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Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor
Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor
Reduction–oxidation factor-1 or apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) is a crucial redox-sensitive activ...
A novel quantitative angiogenesis assay based on visualized vascular organoid
A novel quantitative angiogenesis assay based on visualized vascular organoid
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease pr...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
Innovative Therapies in Hemostasis, Paris Cité University, INSERM, Paris, 75006, FranceDavid M. Smadja, Sven Günther, Bert...
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead...
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesi...
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer
Tumour angiogenesis supports malignant cells with oxygen and nutrients to promote invasion and metastasis. A number of cyt...
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations
Capillary malformations (CM) are congenital vascular irregularities of capillary and venous blood vessels that appear in t...
Inflammasome activation aggravates choroidal neovascularization
Inflammasome activation aggravates choroidal neovascularization
Inflammasome activation is implicated in diseases of aberrant angiogenesis such as age-related macular degeneration (AMD),...
Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1
Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1
The formation and organization of complex blood vessel networks rely on various biophysical forces, yet the mechanisms gov...
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Curren...
The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP
The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP
Apolipoprotein E4 (ApoE4) plays an important role responding to monomeric C-reactive protein (mCRP) via binding to CD31 le...
Senescent endothelial cells: a potential target for diabetic retinopathy
Senescent endothelial cells: a potential target for diabetic retinopathy
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Curr...
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability
The permeability of blood vessels plays a crucial role in the spread of cancer cells, facilitating their metastasis at dis...
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications
Fine-tuning angiogenesis, the development of new blood vessels, is essential for maintaining a healthy circulatory and lym...
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers
Nicotine acts as an angiogenic factor by stimulating endogenous cholinergic pathways. Several subtypes of nicotinic acetyl...
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort
Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with firs...
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer
Colorectal cancer (CRC) is one of the common clinical malignancies and the fourth leading cause of cancer-related death in...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to defi...
ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
The proliferation of the endothelium is a highly coordinated process to ensure the emergence, expansion, and homeostasis o...
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially r...
Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are m...
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular b...
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinop...
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
Snake venoms are intricate mixtures of enzymes and bioactive factors that induce a range of detrimental effects in afflict...
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