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Targeting the microenvironment in the treatment of arteriovenous malformations
Targeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain,...
Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clu...
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular developm...
2022 14th HHT International Scientific Conference Abstracts
2022 14th HHT International Scientific Conference Abstracts
Medical therapeuticsO1 Cure HHT research network: building the roadmap to cure HHTFriday C, MS1; Krock N1; Schaefer N1; Le...
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Kow CS, Ramachandram DS, Hasan SS (2022) The effect of higher-intensity dosing of anticoagulation on the clinical outcomes...
The modes of angiogenesis: an updated perspective
The modes of angiogenesis: an updated perspective
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a varie...
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
School of Medicine, Klinikum Rechts Der Isar, Department of Nephrology, Technical University of Munich, Ismaninger Str. 22...
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating pot...
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms followi...
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Imatinib, an ABL tyrosine-kinase inhibitor, shows promise in restoring endothelial barrier function in patients with COVID...
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulti...
Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay
Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay
Modern drug development increasingly requires comprehensive models that can be utilized in the earliest stages of compound...
FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2
FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2
The forkhead box O1 (FOXO1) is an important transcription factor related to proliferation, metabolism, and homeostasis, wh...
Correction to: BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways
Correction to: BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways
BI1 was downregulated in response to the IR injury in the infarcted area. WT mice underwent the 45-min ischemia and 0–24-h...
Capillary rarefaction: a missing link in renal and cardiovascular disease?
Capillary rarefaction: a missing link in renal and cardiovascular disease?
Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality. Capillary ra...
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Longitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for developing novel therapeutics and pa...
The dynamics of the endothelial glycocalyx: a rare snapshot by electron microscopy
The dynamics of the endothelial glycocalyx: a rare snapshot by electron microscopy
In the current study, EM imaging was performed on slices of peripheral kidney tissue from healthy C57BL/6 J wild-type mice...
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and lea...
Correction: Nectins and Nectin-like molecules drive vascular development and barrier function
Correction: Nectins and Nectin-like molecules drive vascular development and barrier function
Department of Immunology and Infection, UHasselt, Biomedical Research Institute (BIOMED), Diepenbeek, BelgiumDoryssa Herma...
Damage to endothelial barriers and its contribution to long COVID
Damage to endothelial barriers and its contribution to long COVID
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At the same time, a subset of con...
Pathological angiogenesis: mechanisms and therapeutic strategies
Pathological angiogenesis: mechanisms and therapeutic strategies
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-existing ones, is an essential proce...
Expansion and collapse of VEGF diversity in major clades of the animal kingdom
Expansion and collapse of VEGF diversity in major clades of the animal kingdom
Together with the platelet-derived growth factors (PDGFs), the vascular endothelial growth factors (VEGFs) form the PDGF/V...
Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis
Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis
APJ has been extensively described in the pathophysiology of angiogenesis and cell proliferation. The prognostic value of ...
Diminished vasculogenesis under inflammatory conditions is mediated by Activin A
Diminished vasculogenesis under inflammatory conditions is mediated by Activin A
Severe inflammatory stress often leads to vessel rarefaction and fibrosis, resulting in limited tissue recovery. However, ...
FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP
FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP
Hyperglycemia in early postnatal life of preterm infants with incompletely vascularized retinas is associated with increas...
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
The molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and...
Nectins and Nectin-like molecules drive vascular development and barrier function
Nectins and Nectin-like molecules drive vascular development and barrier function
Angiogenesis, barriergenesis, and immune cell migration are all key physiological events that are dependent on the functio...
Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule
Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule
Angiogenesis plays an essential role in embryonic development, organ remodeling, wound healing, and is also associated wit...
Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription
Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription
Precise and specific spatiotemporal domains of gene expression regulation are critical for embryonic development. Recent s...
Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation
Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation
Cerebral cavernous malformations (CCMs) refer to a common vascular abnormality that affects up to 0.5% of the population. ...
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