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Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged pathogenic human coronavirus that belon...
Feeding IgA+ plasma cells
Feeding IgA+ plasma cells
Diurnal rhythmicity of IgA production by intestinal plasma cells is entrained by time of feeding, with effects on composit...
Three-dimensional genome organization in immune cell fate and function
Three-dimensional genome organization in immune cell fate and function
Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dim...
Human and planetary health on fire
Human and planetary health on fire
Wildfires are increasing globally, with several recent catastrophic wildfires linked to climate change. Here, we consider ...
Defining the ‘exhausted’ T cells that respond to PD1 checkpoint blockade
Defining the ‘exhausted’ T cells that respond to PD1 checkpoint blockade
MYB-dependent precursors of exhausted T cells show stem-like properties and mediate the response to PD1 immune checkpoint ...
Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with ...
All life senses infections via pattern recognition
Although plants, animals and fungi all use NOD-like receptors (NLRs) to sense pathogen-associated molecular patterns (PAMP...
Unconventional T cells shape tissue-specific lymph node responses
Unconventional T cells shape tissue-specific lymph node responses
Unconventional T cells of different lineages migrate from peripheral tissues to draining lymph nodes, where they operate a...
Focusing on the correct gene signatures for SLE
Systemic lupus erythematosus (SLE) is an autoimmune condition that involves multiple organs and has an unpredictable disea...
Targeting malaria transmission
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Obesity-associated autoreactivity
Obesity-associated autoreactivity
A bad diet, rich in fats and sugars, not only causes low-grade chronic inflammation but also activates antigen-specific au...
Tuning immunity through tissue mechanotransduction
Tuning immunity through tissue mechanotransduction
Immune responses are governed by signals from the tissue microenvironment, and in addition to biochemical signals, mechani...
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the ...
Fungus hijacks TLR4 to build a type 2 immune niche
Fungus hijacks TLR4 to build a type 2 immune niche
A fungal virulence factor promotes pathogenic type 2 immunity via Toll-like receptor 4.
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?
Hybrid immunity occurs in those who have been both infected with and vaccinated against SARS-CoV-2. But how well does such...
The roles of extracellular vesicles in the immune system
The roles of extracellular vesicles in the immune system
The twenty-first century has witnessed major developments in the field of extracellular vesicle (EV) research, including s...
ZBP1 induces immunopathology caused by loss of ADAR1-mediated RNA editing
ZBP1 induces immunopathology caused by loss of ADAR1-mediated RNA editing
Three papers in Nature identify ZBP1 as a key effector of cell death and inflammation downstream of ADAR mutation, as occu...
Understanding COVID-19-associated coagulopathy
Understanding COVID-19-associated coagulopathy
COVID-19-associated coagulopathy (CAC) is a life-threatening complication of SARS-CoV-2 infection. However, the underlying...
Will anti-vaccine activism in the USA reverse global goals?
In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with ...
Mitochondrial control of inflammation
Mitochondrial control of inflammation
Numerous mitochondrial constituents and metabolic products can function as damage-associated molecular patterns (DAMPs) an...
Encouraging vaccine uptake: lessons from behavioural science
Encouraging vaccine uptake: lessons from behavioural science
Understanding the behaviour surrounding vaccine uptake involves issues of capability, opportunity and motivation. Despite ...
Tissue-specific epigenomics of resident memory CD8+ T cells
A preprint by Buquicchio et al. looks at the chromatin landscape of memory CD8+ T cells over the course of their developme...
XXtra killer cells
A preprint by Cheng et al. describes how differential expression of the X-chromosome-encoded epigenetic regulator UTX cont...
Vitamin D for COVID-19: where are we now?
Vitamin D for COVID-19: where are we now?
Vitamin D has received much interest during the COVID-19 pandemic as a potential prophylactic or therapeutic agent —...
IL-17A–HIF1α axis in epithelial wound repair
IL-17A–HIF1α axis in epithelial wound repair
IL-17 production by skin-resident γδ T cells is required for optimal HIF1α activation in damaged epithelium...
Respiratory syncytial virus after the SARS-CoV-2 pandemic — what next?
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection. It is a large contributor to infa...
DNA damage and repair in age-related inflammation
DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is believed to contribute to ageing b...
Thymic masqueraders
Thymic masqueraders
Medullary thymic epithelial cells co-opt lineage-defining transcription factors to mimic numerous peripheral cell types an...
Considering innate immune responses in SARS-CoV-2 infection and COVID-19
During the COVID-19 pandemic, much of the media focus has been on adaptive immunity, particularly antibody levels and memo...
IL-17 and IL-17-producing cells in protection versus pathology
IL-17 and IL-17-producing cells in protection versus pathology
IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but ...