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Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease
Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also reg...
Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes
Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes
Schizophrenia is a complex multifactorial disorder and increasing evidence suggests the involvement of immune dysregulatio...
Microglia in the aged brain develop a hypoactive molecular phenotype after surgery
Microglia in the aged brain develop a hypoactive molecular phenotype after surgery
Microglia, the resident immune cells of the brain, play a crucial role in maintaining homeostasis in the central nervous s...
Peripheral immune cell dysregulation following diffuse traumatic brain injury in pigs
Peripheral immune cell dysregulation following diffuse traumatic brain injury in pigs
Traumatic brain injury (TBI) is a global health problem affecting millions of individuals annually, potentially resulting ...
Dorsoventral photobiomodulation therapy safely reduces inflammation and sensorimotor deficits in a mouse model of multiple sclerosis
Dorsoventral photobiomodulation therapy safely reduces inflammation and sensorimotor deficits in a mouse model of multiple sclerosis
Non-invasive photobiomodulation therapy (PBMT), employing specific infrared light wavelengths to stimulate biological tiss...
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis
Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis
The Gas6/TAM (Tyro3, Axl, and Mer) receptor system has been implicated in demyelination and delayed remyelination in exper...
Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice
Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice
Glyphosate use in the United States (US) has increased each year since the introduction of glyphosate-tolerant crops in 19...
Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
Uveitis manifests as immune-mediated inflammatory disorders within the eye, posing a serious threat to vision. The ketogen...
Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are leading neurodegenerative disorders marked by protei...
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine
Chronic migraine (CM) is a serious neurological disorder. Central sensitization is one of the important pathophysiological...
A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats
A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats
Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with motor incoordination which is reproduced ...
TRPM7 contributes to pyroptosis and its involvement in status epilepticus
TRPM7 contributes to pyroptosis and its involvement in status epilepticus
Pyroptosis, a novel form of programmed cell death, has been implicated in neurodegeneration diseases. However, its role in...
Impact of perinatal factors on T cells and transcriptomic changes in preterm infant brain injury
Impact of perinatal factors on T cells and transcriptomic changes in preterm infant brain injury
T cells have been implicated in various neurological conditions, yet their role in neonatal brain injuries remains unclear...
CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder
CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorder (NMOSD) is an autoantibody-triggered central nervous system (CNS) demyelinating dis...
Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in cerebral ischemia
Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in cerebral ischemia
Neuronal death is the primary cause of poor outcomes in cerebral ischemia. The inflammatory infiltration in the early phas...
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2+/− rat model
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2+/− rat model
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been prev...
Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
Brain takes up approximately 20% of the total body oxygen and glucose consumption due to its relatively high energy demand...
Taprenepag restores maternal–fetal interface homeostasis for the treatment of neurodevelopmental disorders
Taprenepag restores maternal–fetal interface homeostasis for the treatment of neurodevelopmental disorders
Neurodevelopmental disorders (NDDs) are characterized by abnormalities in brain development and neurobehaviors, including ...
Engrailed-2 and inflammation convergently and independently impinge on cerebellar Purkinje cell differentiation
Engrailed-2 and inflammation convergently and independently impinge on cerebellar Purkinje cell differentiation
Autism spectrum disorders (ASD) have a complex pathogenesis thought to include both genetic and extrinsic factors. Among t...
Imaging the eye as a window to brain health: frontier approaches and future directions
Imaging the eye as a window to brain health: frontier approaches and future directions
Recent years have seen significant advances in diagnostic testing of central nervous system (CNS) function and disease. Ho...
TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure
TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure
Obesity has become a global pandemic, marked by significant shifts in both the homeostatic and hedonic/reward aspects of f...
Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling
Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of neurological and immunological effects thr...
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage
The incidence of growth hormone deficiency (GHD) after subarachnoid hemorrhage (SAH) is significantly higher than that of ...
IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production
IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production
Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis ...
Sentinels of neuroinflammation: the crucial role of myeloid cells in the pathogenesis of gliomas and neurodegenerative diseases
Sentinels of neuroinflammation: the crucial role of myeloid cells in the pathogenesis of gliomas and neurodegenerative diseases
The inflammatory processes that drive pathologies of the central nervous system (CNS) are complex and involve significant ...
Fueling neurodegeneration: metabolic insights into microglia functions
Fueling neurodegeneration: metabolic insights into microglia functions
Microglia, the resident immune cells of the central nervous system, emerge in the brain during early embryonic development...
The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy
The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy
Despite great advances in proliferative diabetic retinopathy (PDR) therapy over the last decades, one third of treated pat...
Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism
Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals a...
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss
Diabetes-associated cognitive dysfunction, characterized by hippocampal synaptic loss as an early pathological feature, se...
Reimagining the meninges from a neuroimmune perspective: a boundary, but not peripheral
Reimagining the meninges from a neuroimmune perspective: a boundary, but not peripheral
Recent advances in neuroscience have transformed our understanding of the meninges, the layers surrounding the central ner...
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