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TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription
TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription
Triple-negative breast cancer (TNBC) represents a highly aggressive subset of breast malignancies characterized by its cha...
Association of early menarche with breast tumor molecular features and recurrence
Association of early menarche with breast tumor molecular features and recurrence
Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognos...
Trastuzumab-functionalized bionic pyrotinib liposomes for targeted therapy of HER2-positive breast cancer
Trastuzumab-functionalized bionic pyrotinib liposomes for targeted therapy of HER2-positive breast cancer
In this study, we prepared a bionic nanosystem of trastuzumab-functionalized SK-BR-3 cell membrane hybrid liposome-coated ...
Trends in chemotherapy use for early-stage breast cancer from 2006 to 2019
Trends in chemotherapy use for early-stage breast cancer from 2006 to 2019
Little is known about how use of chemotherapy has evolved in breast cancer patients. We therefore describe chemotherapy pa...
An essential gene signature of breast cancer metastasis reveals targetable pathways
An essential gene signature of breast cancer metastasis reveals targetable pathways
The differential gene expression profile of metastatic versus primary breast tumors represents an avenue for discovering n...
Pre-treatment peripheral blood immunophenotyping and response to neoadjuvant chemotherapy in operable breast cancer
Pre-treatment peripheral blood immunophenotyping and response to neoadjuvant chemotherapy in operable breast cancer
Tumor immune infiltration and peripheral blood immune signatures have prognostic and predictive value in breast cancer. Wh...
Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cel...
Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer
Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer
Breast cancers treated with aromatase inhibitors (AIs) can develop AI resistance, which is often driven by estrogen recept...
Inflammation at diagnosis and cognitive impairment two years later in breast cancer patients from the Canto-Cog study
Inflammation at diagnosis and cognitive impairment two years later in breast cancer patients from the Canto-Cog study
Inflammation could be related to cancer-related cognitive impairment (CRCI) and might be used as a predictive marker of lo...
Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells
Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells
Identifying new targets in triple negative breast cancer (TNBC) remains critical. REG3A (regenerating islet-derived protei...
NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation
NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation
RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransfe...
Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer
Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer
Early-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there i...
Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP ...
EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis
EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis
Despite progress understanding the mechanisms underlying tumor spread, metastasis remains a clinical challenge. We identif...
Breast cancer patients enrolled in the Swiss mammography screening program “donna” demonstrate prolonged survival
Breast cancer patients enrolled in the Swiss mammography screening program “donna” demonstrate prolonged survival
We compared the survival rates of women with breast cancer (BC) detected within versus outside the mammography screening p...
Deep learning of mammogram images to reduce unnecessary breast biopsies: a preliminary study
Deep learning of mammogram images to reduce unnecessary breast biopsies: a preliminary study
Patients with a Breast Imaging Reporting and Data System (BI-RADS) 4 mammogram are currently recommended for biopsy. Howev...
Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial
Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial
Cancer-related fatigue (CRF) is a pervasive, persistent, and distressing symptom experienced by cancer patients, for which...
Reporting on patient’s body mass index (BMI) in recent clinical trials for patients with breast cancer: a systematic review
Reporting on patient’s body mass index (BMI) in recent clinical trials for patients with breast cancer: a systematic review
The proportion of patients with breast cancer and obesity is increasing. While the therapeutic landscape of breast cancer ...
Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despi...
Association of area- and volumetric-mammographic density and breast cancer risk in women of Asian descent: a case control study
Association of area- and volumetric-mammographic density and breast cancer risk in women of Asian descent: a case control study
Mammographic density (MD) has been shown to be a strong and independent risk factor for breast cancer in women of European...
Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
Metastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with ...
TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is r...
siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression
siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression
Breast cancer, the most prevalent cancer in women worldwide, faces treatment challenges due to drug resistance, posing a s...