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Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma
Volume 12, Issue 10, October 2022, Pages 3952-3971AbstractBacterial antitumor therapy has great application potential give...
Localized delivery of nanomedicine and antibodies for combating COVID-19
Available online 23 September 2022AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has be...
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases
Available online 25 September 2022AbstractThe NLRP3 inflammasome’s core and most specific protein, NLRP3, has a variety of...
Recent advances in bacterial therapeutics based on sense and response
Available online 25 September 2022AbstractIntelligent drug delivery is a promising strategy for cancer therapies. In recen...
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine
Available online 21 September 2022AbstractCancer is the second leading cause of mortality globally which remains a continu...
Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers
Available online 16 September 2022AbstractTo expand the single-dose duration over which noninvasive clinical and preclinic...
The role of phosphatidylcholine 34:1 in the occurrence, development and treatment of ulcerative colitis
Available online 13 September 2022AbstractLipid homeostasis is considered to be related to intestinal metabolic balance, w...
Research and development of Chinese anti-COVID-19 drugs
Available online 13 September 2022AbstractThe outbreak and spread of coronavirus disease 2019 (COVID-19) highlighted the i...
CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain
Pain is often debilitating, and current treatments are neither universally efficacious nor without risks. Transient recept...
Expression and functions of transient receptor potential channels in liver diseases
Available online 15 September 2022AbstractLiver diseases constitute a major healthcare burden globally, including acute he...
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition
Available online 12 September 2022AbstractCancer immunotherapy has become a promising strategy. However, the effectiveness...
Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo
Available online 12 September 2022AbstractRadiation protection drugs are often accompanied by toxicity, even amifostine, w...
Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum
Available online 13 September 2022AbstractOxalicine B (1) is an ɑ-pyrone meroterpenoid with a unique bispirocyclic ring sy...
A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis
Available online 5 September 2022AbstractPulmonary fibrosis (PF) is a pathological change caused by repeated injuries and ...
Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria
Available online 5 September 2022AbstractSodium-glucose cotransporter 2 (SGLT2) inhibitors have been reapproved for heart ...
Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses
Pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present,...
Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy
Available online 5 September 2022AbstractIn situ and real-time monitoring of responsive drug release is critical for the a...
Sodium alginate coating simultaneously increases the biosafety and immunotherapeutic activity of the cationic mRNA nanovaccine
Available online 27 August 2022AbstractThe extraordinary advantages associated with mRNA vaccines, including their high ef...
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
Available online 27 August 2022AbstractFarnesoid X receptor (FXR) is widely accepted as a promising target for various liv...
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
Available online 27 August 2022AbstractNatural products, and especially the active ingredients found in traditional Chines...
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients
Available online 28 August 2022AbstractThe liver plays a central role in the pharmacokinetics of drugs through drug metabo...
Drug discovery in China: a snapshot of recent progress
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances
Available online 28 August 2022AbstractCellular nanovesicles which are referred to as cell-derived, nanosized lipid bilaye...
Reprogrammed siTNFα/neutrophil cytopharmaceuticals targeting inflamed joints for rheumatoid arthritis therapy
Available online 23 August 2022AbstractRheumatoid arthritis (RA) is an autoimmune disease characterized by severe synovial...