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Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse
Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse
Ulcerative colitis (UC) is a refractory inflammatory disease that affects the rectum and colon, with pivotal involvement o...
An integrative multi-omics analysis reveals a multi-analyte signature of pancreatic ductal adenocarcinoma in serum
An integrative multi-omics analysis reveals a multi-analyte signature of pancreatic ductal adenocarcinoma in serum
Pancreatic ductal adenocarcinoma (PDAC) remains a formidable health challenge due to its detection at a late stage and a l...
WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway
WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway
The proto-oncogene WWP1 is overexpressed in various cancers and contributes to tumor growth and poor prognosis. Recently, ...
Impact of preceding treatment for head and neck squamous cell carcinoma on synchronous superficial esophageal squamous cell carcinoma
Impact of preceding treatment for head and neck squamous cell carcinoma on synchronous superficial esophageal squamous cell carcinoma
Patients with esophageal squamous cell carcinoma (ESCC) frequently develop synchronous head and neck squamous cell carcino...
Serum Mac2-binding protein glycosylated isomer (M2BPGi) as a prognostic biomarker in pancreatic ductal adenocarcinoma: iCAFs-derived M2BPGi drives tumor invasion
Serum Mac2-binding protein glycosylated isomer (M2BPGi) as a prognostic biomarker in pancreatic ductal adenocarcinoma: iCAFs-derived M2BPGi drives tumor invasion
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Mac2-binding protein glycosylat...
Serum IL-6 concentration is a useful biomarker to predict the efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma
Serum IL-6 concentration is a useful biomarker to predict the efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma
This study aims to identify biomarkers for treatment response of atezolizumab plus bevacizumab (Atezo+Bev) in patients wit...
Validation of the Japanese version of the Esophageal Hypervigilance and Anxiety Scale for esophageal symptoms
Validation of the Japanese version of the Esophageal Hypervigilance and Anxiety Scale for esophageal symptoms
The Esophageal Hypervigilance and Anxiety Scale (EHAS) is an English questionnaire created in the USA to assess these fact...
Standard technique in Japan for measuring hepatic venous pressure gradient
Standard technique in Japan for measuring hepatic venous pressure gradient
Direct measurement of portal venous pressure (PVP) is invasive, so the hepatic venous pressure gradient (HVPG) is commonly...
Utility of Mac-2 binding protein glycosylation isomer as an excellent biomarker for the prediction of liver fibrosis, activity, and hepatocellular carcinoma onset: an expert review
Utility of Mac-2 binding protein glycosylation isomer as an excellent biomarker for the prediction of liver fibrosis, activity, and hepatocellular carcinoma onset: an expert review
Mac-2 binding protein glycosylation isomer (M2BPGi) is a liver fibrosis biomarker that originated in Japan and has been co...
Behçet’s disease: incidence, prevalence, and real-word data on the use of biologic agents in Japan
Behçet’s disease: incidence, prevalence, and real-word data on the use of biologic agents in Japan
Behçet’s disease (BD) is an autoinflammatory disease that can affect multiple organs, including the gastrointes...
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Lymphovascular invasion (LVI) or pT1b is noncurative after endoscopic resection (ER) for esophageal squamous cell carcinom...
Estimating cancer risk in immune-mediated inflammatory diseases exposed to varying doses of tumour necrosis factor inhibitors
Estimating cancer risk in immune-mediated inflammatory diseases exposed to varying doses of tumour necrosis factor inhibitors
The safety profile of high doses of tumour necrosis factor inhibitors (TNFi) therapy for cancer risk in immune-mediated in...
Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting
Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting
S-1 monotherapy had previously been widely used as a second-line treatment for pancreatic cancer (PC) after gemcitabine-ba...
Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection
Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection
The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleedin...
Fungal mycobiome dysbiosis in choledocholithiasis concurrent with cholangitis
Fungal mycobiome dysbiosis in choledocholithiasis concurrent with cholangitis
The gut mycobiome might have an important influence on the pathogenesis of choledocholithiasis concurrent with cholangitis...
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-...
