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Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
ChemoimmunotherapyTargeted drug deliveryEndoplasmic reticulumEndoplasmic reticulum stressImmunogenic cell deathsiRNAExosom...
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Non-covalent PLpro inhibitorsAntiviral activityStructural-based drug designImidazo[4,5-b]pyridine scaffold© 2024 Published...
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
Available online 10 April 2024Author links open overlay panel, , , , , , , , , , , , , , , AbstractCoumarins, derived from...
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared...
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
3,5-JulolidinylAza-BODIPYNanocarriersNear-infrared IIFluorescence imagingAggregation-caused quenchingPolymeric micellesPol...
Characteristic roadmap of linker governs the rational design of PROTACs
Characteristic roadmap of linker governs the rational design of PROTACs
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging th...
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB
α-Methylene-γ-butyrolactoneRheumatoid arthritisNF-κB p65Synovial microenvironmentSesquiterpene lactones© 2024 The Authors....
Author correction to ‘FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis’ [Acta Pharmaceutica Sinica B 14(2024)1605-1623]
Author correction to ‘FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis’ [Acta Pharmaceutica Sinica B 14(2024)1605-1623]
Available online 9 April 2024Author links open overlay panel, , , , , , , , , , , , , , , © 2024 The Author(s). Published ...
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Pancreatic cancerTumor adjacent normal tissue fibroblasts (NAF)DesmoplasiaExtracellular vesiclesExosomesTumor targetingOrm...
Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis
Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis
Available online 5 April 2024Author links open overlay panel, , , , , , , , , , , , AbstractGlycosylation is an important ...
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy
Bimetallic nanoparticlesRadio-immunotherapyCascade sensitizing amplifierOxaliplatinFenton-type Haber‒Weiss reactionRadiose...
Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform
Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform
Droplet microfluidicsAntimicrobial resistanceAntibiotic combinatorial screeningContact printingRoboticsPharmaceutical anal...
A novel deep generative model for mRNA vaccine development: Designing 5′ UTRs with N1-methyl-pseudouridine modification
A novel deep generative model for mRNA vaccine development: Designing 5′ UTRs with N1-methyl-pseudouridine modification
Volume 14, Issue 4, April 2024, Pages 1814-1826Author links open overlay panel, , , , , , , , , , , , , , , , , , Abstract...
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches
immunogenic cell deathImmunogenic eradicationNanomedicinesDrug deliverycancer immunotherapyAntitumor immunityT cellsTumor ...
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood-brain barrier
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood-brain barrier
Available online 20 March 2024Author links open overlay panel, , , , , , , , , , , , KeywordsNanoparticleDrug delivery sys...
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases
Available online 21 March 2024Author links open overlay panel, , , , , , , , , , , , AbstractLipogenesis is often highly u...
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis
Available online 18 March 2024Author links open overlay panel, , , , , , , , AbstractSrc homology 2 domain-containing tyro...
Computer-aided molecular design and optimization of potent inhibitors disrupting APC‒Asef interaction
Computer-aided molecular design and optimization of potent inhibitors disrupting APC‒Asef interaction
APC‒AsefPeptidomimeticComputer-aided molecular designONIOM modelπ‒π stackingMetastatic colorectal cancer© 2024 Published b...
Nanotherapeutics targeting autophagy regulation for improved cancer therapy
Nanotherapeutics targeting autophagy regulation for improved cancer therapy
Autophagy regulationNanotherapeuticCombination strategiesCancer therapySignal transduction pathwayDelivery strategiesDual ...
Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer
Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer
Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lu...
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer
Triple-negative breast cancerAndrogen receptorCheckpoint kinase 1EnzalutamideMK-8776SynergyHMnO2Nanodrug delivery system© ...
Single-domain antibodies as therapeutics for solid tumor treatment
Single-domain antibodies as therapeutics for solid tumor treatment
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNA...
Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases
Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases
Available online 15 March 2024Author links open overlay panel, , , , , , AbstractDrug repurposing offers a valuable strate...
Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling
Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling
glp-1 RasSTING signalingRetinal endothelial cellsMitochondrial leakageRetinal vascular dysfunctionDiabetic retinopathyCREB...
An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota
An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota
Helicobacter pylori infectionAntibiotic-freeBiofilmsAutophagyGastric mucosal repairDrug resistanceIntestinal microbiotaAnt...
Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway
Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway
Available online 10 March 2024Author links open overlay panel, , , , , , , , , , , , , , AbstractOncolytic viruses (OVs), ...
Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma
Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma
Available online 10 March 2024Author links open overlay panel, , , , , , , , , , AbstractCyclin D1 has been recognized as ...
Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis
Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis
IdebenoneDOX-induced cardiotoxicityFerroptosisFSP1UbiquitinationLipid peroxidationIron overloadClinical translation© 2024 ...
Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy
Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy
ComplicationsComorbiditiesChemotherapyPreclinical cancer modelsDrug designDrug delivery© 2024 The Authors. Published by El...
ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT
ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT
Histone lactylationAtherosclerosisEndothelial-to-mesenchymal transitionASF1ASNAI1Endothelial dysfunctionLactateEpigenetic©...
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