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PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction
PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction
Cerebral infarction induces substantial neuronal apoptosis and neuroinflammation in the ipsilateral nonischemic thalamus a...
Cinnamaldehyde and its combination with deferoxamine ameliorate inflammation, ferroptosis and hematoma expansion after intracerebral hemorrhage in mice
Cinnamaldehyde and its combination with deferoxamine ameliorate inflammation, ferroptosis and hematoma expansion after intracerebral hemorrhage in mice
Intracerebral hemorrhage (ICH) is a most serious type of hemorrhagic stroke with a continuously rising incidence globally,...
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis
Sepsis-associated encephalopathy (SAE) is a severe neurological condition caused by sepsis, and presents with symptoms ran...
Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection
Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection
A craniotomy is a neurosurgical procedure performed to access the intracranial space. In 3–5% of cases, infections c...
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning
Chronic migraine is a prevalent and potentially debilitating neurological disorder that is often comorbid with mental heal...
Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia
Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia
Microglia mediate the immune response in the central nervous system to many insults, including lipopolysaccharide (LPS), a...
Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation
Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation
Cerebral endothelial cells (CEC) that form the brain capillaries are the principal constituents of the blood brain barrier...
The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions
The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions
Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxici...
Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice
Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice
In this study the retinal transcriptome was investigated during the development of experimental autoimmune uveoretinitis (...
Inflammatory responses revealed through HIV infection of microglia-containing cerebral organoids
Inflammatory responses revealed through HIV infection of microglia-containing cerebral organoids
Cerebral organoids (COs) are valuable tools for studying the intricate interplay between glial cells and neurons in brain ...
α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease
α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease
Recently, the role of T cells in the pathology of α-synuclein (αS)-mediated neurodegenerative disorders called s...
Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders
Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders
Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as a critic...
Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing
Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing
Vestibular schwannoma (VS) is an intracranial tumor arising from the Schwann cells of the vestibular nerve and is an impor...
Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology
Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology
Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy...
CD22 modulation alleviates amyloid β-induced neuroinflammation
CD22 modulation alleviates amyloid β-induced neuroinflammation
Neuroinflammation is a crucial driver of multiple neurodegenerative diseases, including Alzheimer’s disease (AD), am...
Microglial C/EBPβ-Fcgr1 regulatory axis blocking inhibits microglial pyroptosis and improves neurological recovery
Microglial C/EBPβ-Fcgr1 regulatory axis blocking inhibits microglial pyroptosis and improves neurological recovery
CAAT/Enhancer Binding Protein β (C/EBPβ) is associated with inflammatory responses in neurodegenerative patholog...
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Parkinson’s disease (PD) is a progressive degenerative disease of the central nervous system associated with neuroin...
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats
Painful diabetic neuropathy (PDN) is one of the most common complications of diabetes. Recent studies suggested that gut m...
APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease
APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease
The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is link...
Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation
Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation
Seizures is a prevalent neurological disorder with a largely elusive pathogenesis. In this study, we identified the key ge...
Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury
Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury
Astrocytes have a beneficial role in tissue repair after central nervous system (CNS) injury. Although astrocyte prolifera...
Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism
Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism
Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related...
Characteristics of TSPO expression in marmoset EAE
Characteristics of TSPO expression in marmoset EAE
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-...
Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain
Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain
Tick-borne encephalitis (TBE) is the most common tick-borne viral infection in Eurasia. Outcomes range from asymptomatic i...
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway
Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in pro...
Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration
Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration
The retinal degenerative diseases retinitis pigmentosa (RP) and atrophic age- related macular degeneration (AMD) are chara...
Hyperhomocysteinemia-induced VCID results in visual deficits, reduced neuroinflammation and vascular alterations in the retina
Hyperhomocysteinemia-induced VCID results in visual deficits, reduced neuroinflammation and vascular alterations in the retina
Over recent years, the retina has been increasingly investigated as a potential biomarker for dementia. A number of studie...
Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis
Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis
B cell immune dysregulation plays a critical role in myasthenia gravis (MG). However, targeted B-cell th...
Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus
Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus
The brain presents various structural and functional sex differences, for which multiple factors are attributed: genetic, ...
Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury
Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury
Therapeutic translation is challenging in spinal cord injury (SCI) and large animal models with high clinical relevance ma...
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