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Harnessing our lived experience for science communication
Harnessing our lived experience for science communication
Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’...
Weaker skin immunity in males due to androgen effects on ILC2s
Weaker skin immunity in males due to androgen effects on ILC2s
Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activa...
Engineering immune-evasive allogeneic cellular immunotherapies
Engineering immune-evasive allogeneic cellular immunotherapies
Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to their potential cost-effectiveness,...
Cancer cell metabolism and antitumour immunity
Cancer cell metabolism and antitumour immunity
Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour progression not only by providin...
Neuronal TLR9 signalling crucial for memory formation
Memories are encoded by microcircuits of hippocampal neurons. These cells undergo energy-intensive molecular adaptations d...
Tumour cell consumption of taurine exhausts CD8+ T cells
The amino acid taurine is marketed as a nutritional supplement. Cao et al. now show that taurine can enhance the malignant...
Bacterial serotonin induces Treg cells in neonates
The gut microbiota has a crucial role in immune development in early life. Sanidad et al. show that the mouse neonatal sma...
Rejuvenating an old immune system
Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.
Short-chain fatty acids: linking diet, the microbiome and immunity
Short-chain fatty acids: linking diet, the microbiome and immunity
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in t...
Generating prophylactic immunity against arboviruses in vertebrates and invertebrates
Generating prophylactic immunity against arboviruses in vertebrates and invertebrates
The World Health Organization recently declared a global initiative to control arboviral diseases. These are mainly caused...
PANINI: Combined protein and nucleic acid imaging in tissues
Sizun Jiang (while in the Garry Nolan lab) describes a method termed PANINI that allows simultaneous detection of nucleic ...
A pre-TCRα-independent pathway of αβ T cell differentiation
A pre-TCRα-independent pathway of αβ T cell differentiation
A study in Science reports 10 individuals with pre-TCRα deficiency who have late-onset or no clinical phenotype, whic...
Strategies for targeting cytokines in inflammatory bowel disease
Strategies for targeting cytokines in inflammatory bowel disease
Cytokines produced by immune cells contribute to the development and perpetuation of inflammatory bowel disease (IBD), nam...
Bone marrow inflammation in haematological malignancies
Bone marrow inflammation in haematological malignancies
Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts ...
Breaking tolerance: the autoimmune aspect of atherosclerosis
Breaking tolerance: the autoimmune aspect of atherosclerosis
Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the arterial walls and is characterize...
Author Correction: Using BCG vaccination to protect against COVID-19: when reality fails to meet expectation
Authors and AffiliationsDepartment of Paediatrics, The University of Melbourne, Parkville, Victoria, AustraliaLaure F. Pit...
Author Correction: Clonal haematopoiesis-associated, age-related motor deficits caused by monocyte-derived microglia
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Regulation of innate-like activities of neonatal CD8+ T cells
Recent studies have shown that neonatal CD8+ T cells can undergo ‘bystander activation’ in response to inflammatory cytoki...
The eye provides an immunological gateway to the brain
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
CARD8 kills CD4+ T cells in response to HIV entry
In humans, infection with HIV-1 is associated with loss of CD4+ T cells, causing severe immunodeficiency and progression t...
Made to order: emergency myelopoiesis and demand-adapted innate immune cell production
Made to order: emergency myelopoiesis and demand-adapted innate immune cell production
Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haem...
A Treg cell duo for VAT control
Changes in populations of regulatory T (Treg) cells in visceral adipose tissue (VAT) have been linked to metabolic disorde...
Lymph node resection does not impair cancer immunotherapy responses
A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not ...
Author Correction: Clonal haematopoieis-associated, age-related motor deficits caused by monocyte-derived microglia
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Pre-existing antibody allows for maturation of new B cells in ‘recall’ germinal centres
Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall̵...
Osteoblast-derived ATP maintains bone marrow plasma cells
Osteoblast-derived ATP maintains bone marrow plasma cells
Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven a...
The OrganiX microfluidic system to recreate the complex tumour microenvironment
The OrganiX microfluidic system to recreate the complex tumour microenvironment
In this Tools of the Trade article, Giulia Adriani and Andrea Pavesi describe a new microfluidic device that supports the ...
ComplexEye: a multi-lens array microscope for high-throughput cell migration analysis
ComplexEye: a multi-lens array microscope for high-throughput cell migration analysis
In this Tools of the Trade article, Zülal Cibir and Matthias Gunzer introduce their multi-lens array microscope calle...
The conneXion between sex and immune responses
The conneXion between sex and immune responses
There are notable sex-based differences in immune responses to pathogens and self-antigens, with female individuals exhibi...
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central role in regulating im...
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