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The molecular biology of sporadic acromegaly
The molecular biology of sporadic acromegaly
Acromegaly/gigantism is characterized by increased levels of growth hormone (GH) and the effector of most of its biologica...
Histopathology of growth hormone-secreting pituitary tumors: state of the art and new perspectives
Histopathology of growth hormone-secreting pituitary tumors: state of the art and new perspectives
Pituitary adenomas (PAs)/Pituitary Neuroendocrine Tumors (PitNETs) are a very heterogenous group of tumors in terms of cli...
Predictors of biochemical response to somatostatin receptor ligands in acromegaly
Predictors of biochemical response to somatostatin receptor ligands in acromegaly
Acromegaly, a rare and subtle condition, frequently escapes early detection, resulting in delayed diagnosis. As a conseque...
Genetic diagnosis in acromegaly and gigantism: from research to clinical practice
Genetic diagnosis in acromegaly and gigantism: from research to clinical practice
It is usually considered that only 5% of all pituitary neuroendocrine tumours are due to inheritable causes. Since this es...
Real-world value of cabergoline in the treatment of acromegaly
Real-world value of cabergoline in the treatment of acromegaly
Acromegaly is a chronic condition caused by a growth hormone (GH)-secreting pituitary adenoma leading to excess production...
Treatment of acromegaly with oral octreotide
Treatment of acromegaly with oral octreotide
Acromegaly is a rare chronic disease caused in most cases by a growth hormone (GH) secreting pituitary adenoma. The estima...
“Micromegaly”: Acromegaly with apparently normal GH, an entity on its own?
“Micromegaly”: Acromegaly with apparently normal GH, an entity on its own?
Acromegaly is a rare and underdiagnosed disorder caused, in more than 95% of cases, by a growth hormone (GH)-secreting pit...
Surgical outcomes in patients with acromegaly: microscopic vs. endoscopic transsphenoidal surgery
Surgical outcomes in patients with acromegaly: microscopic vs. endoscopic transsphenoidal surgery
Transsphenoidal resection of growth hormone-secreting pituitary neuroendocrine tumors remains the first-line treatment for...
The clinical and biochemical spectrum of ectopic acromegaly
The clinical and biochemical spectrum of ectopic acromegaly
Available online 14 February 2024, 101877Author links open overlay panel, , , , AbstractEctopic acromegaly is a rare condi...
Vitamin D deficiency or resistance and hypophosphatemia
Vitamin D deficiency or resistance and hypophosphatemia
Available online 30 January 2024, 101876Author links open overlay panel, , , AbstractVitamin D is mainly produced in the s...
Current role of pasireotide in the treatment of acromegaly
Current role of pasireotide in the treatment of acromegaly
Available online 24 January 2024, 101875Author links open overlay panel, Abstract“First-generation” somatostatin receptor ...
Primary hyperparathyroidism
Primary hyperparathyroidism
Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal wom...
Revisiting Hypophosphatemic rickets/osteomalacia
Revisiting Hypophosphatemic rickets/osteomalacia
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Premenstrual disorders and PMDD - a review
Premenstrual disorders and PMDD - a review
AbbreviationsPMDDpremenstrual dysphoric disorderMDTmulti-disciplinary teamICDinternational classification of diseasesPMTSp...
Best practice & research clinical endocrinology & metabolism focusing on the menopause – Diagnostic and therapeutic strategies
Best practice & research clinical endocrinology & metabolism focusing on the menopause – Diagnostic and therapeutic strategies
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Psychological issues and hormone therapy
Psychological issues and hormone therapy
Premenstrual symptoms have been recognised since Hippocrates in 370AD when menstrual bleeding was thought to purge melanch...
Best Practice & Research Clinical Endocrinology & Metabolism focusing on The Menopause - Diagnostic and Therapeutic Strategies
Best Practice & Research Clinical Endocrinology & Metabolism focusing on The Menopause - Diagnostic and Therapeutic Strategies
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Menopause: physiology, definitions, and symptoms
Menopause: physiology, definitions, and symptoms
Menopause is a time of transition, with menopausal symptoms often commencing 1–2 years prior to the last menstrual period,...
Post cancer care in women with an increased risk of malignancy or previous malignancy: the use of hormone replacement therapy and alternative treatments.
Post cancer care in women with an increased risk of malignancy or previous malignancy: the use of hormone replacement therapy and alternative treatments.
Nine million women globally are diagnosed with cancer every year, of whom 66% will survive long term in high-income countr...
The pathophysiology of hypophosphatemia
The pathophysiology of hypophosphatemia
The level of serum phosphate (Pi) is tightly regulated to remain in the optimal range. However, long-term disruption of th...
Inherited fibroblast growth factor 23 excess
Inherited fibroblast growth factor 23 excess
Since the identification of fibroblast growth factor 23 (FGF-23) by positional cloning in 2000 as the gene implicated in a...
Best Practice and Research Clinical Endocrinology and Metabolism focusing on Growth Hormone Deficiency in Adults – New Perspectives
Best Practice and Research Clinical Endocrinology and Metabolism focusing on Growth Hormone Deficiency in Adults – New Perspectives
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Inherited non-FGF23-mediated phosphaturic disorders: a kidney-centric review
Inherited non-FGF23-mediated phosphaturic disorders: a kidney-centric review
The study of inherited non-FGF23 mediated phosphaturic disorders has provided fascinating insights into the pathophysiolog...
Traumatic brain injury, abnormal growth hormone secretion, and gut dysbiosis
Traumatic brain injury, abnormal growth hormone secretion, and gut dysbiosis
Available online 19 November 2023, 101841Author links open overlay panel, , , , , , , , , SummaryThe gut microbiome has be...
Is there a role for growth hormone replacement in adults to control acute and post-acute COVID-19?
Is there a role for growth hormone replacement in adults to control acute and post-acute COVID-19?
Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2), a member of the Coronaviridae family, emerged in Wuhan, Chin...
Established and novel circulating neuroendocrine tumor biomarkers for diagnostic, predictive and prognostic use
Established and novel circulating neuroendocrine tumor biomarkers for diagnostic, predictive and prognostic use
Neuroendocrine tumors (NETs) are rare and heterogeneous neoplasms of epithelial origin arising from cells of the neuroendo...
Choosing the best systemic treatment sequence for control of tumour growth in gastro-enteropancreatic neuroendocrine tumours (GEP-NETs): What is the recent evidence?
Choosing the best systemic treatment sequence for control of tumour growth in gastro-enteropancreatic neuroendocrine tumours (GEP-NETs): What is the recent evidence?
Neuroendocrine tumours (NETs) represent a rare and highly heterogeneous entity, with increasing incidence [1], [2]. More t...
Meta-analysis of mortality in adults with growth hormone deficiency: Does growth hormone replacement therapy really improve mortality rates?
Meta-analysis of mortality in adults with growth hormone deficiency: Does growth hormone replacement therapy really improve mortality rates?
AbbreviationsGHDgrowth hormone deficiencyGHRTgrowth hormone replacement therapyHypoCCSHypopituitary Control and Complicati...
Phosphate: An underrated component of primary hyperparathyroidism
Phosphate: An underrated component of primary hyperparathyroidism
Primary hyperparathyroidism (PHPT) is a systemic disease. Although it affects explicitly the kidney, ureter, bladder compl...
Acquired disorders of phosphaturia: beyond tumor-induced osteomalacia
Acquired disorders of phosphaturia: beyond tumor-induced osteomalacia
Phosphate is an essential building block of life. It is one of the most abundant minerals in the human body and has vital ...
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