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Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
Chitinase-like proteins (CLPs) play a key role in immunosuppression under inflammatory conditions such as cancer. CLPs are...
Selective omission of sentinel lymph node biopsy in mastectomy for ductal carcinoma in situ: identifying eligible candidates
Selective omission of sentinel lymph node biopsy in mastectomy for ductal carcinoma in situ: identifying eligible candidates
Sentinel lymph node biopsy (SLNB) is recommended for patients with ductal carcinoma in situ (DCIS) undergoing mastectomy, ...
Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy with TCbHP regimen in HER2 + breast cancer
Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy with TCbHP regimen in HER2 + breast cancer
This study aimed to explore potential indicators associated with the neoadjuvant efficacy of TCbHP regimen (taxane, carbop...
Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
Patients with hormone receptor positive breast cancer are recommended at least five years of adjuvant endocrine therapy, b...
Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival
Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival
Breast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, se...
U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression
U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression
Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate c...
Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications
Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies
Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies
Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex ...
Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective review
Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective review
Breast cancer-related leptomeningeal disease (BC-LMD) is a dire diagnosis for 5–8% of patients with breast cancer (B...
Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer
Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer
Patient-derived organoid models of estrogen receptor-positive (ER+) breast cancer would provide a much-needed tool to unde...
Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells
Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells
Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activ...
TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC p...
Expression- and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status
Expression- and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status
Although several transcriptome-wide association studies (TWASs) have been performed to identify genes associated with over...
Factors associated with engraftment success of patient-derived xenografts of breast cancer
Factors associated with engraftment success of patient-derived xenografts of breast cancer
Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They cl...
BIRC5 expression by race, age and clinical factors in breast cancer patients
BIRC5 expression by race, age and clinical factors in breast cancer patients
Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therape...
Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
Breast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Under...
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that regulates ERα expression in triple...
The role of surgical tissue injury and intraoperative sympathetic activation in postoperative immunosuppression after breast-conserving surgery versus mastectomy: a prospective observational study
The role of surgical tissue injury and intraoperative sympathetic activation in postoperative immunosuppression after breast-conserving surgery versus mastectomy: a prospective observational study
Breast cancer is the second most common cause of death from cancer in women worldwide. Counterintuitively, large populatio...
Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential
Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential
Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade local...
HER2-low and tumor infiltrating lymphocytes in triple-negative breast cancer: Are they connected?
HER2-low and tumor infiltrating lymphocytes in triple-negative breast cancer: Are they connected?
Most patients with triple-negative breast cancer (TNBC) are not candidates for targeted therapy, leaving chemotherapy as t...
How does weight gain since the age of 18 years affect breast cancer risk in later life? A meta-analysis
How does weight gain since the age of 18 years affect breast cancer risk in later life? A meta-analysis
Early life factors are important risk factors for breast cancer. The association between weight gain after age 18 and brea...
The FBXW7-binding sites on FAM83D are potential targets for cancer therapy
The FBXW7-binding sites on FAM83D are potential targets for cancer therapy
Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how FAM83D exerts its oncogenic function r...
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
The clinical utility of gene signatures in older breast cancer patients remains unclear. We aimed to determine signature p...
A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer
A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer
Hyperglycemia is an on-target effect of PI3Kα inhibitors. Early identification and intervention of treatment-induced ...
Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis
Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a poor prognosis. Doxorubicin is part of ...
PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHr...
A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic Her2-negative breast cancer
A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic Her2-negative breast cancer
Zilovertamab is a humanized monoclonal antibody targeting ROR1, an onco-embryonic antigen expressed by malignant cells of ...
Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
Estrogen receptor (ER) positive patients compromise about 70% of breast cancers. Tamoxifen, an antagonist of ERα66 (t...
Augmented interpretation of HER2, ER, and PR in breast cancer by artificial intelligence analyzer: enhancing interobserver agreement through a reader study of 201 cases
Augmented interpretation of HER2, ER, and PR in breast cancer by artificial intelligence analyzer: enhancing interobserver agreement through a reader study of 201 cases
Accurate classification of breast cancer molecular subtypes is crucial in determining treatment strategies and predicting ...
The prostate-specific membrane antigen holds potential as a vascular target for endogenous radiotherapy with [177Lu]Lu-PSMA-I&T for triple-negative breast cancer
The prostate-specific membrane antigen holds potential as a vascular target for endogenous radiotherapy with [177Lu]Lu-PSMA-I&T for triple-negative breast cancer
Overexpression of prostate-specific membrane antigen (PSMA) on the vasculature of triple-negative breast cancer (TNBC) pre...
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