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Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease ...
A novel method to efficiently differentiate human osteoclasts from blood-derived monocytes
A novel method to efficiently differentiate human osteoclasts from blood-derived monocytes
Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, ...
Efficient and scalable gene delivery method with easily generated cationic carbon dots
Efficient and scalable gene delivery method with easily generated cationic carbon dots
Gene delivery is a complex process with several challenges when attempting to incorporate genetic material efficiently and...
Correction: Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
Correction: Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug...
Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
Methyl β-Cyclodextrin-sperm-mediated gene editing (MBCD-SMGE): a simple and efficient method for targeted mutant mouse production
Generating targeted mutant mice is a crucial technology in biomedical research. This study focuses on optimizing the CRISP...
Standardized Pre-clinical Surgical Animal Model Protocol to Investigate the Cellular and Molecular Mechanisms of Ischemic Flap Healing
Standardized Pre-clinical Surgical Animal Model Protocol to Investigate the Cellular and Molecular Mechanisms of Ischemic Flap Healing
Some of the most complex surgical interventions to treat trauma and cancer include the use of locoregional pedicled and fr...
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
Gastric cancer (GC) is a common malignancy and a leading cause of cancer-related death with high morbidity and mortality. ...
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, incl...
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Renal cancer therapies are challenging owing to the extensive spreading of this cancer to other organs and its ability to ...
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cance...
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
Ischemic stroke (IS) occurs when a blood vessel supplying the brain becomes obstructed, resulting in cerebral ischemia. Th...
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One grou...
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transpo...
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propen...
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including...
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular ...
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell l...
Correction: Circ‑ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA‑128‑3p/ZEB1 axis
Correction: Circ‑ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA‑128‑3p/ZEB1 axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the bindi...
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung ca...
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigene...
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatin...
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
One of the most prominent questions in the field of transgenesis is ‘Where in the genome to integrate a transgene?&#...
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H2O2-induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H2O2-induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromo...
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
Immunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells in...
Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients
Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients
Deep learning has been extensively used in digital histopathology. The purpose of this study was to test deep learning (DL...
Correction: Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study
Correction: Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
The treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between ...
Correction: The role of three‑dimensional scaffolds based on polyglycerol sebacate/ polycaprolactone/ gelatin in the presence of Nanohydroxyapatite in promoting chondrogenic differentiation of human adipose‑derived mesenchymal stem cells
Correction: The role of three‑dimensional scaffolds based on polyglycerol sebacate/ polycaprolactone/ gelatin in the presence of Nanohydroxyapatite in promoting chondrogenic differentiation of human adipose‑derived mesenchymal stem cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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