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CAR T cells take to the airways
CAR T cells take to the airways
CAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.
Engineered γδ T cells show promise in bone tumours
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as...
Heart failure affects innate immune memory
A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose...
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. ...
Ultra-processed foods: increasing the risk of inflammation and immune dysregulation?
Ultra-processed foods: increasing the risk of inflammation and immune dysregulation?
Ultra-processed foods (UPFs) are industrially formulated products that contain synthetic ingredients but minimal whole-foo...
Chimeric antigen receptor T cell therapy for autoimmune disease
Chimeric antigen receptor T cell therapy for autoimmune disease
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a success...
A guide to adaptive immune memory
A guide to adaptive immune memory
Immune memory — comprising T cells, B cells and plasma cells and their secreted antibodies — is crucial for hu...
Stiff tumours exhaust T cells
CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through th...
Author Correction: Cancer cell metabolism and antitumour immunity
Authors and AffiliationsDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USAMara De Martino, Lorenz...
Breast cancer-associated fibroblasts maintain self-renewing immunosuppressive macrophages
A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity...
Intestinal tuft cells: weep, sweep … secrete
Intestinal tuft cells: weep, sweep … secrete
Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helm...
Universal LIPSTIC: a new tool for decoding cellular interactions
In this Tools of the Trade article, Sandra Nakandakari-Higa (of the Gabriel Victora lab) describes the latest version of t...
Connecting vitamin D, the microbiome and anticancer immunity
Vitamin D has a role in immune modulation and in shaping commensal microbial communities. Reis e Sousa and colleagues show...
How the brain regulates inflammation
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Time of day determines cancer immunotherapy response
Wang et al. show that immune cell infiltration of tumours, as well as immune cell phenotype, oscillate in a circadian mann...
Protect the periportals
Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
Atypical chemokine receptors in the immune system
Atypical chemokine receptors in the immune system
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and l...
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cel...
Opportunities and challenges for T cell-based influenza vaccines
Opportunities and challenges for T cell-based influenza vaccines
Vaccination remains our main defence against influenza, which causes substantial annual mortality and poses a serious pand...
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss ...
Noncanonical inflammasome mediates BBB breakdown
Wei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain bar...
FAS signalling pathway is crucial for CAR T cell persistence
A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphoc...
Harnessing our lived experience for science communication
Harnessing our lived experience for science communication
Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’...
Weaker skin immunity in males due to androgen effects on ILC2s
Weaker skin immunity in males due to androgen effects on ILC2s
Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activa...
Engineering immune-evasive allogeneic cellular immunotherapies
Engineering immune-evasive allogeneic cellular immunotherapies
Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to their potential cost-effectiveness,...
Cancer cell metabolism and antitumour immunity
Cancer cell metabolism and antitumour immunity
Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour progression not only by providin...
Neuronal TLR9 signalling crucial for memory formation
Memories are encoded by microcircuits of hippocampal neurons. These cells undergo energy-intensive molecular adaptations d...
Tumour cell consumption of taurine exhausts CD8+ T cells
The amino acid taurine is marketed as a nutritional supplement. Cao et al. now show that taurine can enhance the malignant...
Bacterial serotonin induces Treg cells in neonates
The gut microbiota has a crucial role in immune development in early life. Sanidad et al. show that the mouse neonatal sma...
Rejuvenating an old immune system
Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.