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BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy
BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy
Dilated cardiomyopathy (DCM) stands as one of the most prevalent and severe causes of heart failure. Inflammation plays a ...
Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway
Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway
Sepsis-induced acute lung injury (ALI) is a severe clinical condition accompanied with high mortality. Tangeretin, which i...
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src
The treatment options to delay the progression of diabetic nephropathy (DN), a key contributor to chronic kidney disease (...
Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve
Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve
Paclitaxel-induced peripheral neuropathy (PIPN) is prevalent among patients receiving paclitaxel chemotherapy, which resul...
Network pharmacology: a crucial approach in traditional Chinese medicine research
Network pharmacology: a crucial approach in traditional Chinese medicine research
Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) ...
Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule
Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule
Cell membrane chromatography (CMC) is a biochromatography with a dual function of recognition and separation, offering a d...
Construction of machine learning-based models for screening the high-risk patients with gastric precancerous lesions
Construction of machine learning-based models for screening the high-risk patients with gastric precancerous lesions
The individualized prediction and discrimination of precancerous lesions of gastric cancer (PLGC) is critical for the earl...
Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has d...
Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model
Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model
Magnolia kobus DC (MO), as a plant medicine, has been reported to have various physiological activities, including neuropr...
Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway
Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway
With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined wit...
Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1
Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1
This research aims to explore the anti-obesity potential of Wu-Mei-Wan (WMW), particularly its effects on adipose tissue r...
Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke
Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke
Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism r...
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis
Lovastatin, the main lipid-lowering component in red yeast rice, is a golden anti-lipid drug, but its long-term applicatio...
Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells
Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells
Liver fibrosis is a complex reparative process in response to chronic liver injuries, with limited effective therapeutic o...
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective me...
Indole-3-carbinol alleviates allergic skin inflammation via periostin/thymic stromal lymphopoietin suppression in atopic dermatitis
Indole-3-carbinol alleviates allergic skin inflammation via periostin/thymic stromal lymphopoietin suppression in atopic dermatitis
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disorder with a complex etiology. D...
Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota
Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota
Liuweizhiji Gegen-Sangshen oral liquid (LGS), as a Chinese medicinal preparation, is developed from a Traditional Chinese ...
Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway
Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway
Chronic inflammatory pain is a pervasive condition, and electroacupuncture (EA) is an effective treatment, but its mechani...
Pulsatilla chinensis functions as a novel antihyperlipidemic agent by upregulating LDLR in an ERK-dependent manner
Pulsatilla chinensis functions as a novel antihyperlipidemic agent by upregulating LDLR in an ERK-dependent manner
Pulsatilla chinensis (PC) is a traditional Chinese medicine (TCM) known for its beneficial activities. It has been histori...
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP+-induced model of Parkinson’s disease
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP+-induced model of Parkinson’s disease
Parkinson's disease (PD) is a degenerative neurological disease that worsens over time. Ferroptosis has been proven to...
Integrated analysis of metabolome, lipidome, and gut microbiome reveals the immunomodulation of Astragali radix in healthy human subjects
Integrated analysis of metabolome, lipidome, and gut microbiome reveals the immunomodulation of Astragali radix in healthy human subjects
As a typical medicinal food homology species, Chinese herbal medicine Astragali radix (AR) has been widely used to regulat...
Zhishi Xiebai Guizhi Decoction modulates hypoxia and lipid toxicity to alleviate pulmonary vascular remodeling of pulmonary hypertension in rats
Zhishi Xiebai Guizhi Decoction modulates hypoxia and lipid toxicity to alleviate pulmonary vascular remodeling of pulmonary hypertension in rats
Pulmonary hypertension (PH) is a severe cardio-pulmonary vascular disease, involves complex molecular mechanism especially...
Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence
Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence
Blood–brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (...
Mentha haplocalyx Briq. (Mint): a comprehensive review on the botany, traditional uses, nutritional value, phytochemistry, health benefits, and applications
Mentha haplocalyx Briq. (Mint): a comprehensive review on the botany, traditional uses, nutritional value, phytochemistry, health benefits, and applications
Mentha haplocalyx Briq. (M. haplocalyx), a notable member of the Lamiaceae family, occupies a significant role in the real...
Siwu decoction mitigates radiation-induced immune senescence by attenuating hematopoietic damage
Siwu decoction mitigates radiation-induced immune senescence by attenuating hematopoietic damage
To investigate the long term effects of ionizing radiation (IR) on hematopoietic stem/progenitor cells (HSPCs), immune tis...
Mechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics
Mechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics
Heart failure (HF) is associated with high mortality and rehospitalization rates, highlighting the need for novel therapeu...
Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation
Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation
The Nuclear factor erythroid 2–related factor (Nrf2)/ Heme oxygenase-1 (HO-1) pathway, known for its significant rol...
Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial
Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial
Whether gastrointestinal hormones in patients with postprandial distress syndrome (PDS) are altered by acupuncture, and wh...
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis
Diabetic cardiomyopathy (DCM), characterized by myocardial fibrosis, is a major cause of mortality and morbidity in diabet...
Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade
Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade
Mitochondrial dysfunction emerges as an early pathological hallmark of Alzheimer's disease (AD). The reduction in mito...
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