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Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Erythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the mo...
Microglial Metabolic Reprogramming: Emerging Insights and Therapeutic Strategies in Neurodegenerative Diseases
Microglial Metabolic Reprogramming: Emerging Insights and Therapeutic Strategies in Neurodegenerative Diseases
Microglia, the resident immune cells of the central nervous system, play a critical role in maintaining brain homeostasis....
APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
Alzheimer’s disease (AD) is characterized pathologically by amyloid β (Aβ)-containing plaques. Generation ...
The Mechanisms of Ferroptosis Under Hypoxia
The Mechanisms of Ferroptosis Under Hypoxia
Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid per...
Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns
Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns
Bone marrow-derived mononuclear cells (BMMNCs) have been used for decades in preclinical and clinical studies to treat var...
Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects up to one-third of stroke sur...
Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study
Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study
The clearance of brain interstitial fluid (ISF) is important in maintaining brain homeostasis. ISF clearance impairment le...
Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus
Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus
Heterozygous mutations affecting FOXJ1, a transcription factor governing multiciliated cell development, have been associa...
Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway
Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway
Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy for treating traumatic brain in...
Biosensors, Recent Advances in Determination of BDNF and NfL
Biosensors, Recent Advances in Determination of BDNF and NfL
Key biomarkers such as Brain Derived Neurotrophic Factor (BDNF) and Neurofilament light chain (NfL) play important roles i...
Sleep Disorder Kleine–Levin Syndrome (KLS) Joins the List of Polygenic Brain Disorders Associated with Obstetric Complications
Sleep Disorder Kleine–Levin Syndrome (KLS) Joins the List of Polygenic Brain Disorders Associated with Obstetric Complications
Kleine–Levin Syndrome is a rare neurological disorder with onset typically during adolescence that is characterized ...
The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Stroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by...
Single-Cell RNA-Sequencing in Astrocyte Development, Heterogeneity, and Disease
Single-Cell RNA-Sequencing in Astrocyte Development, Heterogeneity, and Disease
Astrocytes are the most plentiful cell type in the central nervous system (CNS) and perform complicated functions in healt...
Expression Profile, Molecular Association, and Clinical Significance of POLD4 in Glioblastoma
Expression Profile, Molecular Association, and Clinical Significance of POLD4 in Glioblastoma
The POLD4 gene encodes a subunit (δ4) of DNA polymerase delta, which is a key enzyme involved in DNA replication and ...
Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer’s disease (AD). In ...
PGC-1α Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1
PGC-1α Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1
PPARγ coactivator-1 alpha (PGC-1α) is an essential transcription factor co-activator that regulates gene transcr...
Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11
Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11
Programed cell death plays a key role in promoting human development and maintaining homeostasis. Ferroptosis is a recentl...
A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson’s Disease
A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson’s Disease
Parkinson’s disease (PD) can dramatically change cortical neurophysiology. The molecular basis for PD-related cortic...
Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage
Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage
Microglia, the resident macrophages of the central nervous system, are essential players during physiological and patholog...
Crosstalk Between Autophagy and Inflammation in Chronic Cerebral Ischaemia
Crosstalk Between Autophagy and Inflammation in Chronic Cerebral Ischaemia
Chronic cerebral ischaemia (CCI) is a high-incidence cardiovascular and cerebrovascular disease that is very common in cli...
Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition
Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition
Nerve tissue regeneration is a significant problem. After neural diseases and damage such as spinal cord injury (SCI), the...
Revisiting a Telencephalic Extent of the Ascending Reticular Activating System
Revisiting a Telencephalic Extent of the Ascending Reticular Activating System
Is the cerebrum involved in its own activation to states of attention or arousal? “Telencephalon” is a term bo...
The Role of MicroRNAs in Predicting the Neurological Outcome of Patients with Subarachnoid Hemorrhage: A Meta-analysis
The Role of MicroRNAs in Predicting the Neurological Outcome of Patients with Subarachnoid Hemorrhage: A Meta-analysis
Subarachnoid hemorrhage (SAH) is a hemorrhagic cerebrovascular disease with an extremely poor prognosis. The molecular mec...
Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling
Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling
The application of glial cell line-derive neurotrophic factor (GDNF) to cell cultures and animal models has demonstrated p...
The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application
The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application
MicroRNAs (miRNAs) are non-coding RNAs with only 20–22 nucleic acids that inhibit gene transcription and translation...
A Study on Autophagy Related Biomarkers in Alzheimer’s Disease Based on Bioinformatics
A Study on Autophagy Related Biomarkers in Alzheimer’s Disease Based on Bioinformatics
Alzheimer’s disease (AD) is a neurodegenerative disease with an annual incidence increase that poses significant hea...
BMECs Ameliorate High Glucose-Induced Morphological Aberrations and Synaptic Dysfunction via VEGF-Mediated Modulation of Glucose Uptake in Cortical Neurons
BMECs Ameliorate High Glucose-Induced Morphological Aberrations and Synaptic Dysfunction via VEGF-Mediated Modulation of Glucose Uptake in Cortical Neurons
It has been demonstrated that diabetes cause neurite degeneration in the brain and cognitive impairment and neurovascular ...
The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes
The Effects of Whole Body Gamma Irradiation on Mice, Age-Related Behavioral, and Pathophysiological Changes
We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a sing...
A Novel Mouse Model for Polysynaptic Retrograde Tracing and Rabies Pathological Research
A Novel Mouse Model for Polysynaptic Retrograde Tracing and Rabies Pathological Research
Retrograde tracing is an important method for dissecting neuronal connections and mapping neural circuits. Over the past d...
Pearls and Pitfalls of Isolating Rat OPCs for In Vitro Culture with Different Methods
Pearls and Pitfalls of Isolating Rat OPCs for In Vitro Culture with Different Methods
There are several in vitro models to study the biology of oligodendrocyte progenitor cells (OPCs). The use of models based...
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