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A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies
A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies
Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of res...
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blo...
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and deme...
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-assoc...
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigat...
Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basa...
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patien...
Impact of microglia isolation and culture methodology on transcriptional profile and function
Impact of microglia isolation and culture methodology on transcriptional profile and function
Microglial isolation and culturing methods continue to be explored to maximize cellular yield, purity, responsiveness to s...
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. T...
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central ner...
Bi-directional neuro-immune dysfunction after chronic experimental brain injury
Bi-directional neuro-immune dysfunction after chronic experimental brain injury
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function ...
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). Howeve...
Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Alzheimer’s disease (AD) is recognized as the predominant cause of dementia, and neuroimmune processes play a pivota...
Cranial irradiation disrupts homeostatic microglial dynamic behavior
Cranial irradiation disrupts homeostatic microglial dynamic behavior
Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the bra...
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling
Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease ...
Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Neuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a c...
The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks
The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks
Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent s...
Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and m...
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resu...
Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer’s disease...
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer’s disease
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer’s disease
Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory e...
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms...
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
Guillain–Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the periphera...
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Blood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic...
Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis
Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis
Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseas...
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stro...
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury
Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia–reperfusion (I/R) injury via produci...
Macrophages coordinate immune response to laser-induced injury via extracellular traps
Macrophages coordinate immune response to laser-induced injury via extracellular traps
Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers periphe...
Border-associated macrophages in the central nervous system
Border-associated macrophages in the central nervous system
Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the...
TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repe...
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