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The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
Vulvar squamous cell carcinoma (VSCC) is a rare disease with a poor prognosis. To date, there’s no proper in vitro m...
Compartmental Syndecan-1 (CD138) expression as a novel prognostic marker in triple-negative metaplastic breast cancer
Compartmental Syndecan-1 (CD138) expression as a novel prognostic marker in triple-negative metaplastic breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype, representing about 10–15% of all malignant ...
Carney Complex: A Clinicopathologic Study on A Single Family from Several Canadian Provinces
Carney Complex: A Clinicopathologic Study on A Single Family from Several Canadian Provinces
Carney complex (CNC, also known as Carney syndrome, NAME syndrome [Nevi, Atrial Myxoma, Myxoid neurofibromas, and Ephelide...
A Fetal Rat Model of Ventricular Non-compaction Caused by Intrauterine Hyperglycemia
A Fetal Rat Model of Ventricular Non-compaction Caused by Intrauterine Hyperglycemia
MethodsFemale SD rats were categorized into STZ, RA, and normal control (NC) groups. The STZ group was given a high-fat di...
Emerging role and clinical implication of mRNA scavenger decapping enzyme in colorectal cancer
Emerging role and clinical implication of mRNA scavenger decapping enzyme in colorectal cancer
BackgroundTurnover of RNA is a regulated process that in part controls gene expression. This process is partly controlled ...
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β is related to the function of T cells in the tumor microenvironment. However, the characteristics of TGF-β...
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
In recent years, there have been great improvements in the therapy of renal cell carcinoma. Nevertheless, the therapeutic ...
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in...
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
High levels of heterogeneity and immunosuppression characterize the HCC immune microenvironment (TME). Unfortunately, the ...
Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review
Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review
The BRAF p.V600E genetic variant facilitates the pathogenesis of various tumors by triggering tumor proliferation and prog...
Gnathic Schwannomas: A Report of Two Cases and Systematic Review of the Literature
Gnathic Schwannomas: A Report of Two Cases and Systematic Review of the Literature
The intraosseous schwannoma (IS) is a benign peripheral nerve sheath tumor postulated to arise de novo or from nerve fiber...
Benign Mesothelial Cells in transbronchial biopsy specimens: A potential diagnostic pitfall for lung cancer
Benign Mesothelial Cells in transbronchial biopsy specimens: A potential diagnostic pitfall for lung cancer
Recent advances in the diagnosis and treatment of lung cancer have dramatically improved the therapeutic landscape [1]. A ...
A bioinformatics-based approach and expression assay for identification of dysregulated genes in pituitary adenoma
A bioinformatics-based approach and expression assay for identification of dysregulated genes in pituitary adenoma
Pituitary neuroendocrine tumors (PitNETs) are classified as a type of intracranial tumors [2]. Patients affected by these ...
Transbronchial brushing cytology and paired biopsy in endobronchial tuberculosis: A report of 72 cases focusing on the morphological features
Transbronchial brushing cytology and paired biopsy in endobronchial tuberculosis: A report of 72 cases focusing on the mor...
Role of O-GlcNAcylation in cancer biology
Role of O-GlcNAcylation in cancer biology
It is well known that post-translational modification of proteins is essential to control and regulate cell processes, the...
BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands
BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands
Salivary gland tumors represent about 6% of neoplasms in the head and neck region and comprise a wide variety of benign an...