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PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
By complexing poly (ADP-ribose) (PAR) in reaction to broke strand, PAR polymerase1 (PARP1) acts as the key enzyme particip...
A novel mitochondrial-related lncRNA signature mediated prediction of overall survival, immune landscape, and the chemotherapeutic outcomes for bladder cancer patients
A novel mitochondrial-related lncRNA signature mediated prediction of overall survival, immune landscape, and the chemotherapeutic outcomes for bladder cancer patients
To develop a prognostic risk model for Bladder Cancer (BLCA) based on mitochondrial-related long non-coding RNAs (lncRNAs)...
Breast cancer stage and molecular subtype distribution: real-world insights from a regional oncological center in Hungary
Breast cancer stage and molecular subtype distribution: real-world insights from a regional oncological center in Hungary
Examining the distribution of breast cancer (BC) stage and molecular subtype among women aged below (< 45&...
PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy
PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy
To investigate the potential of group I pepsinogen (PG I) and group II pepsinogen (PG II) as diagnostic markers for recurr...
Effect of exercise on postoperative recovery of patients with non-small cell lung cancer: a systematic review and meta-analysis
Effect of exercise on postoperative recovery of patients with non-small cell lung cancer: a systematic review and meta-analysis
Patients with non-small cell lung cancer (NSCLC) in the postoperative recovery period often experience reduced exercise ca...
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 recept...
Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment
Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment
Colorectal cancer is one of the common cancers worldwide and the second leading cause of cancer-related death. The current...
Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members
Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members
Acute myeloid leukemia (AML) remains challenging due to chemotherapeutic drug-resistance (CDR). Aberrant expression B7 fam...
Insights into the prognostic value and immunological role of CD74 in pan-cancer
Insights into the prognostic value and immunological role of CD74 in pan-cancer
CD74 is a non-polymorphic type II transmembrane glycoprotein. It is involved in the regulation of T and B cell development...
Efficacy of immunotherapy in ARID1A-mutant solid tumors: a single-center retrospective study
Efficacy of immunotherapy in ARID1A-mutant solid tumors: a single-center retrospective study
Immune checkpoint inhibitors (ICIs), especially those targeting programmed cell death-1 (PD-1) and programmed cell death l...
A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency
A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency
Deficiency of citrin, the liver-type aspartate-glutamate carrier, arises from biallelic mutations of the gene SLC25A13. Al...
The potent potential of MFAP2 in prognosis and immunotherapy of triple-negative breast cancer
The potent potential of MFAP2 in prognosis and immunotherapy of triple-negative breast cancer
Microfibril-associated protein 2 (MFAP2) is a protein presenting in the extracellular matrix that governs the activity of ...
The relationship between contrast-enhanced computed tomography radiomics features and mitosis karyorrhexis index in neuroblastoma
The relationship between contrast-enhanced computed tomography radiomics features and mitosis karyorrhexis index in neuroblastoma
Mitosis karyorrhexis index (MKI) can reflect the proliferation status of neuroblastoma cells. This study aimed to investig...
Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy
Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy
Tumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of...
A new prognostic model based on gamma-delta T cells for predicting the risk and aiding in the treatment of clear cell renal cell carcinoma
A new prognostic model based on gamma-delta T cells for predicting the risk and aiding in the treatment of clear cell renal cell carcinoma
ccRCC is the prevailing form of RCC, accounting for the majority of cases. The formation of cancer and the body's abil...
Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity
Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity
Strobilurins act as antifungal agents by inhibiting the mitochondrial respiratory chain. The cytotoxic activity of strobil...
Highly expressed of BID indicates poor prognosis and mediates different tumor microenvironment characteristics in clear cell renal cell carcinoma
Highly expressed of BID indicates poor prognosis and mediates different tumor microenvironment characteristics in clear cell renal cell carcinoma
Studies have found that BH3 interacting domain death agonist (BID) is closely related to the occurrence and development of...
Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression
Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression
Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cau...
A cuproptosis-related signature predicts prognosis and indicates cross-talk with immunocyte in ovarian cancer
A cuproptosis-related signature predicts prognosis and indicates cross-talk with immunocyte in ovarian cancer
Cuproptosis, programmed cell death by intracellular copper-mediated lipoylated protein aggregation, is involved in various...
Longitudinal tracking of circulating rare events in the liquid biopsy of stage III–IV non-small cell lung cancer patients
Longitudinal tracking of circulating rare events in the liquid biopsy of stage III–IV non-small cell lung cancer patients
In the United States, lung cancer is the second most common type of cancer with non-small cell lung cancer (NSCLC) encompa...
circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer
circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer
Pancreatic cancer (PC) is one of the most lethal malignant gastrointestinal tumors (GI) characterized by a poor prognosis....
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
C-X-C motif chemokine ligand 1 (CXCL1) and epithelial growth factor (EGF) are highly secreted by oral squamous cell carcin...
The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma
The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early dia...
Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion
Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion
The research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness. Specifically, there is a...
miRNA-200c-3p deficiency promotes epithelial-mesenchymal transition in triple-negative breast cancer by activating CRKL expression
miRNA-200c-3p deficiency promotes epithelial-mesenchymal transition in triple-negative breast cancer by activating CRKL expression
Epithelial-mesenchymal transition (EMT) plays an important role in malignant progression of Triple-negative breast cancer ...
CXCL10 could be a prognostic and immunological biomarker in bladder cancer
CXCL10 could be a prognostic and immunological biomarker in bladder cancer
As proteins that promote immune cell differentiation, chemokines have attracted great interest regarding their role in ant...
Nomogram for predicting survival in T1–T2 stage patients with supraglottic squamous cell carcinoma
Nomogram for predicting survival in T1–T2 stage patients with supraglottic squamous cell carcinoma
Supraglottic squamous cell carcinoma (SGSCC) is characterized by low differentiation, rapid growth, and inconspicuous init...
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
Interleukin-4 inducible gene 1 (IL4I1) regulates tumor progression in numerous tumor types. However, its correlation with ...
Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA
Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA
Breast cancer (BC) ranks first among female malignant tumors and involves hormonal changes and genetic as well as environm...
Identification of a pyroptosis-immune-related lncRNA signature for prognostic and immune landscape prediction in bladder cancer patients
Identification of a pyroptosis-immune-related lncRNA signature for prognostic and immune landscape prediction in bladder cancer patients
Individualized medicine has become increasingly important in bladder cancer treatment, whereas useful biomarkers for progn...
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