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TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage
Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for ...
Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide
Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide
Available online 19 September 2023Author links open overlay panel, , , , , , , , AbstractPeptides are a particular molecul...
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus
Solute carriers (SLCs) constitute the largest superfamily of membrane transporter proteins. These transporters, present in...
Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies
Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies
Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decad...
Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection
Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection
Available online 9 September 2023Author links open overlay panel, , , , , , , , , , , , , , , , , , , …AbstractThe bacteri...
pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy
pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy
siRNAOcular delivery systemBlock polymerEndosomal escapeRetinal neovascularizationBlood‒retinal barrierVEGFASafety© 2023 C...
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy
bacteria-mediated cancer therapyTumor microenvironmentCalcium carbonateMineralizationMetalloimmunologyAutologous tumor vac...
Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application
Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application
Amorphous calcium carbonateDrug delivery systemsNanoparticlesAcid sensitivityWater instabilityTumor therapyTissue engineer...
Plant-derived nanovesicles as an emerging platform for cancer therapy
Plant-derived nanovesicles as an emerging platform for cancer therapy
Plant-derived nanovesicles (PDNVs) derived from natural green products have emerged as an attractive nanoplatform in biome...
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage
Available online 3 September 2023Author links open overlay panel, , , , , AbstractCancer, a complex and heterogeneous dise...
Emerging delivery systems based on aqueous two-phase systems: A review
Emerging delivery systems based on aqueous two-phase systems: A review
Aqueous two-phase systemsDrug delivery systemsBiomaterialsMicrocapsulesMicroparticlesCell therapyCancer treatmentOrgan reg...
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects
Phage-derived polysaccharide depolymerasesBacteriophage proteinsBacterial capsulesPolysaccharide capsulesAntibiotic resist...
Cancer cell membrane-coated bacterial ghosts for highly efficient paclitaxel delivery against metastatic lung cancer
Cancer cell membrane-coated bacterial ghosts for highly efficient paclitaxel delivery against metastatic lung cancer
Available online 19 August 2023Author links open overlay panel, , , , , , , AbstractChemotherapy is one of the major appro...