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Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway
Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway
The aim of this study was to investigate the key targets and signaling pathways of paeoniflorin (PF) for the treatment of ...
Immune-oncology targets and therapeutic response of cell pyroptosis-related genes with prognostic implications in neuroblastoma
Immune-oncology targets and therapeutic response of cell pyroptosis-related genes with prognostic implications in neuroblastoma
Construction of a neuroblastoma (NB) prognostic predictive model based on pyroptosis-related genes (PRGs) to improve indiv...
Survival prediction in patients with head and neck squamous cell carcinoma and novel mechanistic insights of S100A8/A9
Survival prediction in patients with head and neck squamous cell carcinoma and novel mechanistic insights of S100A8/A9
S100A8/A9, an innate immune protein, significantly regulates inflammatory processes and immune responses. While S100A8/A9 ...
Succinylation modification-mediated upregulation of Sp1 promotes hepatocellular carcinoma cell proliferation
Succinylation modification-mediated upregulation of Sp1 promotes hepatocellular carcinoma cell proliferation
Hepatocellular carcinoma (HCC) remains one of the most prevalent malignant tumors globally, characterized by high incidenc...
MicroRNA-mediated autophagy and drug resistance in cancer: mechanisms and therapeutic strategies
MicroRNA-mediated autophagy and drug resistance in cancer: mechanisms and therapeutic strategies
This paper provides an exhaustive overview of the intricate interplay between microRNAs (miRNAs) and autophagy in the cont...
Correlation between thyroid dysfunction and efficacy of immune checkpoint inhibitors in patients with advanced solid tumors
Correlation between thyroid dysfunction and efficacy of immune checkpoint inhibitors in patients with advanced solid tumors
Immune checkpoint inhibitors (ICIs) are currently the first line of tumor immunotherapy for the treatment of a wide range ...
Single-cell data revealed the regulatory mechanism of TNK cell heterogeneity in liver metastasis from gastric cancer
Single-cell data revealed the regulatory mechanism of TNK cell heterogeneity in liver metastasis from gastric cancer
The present work set out to classify cell subpopulations related to liver metastasis from gastric cancer (GC) and the mech...
Circ_0001068 accelerates the development of ovarian cancer by promoting FXYD5 expression through inhibiting mir-149-5p activity
Circ_0001068 accelerates the development of ovarian cancer by promoting FXYD5 expression through inhibiting mir-149-5p activity
Ovarian cancer (OC) is one of the common malignancies of the female reproductive organs. Microarray analysis shows that ci...
Developing hypoxia and lactate metabolism-related molecular subtypes and prognostic signature for clear cell renal cell carcinoma through integrating machine learning
Developing hypoxia and lactate metabolism-related molecular subtypes and prognostic signature for clear cell renal cell carcinoma through integrating machine learning
The microenvironment of clear cell renal cell carcinoma (ccRCC) is characterized by hypoxia and increased lactate producti...
Triglyceride-glucose index predicts postoperative overall survival in hepatocellular carcinoma: a retrospective cohort study
Triglyceride-glucose index predicts postoperative overall survival in hepatocellular carcinoma: a retrospective cohort study
Insulin resistance is important in hepatocellular carcinoma (HCC) carcinogenesis and progression. The triglyceride-glucose...
Development and validation of survival nomograms for patients with anaplastic thyroid carcinoma: a SEER program-based study
Development and validation of survival nomograms for patients with anaplastic thyroid carcinoma: a SEER program-based study
We aimed to study the prognostic risk factors affecting patients with anaplastic thyroid carcinoma (ATC), develop a clinic...
Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes
Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes
In this perspective, we highlight and reflect on the current knowledge with respect to serine/glycine metabolism in cancer...
Comprehensive analysis of single-cell and bulk RNA sequencing reveals postoperative progression markers for non-muscle invasive bladder cancer and predicts responses to immunotherapy
Comprehensive analysis of single-cell and bulk RNA sequencing reveals postoperative progression markers for non-muscle invasive bladder cancer and predicts responses to immunotherapy
Non-muscle-invasive bladder cancer (NMIBC) is renowned for its high recurrence, invasiveness, and poor prognosis. Conseque...
Development of a novel disulfidptosis-correlated m6A/m1A/m5C/m7G gene signature to predict prognosis and therapeutic response for lung adenocarcinoma patients by integrated machine-learning
Development of a novel disulfidptosis-correlated m6A/m1A/m5C/m7G gene signature to predict prognosis and therapeutic response for lung adenocarcinoma patients by integrated machine-learning
Lung adenocarcinoma (LUAD) represents a significant global health burden, necessitating advanced prognostic tools for impr...
Development and validation of a risk predictive nomogram for colon cancer-specific mortality: a competing risk model based on the SEER database
Development and validation of a risk predictive nomogram for colon cancer-specific mortality: a competing risk model based on the SEER database
Utilizing the SEER database, we developed a competing risk model along with a nomogram designed for the early identificati...
