SCI时时刷

search
+
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
In many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmenta...
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
Volume 52, June 2024, 100996Author links open overlay panel, , , , , , AbstractPapillary thyroid carcinoma (PTC) is the mo...
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]
Volume 51, May 2024, 100995Author links open overlay panelJae Eun Choi a b c, Monique E. Verhaegen d, Sahr Yazdani a c, Ro...
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Volume 51, May 2024, 100989Author links open overlay panel, , , , , , AbstractGene mutations are a source of genetic insta...
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
KeywordsMechanotherapeuticsSonopermeationNanomedicineImmune checkpoint inhibitionUltrasoundAbbreviationsTMEtumor microenvi...
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
BackgroundEarly-onset colorectal cancer (EO-CRC) incidence and prevalence trends in the rise in high income countries, suc...
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
KeywordsDihydroartemisinin (DHA)CisplatinEndoplasmic reticulum (ER) stressReactive oxygen species (ROS)Prostaglandin G/H s...
Corrigendum to “Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment” [Neoplasia, Volume 22, Issue 2 (2020) 111–119]
Corrigendum to “Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment” [Neoplasia, Volume 22, Issue 2 (2020) 111–119]
Volume 51, May 2024, 100986Author links open overlay panelSteven Kregel a b c, Chao Wang d, Xin Han d, Lanbo Xiao a b c, E...
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but th...
Advancing glioblastoma treatment by targeting metabolism
Advancing glioblastoma treatment by targeting metabolism
Volume 51, May 2024, 100985Author links open overlay panel, , , , , , AbstractAlterations in cellular metabolism are impor...
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
Volume 51, May 2024, 100984Author links open overlay panel, , , , , , , AbstractIntroductionColorectal cancer is the third...
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
Volume 50, April 2024, 100981Author links open overlay panel, , , , , , , AbstractPurposeHelicobacter pylori (H. pylori) i...
Glypican-1-targeted antibody–drug conjugate inhibits the growth of glypican-1-positive glioblastoma
Glypican-1-targeted antibody–drug conjugate inhibits the growth of glypican-1-positive glioblastoma
KeywordsAntibody–drug conjugateGlypican-1Monomethyl auristatin EGlioblastomaBlood–brain barrierEvans blueAbbreviationsADCa...
A deep learning based holistic diagnosis system for immunohistochemistry interpretation and molecular subtyping
A deep learning based holistic diagnosis system for immunohistochemistry interpretation and molecular subtyping
BackgroundBreast cancer in different molecular subtypes, which is determined by the overexpression rates of human epiderma...
Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations
Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations
While BRAF alterations have been established as a driver in various solid malignancies, the characterization of BRAF alter...
Corrigendum to “Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.” [Neoplasia Volume 23, Issue 9, September 2021, Pages 1002-1015]
Corrigendum to “Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.” [Neoplasia Volume 23, Issue 9, September 2021, Pages 1002-1015]
Volume 50, April 2024, 100978Author links open overlay panelChinnadurai Mani a, Kaushlendra Tripathi b, Sandeep Chaudhary ...
Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection
Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection
Volume 50, April 2024, 100979Author links open overlay panel, , , , , , , AbstractBackgroundDespite promising overall surv...
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) and oropharyngeal carcinoma (OPC) are subtypes of head and neck cancer with different treat...
Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors
Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors
Volume 50, April 2024, 100974Author links open overlay panel, , , , AbstractMultiple myeloma is a hematological malignancy...
Tumor microenvironment(TME) and single-source dual-energy CT(ssDECT) on assessment of inconformity between RECIST1.1 and pathological remission in neoadjuvant immunotherapy of NSCLC
Tumor microenvironment(TME) and single-source dual-energy CT(ssDECT) on assessment of inconformity between RECIST1.1 and pathological remission in neoadjuvant immunotherapy of NSCLC
KeywordsImmunotherapyNeoadjuvant therapyNon-small cell lung cancerPathologyTumor microenvironmentSingle-source dual-energy...
A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy
A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy
BackgroundPancreatic ductal adenocarcinoma (PDAC) is often treated with FOLFIRINOX, a chemotherapy associated with high to...
Molecular heterogeneity in histomorphologic subtypes of lung adeno carcinoma represents a challenge for treatment decision
Molecular heterogeneity in histomorphologic subtypes of lung adeno carcinoma represents a challenge for treatment decision
Lung cancer is the leading cause in cancer related death, with non-small cell lung cancer (NSCLC) being the most frequent ...
Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis
Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis
Volume 49, March 2024, 100971Author links open overlay panel, , , , , , , , , , , , , AbstractMore than half of all cancer...
High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer
High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer
Volume 49, March 2024, 100970Author links open overlay panel, , , , , , AbstractThe maintenance of DNA sequence integrity ...
FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS–STING pathway activation
FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS–STING pathway activation
Volume 49, March 2024, 100973Author links open overlay panel, , , , , , , , AbstractF-box only protein 38 (FBXO38) is a me...
DNA methylation landscape reveals GNAS as a decitabine-responsive marker in patients with acute myeloid leukemia
DNA methylation landscape reveals GNAS as a decitabine-responsive marker in patients with acute myeloid leukemia
KeywordsAcute myeloid leukemiaPrognostic biomarkerDecitabineDifferentially methylated regionDNA methylation sequencingGNAS...
Tozasertib activates anti-tumor immunity through decreasing regulatory T cells in melanoma
Tozasertib activates anti-tumor immunity through decreasing regulatory T cells in melanoma
Volume 48, February 2024, 100966Author links open overlay panel, , , , , , , , AbstractAlthough immune checkpoint therapy ...
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling
Papillary thyroid cancer (PTC) is the most prevalent endocrine cancer worldwide. Approximately 30 % of PTC patients will p...
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
Volume 49, March 2024, 100953Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•Peripheral b...
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells
Triple-negative breast cancer (TNBC) stands out as the most aggressive subtype within the spectrum of breast cancer. The c...
阅读更多
format_indent_increase