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Innate lymphoid cell control of neuronal synapse development
Innate lymphoid cell control of neuronal synapse development
ILC2s promote inhibitory synapse formation in the postnatal mouse brain through the production of IL-13.
Integrating natural commensals and pathogens into preclinical mouse models
Integrating natural commensals and pathogens into preclinical mouse models
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. T...
Viral infection and antiviral immunity in the oral cavity
Viral infection and antiviral immunity in the oral cavity
Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characterist...
Charge-based immunoreceptor signalling in health and disease
Charge-based immunoreceptor signalling in health and disease
Immunoreceptors have crucial roles in sensing environmental signals and initiating immune responses to protect the host. D...
The danger theory of immunity revisited
The danger theory of immunity revisited
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue stress, damage or infection has a...
Adipokines: masterminds of metabolic inflammation
Adipokines: masterminds of metabolic inflammation
Adipose tissue is an immunologically active organ that controls host physiology, partly through the release of mediators t...
Insights into immune cell–fibroblast communication in heart disease
Inflammation and fibrosis are linked to organ dysfunction. Two studies in Nature investigate the cross-talk between immune...
Decoding the human prenatal immune system with single-cell multi-omics
Decoding the human prenatal immune system with single-cell multi-omics
The human immune system is made up of a huge variety of cell types each with unique functions. Local networks of resident ...
Obesity-associated intratumoral acidity promotes pro-tumorigenic macrophages
Obesity-associated intratumoral acidity promotes pro-tumorigenic macrophages
Increased intratumoral acidity associated with a high-fat diet accelarates tumour growth through the acid-sensing receptor...
Targeting ER stress sensor restores immunogenicity of chemotherapy
Targeting ER stress sensor restores immunogenicity of chemotherapy
Blocking the RNase activity of IRE1α can convert 'cold' tumours to immunologically 'hot' ones that re...
From TCR fundamental research to innovative chimeric antigen receptor design
From TCR fundamental research to innovative chimeric antigen receptor design
Engineered T cells that express chimeric antigen receptors (CARs) have transformed the treatment of haematological cancers...
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment
T cells have a critical role in mediating antitumour immunity. The success of immune checkpoint inhibitors (ICIs) for canc...
Human macrophages in pancreas and skin shape prenatal organogenesis
Human macrophages in pancreas and skin shape prenatal organogenesis
Two studies in Cell Stem Cell and Nature use single-cell transcriptomics of human fetal tissue to investigate the roles of...
The roles of arginases and arginine in immunity
The roles of arginases and arginine in immunity
Arginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysreg...
The role of the AHR in host–pathogen interactions
The role of the AHR in host–pathogen interactions
Host–microorganism encounters take place in many different ways and with different types of outcomes. Three major ty...
Fever affects T cell fate
Fever affects T cell fate
Febrile temperatures disrupt metabolism and induce DNA damage disproportionately in T helper 1 cell subsets. Cells that su...
Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection
CD8+ T cells are crucial in controlling infection with hepatitis B virus (HBV) but are functionally impaired during chroni...
How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia
How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia
Most eukaryotes require oxygen for their survival and, with increasing multicellular complexity, oxygen availability and d...
Induced pluripotent stem cell-derived macrophages as a platform for modelling human disease
Induced pluripotent stem cell-derived macrophages as a platform for modelling human disease
Macrophages are innate immune cells that are present in essentially all tissues, where they have vital roles in tissue dev...
An inhibitory PRR reels in the neutrophil response to NETs
An inhibitory PRR reels in the neutrophil response to NETs
MICL regulates neutrophil responses by serving as an inhibitory pattern-recognition receptor for NETs.
Understanding vertebrate immunity through comparative immunology
Understanding vertebrate immunity through comparative immunology
Evolutionary immunology has entered a new era. Classical studies, using just a handful of model animal species, combined w...
Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond
Authors and AffiliationsDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanRi...
Mitochondrial tonic for adoptive T cell therapies
Mitochondrial tonic for adoptive T cell therapies
A study in Cell describes a platform to supply exogenous mitochondria to CD8+ T cells via nanotubes, which boosts their an...
Inducible antibacterial responses in macrophages
Inducible antibacterial responses in macrophages
Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled antimicrobial responses, such as the ge...
Antigen presentation for central tolerance induction
Antigen presentation for central tolerance induction
The extent of central T cell tolerance is determined by the diversity of self-antigens that developing thymocytes ‘s...
Striking a balance: new perspectives on homeostatic dendritic cell maturation
Striking a balance: new perspectives on homeostatic dendritic cell maturation
Dendritic cells (DCs) are crucial gatekeepers of the balance between immunity and tolerance. They exist in two functional ...
Mast cell BH4–serotonin metabolic network implicated in postoperative pain
Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstr...
Using art and history to communicate immunology to a broad audience
Using art and history to communicate immunology to a broad audience
Francesca Di Rosa works on T cells and is committed to science outreach. Together with Adrian Hayday, she recently concept...
Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy
Authors and AffiliationsUnit for Clinical Pediatrics, Dept. of Women’s and Children’s Health, Karolinska Institutet, Solna...
Have a cake and eat it too: the importance of metaphors in research communication
Have a cake and eat it too: the importance of metaphors in research communication
Anne Spurkland is a professor of medicine, and her research interests include T cell activation and autoimmunity. She is a...
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