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Nanotechnology-based tumor metabolic reprogramming: Insights into nutrient-delivery and metabolism reactivation therapy
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RMC-7977, a highly selective inhibitor of the active RAS-GTP to treat pancreatic cancer
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Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA
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Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy
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Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches
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Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms and therapeutic strategies
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The microneedle bandages provide new hope for healing diabetic wounds
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Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF
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Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay (PEGibody): A strategy for prolonged tumor retention with fast blood clearance
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Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms.
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Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway
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Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
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Jun12682, a potent SARS-CoV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice
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Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity
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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors
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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice
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Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
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Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect
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The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
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Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach
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Disease-derived circulating extracellular vesicle preconditioning: A promising strategy for precision mesenchymal stem cell therapy
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Allosteric regulation of Keap1 by 8β-hydroxy-α-cyclocostunolide for the treatment of acute lung injury
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Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases
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Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing
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Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins
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Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus
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Genome-wide pan-GPCR cell libraries accelerate drug discovery
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Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing
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PEGylated bacteria restore intestinal mucosal barrier
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Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagy-dependent ferroptosis
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