Comprehensive pathological evaluation of risk factors for metastasis after endoscopic resection of superficial esophageal squamous cell carcinoma
Comprehensive pathological evaluation of risk factors for metastasis after endoscopic resection of superficial esophageal squamous cell carcinoma
Esophageal cancer is a major cause of cancer mortality worldwide. Endoscopic resection (ER) is a curative treatment for es...
Development and validation of a claims-based algorithm to identify incidents and determine the progression phases of gastric cancer cases in Japan
Development and validation of a claims-based algorithm to identify incidents and determine the progression phases of gastric cancer cases in Japan
Although health insurance claims data can address questions that clinical trials cannot answer, the uncertainty of disease...
Liver fibrotic burden across the spectrum of hypothyroidism
Liver fibrotic burden across the spectrum of hypothyroidism
Data regarding the prevalence of hepatic fibrotic burden across the spectrum of hypothyroidism are scarce. Hence, we aimed...
Impact of ursodeoxycholic acid treatment on Fontan-associated liver disease
Impact of ursodeoxycholic acid treatment on Fontan-associated liver disease
Fontan-associated liver disease (FALD) is a type of progressive liver fibrosis that occurs following Fontan surgery and ca...
Histological improvement of fibrosis in patients with hepatitis C who achieved a 5-year sustained virological response to treatment with direct-acting antivirals
Histological improvement of fibrosis in patients with hepatitis C who achieved a 5-year sustained virological response to treatment with direct-acting antivirals
The histological improvement in liver fibrosis in patients with hepatitis C who achieved a sustained virological response ...
The landscape of 142 Epstein–Barr viral whole genomes in gastric cancer
The landscape of 142 Epstein–Barr viral whole genomes in gastric cancer
A substantial portion of gastric cancer (GC) is linked to Epstein–Barr virus (EBV) infection. The characteristics of...
Association between homologous recombination deficiency and time to treatment failure to platinum-based chemotherapy for pancreatic cancer by using the C-CAT database
Association between homologous recombination deficiency and time to treatment failure to platinum-based chemotherapy for pancreatic cancer by using the C-CAT database
Since homologous recombination deficiency (HRD) is relatively uncommon in pancreatic cancer (PC), its impact on time-to-tr...
Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLD
Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLD
The biological process of aging plays an important role in the progress of liver fibrosis. However, epidemiological eviden...
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study
Although specific biomarkers for primary sclerosing cholangitis (PSC) are required, no such biomarkers have been identifie...
YAP acts as an independent prognostic marker and regulates growth and metastasis of gastrointestinal stromal tumors via FBXW7-YAP pathway
YAP acts as an independent prognostic marker and regulates growth and metastasis of gastrointestinal stromal tumors via FBXW7-YAP pathway
Although imatinib (IM) and subsequent tyrosine kinase inhibitors (TKIs) significantly improve the prognosis of GIST patien...
Liver transplantation for gastroenteropancreatic neuroendocrine liver metastasis: optimal patient selection and perioperative management in the era of multimodal treatments
Liver transplantation for gastroenteropancreatic neuroendocrine liver metastasis: optimal patient selection and perioperative management in the era of multimodal treatments
Gastroenteropancreatic neuroendocrine tumors (NET) often metastasize to the liver. Although curative liver resection provi...
Clinical factors to predict changes of esophagogastric varices after sustained viral response with direct-acting antiviral therapy
Clinical factors to predict changes of esophagogastric varices after sustained viral response with direct-acting antiviral therapy
The clinical course of esophagogastric varices (EGV) after sustained virological response (SVR) with direct-acting antivir...
FGFR2 fusions assessed by NGS, FISH, and immunohistochemistry in intrahepatic cholangiocarcinoma
FGFR2 fusions assessed by NGS, FISH, and immunohistochemistry in intrahepatic cholangiocarcinoma
FGFR2 fusion has become a promising therapeutic target in iCCAs; however, the procedure for screening FGFR2 fusion has not...
Determination of optimal cutoff value of ulcerative colitis intestinal ultrasound index to estimate endoscopic improvement in ulcerative colitis
Determination of optimal cutoff value of ulcerative colitis intestinal ultrasound index to estimate endoscopic improvement in ulcerative colitis
The ulcerative colitis intestinal ultrasound (UC-IUS) index (UII) has been reported as a sonographic scoring system correl...
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