Prognosis and immunotherapy significances of a cancer-associated fibroblasts-related gene signature in bladder urothelial carcinoma
Prognosis and immunotherapy significances of a cancer-associated fibroblasts-related gene signature in bladder urothelial carcinoma
The biological significance of cancer-associated fibroblasts (CAFs) in bladder urothelial carcinoma (BUC) warrants further...
Unraveling the role of heavy metals xenobiotics in cancer: a critical review
Unraveling the role of heavy metals xenobiotics in cancer: a critical review
Cancer is a multifaceted disease characterized by the gradual accumulation of genetic and epigenetic alterations within ce...
Identifying causal relationships between 35 blood and urine biomarkers and urologic cancers: MR-meta combined with Bayesian colocalization Mendelian randomization analysis
Identifying causal relationships between 35 blood and urine biomarkers and urologic cancers: MR-meta combined with Bayesian colocalization Mendelian randomization analysis
Blood and urine biomarkers have been associated with urologic tumors, but their causal relationship with urologic tumors i...
Unveiling the Immune effects of AHR in tumors: a decade of insights from bibliometric analysis (2010–2023)
Unveiling the Immune effects of AHR in tumors: a decade of insights from bibliometric analysis (2010–2023)
The Aryl Hydrocarbon Receptor (AHR) is a transcription factor that regulates several biological processes. Its potential i...
The diagnosis and oncological outcomes of obturator and internal iliac lymph node metastasis in middle–low rectal cancer: results of a multicenter Lateral Node Collaborative Group study in China
The diagnosis and oncological outcomes of obturator and internal iliac lymph node metastasis in middle–low rectal cancer: results of a multicenter Lateral Node Collaborative Group study in China
Lateral lymph node dissection (LLND) can decrease local recurrence to lateral compartments in middle-low rectal cancer, bu...
ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma
ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma
Cancer cells encounter unavoidable stress during tumor growth. The stress-induced transcription factor, activating transcr...
LINC00342 regulates the PI3K-AKT signaling pathway via the miR-149-5p/FGF11 axis and affects the progression of oral cancer
LINC00342 regulates the PI3K-AKT signaling pathway via the miR-149-5p/FGF11 axis and affects the progression of oral cancer
A large number of long non-coding RNAs (lncRNAs) have been implicated in the progression of oral cancer (OC). This study a...
Decoding core genes and intercellular communication in osteosarcoma: bioinformatic investigation and immune cell profiling for diagnostic and therapeutic insights
Decoding core genes and intercellular communication in osteosarcoma: bioinformatic investigation and immune cell profiling for diagnostic and therapeutic insights
The study focusing on developing an artificial neural network (ANN) model in accordance with genetic characteristics of os...
Identification and validation of CCN family genes to predict the prognosis in gastric cancer
Identification and validation of CCN family genes to predict the prognosis in gastric cancer
Gastric cancer (GC) is a deadly malignancy with an ever-increasing incidence worldwide. The cellular communication network...
The inhibitory efficacy of Ginsenoside Rg3 on proliferation and migration of colonic carcinoma cells through the JAK3/STAT5 signaling pathway
The inhibitory efficacy of Ginsenoside Rg3 on proliferation and migration of colonic carcinoma cells through the JAK3/STAT5 signaling pathway
To elucidate the efficacy of Ginsenoside Rg3 on the reproduction and immigration of HCT-116 cells and its molecular mechan...
Unraveling the causal association between lifestyle and metabolic factors with endometrial cancer: evidence from a Mendelian randomization study
Unraveling the causal association between lifestyle and metabolic factors with endometrial cancer: evidence from a Mendelian randomization study
Endometrial carcinoma (EC) remain a malignancy with incompletely understood risk factors. To address this knowledge gap, w...
LINC01518 predicts poor prognosis of prostate cancer and promotes its progression by regulating hsa-miR-320a/CNKSR2 axis
LINC01518 predicts poor prognosis of prostate cancer and promotes its progression by regulating hsa-miR-320a/CNKSR2 axis
Prostate cancer (PCa) is the most common malignancy of the male genitourinary system. Understanding the molecular mechanis...
Venous thromboembolism and ovarian cancer risk: a Mendelian randomized study
Venous thromboembolism and ovarian cancer risk: a Mendelian randomized study
A potential link between venous thromboembolism and the risk of ovarian cancer has been identified in clinical practice. H...
Primary central nervous system lymphoma: a series report and literature review
Primary central nervous system lymphoma: a series report and literature review
This study aims to analyze the clinical features, Radiological findings and diagnostic characteristics (tissue biopsy, flo...
Non-invasive miRNAs for early detection and diagnosis of lacrimal adenoid cystic carcinoma
Non-invasive miRNAs for early detection and diagnosis of lacrimal adenoid cystic carcinoma
Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignant epithelial tumors of the lacrimal gland, char...
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