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Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease
Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease
Eosinophils are bone marrow-derived granulocytes that are traditionally associated with type 2 immune responses, such as t...
Elixir for DCs
Elixir for DCs
Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipi...
Understanding NK cell heterogeneity
Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different typ...
Online immunology education for a global world
Online immunology education for a global world
Online technologies for immunology education can facilitate global outreach, incorporate local expertise, promote inclusiv...
How bile acids and the microbiota interact to shape host immunity
How bile acids and the microbiota interact to shape host immunity
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, ...
Actin branching maintains tissue-resident mast cells
A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance...
Rethinking pDCs: a questionable ally in immunity?
A preprint by Ngo et al. reports a new mouse model for the constitutive depletion of pDCs, showing that pDCs are dispensab...
Microbiota licenses protective CD8+ T cell responses against neonatal influenza
A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal...
Defining myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activ...
Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell analysis has become a powerful tool fo...
CAR T cells take to the airways
CAR T cells take to the airways
CAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.
Engineered γδ T cells show promise in bone tumours
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as...
Heart failure affects innate immune memory
A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose...
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. ...
Ultra-processed foods: increasing the risk of inflammation and immune dysregulation?
Ultra-processed foods: increasing the risk of inflammation and immune dysregulation?
Ultra-processed foods (UPFs) are industrially formulated products that contain synthetic ingredients but minimal whole-foo...
Chimeric antigen receptor T cell therapy for autoimmune disease
Chimeric antigen receptor T cell therapy for autoimmune disease
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a success...
A guide to adaptive immune memory
A guide to adaptive immune memory
Immune memory — comprising T cells, B cells and plasma cells and their secreted antibodies — is crucial for hu...
Stiff tumours exhaust T cells
CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through th...
Author Correction: Cancer cell metabolism and antitumour immunity
Authors and AffiliationsDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USAMara De Martino, Lorenz...
Breast cancer-associated fibroblasts maintain self-renewing immunosuppressive macrophages
A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity...
Intestinal tuft cells: weep, sweep … secrete
Intestinal tuft cells: weep, sweep … secrete
Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helm...
Universal LIPSTIC: a new tool for decoding cellular interactions
In this Tools of the Trade article, Sandra Nakandakari-Higa (of the Gabriel Victora lab) describes the latest version of t...
Connecting vitamin D, the microbiome and anticancer immunity
Vitamin D has a role in immune modulation and in shaping commensal microbial communities. Reis e Sousa and colleagues show...
How the brain regulates inflammation
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Time of day determines cancer immunotherapy response
Wang et al. show that immune cell infiltration of tumours, as well as immune cell phenotype, oscillate in a circadian mann...
Protect the periportals
Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
Atypical chemokine receptors in the immune system
Atypical chemokine receptors in the immune system
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and l...
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cel...
Opportunities and challenges for T cell-based influenza vaccines
Opportunities and challenges for T cell-based influenza vaccines
Vaccination remains our main defence against influenza, which causes substantial annual mortality and poses a serious pand...
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss ...
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