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Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
The role of vasculature and angiogenesis in respiratory diseases
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-thre...
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progress...
Microglia in retinal angiogenesis and diabetic retinopathy
Microglia in retinal angiogenesis and diabetic retinopathy
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression a...
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time ...
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harm...
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (n...
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prem...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are kn...
A high-resolution view of the heterogeneous aging endothelium
A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While stud...
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Heterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrh...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Paris Cité University, Innovative Therapies in Hemostasis, INSERM, 75006, Paris, FranceDavid M. Smadja, Aurélien Philippe,...
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogene...
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
The Fig. 3a of this article originally contained an incorrect picture showing “HDAC7/AKAP12 siRNA” condition at t = 0 h. I...
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to del...
Targeting the microenvironment in the treatment of arteriovenous malformations
Targeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain,...
Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clu...
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular developm...
2022 14th HHT International Scientific Conference Abstracts
2022 14th HHT International Scientific Conference Abstracts
Medical therapeuticsO1 Cure HHT research network: building the roadmap to cure HHTFriday C, MS1; Krock N1; Schaefer N1; Le...
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Kow CS, Ramachandram DS, Hasan SS (2022) The effect of higher-intensity dosing of anticoagulation on the clinical outcomes...
The modes of angiogenesis: an updated perspective
The modes of angiogenesis: an updated perspective
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a varie...
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
School of Medicine, Klinikum Rechts Der Isar, Department of Nephrology, Technical University of Munich, Ismaninger Str. 22...
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating pot...
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms followi...
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Imatinib, an ABL tyrosine-kinase inhibitor, shows promise in restoring endothelial barrier function in patients with COVID...
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulti...
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