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‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity
A phenomenon called 'autosomal random monoallelic expression' (aRMAE) may explain phenotypic variability of clinic...
Gasdermin pores on extracellular vesicles spread cell death
A study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce py...
How macrophage heterogeneity affects tuberculosis disease and therapy
How macrophage heterogeneity affects tuberculosis disease and therapy
Macrophages are the primary host cell type for infection by Mycobacterium tuberculosis in vivo. Macrophages are also key i...
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes...
In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery
A preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cel...
Endogenous thymic regeneration: restoring T cell production following injury
Endogenous thymic regeneration: restoring T cell production following injury
Despite its importance for generating and maintaining a healthy and broad T cell repertoire, the thymus is exquisitely sen...
IL-22 protects against stress-induced anxiety
Stress-induced gut leakage and immune activation lead to the release of IL-22, which acts directly on septal neurons in th...
Cancer immune evasion, immunoediting and intratumour heterogeneity
Cancer immune evasion, immunoediting and intratumour heterogeneity
Cancers can avoid immune-mediated elimination by acquiring traits that disrupt antitumour immunity. These mechanisms of im...
Transposon-derived decoy fine-tunes IFN responses
Transposon-derived decoy fine-tunes IFN responses
A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN ...
Muscle spindle macrophages regulate motor coordination
Muscle spindle macrophages regulate motor coordination
Yan et al. report the identification of a population of muscle spindle macrophages, which regulate the muscle stretch refl...
Systematic identification of cell state-specific transcription factors in T cells
A preprint by Chung et al. presents a framework for the use of transcriptomic and epigenomic data to identify novel transc...
Neuroinflammation in Alzheimer disease
Neuroinflammation in Alzheimer disease
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the mo...
Publisher Correction: Inflammasome components as new therapeutic targets in inflammatory disease
Authors and AffiliationsWellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UKRebec...
Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease
Authors and AffiliationsWellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UKRebec...
Guardians of immune privilege
Guardians of immune privilege
Endogenous self-peptides derived from CNS antigens are presented on MHC class II molecules at the borders of the CNS and e...
Sialylated IgG restrains lung inflammation
Sialylated IgG protects against severe influenza by inducing the transcriptional repressor REST, which dampens the inflamm...
Redefining PD1 as a guardian of stem-like T cells
A preprint by Hor et al. shows that PD1 signalling regulates the maintenance of a high-affinity, stem-like T cell subset i...
Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis
A preprint by Villar-Vesga et al. shows that monocyte-derived cells in the central nervous system produce mitochondrial re...
Innate lymphoid cell control of neuronal synapse development
Innate lymphoid cell control of neuronal synapse development
ILC2s promote inhibitory synapse formation in the postnatal mouse brain through the production of IL-13.
Integrating natural commensals and pathogens into preclinical mouse models
Integrating natural commensals and pathogens into preclinical mouse models
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. T...
Viral infection and antiviral immunity in the oral cavity
Viral infection and antiviral immunity in the oral cavity
Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characterist...
Charge-based immunoreceptor signalling in health and disease
Charge-based immunoreceptor signalling in health and disease
Immunoreceptors have crucial roles in sensing environmental signals and initiating immune responses to protect the host. D...
The danger theory of immunity revisited
The danger theory of immunity revisited
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue stress, damage or infection has a...
Adipokines: masterminds of metabolic inflammation
Adipokines: masterminds of metabolic inflammation
Adipose tissue is an immunologically active organ that controls host physiology, partly through the release of mediators t...
Insights into immune cell–fibroblast communication in heart disease
Inflammation and fibrosis are linked to organ dysfunction. Two studies in Nature investigate the cross-talk between immune...
Decoding the human prenatal immune system with single-cell multi-omics
Decoding the human prenatal immune system with single-cell multi-omics
The human immune system is made up of a huge variety of cell types each with unique functions. Local networks of resident ...
Obesity-associated intratumoral acidity promotes pro-tumorigenic macrophages
Obesity-associated intratumoral acidity promotes pro-tumorigenic macrophages
Increased intratumoral acidity associated with a high-fat diet accelarates tumour growth through the acid-sensing receptor...
Targeting ER stress sensor restores immunogenicity of chemotherapy
Targeting ER stress sensor restores immunogenicity of chemotherapy
Blocking the RNase activity of IRE1α can convert 'cold' tumours to immunologically 'hot' ones that re...
From TCR fundamental research to innovative chimeric antigen receptor design
From TCR fundamental research to innovative chimeric antigen receptor design
Engineered T cells that express chimeric antigen receptors (CARs) have transformed the treatment of haematological cancers...
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment
T cells have a critical role in mediating antitumour immunity. The success of immune checkpoint inhibitors (ICIs) for canc...
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