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Forced Degradation Products of Liraglutide: A Comparative Study of Similarity Between Originator and Analogue Version by Liquid Chromatography–Mass Spectrometry
Forced Degradation Products of Liraglutide: A Comparative Study of Similarity Between Originator and Analogue Version by Liquid Chromatography–Mass Spectrometry
The drug Liraglutide is an acylated analogue of glucagon-like peptide-1 (GLP-1) which is indicated for the treatment of ty...
In Situ Assembly of Melittin-PHA Microspheres for Enhancing Therapeutic Efficacy in Cancer Treatment
In Situ Assembly of Melittin-PHA Microspheres for Enhancing Therapeutic Efficacy in Cancer Treatment
Amphiphilic cationic peptide (ACP) is a widely studied biofilm-active peptide that has great potential in cancer treatment...
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Antimicrobial peptides (AMPs) are promising candidates for the development of new drugs. However, thorough studies on the ...
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Biofilm formation empowers microorganisms to withstand clearance mechanisms produced by host and synthetic sources. Biofil...
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Imidazole peptides possess multiple functions, including antioxidant effects, although their biological activities are lar...
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Gross morphology of knee joint surfaces; femoral condyles (F) and tibial plateaus (T). Arrowheads indicate the MIA-induced...
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, an inhibitor of voltage-gated sodium and potassium channels, is derived from the venom of the spider Chilobrachys ...
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Snake venom metalloproteinases (SVMPs) are enzymatic proteins found in snake venom and are known for their diverse biologi...
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
Dental caries is a prevalent and costly disease throughout the world. Streptococcus mutans is widely recognized as one of ...
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
Viral infections are continually emerging with new characteristics and the potential to cause outbreaks or pandemics. Ther...
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Over the last three decades, treatment of stroke and acute myocardial infarction (AMI) has been improved, but it has stagn...
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
Human tankyrase-1 is an important regulator of poly(ADP-ribosyl)ation (PARylation) of Wnt/β-catenin signaling and has...
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Kyotorphin (KTP) dipeptide (l-Tyrosine-l-Arginine) and their derivatives possess a multitude of functions, qualifying them...
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptides, as therapeutic agents, can mimic the actions of molecules involved in inflammatory disorders. Antimicrobial pept...
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
The peptide melittin is a promising possibility for cancer treatment. The present research evaluated the anticancer impact...
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Endotoxin, also identified as lipopolysaccharide (LPS), is considered the pathogenic factor of septic shock triggered by G...
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties enco...
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Eupolyphaga sinensis Walker (ESW), an animal drug in traditional Chinese medicine, has been used clinically for thousands ...
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Diabetes mellitus (DM) is a chronic endocrine disorder with lifelong implications. The prevalence of this condition is ste...
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
In this comprehensive investigation, we conducted a rigorous analysis of antimicrobial peptides (AMPs) within two venomous...
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
In this study, an antimicrobial protein (AMP) from the epidermis of catfish (Clarias batrachus) was purified and character...
Investigating the Characteristics of Nanoliposomes Carrying Bioactive Peptides Obtained from Shrimp Waste
Investigating the Characteristics of Nanoliposomes Carrying Bioactive Peptides Obtained from Shrimp Waste
The aim of the paper was to develop chitosan-coated nanoliposomes for carrying bioactive peptides derived from hydrolyzed ...
Lipopeptide Biosurfactant Produced by Acinetobacter junii B6 Attenuates Lung Inflammatory, Oxidative, and Histopathological Alterations due to Asthma in Rats
Lipopeptide Biosurfactant Produced by Acinetobacter junii B6 Attenuates Lung Inflammatory, Oxidative, and Histopathological Alterations due to Asthma in Rats
The two main characteristics of asthma pathogenesis are severe inflammation and excessive oxidative stress production. Bio...
Systematic Profiling of Mitogen-Inducible Gene 6 and Its Derived Peptides Binding to Receptor Tyrosine Kinases in Bone Cancers at Molecular and Cellular Levels
Systematic Profiling of Mitogen-Inducible Gene 6 and Its Derived Peptides Binding to Receptor Tyrosine Kinases in Bone Cancers at Molecular and Cellular Levels
Mitogen-inducible gene 6 (Mig6) is a tumor suppressor that inactivates oncogenic kinases by disrupting the dimerization of...
Design and Production of a Chimeric Enzyme with Efficient Antibacterial Properties on Staphylococcus aureus
Design and Production of a Chimeric Enzyme with Efficient Antibacterial Properties on Staphylococcus aureus
Improper use of antibiotics has alarmingly led to the emergence of antibiotic resistance. Hence, this necessitated an urge...
The Types and Applications of Peptibodies
The Types and Applications of Peptibodies
Peptides as drugs are a promising therapeutic method. Peptides modulate diverse biological processes and are synthesized w...
Scaled-up Synthesis and Characterization of Oxytocin Trisulfide
Scaled-up Synthesis and Characterization of Oxytocin Trisulfide
The title peptide, oxytocin trisulfide (3), was required on a multi-100 mg scale, as part of an analytical method...
Evaluation of the Antimicrobial Efficacy of Epidermal Mucus Extract from Air-Breathing Fish (Channa punctatus) and Identification of the Peptides Serving as Immune Components
Evaluation of the Antimicrobial Efficacy of Epidermal Mucus Extract from Air-Breathing Fish (Channa punctatus) and Identification of the Peptides Serving as Immune Components
Fish and other members of aquatic habitats are in constant contact with the microbes that trigger their immune system to p...
Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth factor receptor (EGFR) and its d...
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers....
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