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Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy
KeywordsOrexinOrexin receptor antagonistSleepSleep disordersSeizureEpilepsyAbbreviations5-HT5-hydroxytriptophan or seroton...
The role of sensory and sympathetic nerves in craniofacial bone regeneration
Multiple factors regulate the regeneration of craniofacial bone defects. The nervous system is recognized as one of the cr...
Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain
The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a ...
PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury
KeywordsTrigeminal neuralgiaNeuropathic painVolt-gated sodium channels(VGSCs)Pituitary adenylate cyclase-activating polype...
Interactions between the regulatory peptide 26RFa (QRFP) and insulin in the regulation of glucose homeostasis in two complementary models: The high fat 26RFa-deficient mice and the streptozotocin insulin-deficient mice
The regulatory peptide 26RFa (QRFP) is involved in the control of glucose homeostasis at the periphery by acting as an inc...
Sex-dimorphic hindbrain lactate regulation of ventromedial hypothalamic nucleus glucoregulatory neuron 5’-AMP-activated protein kinase activity and transmitter marker protein expression
BackgroundThe oxidizable glycolytic end-product L-lactate is a gauge of nerve cell metabolic fuel stability that metabolic...
The stress-induced antinociceptive responses to the persistent inflammatory pain involve the orexin receptors in the nucleus accumbens
Stress suppresses the sense of pain, a physiological phenomenon known as stress-induced analgesia (SIA). Brain orexin pept...
Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression
Depression is the second leading cause of disability in the world population, for which currently available pharmacologica...
Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies
KeywordsProlactin-releasing peptideLipidizationGPR10NPFF-R2NPFF-R1ERKAkt activationStabilityFood intakeAbbreviationsANOVAA...
Curcumin attenuates morphine dependence by modulating μ-opioid receptors and glial cell-activated neuroinflammation in rat
In recent years, the association between neuroinflammation and opioid dependence has attracted considerable attention. Cur...
Investigating the potential of GalR2 as a drug target for neuropathic pain
Neuropathic pain is a chronic and debilitating condition characterised by episodes of hyperalgesia and allodynia. It occur...
The management and metabolic characterization: hyperthyroidism and hypothyroidism
Hyperthyroidism and hypothyroidism are common diseases resulting from thyroid dysfunction, and are simple to diagnose and ...
Organization of the galaninergic neuronal system in the brain of the gecko Hemidactylus frenatus
Galanin (GAL) is a 29 amino acid peptide present in the central nervous system (CNS) as well as peripheral tissues in vert...
Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice
Apolipoprotein E (ApoE) is the main cholesterol carrier of the brain and the ε4 gene variant (APOE4) is the most prevalent...
Analgesic tolerance and cross-tolerance to the bifunctional opioid/neuropeptide FF receptors agonist EN-9 and μ-opioid receptor ligands at the supraspinal level in mice
The chimeric peptide EN-9 was reported as a κ-opioid/neuropeptide FF receptors bifunctional agonist that modulated chronic...
Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews
Background and aimsThe contractile effects of tachykinins on the gastrointestinal tract are well-known, but how they modul...
Expression of phoenixin-14 and nesfatin-1 in the hypothalamo–pituitary–gonadal axis in the phases of the estrous cycle
Phoenixin-14 (PNX-14) and nucleobindin 2 (NUCB2)/nesfatin-1 are regulatory neuropeptides expressed in the hypothalamus. Th...
Neurotensin modulation of lipopolysaccharide induced inflammation of gut-liver axis: Evaluation using neurotensin receptor agonist and antagonist
Lipopolysaccharide (LPS), a toxic component of the cell wall of Gram-negative bacteria, is a potent immune stressor. LPS-i...
4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats
Autism is a neuropsychiatric disorder characterized by a neurotransmitter imbalance that impairs neurodevelopment processe...
Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation
PurposeWe aim to determine the effect of local and systemic administration of kisspeptin-54 on ovarian hyperstimulation.Me...
Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine
BackgroundCerebellar ataxia (CA) is a form of ataxia that adversely affects the cerebellum. This study aims to investigate...
Protective effect of N-acetyl cysteine on the mitochondrial dynamic imbalance in temporal lobe epilepsy: Possible role of mTOR
Understanding the underlying molecular mechanisms involved in epilepsy is critical for the development of more effective t...
Intravenous administration of xenin-25 accelerates cyclic ruminal contractions in healthy conscious sheep
The present study aimed to determine the effect and mode of action of the intravenous injection of xenin-25 on cyclic cont...
Antagonism of the orexin receptors in the ventral tegmental area diminished the stress-induced analgesia in persistent inflammatory pain
Available online 17 September 2022, 102291AbstractAs a part of descending pain inhibitory system, orexin (OXs) in the vent...
Decreased cognitive function of ALG13KO female mice may be related to the decreased plasticity of hippocampal neurons
Available online 18 September 2022, 102290AbstractAsparagine-linked glycosylation 13 (ALG13) is an X-linked gene that enco...
HLDF-6 peptides exhibit neuroprotective effects in the experimental model of preclinical Parkinson's disease
The mechanisms of the neuroprotective action of the hexapeptides HLDF-6 encoded by the amino acid sequence 41–46 of Human ...
Amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice
KeywordsAmylinSteroidogenesis-related enzymes3β-hydroxysteroid dehydrogenaseCytochrome P450 17A1Steroidogenic acute regula...
Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food
Available online 16 September 2022, 102289Highlights•MT-II decreased appetite and consumption.•No aversive or metabolic ef...
NPFF signalling is critical for thermosensory and dietary regulation of thermogenesis
Thermogenesis is a centrally regulated physiological process integral for thermoregulation and energy homeostasis. However...
Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models
Traumatic brain injury (TBI), characterized by acute neurological impairment, is associated with a higher incidence of neu...
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