SCI时时刷

search
+
Metabolic response to CNS infection with flaviviruses
Metabolic response to CNS infection with flaviviruses
Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, in...
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury
Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). ...
The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
To explore the association of systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII) and inflammator...
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators
Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signalin...
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Spinal cord injury (SCI), which causes loss of sensory and motor function in the body below the level of injury, is a deva...
Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection
Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection
Type I interferons (IFN-I) are fundamental in controlling viral infections but fatal interferonopathy is restricted in the...
miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Studies of microglial gene manipulation in mouse models of Alzheimer’s disease (AD) amyloidopathy can cause unpredic...
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
Recent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical ...
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities
Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against ...
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usu...
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been...
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, ...
N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial
N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial
In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurode...
H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately a...
Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke
Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke
Vascular endothelial function is challenged during cerebral ischemia and reperfusion. The endothelial responses are involv...
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our pre...
Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration
Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration
Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and phys...
Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition
Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition
Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change and sy...
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling
Astrocytes contribute to chronic neuroinflammation in a variety of neurodegenerative diseases, including Parkinson's d...
Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen r...
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
Epidemiological data suggests statins could reduce the risk of dementia, and more specifically, Alzheimer’s disease ...
Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
Most current disease-modifying therapies approved for multiple sclerosis (MS) are immunomodulatory drugs that counteract t...
Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortic...
TSLP in DRG neurons causes the development of neuropathic pain through T cells
TSLP in DRG neurons causes the development of neuropathic pain through T cells
Peripheral nerve injury to dorsal root ganglion (DRG) neurons develops intractable neuropathic pain via induction of neuro...
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain
Medical advances have made it increasingly possible for spinal cord injury (SCI) survivors to survive decades after the in...
Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis
Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis
Bruton’s tyrosine kinase (BTK) is a key signaling node in B cell receptor (BCR) and Fc receptor (FcR) signaling. BTK...
Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chroni...
Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy
Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy
Cortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracere...
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic ...
The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and dimin...
阅读更多
format_indent_increase