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Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease
Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease
Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The expression of each cytokine has been...
The first comprehensive genomic characterization of rectal squamous cell carcinoma
The first comprehensive genomic characterization of rectal squamous cell carcinoma
Rectal cancers represent 35% of colorectal cancers; 90% are adenocarcinomas, while squamous cell carcinoma accounts for 0....
Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development
Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development
Mutations in Bone Morphogenetic Protein (BMP) Receptor (BMPR)1A and SMAD4 are detected in 50% of juvenil...
Current status and future perspective of linked color imaging for gastric cancer screening: a literature review
Current status and future perspective of linked color imaging for gastric cancer screening: a literature review
Screening endoscopy has advanced to facilitate improvements in the detection and prognosis of gastric cancer. However, mos...
Identification of anti-Helicobacter pylori antibody signatures in gastric intestinal metaplasia
Identification of anti-Helicobacter pylori antibody signatures in gastric intestinal metaplasia
Chronic Helicobacter pylori infection may induce gastric intestinal metaplasia (IM). We compared anti-H. pylori antibody p...
Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression
Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression
To establish a treatment option for liver fibrosis, the possibility of the drug repurposing theory was investigated, with ...
Risk of gastric and oesophageal adenocarcinoma following discontinuation of long-term proton-pump inhibitor therapy
Risk of gastric and oesophageal adenocarcinoma following discontinuation of long-term proton-pump inhibitor therapy
There is uncertainty whether long-term use of proton-pump inhibitors can cause gastric adenocarcinoma (GAC) and oesophagea...
Clinical practice guidelines for duodenal cancer 2021
Clinical practice guidelines for duodenal cancer 2021
Duodenal cancer is considered to be a small intestinal carcinoma in terms of clinicopathology. In Japan, there are no esta...
Clinical features and oncological outcomes of intestinal cancers associated with ulcerative colitis and Crohn’s disease
Clinical features and oncological outcomes of intestinal cancers associated with ulcerative colitis and Crohn’s disease
Patients with longstanding inflammatory bowel disease are at high risk of developing intestinal cancers. In this study, we...
Trends of hepatitis B virus genotype distribution in chronic hepatitis B patients in Japan
Trends of hepatitis B virus genotype distribution in chronic hepatitis B patients in Japan
Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Ja...
A shortened Stroop test to identify covert hepatic encephalopathy and predict overt hepatic encephalopathy in patients with cirrhosis
A shortened Stroop test to identify covert hepatic encephalopathy and predict overt hepatic encephalopathy in patients with cirrhosis
Covert hepatic encephalopathy (CHE) adversely affects the clinical outcomes of patients with cirrhosis but remains largely...
The epidemiology of rare types of hepatobiliary and pancreatic cancer from national cancer registry
The epidemiology of rare types of hepatobiliary and pancreatic cancer from national cancer registry
Information on rare hepatobiliary and pancreatic (HBP) subtypes of cancer is scarce. We aimed to elucidate the incidence a...
The impact of sarcopenia on short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer
The impact of sarcopenia on short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer
Sarcopenia prevalence has increased in proportion to the aging population in Japan. We aimed to investigate the associatio...
Correction to: Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
Correction to: Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Ursodeoxycholic acid is associated with improved long-term outcome in patients with primary sclerosing cholangitis
Ursodeoxycholic acid is associated with improved long-term outcome in patients with primary sclerosing cholangitis
It remains unclear whether ursodeoxycholic acid (UDCA) treatment improves long-term outcomes in patients with primary scle...
Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and immune checkpoint inhibitors. Recent s...
Perspectives on current controversial issues in the management of chronic HBV infection
Perspectives on current controversial issues in the management of chronic HBV infection
Clinical and basic research in the past decades has achieved consensus in the understanding of chronic hepatitis B virus (...
Evidence-based clinical practice guidelines for chronic pancreatitis 2021
Evidence-based clinical practice guidelines for chronic pancreatitis 2021
Chronic pancreatitis (CP) is defined according to the recently proposed mechanistic definition as a pathological fibro-inf...
Reply: Need for evidence on surveillance endoscopy in achalasia-related Barret esophagus and adenocarcinoma in Asian population
Reply: Need for evidence on surveillance endoscopy in achalasia-related Barret esophagus and adenocarcinoma in Asian population
Lee HS, Jeon SW. Barrett esophagus in Asia: same disease with different pattern. Clin Endosc. 2014;47:15–22.Article  ...
Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning
Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning
High-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders (EMDs); however, it requ...
Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity
Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity
Although we know the key role of gut dysbiosis in nonalcoholic fatty liver disease (NAFLD), it remains unclear what microb...
“Pathologist-independent” strategy for T1 colorectal cancer after endoscopic resection
“Pathologist-independent” strategy for T1 colorectal cancer after endoscopic resection
Hashiguchi Y, Muro K, Saito Y, et al. Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2019 for the ...