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Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes
Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal ...
Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the preventi...
Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis
Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis
Diet-induced increase in body weight is a growing health concern worldwide. Often accompanied by a low-grade metabolic inf...
Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis
Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflamma...
Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
Cerebral malaria (CM) is the most lethal complication of malaria, and survivors usually endure neurological sequelae. Nota...
Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain
Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain
Despite the high prevalence of neuropathic pain, treating this neurological disease remains challenging, given the limited...
Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Pneumonia is a common comorbidity in patients with severe traumatic brain injury (TBI), and is associated with increased m...
Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB c...
Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
Hepatic encephalopathy (HE) is closely associated with inflammatory responses. However, as a crucial regulator of the immu...
Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation
Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation
Subarachnoid hemorrhage (SAH), a severe subtype of stroke, is characterized by notably high mortality and morbidity, large...
Maternal immunoglobulin G affects brain development of mouse offspring
Maternal immunoglobulin G affects brain development of mouse offspring
Maternal immunoglobulin (Ig)G is present in breast milk and has been shown to contribute to the development of the immune ...
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous s...
Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing
Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing
Dimethyl fumarate (DMF) is a fumaric acid ester that exhibits immunoregulatory and anti-inflammatory properties. However, ...
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alph...
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive...
CSF1R antagonism results in increased supraspinal infiltration in EAE
CSF1R antagonism results in increased supraspinal infiltration in EAE
Colony stimulating factor 1 receptor (CSF1R) signaling is crucial for the maintenance and function of various myeloid subs...
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal lim...
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain
The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucida...
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades...