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Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma
Volume 35, January 2023, 100855Author links open overlay panelHighlights•Tumor-associated tissue eosinophilia (TATE)-enric...
Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates potent antitumor activity against epithelial ovarian cancer
Volume 35, January 2023, 100853Author links open overlay panelAbstractBackgroundEpithelial ovarian cancer (EOC) is a letha...
Interdisciplinary care of children with diffuse midline glioma
Volume 35, January 2023, 100851Author links open overlay panelHighlights•Diffuse midline glioma is a terminal disease that...
LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice
Tissue-specific inactivation of E-cadherin combined with tumor suppressor loss leads to invasive and metastatic cancers in...
Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer
Volume 35, January 2023, 100850Highlights•F. nucleatum promoted tumour progression and induced PD-L1 expression in CRC•F. ...
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
Volume 35, January 2023, 100846AbstractPediatric brain tumors are the leading cause of cancer-related death in children in...
HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability
Volume 35, January 2023, 100845KeywordsHDAC6EGFRliver cancerHuRmRNA stabilityAbbreviationsHDAC6Histone deacetylase 6MTT3-(...
Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis
Volume 35, January 2023, 100847AbstractIn the development of colon cancer, the intestinal dysbiosis and disruption of barr...
The kinetics of blast clearance are associated with copy number alterations in childhood B-cell acute lymphoblastic leukemia
Volume 35, January 2023, 100840Highlights•The pattern of whole CNAs associates with the kinetics of blasts clearance.•Aber...
Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients
Volume 34, December 2022, 100842AbstractBackgroundSeveral studies suggest a role of gut microbiota in colorectal cancer (C...
Comparison of adjuvant gemcitabine plus S-1 with S-1 monotherapy for pancreatic ductal adenocarcinoma: Retrospective real-world data
Volume 34, December 2022, 100841AbstractBackgroundS-1 has been recognized as one of the standard adjuvant chemotherapies f...
Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis
EGR1, a short-lived transcription factor, regulates several biological processes, including cell proliferation and tumor p...
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Volume 33, November 2022, 100837AbstractKRAS is the most commonly mutated oncogene in human cancers with limited therapeut...
PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A
Volume 33, November 2022, 100835AbstractPeptidylarginine deiminase 4 (PAD4), a Ca2+-dependent enzyme, catalyzes the conver...
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness
Volume 33, November 2022, 100836AbstractBreast cancer is a highly heterogeneous disease both at the histological and molec...
Druggable gene alterations in Japanese patients with rare malignancy
Without a current standard of care, patients with rare malignancy are subjected to precision oncology with next-generation...
Hypoxia induces docetaxel resistance in triple-negative breast cancer via the HIF-1α/miR-494/Survivin signaling pathway
Volume 32, October 2022, 100821AbstractCytotoxic chemotherapy is the major strategy to prevent and reduce triple-negative ...
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype
Volume 32, October 2022, 100830AbstractTumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in th...
Microbiota-driven mechanisms at different stages of cancer development
Volume 32, October 2022, 100829SummaryA myriad of microbes living together with the host constitutes the microbiota, and t...
Metabolic reprogramming by adenosine antagonism and implications in non-small cell lung cancer therapy
Volume 32, October 2022, 100824AbstractNon-small cell lung cancer (NSCLC) is a heterogeneous disease with genetic and envi...
Carcinogenesis induced by space radiation: A systematic review
Volume 32, October 2022, 100828AbstractThe carcinogenic risk from space radiation has always been a health risk issue of g...
SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy
Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attr...
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature
Gain of chromosome arm 13q is one of the most prevalent DNA copy number alterations associated with colorectal adenoma-to-...