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Hard gelatin capsules containing hot melt extruded solid crystal suspension of carbamazepine for improving dissolution: Preparation and in vitro evaluation
Aqueous solubility is one of the key parameters for achieving the desired drug concentration in systemic circulation for b...
In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers
Nanocrystals (NCs) are considered as an effective strategy for the formulation of intravenous injections for poorly water-...
Quality evaluation of white sugar crystals using the friability test and their non-destructive prediction using near-infrared spectroscopy
KeywordsSucrose crystalsNear-infrared spectroscopyReal-time monitoringFriability testLoss of sample weightChemometricsPart...
Sorafenib loaded ZIF-8 metal-organic frameworks as a multifunctional nano-carrier offers effective hepatocellular carcinoma therapy
Hepatocellular carcinoma (HCC) is a primary malignant neoplasia of the liver and sorafenib is one of the most commonly use...
Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation optimization and characterization of enhanced properties
Sorafenib, marketed under the brand name Nexavar®, is a multiple tyrosine kinase inhibitor drug that has been actively use...
Delivery of artemether for the treatment of colorectal cancer liver metastases according to a sugar-coated cannonball strategy
Artemisinin or its derivatives possess a remarkable capacity to exert anti-colorectal cancer (CRC) effects depending on hi...
Anticancer activity of NFκB decoy oligonucleotide-loaded nanoparticles against human lung cancer
Non-small cell lung cancer (NSCLC) is among the leading global causes of cancer-related mortality. Current treatment optio...
Tackling the cytokine storm using advanced drug delivery in allergic airway disease
Asthma is one of the leading causes of mortality worldwide presenting a huge socio-economic burden with rising morbidity a...
Oral lyophilizates obtained using aggressive drying conditions: Effect of excipients
Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and ger...
Bio-inspired synthesis of CdO nanoparticles using Citrus limetta peel extract and their diverse biomedical applications
Nowadays, the green chemistry approach for nanoparticle (NP) synthesis has acquired a plethora of interest due to its expe...
3-Carene-loaded poloxamer micelles against Leishmania: Development, characterization and in vitro proof-of-concept
Leishmaniases are parasitic diseases that affect millions of people around the world. Pharmacotherapy has limitations emph...
A comparison between optimized PLGA and CS-Alg-PLGA microspheres for long-lasting release of glatiramer acetate
Glatiramer acetate (GA, Copaxone, COP, Copolymer-1) is one of the most prescribed drugs to treat relapsing-remitting multi...
Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration
Age-related macular degeneration (AMD) is a major health concern in the ageing human population. Though existing therapeut...
NIR-responsive, lapatinib-loaded gold nanorods for combined photothermal and pharmacological treatment of HER2 positive breast cancer: In vitro evaluation and cell studies
BackgroundLapatinib (LPT)-loaded gold nanorods and pegylated gold nanorods were synthesized in this work with the long-ter...
Fabrication of bergenin nanoparticles based hydrogel against infected wounds: An In vitro and In vivo study
The present study was aimed to fabricate bergenin polymeric nanoparticles based hydrogel and to evaluate its therapeutic e...
Development of dexamethasone suspension eye drops: A comparative investigation of ternary and quaternary cyclodextrin aggregates
Many non-invasive novel nano-formulations were used for delivery from the ocular surface to posterior segment of the eye, ...
Micronization of naringenin in supercritical fluid medium: In vitro and in vivo assays
Naringenin is a citrus flavonoid that shows relevant biological actions. However, naringenin presents low solubility in wa...
Selective targeting of gold nanoparticles for radiosensitization of somatostatin 2 receptor-expressing cancer cells
Lanreotide peptide (LP), a somatostatin analog with high affinity towards somatostatin receptor 2 (SSTR2) is commonly used...
Synergistic effect of vancomycin and gallic acid loaded MCM-41 mesoporous silica nanoparticles for septic arthritis management
Treatment of septic arthritis has become a major challenge due to the increasing frequency of antibiotic resistance develo...
Pulmonary delivery of curcumin and quercetin nanoparticles for lung cancer – Part 2: Toxicity and endocytosis
The delivery of polyphenol compounds via inhalation to treat lung cancer is attractive to enable high drug concentration i...
Quality by design-oriented formulation optimization and characterization of guar gum-pectin based oral colon targeted liquisolid formulation of xanthohumol
In the present study a colon targeted liquisolid powder of xanthohumol was developed using Central Composite Design (CCD)....
Development of doxycycline and atorvastatin-loaded chitosan nanoparticles for local delivery in periodontal disease
The effectiveness of the local treatment depends on the ability of the release system to deliver drugs efficiently as well...
Evodiamine-loaded rhEGF-conjugated bovine serum albumin nanoparticles alleviate indomethacin-associated gastric mucosal injury in male SD rats
Gastric mucosal injury, the most common adverse effect of non-steroidal anti-inflammatory drugs, severely threatens human ...
pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil
The rapid rise of cancer worldwide demonstrates the importance of treatment strategies. In addition to reduce the side eff...
Fabrication of betaxolol hydrochloride-loaded highly permeable ocular bilosomes (HPOBs) to combat glaucoma: In vitro, ex vivo & in vivo characterizations
Betaxolol hydrochloride is a water-soluble antiglaucoma drug suffering from poor ocular bioavailability necessitating frequ...
Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy
The application of nanoparticle-based delivery systems is limited by uncontrolled drug release, limited tumor penetration,...
Antisolvent Eudragit® polymers based in situ forming gel for periodontal controlled drug delivery
In situ forming gel (ISG) is relevant for periodontal pocket drug delivery because of its local administration with sustai...
QbD assisted formulation design and optimization of thiol pectin based Polyethyleneglycol and Montmorillonite(PEG/MMT) nanocomposite films of neomycin sulphate for wound healing
Skin wound healing, especially for chronic sores like diabetic foot ulcers, is still a medical emergency. Despite the abun...
Biocompatible pectin-functionalised-halloysite loaded poly(vinyl alcohol) nanocomposite films for tissue engineering applications
The present study brings out the affirmative knowledge on covalently modified halloysite nanotube (HNT) with the biopolyme...
Anti-biofilm potential against P. aeruginosa biofilm in cystic fibrosis infection by systemically developed garlic extract incorporated liposomal formulation
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