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Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway
Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurb...
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
Inflammatory bowel disease (IBD) poses a significant challenge in modern medicine, with conventional treatments limited by...
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
To assess the impact of prior chronic treatment with angiotensin-converting enzyme inhibitors (ACEIs)/ angiotensin-recepto...
Evaluating the docetaxel effect in an animal model of polyarthritis
Evaluating the docetaxel effect in an animal model of polyarthritis
Rheumatoid arthritis (RA) is immune-mediated, inflammatory disease that affects synovial joints, and characterized by infl...
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and infl...
Atopic dermatitis: treatment and innovations in immunotherapy
Atopic dermatitis: treatment and innovations in immunotherapy
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by itching and skin barrier dysfunction. Modera...
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
This study was aimed to assess the efficacy and safety of two oral Symptomatic Slow Acting Drugs for Osteoarthritis (SYSAD...
Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels
Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels
Based on their high antioxidant capacity and noteworthy phytochemistry, Terminalia ferdinandiana fruit and leaves have att...
Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches
Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches
Gastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic...
Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review
Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review
Inflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioratio...
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
Dextran Sulfate Sodium (DSS) induces ulcerative colitis (UC), a type of inflammatory bowel disease (IBD) that leads to inf...
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic
Snow mountain garlic (SMG) is a trans-Himalayan medicinal plant used in the traditional medicine system for several ailmen...
Autophagy and exosomes; inter-connected maestros in Alzheimer’s disease
Autophagy and exosomes; inter-connected maestros in Alzheimer’s disease
Autophagy is a crucial process involved in the degradation and recycling of cytoplasmic components which are transported t...
Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice
Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice
Gout is a metabolic condition characterized by the accumulation of urate crystals in the synovial joints. These crystal de...
Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview
Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview
Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profo...
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1
Sepsis, a life-threatening condition characterized by dysregulated immune responses, remains a significant clinical challe...
Synergistic effects of mesenchymal stem cell-derived extracellular vesicles and dexamethasone on macrophage polarization under inflammatory conditions
Synergistic effects of mesenchymal stem cell-derived extracellular vesicles and dexamethasone on macrophage polarization under inflammatory conditions
The undesirable inflammation and the excessive M1 macrophage activity may lead to inflammatory diseases. Corticosteroids a...
Exploring the therapeutic potential of Anastatica hierochuntica essential oil in DSS-induced colitis
Exploring the therapeutic potential of Anastatica hierochuntica essential oil in DSS-induced colitis
The aim of this investigation was to explore the protective impacts and mechanisms of Anastatica hierochuntica essential o...
Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure–activity relationships, and potential applications
Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure–activity relationships, and potential applications
Curcumol (Cur), a guaiane-type sesquiterpenoid hemiketal, is an important and representative bioactive component extracted...
Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice
Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the...
Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
The gut and the brain communicate bidirectionally through the autonomic nervous system. The vagus nerve is a key component...
The effects of cholesterol and statins on Parkinson’s neuropathology: a narrative review
The effects of cholesterol and statins on Parkinson’s neuropathology: a narrative review
Parkinson disease (PD) is chronic and progressive neurodegenerative disease of the brain characterized by motor symptoms i...
Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and positively influences pain sensitivity and work capacity
Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and positively influences pain sensitivity and work capacity
The aim of the study was to investigate the effects of rat housing conditions—standard conditions, social isolation,...
Evaluation of the relationship of treatment and vaccination with prognosis in patients with a diagnosis of COVID-19
Evaluation of the relationship of treatment and vaccination with prognosis in patients with a diagnosis of COVID-19
Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide and caused mortality. Many factors have been...
Resveratrol ameliorates DSS-induced ulcerative colitis by acting on mouse gut microbiota
Resveratrol ameliorates DSS-induced ulcerative colitis by acting on mouse gut microbiota
Ulcerative colitis (UC) is a multi-faceted, recurrent immune disorder caused by dextran sulfate sodium (DSS). The intestin...
Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta
Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta
This study evaluated the composition and the antinociceptive and anti-inflammatory activity of the crude extracts and two ...
Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization
Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization
Osteoarthritis (OA) is a chronic disease that may lead to joint structure degeneration, cartilage destruction, osteophyte ...
Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion
Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion
For treating chronic diseases like rheumatoid arthritis, herbal medicines are preferred due to their evident therapeutic e...
3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model
3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model
Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mental ability and interrupts cognitive functi...
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3
Improving inflammation may serve as useful therapeutic interventions for the hindlimb unloading-induced disuse muscle atro...
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