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Internet-based cognitive behavioral intervention for adolescents with anxiety disorders: a study protocol for a parallel three armed randomized controlled trial
Internet-based cognitive behavioral intervention for adolescents with anxiety disorders: a study protocol for a parallel three armed randomized controlled trial
Anxiety disorders are among the most prevalent mental health concerns affecting children and adolescents. Despite their hi...
A randomized controlled trial of a “Small Changes” behavioral weight loss treatment delivered in cardiac rehabilitation for patients with atrial fibrillation and obesity: study protocol for the BE-WEL in CR-AF study
A randomized controlled trial of a “Small Changes” behavioral weight loss treatment delivered in cardiac rehabilitation for patients with atrial fibrillation and obesity: study protocol for the BE-WEL in CR-AF study
Atrial fibrillation (AF) represents a global epidemic. Although international AF practice guidelines indicate weight loss ...
Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial
Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial
Meta-analyses of randomized trials suggest that health checks and health promotion interventions targeting behavior change...
A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children—BENEFICIAL trial
A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children—BENEFICIAL trial
Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vanc...
T2-weighted spoiled gradient echo MRI for forensic age estimation: a study on knee growth plates
T2-weighted spoiled gradient echo MRI for forensic age estimation: a study on knee growth plates
The timing of growth plate fusion is a key indicator for age estimation and is primarily used in forensic investigations. ...
Petrous bones versus tooth cementum for genetic analysis of aged skeletal remains
Petrous bones versus tooth cementum for genetic analysis of aged skeletal remains
A proper sampling strategy is important to obtain sufficient DNA for successful identification of aged skeletal remains. T...
Investigating the effects of co-supplementation with alpha-linolenic acid and L-carnitine on inflammatory status, oxidative stress, clinical symptoms, mental health and quality of life in women with migraine: a protocol for a randomized, triple-blind, placebo-controlled trial
Investigating the effects of co-supplementation with alpha-linolenic acid and L-carnitine on inflammatory status, oxidative stress, clinical symptoms, mental health and quality of life in women with migraine: a protocol for a randomized, triple-blind, placebo-controlled trial
Migraine is a severe neurological disorder that is recognized as one of the most common debilitating diseases worldwide. A...
Consideration of factors of low accrual and methods for setting appropriate accrual periods: Japan Clinical Oncology Group study
Consideration of factors of low accrual and methods for setting appropriate accrual periods: Japan Clinical Oncology Group study
Poor patient accrual can delay reporting of clinical trials and, consequently, the development of new treatments. For redu...
Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial
Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial
Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations...
Concussion Health Improvement Program (CHIP): study protocol for a randomized controlled optimization trial for youth with persistent post-concussive symptoms
Concussion Health Improvement Program (CHIP): study protocol for a randomized controlled optimization trial for youth with persistent post-concussive symptoms
Up to 1.9 million youth in the USA sustain a concussion each year, and up to 30% experience persistent post-concussive sym...
Effects of home disease management strategies based on the dyadic illness management theory on elderly patients with chronic heart failure and informal caregivers’ physical and psychological outcomes: protocol of a randomized controlled trial
Effects of home disease management strategies based on the dyadic illness management theory on elderly patients with chronic heart failure and informal caregivers’ physical and psychological outcomes: protocol of a randomized controlled trial
Currently, most elderly chronic heart failure (CHF) patients go home for rehabilitation after certain treatment in hospita...
Unveiling STRs instability in a colorectal cancer FFPE sample: a case report
Unveiling STRs instability in a colorectal cancer FFPE sample: a case report
In forensic genetics, sometimes formalin-fixed paraffin-embedded (FFPE) biopsy material taken during life is the only biol...
Sex estimation by CT image analysis of the rib cage in a Mediterranean population
Sex estimation by CT image analysis of the rib cage in a Mediterranean population
Sexual dimorphism in the human species is key to the development of sex estimation techniques in the human skeleton. This ...
Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model
Sex as a biological variable. Our study examined male and female mice, and no differences were found between sexes. Anima...
Protocol for a randomized controlled trial: exercise-priming of CBT for depression (the CBT+ trial)
Protocol for a randomized controlled trial: exercise-priming of CBT for depression (the CBT+ trial)
Depression is a leading cause of disability worldwide, and treatments could be more effective. Identifying methods to impr...
Evaluating the effectiveness of Smoke-Free Home SafeCare, an integrated intervention, among families at risk for secondhand smoke exposure and child maltreatment in the United States: a study protocol for a hybrid type 1 trial
Evaluating the effectiveness of Smoke-Free Home SafeCare, an integrated intervention, among families at risk for secondhand smoke exposure and child maltreatment in the United States: a study protocol for a hybrid type 1 trial
Secondhand smoke exposure (SHS) and child maltreatment (CM) are preventable yet have negative lifelong impacts on health. ...
Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the UK, and Germany
Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the UK, and Germany
Conducting high-quality randomized clinical trials (RCTs) is challenging, time consuming, and resource intense. Academic i...
The effect of MIND diet on sleep status, anxiety, depression, and cardiometabolic indices in obese diabetic women with insomnia: study protocol for a randomized controlled clinical trial {1}
The effect of MIND diet on sleep status, anxiety, depression, and cardiometabolic indices in obese diabetic women with insomnia: study protocol for a randomized controlled clinical trial {1}
The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is a plant-based and anti-inflammatory diet th...
Beyond the binary female/male sex classification: The impact of (trans)gender on the identification of human remains
Beyond the binary female/male sex classification: The impact of (trans)gender on the identification of human remains
In cases of unidentified deceased persons, sex determination is a routine task in forensic medicine. However, the binary b...
Development and evaluation of a panel of newly screened Y chromosome InDels for inferring paternal ancestry information in Southwest China
Development and evaluation of a panel of newly screened Y chromosome InDels for inferring paternal ancestry information in Southwest China
Y-InDels (insertions/deletions) are genetic markers which are extremely understudied. It is unknown whether this type of m...
Identification of Postn+ periosteal progenitor cells with bone regenerative potential
Identification of Postn+ P-MPs utilizing scRNA transcriptome profiling. To define all the periosteal populations present ...
MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of ischemia/reperfusion injury after lung transplant
Efferocytosis-related genes are downregulated in M-MDSCs in CLAD. We analyzed single-cell RNA-sequencing data from patien...
Identification of RTS,S/AS01 vaccine–induced humoral biomarkers predictive of protection against controlled human malaria infection
Clinical MedicineImmunologyVaccines Open Access | 10.1172/jci.insight.178801 Rachel L. Spreng...
miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression
Research ArticleHepatologyMetabolism Open Access | 10.1172/jci.insight.168476 Pablo Fernández...
Sparsentan improves glomerular hemodynamics, cell functions, and tissue repair in a mouse model of FSGS
Effects of sparsentan on glomerular hemodynamics under physiological conditions. We first tested the effects of sparsenta...
Immune perturbation following SHIV infection is greater in newborn macaques than in infants
Study design. Twelve animals were assigned to the study, regardless of sex, at approximately 1 week of age. All animals h...
Protein-truncating variant in APOL3 increases chronic kidney disease risk in epistasis with APOL1 risk alleles
Clinical MedicineGeneticsNephrology Open Access | 10.1172/jci.insight.181238 David Y. Zhang,1...
Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease
Research ArticleTherapeuticsVascular biology Open Access | 10.1172/jci.insight.181877 Amit Pr...
The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair
Sex as a biological variable. Sex was not considered as a biological variable in all reported human data. Only males were...
Bank1 modulates the differentiation and molecular profile of key B cell populations in autoimmunity
Bank1 deficiency decreases autoantibody production in TLR7.tg6 and IMQ-treated lupus-prone mice. The effects of Bank1 def...
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