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The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses
Positive-sense RNA virusesPeruvosideAntiviralCDKI signalingViral factoriesCalcium effluxBroad-spectrumGolgi apparatus© 202...
Corynoxine B targets at HMGB1/2 to enhance autophagy for alpha-synuclein clearance in fly and rodent models of Parkinson’s disease
arkinson’s disease (PD) is the most common neurodegenerative movement disease. It is featured by abnormal alpha-synuclein ...
Emerging roles of Aurora-A kinase in cancer therapy resistance
Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in various cellular processes, including mitot...
Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression
NLRP6Neural stem cellsStress resilienceDepressive-like behaviorsECRG4Mitochondrial functionProliferationPioglitazone© 2023...
Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats
Chronic cerebral hypoperfusionTwo vessel occlusionWhite matterCognitive impairmentOligodendrocyteMyelin sheathAutophagy-ly...
Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer
Available online 11 March 2023Author links open overlay panel, , , , , , , , , AbstractEpigenetic therapies that cause gen...
Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis
AutophagyInflammationLipid metabolismNonalcoholic fatty liver diseaseCyclooxygenase 1Phosphatidylinositol 3-phosphateWD re...
Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations
AumolertinibNon-small cell lung cancerOncologyUncommon EGFR mutationsExon 20 insertionEGFR tyrosine kinase inhibitorTarget...
Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs
MonobactamDrug-resistant Gram-negative bacteriaChemoproteomicDual mode of actionSynergistic effect© 2023 Chinese Pharmaceu...
Editorial of Special Issue on RNA Therapeutics and Drug Delivery Technologies for Medical Applications
Available online 8 March 2023Author links open overlay panelWei TaoShow moreRecommended articles© 2023 Chinese Pharmaceuti...
Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system
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Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis
Available online 8 March 2023Author links open overlay panel, , , , , , AbstractMetastasis is the leading cause of cancer-...
Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics
Available online 5 March 2023Author links open overlay panel, , , AbstractChemotherapy has occupied the critical position ...
Plant-derived nanovesicles: Further exploration of biomedical function and application potential
Extracellular vesicles (EVs) are phospholipid bilayer vesicles actively secreted by cells, that contain a variety of funct...
Berberine improves central memory formation of CD8+ T cells: Implications for design of natural product-based vaccines
BerberineCD8+ T cellT cell primingCentral memoryAMPKStat5Vaccine designNaturally occurring compound© 2023 Chinese Pharmace...
Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling
Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of the extracel...
Research advances in peptide‒drug conjugates
Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently coupled to a multifunctional pept...
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment
Available online 1 March 2023Author links open overlay panel, , , , , , , , , , , , , , , AbstractEnzyme-driven micro/nano...
A potentially serious adverse effect of GLP-1 receptor agonists
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Commentary: Deubiquitination complex platform: a plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes
Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome de...
mRNA delivery in cancer immunotherapy
Cancer immunotherapyLipid nanoparticlesLipid-polymer hybrid nanoparticlesMessenger RNAmRNA deliveryPolymeric nanoparticles...
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer
Lung cancerIntratumor heterogeneitySplice variantsIntragenic CpG methylationProtease serine 3Myeloid zinc finger 1UHRF1/DN...
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1
Available online 24 February 2023Author links open overlay panel, , , , , , , AbstractAlcoholic liver disease (ALD) result...
Application of microfluidic technologies on COVID-19 diagnosis and drug discovery
Available online 24 February 2023Author links open overlay panel, , , , AbstractThe ongoing coronavirus disease 2019 (COVI...
Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management
MicroneedlesColchicineSustained-releaseUricaseLiposomeTransdermal administrationGout managementLong-term urate-lowering th...
Disease-specific protein corona formed in pathological intestine enhances the oral absorption of nanoparticles
Oral nanoparticlesPathological intestineDisease-specificIntestinal protein coronaProteomics analysisIntracellular traffick...
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization
COVID-19Mucosal vaccinesLactiplantibacillus plantarumMicroparticleIntranasal administrationViral challengeMiceLung targeti...
Author correction to ‘TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner' [Acta Pharm Sin B 11(12) (2021) 3994–4007]
Available online 2 February 2023Author links open overlay panelHuaqing Zheng †, Xiaolong Li †, Xin Zeng, Chengcui Huang, M...
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19
Coronavirus disease 19Severe acute respiratory syndrome coronavirus 2Therapeutic approachesNanotechnologyNanomaterial tech...
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors
Available online 21 February 2023Author links open overlay panel, , , , , , AbstractInvasive fungal infections (IFIs) have...
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