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Peptide Based Engineering of Extracellular Vesicles for Cancer Theranostics and Vaccine
Peptide Based Engineering of Extracellular Vesicles for Cancer Theranostics and Vaccine
Cancer poses a significant global health challenge, with conventional treatments often leading to high toxicity and limite...
Scorpion Venom Peptides as Therapeutic Agents in Cardiovascular Diseases: A Systematic Review
Scorpion Venom Peptides as Therapeutic Agents in Cardiovascular Diseases: A Systematic Review
Scorpions have evolved a highly efficient venom that serves both to capture prey and for self-defense. As a result, peptid...
Synthetic Studies of the Mutant Proinsulin Syndrome Demonstrate Correlation Between Folding Efficiency and Age of Diabetes Onset
Synthetic Studies of the Mutant Proinsulin Syndrome Demonstrate Correlation Between Folding Efficiency and Age of Diabetes Onset
Heterozygous mutations in the insulin gene can give rise to a monogenic diabetes syndrome due to toxic misfolding of the v...
Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application
Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application
The thymus is the main lymphoid organ that regulates the functions of the immune system, protecting against pathogens, tum...
In vivo Immunogenicity and Antigenicity of MAP-8 Peptides Derived from the Structural and Non-Structural Proteins of Canine Parvovirus Type 2
In vivo Immunogenicity and Antigenicity of MAP-8 Peptides Derived from the Structural and Non-Structural Proteins of Canine Parvovirus Type 2
Canine parvovirus is a viral disease associated with the infection with the canine parvovirus type 2 (CPV-2). Virus-attenu...
Biotinylated Heptapeptides with D-amino Acids Suppress Allergic Reactions by Inhibiting Mast Cell Activation and Antagonizing the Histamine Receptor
Biotinylated Heptapeptides with D-amino Acids Suppress Allergic Reactions by Inhibiting Mast Cell Activation and Antagonizing the Histamine Receptor
Mast cells play an important role in allergic reactions by releasing potent mediators, including histamine and platelet-ac...
Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview
Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview
This review aims to elucidate the mechanisms employed by antiviral peptides in inhibiting coronaviruses as well as related...
Study of Image Processing Method for Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP/CPPS) Mice Model
Study of Image Processing Method for Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP/CPPS) Mice Model
We determine the prostatic interstitium area, the inflammation’s localization, and the impact of different doses on ...
Recent Discoveries of Antifungal Activity in Plant Antimicrobial Peptides
Recent Discoveries of Antifungal Activity in Plant Antimicrobial Peptides
Antimicrobial peptides (AMPs) are positive-charged small molecules of less than 50 amino acids, with antibacterial and ant...
A Specialized and Comprehensive Resource of Antiviral Peptides against Ebola Virus
A Specialized and Comprehensive Resource of Antiviral Peptides against Ebola Virus
Ebola virus (EBOV), a member of the Filoviridae family, causes EBOV disease (EVD), a highly fatal and neglected tropical d...
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. Natural compounds, such as...
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (C...
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
The melanocortin system has been implicated in regulating various physiological pathways including skin and hair pigmentat...
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
One of the problems of diabetic patients is the formation of ulcers in the lower areas, especially the legs, and the treat...
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
The antimicrobial activity of two peptides, Uy234 derived from the venom of the scorpion Urodacus yaschenkoi and a consens...
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Basal insulin therapy is conventionally achieved by one of two broad medicinal approaches that entail either protracted ab...
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
The lionfish, originally from the Indo-Pacific, has become established in the western Atlantic Ocean and the Caribbean Sea...
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Despite significant advancements in peptide chemistry, the persistent occurrence of aspartimide formation during peptide s...
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
This review aims to elucidate the mechanisms employed by Host Defense Peptides (HDPs) in propagating their effector functi...
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
The successful synthesis of a peptide requires the synchronization of several processes, including the efficient execution...
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Bacteria produce antimicrobial compounds to compete for nutrients and space in particular habitat. Bacteria of the genus P...
Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations
Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations
Snakebite envenomation, classified as a neglected tropical disease, represents a significant global health threat, particu...
AI-Driven Design of Cell-Penetrating Peptides for Therapeutic Biotechnology
AI-Driven Design of Cell-Penetrating Peptides for Therapeutic Biotechnology
Cell-penetrating peptides (CPPs) are short sequences of amino acids, typically ranging from 5 to 30 residues, known for th...
Thionin Production in Elicited Plant Cell Suspension and its Application as Antibacterial, Anticancer and Anti-Inflammatory Agent
Thionin Production in Elicited Plant Cell Suspension and its Application as Antibacterial, Anticancer and Anti-Inflammatory Agent
Antibiotic resistance poses a global health threat. It reduces the effectiveness of antibiotics against bacterial infectio...
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation
By outsmarting antibiotics, the multidrug-resistant microbial strains, so-called ‘superbugs’ have rapidly evol...
Exploring Fish Antimicrobial Peptides (Amps): Classification, Biological Activities, and Mechanisms of Action
Exploring Fish Antimicrobial Peptides (Amps): Classification, Biological Activities, and Mechanisms of Action
Despite the growing productivity of aquaculture, economic losses due to infectious diseases, environmental pollution, and ...
Alleviation of LPS-induced Endothelial Injury due to GHRH Antagonist Treatment
Alleviation of LPS-induced Endothelial Injury due to GHRH Antagonist Treatment
GHRH is produced in the hypothalamus and affects various tissues beyond the pituitary, including the lungs.GHRH antagonist...
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers
Disulfide bonds provide a convenient method for chemoselective alteration of peptide and protein structure and function. W...
De Novo Design and Characterization of Novel Antimicrobial Peptides, Lk3 and Lk4, Containing Repeating Unit
De Novo Design and Characterization of Novel Antimicrobial Peptides, Lk3 and Lk4, Containing Repeating Unit
Short cationic antimicrobial peptides (AMPs) have an excellent potential for treating various infections. This study focus...
Moroccan Naja haje Venom and its Peptides: In Vivo Toxicity and In Vitro Antiproliferative Effect on Hepatocellular Carcinoma HepG2 Cells
Moroccan Naja haje Venom and its Peptides: In Vivo Toxicity and In Vitro Antiproliferative Effect on Hepatocellular Carcinoma HepG2 Cells
Snake venom, despite its toxicity, presents notable therapeutic potential by specifically targeting tumor cells to inhibit...
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