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Genomic alterations are associated with response to aromatase inhibitor therapy for ER-positive postmenopausal ductal carcinoma in situ: (CALGB 40903, Alliance)
Genomic alterations are associated with response to aromatase inhibitor therapy for ER-positive postmenopausal ductal carcinoma in situ: (CALGB 40903, Alliance)
CALGB 40903 (Alliance) was a phase II single arm multicenter trial conducted in postmenopausal patients diagnosed with est...
Interaction between APOE Ɛ4 status, chemotherapy and endocrine therapy on cognitive functioning among breast cancer survivors: the CANTO-Cog longitudinal study
Interaction between APOE Ɛ4 status, chemotherapy and endocrine therapy on cognitive functioning among breast cancer survivors: the CANTO-Cog longitudinal study
Apolipoprotein Ɛ4 genotype (APOE4) has been associated with cancer-related cognitive impairment, but its interaction ...
Ultrasound-based quantitative microvasculature imaging for early prediction of response to neoadjuvant chemotherapy in patients with breast cancer
Ultrasound-based quantitative microvasculature imaging for early prediction of response to neoadjuvant chemotherapy in patients with breast cancer
Angiogenic activity of cancerous breast tumors can be impacted by neoadjuvant chemotherapy (NAC), thus potentially serving...
Fluoroestradiol (FES) and Fluorodeoxyglucose (FDG) PET imaging in patients with ER+, HER2-positive or HER2-negative metastatic breast cancer
Fluoroestradiol (FES) and Fluorodeoxyglucose (FDG) PET imaging in patients with ER+, HER2-positive or HER2-negative metastatic breast cancer
18F-Fluorodeoxyglucose (FDG) and 18F-Fluorestradiol (FES) have been FDA approved for measuring tumor glycolytic activity a...
Clinical efficacy and therapy response prediction of neoadjuvant dalpiciclib plus letrozole in postmenopausal patients with HR+/HER2- stage II-III breast cancer (DARLING 01): a single-arm, open-label, exploratory study
Clinical efficacy and therapy response prediction of neoadjuvant dalpiciclib plus letrozole in postmenopausal patients with HR+/HER2- stage II-III breast cancer (DARLING 01): a single-arm, open-label, exploratory study
Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer is the most common s...
HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN
HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN
New data show that not only HER2-overexpressing breast cancer (BC) tumors but also HER2-low tumors, classically considered...
SMYD4 promotes MYH9 ubiquitination through lysine monomethylation modification to inhibit breast cancer progression
SMYD4 promotes MYH9 ubiquitination through lysine monomethylation modification to inhibit breast cancer progression
Breast cancer is the leading cause of female mortality worldwide. (SET And MYND Domain Containing 4) SMYD4 has been report...
Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption
Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption
Breast Cancer (BC) is the most common type of cancer in women around the world and 70% of cases are hormone-receptor posit...
Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women
Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women
Mammographic breast density (MBD), a strong predictor of breast cancer, is highly influenced by body mass index (BMI) in c...
Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation
Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation
Tumour vascular density assessed from CD-31 immunohistochemistry (IHC) images has previously been shown to have prognostic...
Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer
Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer
Trastuzumab deruxtecan (T-DXd) is FDA-approved for treatment of patients with HER2 positive and HER2-low metastatic breast...
CXCR4 promotes tumor stemness maintenance and CDK4/6 inhibitors resistance in ER-positive breast cancer
CXCR4 promotes tumor stemness maintenance and CDK4/6 inhibitors resistance in ER-positive breast cancer
CDK4/6 inhibitors have significantly improved the survival of patients with HR-positive/HER2-negative breast cancer, becom...
Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])
Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])
The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer r...
Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers
Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers
Tumor-infiltrating lymphocytes are considered clinically beneficial in breast cancer, but the significance of natural kill...
Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers
Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers
Pathological complete response (pCR) is an established surrogate marker for prognosis in patients with breast cancer (BC) ...
Obesity increases DNA damage in the breast epithelium
Obesity increases DNA damage in the breast epithelium
Obesity is a modifiable risk factor for breast cancer. Yet, how obesity contributes to cancer initiation is not fully unde...
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Resistance to endocrine therapies remains a major clinical hurdle in breast cancer. Mutations to estrogen receptor alpha (...
Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population
Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population
Hereditary predisposition to breast and ovarian cancer syndrome (HBOC) is a pathological condition with increased cancer r...
Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors
Poly (ADP-Ribose) polymerase inhibitors are approved for treatment of tumors with BRCA1/2 and other homologous recombinati...
Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-positive breast cancer
Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-positive breast cancer
Recent evidence indicates that endocrine resistance in estrogen receptor-positive (ER+) breast cancer is closely correlate...
Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study
Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study
Alcohol intake is associated with a higher risk of estrogen receptor-positive (ER+) breast cancer (BC), presumably through...
Secreted LGALS3BP facilitates distant metastasis of breast cancer
Secreted LGALS3BP facilitates distant metastasis of breast cancer
Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, howev...
Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study
Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study
Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC),...
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models
Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), wi...
Surgical delay-associated mortality risk varies by subtype in loco-regional breast cancer patients in SEER-Medicare
Surgical delay-associated mortality risk varies by subtype in loco-regional breast cancer patients in SEER-Medicare
Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality r...
G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development...
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
Triple negative breast cancer (TNBC) belongs to the worst prognosis of breast cancer subtype probably because of distant m...
Patient-derived response estimates from zero-passage organoids of luminal breast cancer
Patient-derived response estimates from zero-passage organoids of luminal breast cancer
Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testi...
Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. Howeve...
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea
Depression among breast cancer survivors is a significant concern affecting their long-term survivorship and quality of li...
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