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Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of ...
Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression
Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression
Overcoming vascular immunosuppression: lack of endothelial cell (EC) responsiveness to inflammatory stimuli in the proangi...
Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We p...
Inflammation and vascular remodeling in COVID-19 hearts
Inflammation and vascular remodeling in COVID-19 hearts
A wide range of cardiac symptoms have been observed in COVID-19 patients, often significantly influencing the clinical out...
BMP10 functions independently from BMP9 for the development of a proper arteriovenous network
BMP10 functions independently from BMP9 for the development of a proper arteriovenous network
Hereditary hemorrhagic telangiectasia (HHT) is a genetic vascular disorder characterized by the presence of arteriovenous ...
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
Cancer cells are embedded within the tissue and interact dynamically with its components during cancer progression. Unders...
Correction: RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway
Correction: RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway
In the original publication, the incorrect images were arranged in Figs. 4H and 6I inadvertently during the figure prepara...
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia
Peripheral artery disease (PAD) is an occlusive disease of limb arteries. Critical limb ischemia (CLI) is an advanced form...
Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats
Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats
Figures 1a, 4c, 5h, and 7f were published incorrectly in the original publication, and the correct figures are provided in...
Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis
Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis
VEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS) derived from NADPH oxidases (NOX...
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice
Extracranial arteriovenous malformation (AVM) is a congenital vascular anomaly causing disfigurement, bleeding, ulceration...
Tissue oxygenation stabilizes neovessels and mitigates hemorrhages in human atherosclerosis-induced angiogenesis
Tissue oxygenation stabilizes neovessels and mitigates hemorrhages in human atherosclerosis-induced angiogenesis
Progression of atherosclerosis is associated with a maladaptive form of angiogenesis which contributes to intraplaque hemo...
Persistent capillary rarefication in long COVID syndrome
Persistent capillary rarefication in long COVID syndrome
Recent studies have highlighted Coronavirus disease 2019 (COVID-19) as a multisystemic vascular disease. Up to 60% of the ...
Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations
Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations
Orbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnorma...
The rising impact of angiogenesis research
The rising impact of angiogenesis research
While inhibiting pathological angiogenesis has been long associated with the field of oncology, recent advances in angioge...
PDGFD switches on stem cell endothelial commitment
PDGFD switches on stem cell endothelial commitment
The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss-...
Angiogenesis in adipose tissue and obesity
Angiogenesis in adipose tissue and obesity
While most tissues exhibit their greatest growth during development, adipose tissue is capable of additional massive expan...
S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor
S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor
Tumor-induced lymphangiogenesis promotes the formation of new lymphatic vessels, contributing to lymph nodes (LNs) metasta...
Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial
Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial
Patients with critical limb ischemia (CLI) still have a high rate of lower limb amputation, which is associated with not o...
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endot...
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature is becoming the bottleneck ...
A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis
A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis
Sturge-Weber syndrome (SWS) is a sporadic, congenital, neuro-cutaneous disorder characterized by a mosaic, capillary malfo...
TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
The dynamic integrin-mediated adhesion of endothelial cells (ECs) to the surrounding ECM is fundamental for angiogenesis b...
Targeting SMYD2 inhibits angiogenesis and increases the efficiency of apatinib by suppressing EGFL7 in colorectal cancer
Targeting SMYD2 inhibits angiogenesis and increases the efficiency of apatinib by suppressing EGFL7 in colorectal cancer
Angiogenesis is an essential factor affecting the occurrence and development of solid tumors. SET And MYND Domain Containi...
Trafficking in blood vessel development
Trafficking in blood vessel development
Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature...
KIT is dispensable for physiological organ vascularisation in the embryo
KIT is dispensable for physiological organ vascularisation in the embryo
Blood vessels form vast networks in all vertebrate organs to sustain tissue growth, repair and homeostatic metabolism, but...
NRASQ61R mutation in human endothelial cells causes vascular malformations
NRASQ61R mutation in human endothelial cells causes vascular malformations
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and sp...
In vivo dissection of Rhoa function in vascular development using zebrafish
In vivo dissection of Rhoa function in vascular development using zebrafish
The small monomeric GTPase RHOA acts as a master regulator of signal transduction cascades by activating effectors of cell...
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes, and can accelerate diabetes-rel...