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APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of...
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis
Due to the complexity of the mechanisms involved in epileptogenesis, the available antiseizure drugs (ASDs) do not meet cl...
Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats
Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats
Neuronal injury is considered a critical risk factor in the pathogenesis of most neurological and neuropsychiatric disease...
Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
The long-term functional recovery of traumatic brain injury (TBI) is hampered by pathological events, such as parenchymal ...
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the ...
Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury
Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury
Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chro...
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric...
The neuropeptide PACAP alleviates T. gondii infection-induced neuroinflammation and neuronal impairment
The neuropeptide PACAP alleviates T. gondii infection-induced neuroinflammation and neuronal impairment
Cerebral infection with the protozoan Toxoplasma gondii (T. gondii) is responsible for inflammation of the central nervous...
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
Microglia represent the first line of immune feedback in the brain. Beyond immune surveillance, they are essential for mai...
Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency
Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency
Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative pho...
Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular prolif...
Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TB...
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), ...
Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination
Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination
Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contras...
A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations
A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations
Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The ...
ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation
ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation
The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely understood. Axonal stress signals ...
Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting a...
Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury
Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury
The aim of this study was to establish a complete retinal cell atlas of ischemia–reperfusion injury by single-cell R...
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or c...
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory res...
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
Microglia, the innate immune cells in the central nervous system, play an essential role in brain homeostasis, neuroinflam...
Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, whe...