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Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration
Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration
Alcohol consumption is known to cause several brain anomalies. The pathophysiological changes associated with alcohol into...
The Role of Retinal Dysfunction in Myopia Development
The Role of Retinal Dysfunction in Myopia Development
Myopia is a refractive disorder arising from a mismatch between refractive power and relatively long axial length of the e...
Involvement of Ca2+ in Signaling Mechanisms Mediating Muscarinic Inhibition of M Currents in Sympathetic Neurons
Involvement of Ca2+ in Signaling Mechanisms Mediating Muscarinic Inhibition of M Currents in Sympathetic Neurons
Acetylcholine can excite neurons by suppressing M-type (KCNQ) potassium channels. This effect is mediated by M1 muscarinic...
Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors
Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors
Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migra...
Tubulin Cytoskeleton in Neurodegenerative Diseases–not Only Primary Tubulinopathies
Tubulin Cytoskeleton in Neurodegenerative Diseases–not Only Primary Tubulinopathies
Neurodegenerative diseases represent a large group of disorders characterized by gradual loss of neurons and functions of ...
The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach
The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach
Mitochondria are critical to multiple cellular processes, from the production of adenosine triphosphate (ATP), maintenance...
A Novel Role of Nogo Proteins: Regulating Macrophages in Inflammatory Disease
A Novel Role of Nogo Proteins: Regulating Macrophages in Inflammatory Disease
Nogo proteins, also known as Reticulon-4, have been identified as myelin-derived inhibitors of neurite outgrowth in the ce...
The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
Epigenetics play an essential role in the occurrence and improvement of many diseases. Evidence shows that epigenetic modi...
DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway
DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway
Gliomas are the most common and fatal brain tumors worldwide. Abnormal DNA promoter methylation is an important mechanism ...
Deep Succinylproteomics of Brain Tissues from Intracerebral Hemorrhage with Inhibition of Toll-Like Receptor 4 Signaling
Deep Succinylproteomics of Brain Tissues from Intracerebral Hemorrhage with Inhibition of Toll-Like Receptor 4 Signaling
It is unclear how Toll-like receptor (TLR) 4 signaling affects protein succinylation in the brain after intracerebral hemo...
Probiotics and the Treatment of Parkinson's Disease: An Update
Probiotics and the Treatment of Parkinson's Disease: An Update
Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor features. Altho...
Pathophysiology, Diagnosis, Treatment, and Genetics of Carpal Tunnel Syndrome: A Review
Pathophysiology, Diagnosis, Treatment, and Genetics of Carpal Tunnel Syndrome: A Review
Carpal tunnel syndrome (CTS) is a common peripheral canalicular nerve entrapment syndrome in the upper extremities. The co...
Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomati...
Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis
Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis
Microtubules (MTs) are essential cytoskeletal polymers of eukaryote cells implicated in various cell functions, including ...
Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders
Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders
Exploring the microRNAs and aptamers for their therapeutic role as biological drugs has expanded the horizon of its applic...
MACF1, Involved in the 1p34.2p34.3 Microdeletion Syndrome, is Essential in Cortical Progenitor Polarity and Brain Integrity
MACF1, Involved in the 1p34.2p34.3 Microdeletion Syndrome, is Essential in Cortical Progenitor Polarity and Brain Integrity
1p34.2p34.3 deletion syndrome is characterized by an increased risk for autism. Microtubule Actin Crosslinking Factor 1 (M...
Methamphetamine Exposure During Development Causes Lasting Changes to Mesolimbic Dopamine Signaling in Mice
Methamphetamine Exposure During Development Causes Lasting Changes to Mesolimbic Dopamine Signaling in Mice
Methamphetamine (MA) abuse remains a public health issue. Prenatal MA exposure (PME) poses a significant health problem, a...
Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
Ferroptosis is a type of regulated cell death that plays an essential role in various brain diseases, including cranial tr...
The Role of Glia in Addiction: Dopamine as a Modulator of Glial Responses in Addiction
The Role of Glia in Addiction: Dopamine as a Modulator of Glial Responses in Addiction
Addiction is a chronic and potentially deadly disease considered a global health problem. Nevertheless, there is still no ...
In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements
In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements
The blood–brain barrier (BBB) is essential for the homeostasis of the central nervous system (CNS). Functions of the...
Upregulation of miR-499a-5p Decreases Cerebral Ischemia/Reperfusion Injury by Targeting PDCD4
Upregulation of miR-499a-5p Decreases Cerebral Ischemia/Reperfusion Injury by Targeting PDCD4
MiR-499a-5p was significantly downregulated in degenerative tissues and correlated with apoptosis. Nonetheless, the biolog...
Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons
Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons
Spinal motor neurons have the longest axons that innervate the skeletal muscles of the central nervous system. Motor neuro...