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Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3–CA1 Synapses in Mice
Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3–CA1 Synapses in Mice
Wnt signaling plays a role in synaptic plasticity, but the specific cellular events and molecular components involved in W...
Spinal Muscular Atrophy: Current Medications and Re-purposed Drugs
Spinal Muscular Atrophy: Current Medications and Re-purposed Drugs
Spinal muscular atrophy (SMA) is an autosomal recessive genetic neuromuscular disorder that is characterized by gradual mu...
Synergistic Epistasis and Systems Biology Approaches to Uncover a Pharmacogenomic Map Linked to Pain, Anti-Inflammatory and Immunomodulating Agents (PAIma) in a Healthy Cohort
Synergistic Epistasis and Systems Biology Approaches to Uncover a Pharmacogenomic Map Linked to Pain, Anti-Inflammatory and Immunomodulating Agents (PAIma) in a Healthy Cohort
The global public health addiction crisis has been stark, with over 932,400 deaths in the USA and Canada from opi...
Pesticide Exposure and Its Association with Parkinson’s Disease: A Case–Control Analysis
Pesticide Exposure and Its Association with Parkinson’s Disease: A Case–Control Analysis
Parkinson’s disease (PD) is a complex disorder that arises from genetic and environmental factors. The current inves...
Cognitive Impact of Neurotropic Pathogens: Investigating Molecular Mimicry through Computational Methods
Cognitive Impact of Neurotropic Pathogens: Investigating Molecular Mimicry through Computational Methods
Neurotropic pathogens, notably, herpesviruses, have been associated with significant neuropsychiatric effects. As a group,...
Can Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review
Can Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review
The aim of this paper is to summarize the available evidence in the literature regarding the effects generated by exposure...
Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Neurodegeneration
Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Neurodegeneration
The neurotoxicant trimethyltin (TMT) triggers cognitive impairment and hippocampal neurodegeneration. TMT is a useful rese...
Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration
Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration
Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been an abundantly re...
Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective
Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective
Mitochondria, the cellular powerhouses with bacterial evolutionary origins, play a pivotal role in maintaining neuronal fu...
Advancements in Single-Cell RNA Sequencing and Spatial Transcriptomics for Central Nervous System Disease
Advancements in Single-Cell RNA Sequencing and Spatial Transcriptomics for Central Nervous System Disease
The incidence of central nervous system (CNS) disease has persistently increased over the last several years. There is&...
Gut–Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders
Gut–Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders
The increasing prevalence of neurological disorders such as Alzheimer’s, Parkinson’s, and multiple sclerosis p...
Research Progress on the Effects of Different Exercise Modes on the Secretion of Exerkines After Spinal Cord Injury
Research Progress on the Effects of Different Exercise Modes on the Secretion of Exerkines After Spinal Cord Injury
Exercise training is a conventional treatment strategy throughout the entire treatment process for patients with spinal co...
Correction: Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression
Correction: Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Lactobacilli Cell-Free Supernatants Modulate Inflammation and Oxidative Stress in Human Microglia via NRF2-SOD1 Signaling
Lactobacilli Cell-Free Supernatants Modulate Inflammation and Oxidative Stress in Human Microglia via NRF2-SOD1 Signaling
Microglia are macrophage cells residing in the brain, where they exert a key role in neuronal protection. Through the gut&...
Proteomic and Cytokine Profiling in Plasma from Patients with Normal-Tension Glaucoma and Ocular Hypertension
Proteomic and Cytokine Profiling in Plasma from Patients with Normal-Tension Glaucoma and Ocular Hypertension
Primary open-angle glaucoma (POAG) is subdivided depending on eye pressure. Patients with normal-tension glaucoma (NTG) ha...
Application of Optogenetics in Neurodegenerative Diseases
Application of Optogenetics in Neurodegenerative Diseases
Optogenetics, a revolutionary technique integrating optical and genetic methodologies, offers unparalleled precision in sp...
Cerebral Hypoxia-Induced Molecular Alterations and Their Impact on the Physiology of Neurons and Dendritic Spines: A Comprehensive Review
Cerebral Hypoxia-Induced Molecular Alterations and Their Impact on the Physiology of Neurons and Dendritic Spines: A Comprehensive Review
This article comprehensively reviews how cerebral hypoxia impacts the physiological state of neurons and dendritic spines ...
Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon
Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory impairment and cognitive d...
Correction to: Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes
Correction to: Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease
Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease
Parkinsons disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and alpha-synuclein aggr...
Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors
Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological...
Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2
Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2
Sleep is a fundamental conserved physiological state across evolution, suggesting vital biological functions that are yet ...
Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-keeping machinery that regulates a wide range of processes such as sleep/wake, fe...
A Bibliometric Analysis of the Spatial Transcriptomics Literature from 2006 to 2023
A Bibliometric Analysis of the Spatial Transcriptomics Literature from 2006 to 2023
In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential i...
Urine Proteomic Signatures of Mild Hypothermia Treatment in Cerebral Ischemia–Reperfusion Injury in Rats
Urine Proteomic Signatures of Mild Hypothermia Treatment in Cerebral Ischemia–Reperfusion Injury in Rats
Mild hypothermia (MH) is an effective measure to alleviate cerebral ischemia–reperfusion (I/R) injury. However, the ...
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte
C3-positive reactive astrocytes play a neurotoxic role in various neurodegenerative diseases. However, the mechanisms cont...
A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy
A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy
Considering the variability in individual responses to opioids and the growing concerns about opioid addiction, prescribin...
The Role of Beta2-Microglobulin in Central Nervous System Disease
The Role of Beta2-Microglobulin in Central Nervous System Disease
Central nervous system (CNS) disorders represent the leading cause of disability and the second leading cause of death wor...
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
Cell transplantation is a promising treatment option for spinal cord injury (SCI). However, there is no consensus on the c...
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