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Early depletion of gut microbiota shape oligodendrocyte response after traumatic brain injury
Early depletion of gut microbiota shape oligodendrocyte response after traumatic brain injury
White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain i...
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, i...
Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy
Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy
Post-traumatic epilepsy (PTE) is one of the most debilitating consequences of traumatic brain injury (TBI) and is one of t...
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway
The microglia-mediated neuroinflammation have been shown to play a crucial role in the ocular pathological angiogenesis pr...
Role of inflammation in a rat model of radiation retinopathy
Role of inflammation in a rat model of radiation retinopathy
Radiation retinopathy (RR) is a major side effect of ocular tumor treatment by plaque brachytherapy or proton beam therapy...
Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis
Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis
Pediatric acute transverse myelitis (ATM) accounts for 20–30% of children presenting with a first acquired demyelina...
Correction: Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
Correction: Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
Cystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demye...
Estrogen-immuno-neuromodulation disorders in menopausal depression
Estrogen-immuno-neuromodulation disorders in menopausal depression
A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult...
Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period
Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period
Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phas...
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognit...
Delayed plasma kallikrein inhibition fosters post-stroke recovery by reducing thrombo-inflammation
Delayed plasma kallikrein inhibition fosters post-stroke recovery by reducing thrombo-inflammation
Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic strok...
Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation
Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation
Extracellular vesicles (EVs) are released by all cells, can cross the blood–brain barrier, and have been shown to pl...
Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system
Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system
Mounting evidence links glucose intolerance and diabetes as aspects of metabolic dysregulation that are associated with an...
Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging
Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging
Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During ...
Exploratory assessment of the effect of systemic administration of soluble glycoprotein 130 on cognitive performance and chemokine levels in a mouse model of experimental traumatic brain injury
Exploratory assessment of the effect of systemic administration of soluble glycoprotein 130 on cognitive performance and chemokine levels in a mouse model of experimental traumatic brain injury
Uncontrolled neuroinflammation mediates traumatic brain injury (TBI) pathology and impairs recovery. Interleukin-6 (IL-6),...
Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review
Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review
Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly spo...
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with indistinct etiology and ill-defined pathophy...
Therapeutic role of interferon-γ in experimental autoimmune encephalomyelitis is mediated through a tolerogenic subset of splenic CD11b+ myeloid cells
Therapeutic role of interferon-γ in experimental autoimmune encephalomyelitis is mediated through a tolerogenic subset of splenic CD11b+ myeloid cells
Cumulative evidence has established that Interferon (IFN)-γ has both pathogenic and protective roles in Multiple Scle...
Differences in the characteristics and functions of brain and spinal cord regulatory T cells
Differences in the characteristics and functions of brain and spinal cord regulatory T cells
T cells play an important role in the acquired immune response, with regulatory T cells (Tregs) serving as key players in ...
cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma
cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma
Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decision...
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs
Intrauterine inflammation is considered a major cause of brain injury in preterm infants, leading to long-term neurodevelo...
Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury
Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury
The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function followi...
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
The dysregulation of pro- and anti-inflammatory processes in the brain has been linked to the pathogenesis of major depres...
Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming
Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming
Hyperglycemia has been shown to modulate the immune response of peripheral immune cells and organs, but the impact of hype...
CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis
CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis
Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying i...
The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, particularly among the elderly, yet o...
Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhage
Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhage
Perihematomal edema (PHE) after post-intracerebral hemorrhage (ICH) has complex pathophysiological mechanisms that are poo...
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances
Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances
Behcet’s disease (BD) is a rare but globally distributed vasculitis that primarily affects populations in the Medite...
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