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HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membra...
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
Volume 44, October 2023, 100934Author links open overlay panel, , , , , , , , , , , , , , , , , , AbstractBackgroundThe en...
Mutational signatures and their association with survival and gene expression in urological carcinomas
Mutational signatures and their association with survival and gene expression in urological carcinomas
Different sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirr...
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Therapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). ...
Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
Volume 44, October 2023, 100929Author links open overlay panel, , , , , , , , , , Highlights•Resistance to temozolomide is...
BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer
BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer
Volume 44, October 2023, 100930Author links open overlay panelAlessandro Ottaiano a *, Mariachiara Santorsola a *, Luisa C...
Checkpoint inhibitor responses can be regulated by the gut microbiota – A systematic review
Checkpoint inhibitor responses can be regulated by the gut microbiota – A systematic review
BackgroundEvidence suggests that the human gut microbiota modulates the treatment response of immune checkpoint inhibitors...
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma
KeywordsDiffuse intrinsic pontine glioma (DIPG)HypermutantMismatch-repair (MMR)Histone deacetylase inhibitor (HDACi)Quisin...
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
The Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregu...
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Volume 43, September 2023, 100928Author links open overlay panel, , , , Highlights•CRPC patients have abundant SCFAs-produ...
Altered endosomal-lysosomal biogenesis in melanoma
Altered endosomal-lysosomal biogenesis in melanoma
Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate ...
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
Volume 43, September 2023, 100922Author links open overlay panel, , , , , , , AbstractAfatinib, as the first-line treatmen...
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene
PurposeOwing to the close relationship between mast cells and cancer progression, an imaging technique that can be applied...
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
BackgroundImmunotherapy plus tyrosine kinase inhibitor (IO-TKI) has become the first-line management for metastatic renal ...
PI3K-CCL2-CCR2-MDSCs axis: A potential pathway for tumor Clostridia-promoted CD 8+ T lymphocyte infiltration in bile tract cancers
BackgroundMost patients with resected bile tract cancers (BTCs) survive for less than 5 years; however, some achieve bette...
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Volume 43, September 2023, 100918Author links open overlay panel, , , , , , , , , , , AbstractCertain Enterobacteriaceae s...
P110α inhibitor alpelisib exhibits a synergistic effect with pyrotinib and reverses pyrotinib resistant in HER2+ breast cancer
Volume 43, September 2023, 100913Author links open overlay panel, , , , , , AbstractHuman epidermal growth factor receptor...
Challenges in synergizing radiotherapy with immunotherapy to unlock the abscopal effect in metastatic NSCLC: A systematic review
Volume 43, September 2023, 100914Author links open overlay panel, , , , , AbstractBackgroundWith the recent success of imm...
Lung cancer lesion detection in histopathology images using graph‐based sparse PCA network
Volume 42, August 2023, 100911Author links open overlay panel, , , , , , , , , , , AbstractEarly detection of lung cancer ...
PRMT1 methylates METTL14 to modulate its oncogenic function
Volume 42, August 2023, 100912Author links open overlay panel, , , , AbstractN6-methyladenosine (m6A), the most abundant m...
Genomics driven precision oncology in advanced biliary tract cancer improves survival
Disclosures: MMZ – Institutional grant funding from AstraZeneca, MedImmune and Seattle Genetics. VS – Institutional grant ...
Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology
KeywordsImmunotherapyPediatric cancerBrain tumorCentral nervous system tumorAbbreviationsCNScentral nervous systemPNOCPaci...
ALK inhibitors downregulate the expression of death receptor 4 in ALK-mutant lung cancer cells via facilitating Fra-1 and c-Jun degradation and subsequent AP-1 suppression
Volume 42, August 2023, 100908Author links open overlay panel, , , AbstractThe successful treatment of patients with advan...
Nuclear morphology predicts cell survival to cisplatin chemotherapy
The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with treatment initially reducing ove...
Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells
Volume 41, July 2023, 100903Author links open overlay panel, , , , , , , , , , , , , AbstractNicotinamide phosphoribosyltr...
Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity
Volume 41, July 2023, 100902Author links open overlay panel, , , , , , , , , , AbstractMLL rearranged (MLLr) leukemias are...
The circadian clock, aging and its implications in cancer
Volume 41, July 2023, 100904Author links open overlay panel, , AbstractCircadian clock orchestrates the intergenic biochem...
Applying collaborative brain power to pull us out of the dark ages of pediatric neuro-oncology
Volume 41, July 2023, 100905Author links open overlay panelCarl Koschmann a, Michael Prados bShow morePrevious article in ...
Hepatocellular carcinoma-derived FOXO1 inhibits tumor progression by suppressing IL-6 secretion from macrophages
Volume 40, June 2023, 100900Author links open overlay panel, , , , , , Highlights•FOXO1 impairs HCC progression indirectly...
From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy
BackgroundApproximately 95% of Colorectal cancers (CRC) consist of adenocarcinomas originating from colonic Adenomatous po...
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