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ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
The proliferation of the endothelium is a highly coordinated process to ensure the emergence, expansion, and homeostasis o...
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially r...
Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are m...
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular b...
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinop...
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
Snake venoms are intricate mixtures of enzymes and bioactive factors that induce a range of detrimental effects in afflict...
Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes
Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes
Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve skin transplantation. Ho...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis
Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis
Cell cycle regulation is critical to blood vessel formation and function, but how the endothelial cell cycle integrates wi...
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health c...
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype
The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to...
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells
Induced pluripotent stem cell (iPSC) derived endothelial cells (iECs) have emerged as a promising tool for studying vascul...
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesize...
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (...
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriove...
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
We want to thank Peng et. al for the very thoughtful and important comments on our previous publication. They postulated t...
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomple...
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common mor...
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
The role of vasculature and angiogenesis in respiratory diseases
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-thre...
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progress...
Microglia in retinal angiogenesis and diabetic retinopathy
Microglia in retinal angiogenesis and diabetic retinopathy
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression a...
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time ...
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”
Connective tissue serves as a framework for other tissues and organs, supporting their functions, shielding them from harm...
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (n...
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prem...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
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