.insight.165709 Alfonso Galder...
Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3
D2.1 dormancy is immune independent. The D2 series of cells, consisting of D2A1, D2.OR, and D2.1 cell lines that arose fr...
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma
Cytotoxicity and induction of stable global hyperacetylation in patient-derived GSCs treated with QST. QST (JNJ-26481585)...
Cell-based screen identifies porphyrins as FGFR3 activity inhibitors with therapeutic potential for achondroplasia and cancer
A cell-based receptor/adaptor translocation assay to specifically monitor FGFR3 activity. Plant extracts have long been r...
Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.172845 Cláudia Gomes,1 ...
Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease
Increased synaptosomal Aβ42 in patients with aMCI. To determine whether brain Aβ load differentiates preclinical AD from ...
Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.172510 Brock Kingstad-Bakk...