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Gender differences in the relationship between serum uric acid and the long-term prognosis in heart failure: a nationwide study
Gender differences in the relationship between serum uric acid and the long-term prognosis in heart failure: a nationwide study
Serum uric acid (SUA) is an important pathogenetic and prognostic factor for heart failure (HF). Gender differences are ap...
Longitudinal blood glucose level and increased silent myocardial infarction: a pooled analysis of four cohort studies
Longitudinal blood glucose level and increased silent myocardial infarction: a pooled analysis of four cohort studies
Fasting glucose (FG) demonstrates dynamic fluctuations over time and is associated with cardiovascular outcomes, yet curre...
Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis
Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis
The long-term high-fat diet (HFD) can cause myocardial lipotoxicity, which is characterized pathologically by myocardial h...
Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and...
Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses
Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses
The accumulation of visceral and ectopic fat comprise a major cause of cardiometabolic diseases. However, novel drug targe...
Oral-gut microbial transmission promotes diabetic coronary heart disease
Oral-gut microbial transmission promotes diabetic coronary heart disease
Diabetes is a predominant driver of coronary artery disease worldwide. This study aims to unravel the distinct characteris...
Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium
Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium
Histone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Hi...
Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53
Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53
Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lack...
Sodium-glucose cotransporter 2 inhibitors, inflammation, and heart failure: a two-sample Mendelian randomization study
Sodium-glucose cotransporter 2 inhibitors, inflammation, and heart failure: a two-sample Mendelian randomization study
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are increasingly recognized for their role in reducing the risk and imp...
The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension
The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension
Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphoc...
Evidence that tirzepatide protects against diabetes-related cardiac damages
Evidence that tirzepatide protects against diabetes-related cardiac damages
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective antidiabetic drugs with potential cardiovascular benefi...
Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population
Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population
The triglyceride and glucose (TyG) index, a simple surrogate marker of insulin resistance, is related to cardiovascular di...
Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy
Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy
The cumulative effect of postpartum weight retention from each pregnancy in a woman’s life may contribute to her ris...
Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ
Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ
Imeglimin is a new anti-diabetic drug which promotes insulin secretion from pancreatic β-cells and reduces insulin re...