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Fueling neurodegeneration: metabolic insights into microglia functions
Fueling neurodegeneration: metabolic insights into microglia functions
Microglia, the resident immune cells of the central nervous system, emerge in the brain during early embryonic development...
The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy
The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy
Despite great advances in proliferative diabetic retinopathy (PDR) therapy over the last decades, one third of treated pat...
Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism
Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals a...
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss
Diabetes-associated cognitive dysfunction, characterized by hippocampal synaptic loss as an early pathological feature, se...
Reimagining the meninges from a neuroimmune perspective: a boundary, but not peripheral
Reimagining the meninges from a neuroimmune perspective: a boundary, but not peripheral
Recent advances in neuroscience have transformed our understanding of the meninges, the layers surrounding the central ner...
Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring
Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring
Congenital cytomegalovirus (CMV) infections represent one leading cause of human neurodevelopmental disorders. Despite the...
Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review
Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review
Postoperative cognitive dysfunction (POCD) is a frequent neurological complication encountered during the perioperative pe...
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation
Neurodegeneration and neuroinflammation are key components in the pathogenesis of Japanese Encephalitis caused by Japanese...
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway
Circulating miR-30c-2-3p has been closely related to vascular diseases, however, its role and underlying mechanisms in isc...
Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate
Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate
Acute intoxication with cholinesterase inhibiting organophosphates (OP) can produce life-threatening cholinergic crisis an...
Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids
Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids
Neural stem cells have intact innate immune responses that protect them from virus infection and cell death. Yet, viruses ...
Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids
Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids
Chronic ethanol exposure (CEE) is recognized as an important risk factor for depression, and the gut-brain axis has emerge...
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells
Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the molecular underpinnings of thi...
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
Immune dysregulation is a hallmark of autoimmune diseases of the central nervous system (CNS), characterized by an excessi...
Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation
Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation
Immune cell metabolism governs the outcome of immune responses and contributes to the development of autoimmunity by contr...
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent ...
The role of alemtuzumab in the development of secondary autoimmunity in multiple Sclerosis: a systematic review
The role of alemtuzumab in the development of secondary autoimmunity in multiple Sclerosis: a systematic review
Secondary autoimmune disease (SAID) in the context of alemtuzumab treatment is one of the main safety concerns that may ar...
Interleukin-6 deficiency reduces neuroinflammation by inhibiting the STAT3-cGAS-STING pathway in Alzheimer’s disease mice
Interleukin-6 deficiency reduces neuroinflammation by inhibiting the STAT3-cGAS-STING pathway in Alzheimer’s disease mice
The Interleukin-6 (IL-6)-signal transducer and activator of transcription 3 (STAT3) pathway, along with the cyclic GMP-AMP...
Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner
Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner
Genome-wide association studies have identified a protective mutation in the phospholipase C gamma 2 (PLCG2) gene which co...
Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus
Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus
Microglia, a type of resident immune cells within the central nervous system, have been implicated in ethanol-activated ne...
Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression
Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression
Japanese encephalitis virus (JEV) is a neurotropic and neuroinvasive flavivirus causing viral encephalitis, which seriousl...
IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
Brain microglia and infiltrating monocyte-derived macrophages are vital in preserving blood vessel integrity after stroke....
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
Autophagy dysfunction in glial cells is implicated in the pathogenesis of Parkinson’s disease (PD). The previous stu...
Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways
Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways
Bruton’s tyrosine kinase (BTK) is an intracellular signaling enzyme that regulates B-lymphocyte and myeloid cell fun...
Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury
Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury
Delirium affects 50–85% of patients on mechanical ventilation and is associated with increased mortality, prolonged ...
Impairment of neuronal tyrosine phosphatase STEP worsens post-ischemic inflammation and brain injury under hypertensive condition
Impairment of neuronal tyrosine phosphatase STEP worsens post-ischemic inflammation and brain injury under hypertensive condition
Hypertension is associated with poor outcome and higher mortality in patients with ischemic stroke. The impairment of adap...
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive dysfunction in older adults. One of th...
Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model
Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model
Accumulation of immune cells and proteins in the subarachnoid space (SAS) is found during multiple sclerosis and in the an...
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Patients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TB...
Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage
Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which resu...
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