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MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules b...
Anti-cytokine autoantibodies: mechanistic insights and disease associations
Anti-cytokine autoantibodies: mechanistic insights and disease associations
Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease severity in infection, inflammation...
Author Correction: The immunology of long COVID
Authors and AffiliationsDepartment of Immunology and Inflammation, Imperial College London, Hammersmith Hospital, London, ...
Brief diet changes affect immunity
A new study shows that even a short-term switch to a low-fibre diet suppresses immunity to bacterial infection and comprom...
Lymphatic expression of TBX1 helps to heal the heart
This study by Wang et al. identifies a role for the T-box transcription factor TBX1 in mediating tissue repair after myoca...
Lung-migrating helminths can enhance immunity to SARS-CoV-2
There have been conflicting views on whether helminth infections modulate disease outcomes during SARS-CoV-2 infection. In...
A protective role for interferon-ε in ovarian cancer
Interferon-ε (IFNε) is a unique type I IFN that is constitutively expressed by epithelial cells in the female reproductive...
Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important cause of diarrhoeal disease in...
A guide to complement biology, pathology and therapeutic opportunity
A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis....
Orally delivered lactate-producing bacteria limit CNS autoimmunity
Orally delivered lactate-producing bacteria limit CNS autoimmunity
A study in Nature reports a lactate–HIF1α–NDUFA4L2 pathway in intestinal dendritic cells that regulates t...
A platelet-derived factor protects the ageing brain
A platelet-derived factor protects the ageing brain
Platelet factor 4 reduces inflammation and promotes cognition in the ageing brain.
CODEX multiplexed tissue imaging
CODEX multiplexed tissue imaging
In this Tools of the Trade article, Yury Goltsev and Garry Nolan describe a multiplexed tissue imaging technique called CO...
Cell death by phagocytosis
Cell death by phagocytosis
Cells can die as a consequence of being phagocytosed by other cells — a form of cell death that has been called phag...
Immunology of food aversion
Immunology of food aversion
Two studies in Nature describe the mechanisms that underlie allergen avoidance behaviour in mice, linking allergen sensing...
Author Correction: A guide to thymic selection of T cells
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Why do IL-17-targeted therapies have limited efficacy?
Given the strong pro-inflammatory role of IL-17, agents that target IL-17 or the IL-17 receptor (IL-17R) are attractive ca...
Self-reactive MAIT cells are common in healthy individuals
Mucosal-associated invariant T (MAIT) cells have an almost invariant TCRα chain that is paired with a restricted repertoir...
Recruited macrophages are culprits in atrial fibrillation
Atrial fibrillation (AFib) carries the risk of stroke and heart failure and is the most common arrhythmia. Hulsmans et al....
Asymptomatic SARS-CoV-2 linked to HLA-B*15:01
Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cr...
Heterologous immunity: innate function of memory CD4+ T cells
A preprint by Rakebrandt, Yassini et al. investigates the role of CD4+ T helper cells in heterologous immunity, identifyin...
High-fat diet depletes skin Treg cells
A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which ex...
Re-investigating the origin and fates of colonic Treg cell subsets
A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regula...
Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies
Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies
The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers...
The emerging family of RORγt+ antigen-presenting cells
The emerging family of RORγt+ antigen-presenting cells
Antigen-presenting cells (APCs) are master regulators of the immune response by directly interacting with T cells to orche...
A guide to thymic selection of T cells
A guide to thymic selection of T cells
The thymus is an evolutionarily conserved organ that supports the development of T cells. Not only does the thymic environ...
Commensal fungi support granulocyte development
Laboratory mice kept in specific-pathogen free (SPF) conditions are routinely used to dissect the immune system, but they ...
Neutralizing autoantibodies against type 1 interferons identified in West Nile virus encephalitis
Recent studies from the Casanova laboratory and others have shown that autoantibodies against type 1 interferons (IFNs) ar...
Thousands of cGAS-like receptors described in animals
In mammalian cells, cyclic GMP-AMP synthase (cGAS) senses mislocalized double-stranded DNA (dsDNA) and synthesizes the sec...
Microglia regulation of central nervous system myelin health and regeneration
Microglia regulation of central nervous system myelin health and regeneration
Microglia are resident macrophages of the central nervous system that have key functions in its development, homeostasis a...
The immunology of long COVID
The immunology of long COVID
Long COVID is the patient-coined term for the disease entity whereby persistent symptoms ensue in a significant proportion...
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