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Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Resistance to endocrine therapies remains a major clinical hurdle in breast cancer. Mutations to estrogen receptor alpha (...
Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population
Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population
Hereditary predisposition to breast and ovarian cancer syndrome (HBOC) is a pathological condition with increased cancer r...
Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
Poly (ADP-Ribose) polymerase inhibitors are approved for treatment of tumors with BRCA1/2 and other homologous recombinati...
Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-positive breast cancer
Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-positive breast cancer
Recent evidence indicates that endocrine resistance in estrogen receptor-positive (ER+) breast cancer is closely correlate...
Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study
Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study
Alcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through...
Secreted LGALS3BP facilitates distant metastasis of breast cancer
Secreted LGALS3BP facilitates distant metastasis of breast cancer
Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, howev...
Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study
Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study
Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC),...
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models
Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), wi...
Surgical delay-associated mortality risk varies by subtype in loco-regional breast cancer patients in SEER-Medicare
Surgical delay-associated mortality risk varies by subtype in loco-regional breast cancer patients in SEER-Medicare
Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality r...
G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development...
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
Triple negative breast cancer (TNBC) belongs to the worst prognosis of breast cancer subtype probably because of distant m...
Patient-derived response estimates from zero-passage organoids of luminal breast cancer
Patient-derived response estimates from zero-passage organoids of luminal breast cancer
Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testi...
Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. Howeve...
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea
Depression among breast cancer survivors is a significant concern affecting their long-term survivorship and quality of li...
Cilengitide sensitivity is predicted by overall integrin expression in breast cancer
Cilengitide sensitivity is predicted by overall integrin expression in breast cancer
Treatment options for triple-negative breast cancer (TNBC) are limited and patients face a poor prognosis. Here, we sought...
Protective effects of miR-24-2-5p in early stages of breast cancer bone metastasis
Protective effects of miR-24-2-5p in early stages of breast cancer bone metastasis
Bone is the most frequent site of metastasis for breast cancer (BC). Metastatic BC cells interact with bone cells, includi...
A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state
A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state
Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells...
ERBB2/HOXB13 co-amplification with interstitial loss of BRCA1 defines a unique subset of breast cancers
ERBB2/HOXB13 co-amplification with interstitial loss of BRCA1 defines a unique subset of breast cancers
The HOXB13/IL17RB gene expression biomarker has been shown to predict response to adjuvant and extended endocrine therapy ...
Oncogene activated human breast luminal progenitors contribute basally located myoepithelial cells
Oncogene activated human breast luminal progenitors contribute basally located myoepithelial cells
Basal-like breast cancer originates in luminal progenitors, frequently with an altered PI3K pathway, and focally in close ...
Intraoperative radiotherapy versus whole breast radiotherapy in early-stage breast cancer: a retrospective outcome analysis based on ASTRO guidelines on PBI
Intraoperative radiotherapy versus whole breast radiotherapy in early-stage breast cancer: a retrospective outcome analysis based on ASTRO guidelines on PBI
Intraoperative radiotherapy (IORT) is a convenient treatment techniques for patients with early-stage breast cancer. We ai...
Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer
Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer
The tumor immune microenvironment, particularly tumor-infiltrating lymphocytes (TILs), plays a critical role in disease pr...
Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ
Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ
Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer scre...
Alcohol cessation and breast cancer risk stratified by hormone receptor status
Alcohol cessation and breast cancer risk stratified by hormone receptor status
Because alcohol consumption is an established cause of female breast cancer, understanding whether cessation affects risk ...
NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer
NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. While PD-1 based immunotherapies ove...
Social vulnerability is associated with advanced breast cancer presentation and all-cause mortality: a retrospective cohort study
Social vulnerability is associated with advanced breast cancer presentation and all-cause mortality: a retrospective cohort study
Disparities in breast cancer mortality persist despite improvements in screening and therapeutic options. Understanding th...
Image analysis-based identification of high risk ER-positive, HER2-negative breast cancers
Image analysis-based identification of high risk ER-positive, HER2-negative breast cancers
Breast cancer subtypes Luminal A and Luminal B are classified by the expression of PAM50 genes and may benefit from differ...
Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer
Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer
Breast cancer is one of the most common cancers in women and is closely associated with obesity. Gremlin-2 (GREM2), an ant...
Metastatic recurrence in women diagnosed with non-metastatic breast cancer: a systematic review and meta-analysis
Metastatic recurrence in women diagnosed with non-metastatic breast cancer: a systematic review and meta-analysis
To assess proportions of metastatic recurrence in women initially diagnosed with non-metastatic breast cancer by stage at ...
Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response
Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response
Breast cancer (BCa) is a major global health challenge. The BCa genome often carries extensive somatic copy number alterat...
Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study
Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study
Breast cancer, which is the most prevalent form of cancer among women globally, encompasses various subtypes that demand d...
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