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On the origin of cysteamine-induced duodenal cytotoxicity and type II ferroptosis
On the origin of cysteamine-induced duodenal cytotoxicity and type II ferroptosis
Cysteamine (CA) induces duodenal ulcers in rodents (Selye and Szabo, Nature 244:458–459, 1973). Cysteine (Cys), a pr...
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials
Vitamin D, known for its role in bone health, is now being explored for its immunomodulatory effects. This study aimed to ...
Conventional DMARDs therapy decreases disease activity and inflammation in newly diagnosed patients with rheumatoid arthritis by increasing FoxP3, Sema-3A, and Nrp-1 gene expression
Conventional DMARDs therapy decreases disease activity and inflammation in newly diagnosed patients with rheumatoid arthritis by increasing FoxP3, Sema-3A, and Nrp-1 gene expression
Semaphorins are axonal guidance molecules involved in neural development and contribute to the regulation of various phase...
Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration
Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration
Diabetes is one of the common endocrine disorders generally characterized by elevated levels of blood sugar. It can origin...
Janus kinase inhibitors versus tumor necrosis factor inhibitors in rheumatoid arthritis: meta-analytical comparison of efficacy and safety
Janus kinase inhibitors versus tumor necrosis factor inhibitors in rheumatoid arthritis: meta-analytical comparison of efficacy and safety
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by persistent inflammation leading to pr...
Gingerol nanoparticles attenuate complete Freund adjuvant-induced arthritis in rats via targeting the RANKL/OPG signaling pathway
Gingerol nanoparticles attenuate complete Freund adjuvant-induced arthritis in rats via targeting the RANKL/OPG signaling pathway
Rheumatoid arthritis (RA) is characterized by inflammatory joint pathology leading to the degradation of articular bone an...
Injectable smart-blended hydrogel cross-linked with Vanillin to accelerate differentiation of intervertebral disc-derived stem cells (IVDSCs) for promoting degenerative nucleolus pulposus in a rat model
Injectable smart-blended hydrogel cross-linked with Vanillin to accelerate differentiation of intervertebral disc-derived stem cells (IVDSCs) for promoting degenerative nucleolus pulposus in a rat model
The nucleus pulposus (NP) degradation is a primary factor in intervertebral disk degeneration (IVD) and a major contributo...
Natural products: A potential immunomodulators against inflammatory-related diseases
Natural products: A potential immunomodulators against inflammatory-related diseases
The incidence and prevalence of inflammatory-related diseases (IRDs) are increasing worldwide. Current approved treatments...
In vitro and in vivo modulatory effects of fluoxetine on gene expression and antioxidant enzymes in CFA-induced chronic inflammatory model: drug repurposing for arthritis
In vitro and in vivo modulatory effects of fluoxetine on gene expression and antioxidant enzymes in CFA-induced chronic inflammatory model: drug repurposing for arthritis
Fluoxetine, being a selective serotonin uptake inhibitor, has been broadly used to modulate the neurotransmission of serot...
Pentoxifylline in patients with ulcerative colitis treated with mesalamine by modulation of IL-6/STAT3, ZO-1, and S1P pathways: a randomized controlled double-blinded study
Pentoxifylline in patients with ulcerative colitis treated with mesalamine by modulation of IL-6/STAT3, ZO-1, and S1P pathways: a randomized controlled double-blinded study
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that lasts a long time and has a variety of causes. The pri...
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Polyphenolic compounds are among the most widely researched compounds for various therapeutic applications. However, natur...
Talabostat, fibroblast activation protein inhibitor, attenuates inflammation and fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis, where activated fibroblasts ...
Exploring the efficacy and safety of cannabidiol in individuals with epilepsy: an umbrella review of meta-analyses and systematic reviews
Exploring the efficacy and safety of cannabidiol in individuals with epilepsy: an umbrella review of meta-analyses and systematic reviews
Epilepsy ranks among the most prevalent neurological conditions worldwide. Cannabidiol (CBD) has received authorization fo...
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
Neutrophil–lymphocyte ratio and systemic immune-inflammation index as predictors of cardiovascular risk and mortality in prediabetes and diabetes: a population-based study
Neutrophil–lymphocyte ratio and systemic immune-inflammation index as predictors of cardiovascular risk and mortality in prediabetes and diabetes: a population-based study
The neutrophil–lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) are emerging inflammatory markers...
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
This review explores the pivotal role of the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP...
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Mammalian zinc ectopeptidases have significant functions in deactivating neurological and hormonal peptide signals on the ...
Brain resident microglia in Alzheimer’s disease: foe or friends
Brain resident microglia in Alzheimer’s disease: foe or friends
The neurobiology of Alzheimer’s disease (AD) is unclear due to its multifactorial nature. Although a wide range of s...
Metformin effects on plasma zonulin levels correlate with enhanced physical performance in osteoarthritis patients with diabetes
Metformin effects on plasma zonulin levels correlate with enhanced physical performance in osteoarthritis patients with diabetes
Metformin (MTF) shows promise in protecting against physical decline in osteoarthritis (OA), but how it works remains uncl...
Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-κb pathway and the reactive oxygen species-related Nrf2 signaling pathway
Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-κb pathway and the reactive oxygen species-related Nrf2 signaling pathway
Inflammatory diseases often result in bone loss due to persistent inflammation, which activates osteoclasts and increases ...
Chemical characterization of the essential oil from the leaves of Eugenia flavescens DC. (Myrtaceae) and its potential in the treatment of pain, inflammation, and ethanol- and ethanol/HCL-induced gastric ulcers in mice
Chemical characterization of the essential oil from the leaves of Eugenia flavescens DC. (Myrtaceae) and its potential in the treatment of pain, inflammation, and ethanol- and ethanol/HCL-induced gastric ulcers in mice
Eugenia flavescens is a species cultivated in Brazil for food purposes. Given the potential application of essential oils ...
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic effects on femoroacetabular impingement (FAI) patients underg...
Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?
Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?
Apigenin is a flavone-kind of flavonoid present in fruits and vegetables. Apigenin exhibits biological activities includin...
Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases
Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases
Inflammatory diseases, including psoriasis, atherosclerosis, rheumatoid arthritis, and ulcerative colitis, are characteriz...
Fixed oil from the Caatinga palm Syagrus coronata with effect on Complete Freund’s Adjuvant (CFA)-induced arthritis
Fixed oil from the Caatinga palm Syagrus coronata with effect on Complete Freund’s Adjuvant (CFA)-induced arthritis
Syagrus coronata, a native palm tree in the Caatinga domain, produces fixed oil (ScFO) used therapeutically and dietary by...
Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonstero...
Anti-inflammatory potential of Piper betleoides C. DC., a promising Piper species of Northeast India: in vitro and in vivo evidence and mechanistic insight
Anti-inflammatory potential of Piper betleoides C. DC., a promising Piper species of Northeast India: in vitro and in vivo evidence and mechanistic insight
The present study aims to investigate the anti-inflammatory potential of the leaf hydroalcoholic extract of Piper betleoid...
Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region
Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region
Fridericia chica is an Amazonian plant used to treat stomach disorders. However, the pharmacological activity of flavonoid...
The role of IL-1 family of cytokines in the pathogenesis and therapy of Alzheimer’s disease
The role of IL-1 family of cytokines in the pathogenesis and therapy of Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive and irreversible neurological condition that occurs with age and poses a s...
Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management
Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management
Since the start of the pandemic, considerable advancements have been made in our understanding of the effects of SARS-CoV-...
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