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Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinop...
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
Snake venoms are intricate mixtures of enzymes and bioactive factors that induce a range of detrimental effects in afflict...
Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes
Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes
Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve skin transplantation. Ho...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis
Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis
Cell cycle regulation is critical to blood vessel formation and function, but how the endothelial cell cycle integrates wi...
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype
The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to...
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells
Induced pluripotent stem cell (iPSC) derived endothelial cells (iECs) have emerged as a promising tool for studying vascul...
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesize...
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (...
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriove...
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
Systemic glucocorticoids use in post-COVID-syndrome patients does not affect retinal microcirculation
We want to thank Peng et. al for the very thoughtful and important comments on our previous publication. They postulated t...
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomple...
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common mor...
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ...
The role of vasculature and angiogenesis in respiratory diseases
The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-thre...
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progress...
Microglia in retinal angiogenesis and diabetic retinopathy
Microglia in retinal angiogenesis and diabetic retinopathy
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression a...
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time ...
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (n...
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prem...
Group XIV C-type lectins: emerging targets in tumor angiogenesis
Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of gly...
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more ph...
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular de...
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are kn...
A high-resolution view of the heterogeneous aging endothelium
A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While stud...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...