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Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Recent studies have shown that, coupled with other environmental factors, aluminium exposure may lead to neurodegeneration...
Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway
Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway
Necroptosis, a programmed form of necrotic cell death carried out by receptor-interacting serine/threonine protein kinase ...
Hyaluronic acid/diminazene aceturate combination ameliorates osteoarthritic anomalies in a rodent model: a role of the ACE2/Ang1-7/MasR axis
Hyaluronic acid/diminazene aceturate combination ameliorates osteoarthritic anomalies in a rodent model: a role of the ACE2/Ang1-7/MasR axis
The implication of the tissue-localized renin-angiotensin system (RAS) in the pathogenesis of osteoarthritis (OA) has been...
Attention-deficit/hyperactivity disorder and inflammation: natural product-derived treatments—a review of the last ten years
Attention-deficit/hyperactivity disorder and inflammation: natural product-derived treatments—a review of the last ten years
Attention-deficit hyperactivity disorder (ADHD) is a psychiatric disorder characterized by symptoms of inattention, hypera...
The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials
The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials
Despite the increasing evidence for probiotics’ anti-inflammatory effects, the results of meta-analyses remain incon...
Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like Foeniculum vulgare and Peumus bol...
John Alexander Mullin (1835–1899): The Canadian Physician who first described Osler’s Nodes
John Alexander Mullin (1835–1899): The Canadian Physician who first described Osler’s Nodes
Sir William Osler (1849–1919), who became Regius Professor of Medicine at Oxford in 1905, first drew attention in 19...
The illness of William Soutar (1898–1943)
The illness of William Soutar (1898–1943)
William Soutar (1898–1943) was a Scottish poet, but many are unaware of his scholarly work which includes his famous...
Spondyloarthropathies and arthritis post-infection: a historical perspective
Spondyloarthropathies and arthritis post-infection: a historical perspective
The spondyloarthropathies are a group of conditions characterised by spinal joint pain and have related clinical, epidemio...
Medical aspects of the tour by Martin Martin (c 1660–1719) of the Western and Northern Islands of Scotland, Circa 1695
Medical aspects of the tour by Martin Martin (c 1660–1719) of the Western and Northern Islands of Scotland, Circa 1695
This review is based investigations on the Western Isles, Scotland, by Martin Martin, a notable Scottish Highlander, acade...
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291
In the scope of a research program with the goal of developing treatments for inflammatory diseases, the pharmacological e...
A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
Considering the prevalence of oral mucositis, we aimed to use the analgesic effects of doxepin with chitosan’s antim...
A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
Naloxone is a non-selective opiate receptor antagonist that is mainly used in the management of acute opioid overdose or i...
The effect of magnesium sulfate on gene expression and serum level of inflammatory cytokines in coronary artery disease patients
The effect of magnesium sulfate on gene expression and serum level of inflammatory cytokines in coronary artery disease patients
To evaluate the effect of oral magnesium sulfate (MgSO4) on the gene expression and serum levels of inflammatory cytokines...
Voglibose attenuates cognitive impairment, Aβ aggregation, oxidative stress, and neuroinflammation in streptozotocin-induced Alzheimer’s disease rat model
Voglibose attenuates cognitive impairment, Aβ aggregation, oxidative stress, and neuroinflammation in streptozotocin-induced Alzheimer’s disease rat model
Alzheimer’s disease (AD) is an age-dependent neurodegenerative disease hallmarked by Amyloid-β (Aβ) aggreg...
The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose–response meta-analysis
The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose–response meta-analysis
L-carnitine supplementation may be beneficial in improving inflammatory conditions and reducing the level of inflammatory ...
Meta-analysis of the anti-oxidative and anti-inflammatory effects of hypoglycaemic plant-derived medicines
Meta-analysis of the anti-oxidative and anti-inflammatory effects of hypoglycaemic plant-derived medicines
The pivotal role of oxidative stress and inflammation in the pathophysiology of type 2 diabetes mellitus (T2DM) has been f...
Treatment of ankylosing spondylitis with TNFα inhibitors does not affect serum levels of tryptophan metabolites
Treatment of ankylosing spondylitis with TNFα inhibitors does not affect serum levels of tryptophan metabolites
The imbalance between the kynurenine and serotonin pathways can have serious consequences, e.g., depression. One of the fa...
Preemptive QP001, a fast-acting meloxicam formulation, provides analgesia and reduces opioid consumption following abdominal surgery: a randomized controlled trial
Preemptive QP001, a fast-acting meloxicam formulation, provides analgesia and reduces opioid consumption following abdominal surgery: a randomized controlled trial
QP001, a novel meloxicam formulation, has been developed to manage moderate to severe postoperative pain. This study aimed...
Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties
Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties
The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from ...
Treatment of rheumatic musculoskeletal disorders
Treatment of rheumatic musculoskeletal disorders
Non-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centu...
Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide
Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide
Folic acid (FA) plays an important role in the maintenance of normal neurological functions such as memory and learning fu...
High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis
High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis
Sepsis is a complex, multifactorial syndrome characterized by a dysregulated host response to infection, leading to severe...
Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation
Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation
Up to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus nephritis (LN). In low to middle income ...
Comparison of gastrointestinal adverse events between fast release tablets and regular acetylsalicylic acid (aspirin) galenics after short-term use: a meta-analysis of randomized clinical trials
Comparison of gastrointestinal adverse events between fast release tablets and regular acetylsalicylic acid (aspirin) galenics after short-term use: a meta-analysis of randomized clinical trials
This study aimed at determining whether there is a difference in the safety profile between fast release (FR) aspirin tabl...
Ibuprofen, other NSAIDs and COVID-19: a narrative review
Ibuprofen, other NSAIDs and COVID-19: a narrative review
At the start of the coronavirus disease 2019 (COVID-19) pandemic (March 2020), there was speculation that non-steroidal an...
Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota
Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota
Myocardial infarction (MI), commonly referred to as a heart attack, occurs when the blood flow to a portion of the heart i...
The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
The prominence of autophagy in the modulation of neurodegenerative disorders has sparked interest to investigate its stimu...
Sesquiterpene from Artemisia argyi seed extracts: A new anti-acute peritonitis agent that suppresses the MAPK pathway and promotes autophagy
Sesquiterpene from Artemisia argyi seed extracts: A new anti-acute peritonitis agent that suppresses the MAPK pathway and promotes autophagy
To find novel anti-inflammatory drugs, we screened anti-inflammatory compounds from 18 different types of Artemisia argyi ...
Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury
Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury
Neuroinflammation plays an important role in spinal cord injury (SCI), and an increasing number of studies have focused on...
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