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Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
The relationship between liver fibrosis and inflammation and Mac-2-binding protein glycosylation isomer (M2BPGi) in patien...
The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis
The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis
MASLD can manifest as hepatocellular damage, which can result in mild elevation of aminotransferases. However, in some pat...
Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals
Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals
Information on the dynamics of metabolic dysfunction-associated steatotic liver disease (MASLD) among hepatitis C virus pa...
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory ...
Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma
Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma
During systemic therapy, the management of portal hypertension (PH)-related complications is vital. This study aimed to cl...
Natural history of lean and non-lean metabolic dysfunction-associated steatotic liver disease
Natural history of lean and non-lean metabolic dysfunction-associated steatotic liver disease
Conflicting evidence regarding the prognosis of lean metabolic dysfunction-associated steatotic liver disease (MASLD) has ...
iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study
iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study
Several preliminary reports have suggested the utility of ultrasound attenuation coefficient measurements based on B-mode ...
CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
Calcium voltage-gated channel auxiliary subunit alpha 2/delta 1 (CACNA2D1), a gene encoding a voltage-gated calcium channe...
Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
The branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is used to evaluate the progression of chronic l...
Severe induction of aberrant DNA methylation by nodular gastritis in adults
Severe induction of aberrant DNA methylation by nodular gastritis in adults
Nodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diff...
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Corticosteroids are recommended only for induction of remission in inflammatory bowel disease (IBD), including ulcerative ...
Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
We compared the efficacy, tolerability, and safety of oral sulfate tablets (OST, which contains simethicone) and 2 L-polye...
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
Achalasia is an esophageal motility disorder with an unknown etiology. We aimed to determine the pathogenesis of achalasia...
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
The tumor microbiome has been characterized in several malignancies; however, no previous studies have investigated its ro...
Prevalence of colonoscopy in Japan using a large-scale health claims data compared to esophagogastroduodenoscopy
Prevalence of colonoscopy in Japan using a large-scale health claims data compared to esophagogastroduodenoscopy
Prevalence of colonoscopy (CS) is an important countermeasure against colorectal cancer (CRC). In this study, we used larg...
Assessing the side effects and resistance in H. pylori treatment: a discussion on minocycline versus tetracycline therapy
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Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail...
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, re...
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a rapidly progressing chronic liver disease of global significance. However, the u...
A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA
A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA
Currently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B...
CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation
CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation
Liver fibrosis can progress to cirrhosis and hepatic carcinoma without treatment. CircDCBLD2 was found to be downregulated...
Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study
Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study
Research on whether gastrointestinal symptoms correlate with the severity of Coronavirus Disease 2019 (COVID-19) has been ...
Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria
Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria
Hospitalization for ulcerative colitis (UC) is potentially life-threatening. Severe disease in the Japanese criteria which...
Prevalence and risk factors for medication-refractory reflux esophagitis in patients with systemic sclerosis in Japan
Prevalence and risk factors for medication-refractory reflux esophagitis in patients with systemic sclerosis in Japan
Patients with systemic sclerosis (SSc) often have esophageal motility abnormalities and weak esophago-gastric junction (EG...
Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study
Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study
Patients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the cl...
Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer
Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer
We have previously reported apolipoprotein A2-isoforms (apoA2-is) as candidate plasma biomarkers for early-stage pancreati...
Non-alcoholic fatty liver disease in patients with morbid obesity: the gut microbiota axis as a potential pathophysiology mechanism
Non-alcoholic fatty liver disease in patients with morbid obesity: the gut microbiota axis as a potential pathophysiology mechanism
Alterations in gut microbiota are associated with the pathogenesis of metabolic diseases, including metabolic-associated f...
A combination of bowel wall thickness and submucosa index is useful for estimating endoscopic improvement in ulcerative colitis: external validation of the Kyorin Ultrasound Criterion
A combination of bowel wall thickness and submucosa index is useful for estimating endoscopic improvement in ulcerative colitis: external validation of the Kyorin Ultrasound Criterion
Endoscopic improvement (EI; a Mayo endoscopic subscore of 0 or 1) is considered a therapeutic target in ulcerative colitis...
Gastric intestinal metaplasia: progress and remaining challenges
Gastric intestinal metaplasia: progress and remaining challenges
Most gastric cancers arise in the setting of chronic inflammation which alters gland organization, such that acid-pumping ...
Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma
Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma
Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue poten...
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