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Clonal haematopoiesis and dysregulation of the immune system
Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including excessive inflammation, autoreact...
CXCL8 blockade reduces fibrosis in endometriosis
Endometriosis is a common condition that leads to pain and infertility, but treatment options are limited. The disease is ...
Repurposing metabolic drugs for COVID-19
Patients with obesity and/or diabetes have worse outcomes in SARS-CoV-2 infection, and the virus has been shown to promote...
Autoantibodies against chemokines linked with better disease outcomes in COVID-19
Autoantibodies against interferons and other immune mediators have been linked to negative outcomes following infection wi...
Tissue-specific macrophages: how they develop and choreograph tissue biology
Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell...
Immune dysregulation in Down syndrome
Immune dysregulation in Down syndrome
The immune system in individuals with Down syndrome is characterized by steady state increases in cytokine expression, T c...
Fasting affects monocyte lifespan and migration
Fasting then re-feeding in mice causes monocyte disequilibrium and can affect host responses to pathogens.
Trained to fight cancer
Influenza viral infection trains mucosal-resident alveolar macrophages to confer long-lasting and tissue-specific immunity...
Immune checkpoint blockade breaches the mucosal firewall to induce gut microbiota translocation
Immune checkpoint blockade breaches the mucosal firewall to induce gut microbiota translocation
Choi et al. show that in mice with melanoma, immune checkpoint blockade therapy increases the translocation of live intest...
Linking the maternal milk microbiota and infant respiratory infections
A preprint by Sikder et al. identifies a role for the maternal milk microbiota in conferring resistance to severe lower re...
Negative regulation of AHR essential for intestinal homeostasis
Negative regulation of AHR essential for intestinal homeostasis
Although the aryl hydrocarbon receptor has an essential role in supporting homeostasis of intestinal intraepithelial lymph...
Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USABarton F. Haynes, Kevin Wiehe, Kevin O. S...
Human T follicular regulatory cells with helper and regulatory lineage origins
A preprint by Le Coz et al. identifies that human T follicular regulatory cells with differences in T cell suppressive and...
Control of immune cell function by the unfolded protein response
Control of immune cell function by the unfolded protein response
Initiating and maintaining optimal immune responses requires high levels of protein synthesis, folding, modification and t...
You are what you ate: myeloid cells trained by fatty acids
Hato et al. fed mice a high-fat diet to induce obesity before placing them on a regular diet (HFD-RD). After six weeks on ...
You can’t live forever — but perhaps your T cells can
Masopust and colleagues have found that memory CD8+ T cells can retain the capacity for cell division for longer than the ...
Natural killer cells adapt to malaria exposures
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
γδ T cells mediate immunotherapy responses when cancers lack MHC class I
γδ T cells mediate immunotherapy responses when cancers lack MHC class I
γδ T cells are important for responding to immune checkpoint blockade therapy in patients whose cancers have dow...
Sensational role for skin T cells
Sensational role for skin T cells
Commensal-specific T cells promote the regeneration of damaged sensory nerves in the skin, through an IL-17-dependent path...
The therapeutic age of the neonatal Fc receptor
The therapeutic age of the neonatal Fc receptor
IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Com...
MHCing the tumour’s dark genome
A preprint by Lozano-Rabella et al. uses a proteogenomics approach to identify an underappreciated class of non-canonical ...
How to build anti-PD1 agonist antibodies
A paper in Science Immunology describes the crucial features of agonist antibodies to the checkpoint molecule PD1.
Locally sourced: site-specific immune barriers to metastasis
Locally sourced: site-specific immune barriers to metastasis
Tumour cells migrate very early from primary sites to distant sites, and yet metastases often take years to manifest thems...
The biology of TREM receptors
The biology of TREM receptors
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by ...
Can we predict T cell specificity with digital biology and machine learning?
Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough solutions to problems such as prote...
T-regulating opioid withdrawal
A paper in Cell describes a role for regulatory T cells in mediating the symptoms of opioid withdrawal through effects on ...
The role of platelets in immune-mediated inflammatory diseases
The role of platelets in immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis,...
The role of galectins in immunity and infection
The role of galectins in immunity and infection
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and b...
Glomerulonephritis: immunopathogenesis and immunotherapy
Glomerulonephritis: immunopathogenesis and immunotherapy
‘Glomerulonephritis’ (GN) is a term used to describe a group of heterogeneous immune-mediated disorders charac...
Sex-specific role for microglial CST7 in Alzheimer’s disease
A preprint by Daniels et al. reports a sex-specific role for the microglial protein CST7 in the regulation of phagocytosis...
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