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Offspring attachment
Infant attachment to the mother in rodents and monkeys is shown to rely on regulation of hypothalamic oxytocin release by ...
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair
The nervous and immune systems control whole-body homeostasis and respond to various types of tissue injury, including str...
SMN linked to SNARE complex assembly
SMN linked to SNARE complex assembly
New findings indicate a role for SMN protein in assembly of the synaptic SNARE complex at neuromuscular junctions, providi...
(New neurons) singing in the avian brain
In this Journal Club, María Llorens-Martín describes a 1983 paper that revealed ongoing neurogenesis in the brai...
Shaping the brain vasculature in development and disease in the single-cell era
Shaping the brain vasculature in development and disease in the single-cell era
The CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis an...
Independent microtubule regulation for migration and polarization
Independent microtubule regulation for migration and polarization
The centrosome is crucial for the microtubule dynamics that underlie the radial migration of developing rodent neurons but...
Delving into thalamic drive
A new study examines thalamic innervation of cortical layer 2/3 pyramidal neurons and models how this thalamic connectivit...
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and funct...
Integrated cardio-behavioural defensive states
Different defensive responses are characterized by transient behavioural and cardiac components, which are constrained by ...
Investigating human visual cortex variability
A 1997 paper, described here by Hiromasa Takemura, showed that variations in the size of the visual cortex in humans are c...
Raising the alarm
The ability to be woken from deep sleep by a sound (such as an alarm) is shown to be mediated by a specialized glutamaterg...
Developmental mechanisms underlying the evolution of human cortical circuits
Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable higher cognitive functions. These ca...
Classifying inhibitory synapses in the cortex: beyond cell types
Seung-Hee Lee describes findings published in 2000 that gave us insight into the principles by which different types of GA...
Linking microbiota to tau-mediated neuronal loss
In a mouse model of tauopathy, neurodegeneration is dependent on the gut microbiota and is affected by apolipoprotein E is...
To fire or not to fire: decisions mediated by localized processing and dendritic spikes
Akiko Hayashi-Takagi discusses the discovery of dendritic ‘NMDA spikes’ in 2000 and its transformation of our ...
Attraction signals
In both human radiation-induced brain injury and a mouse model of this condition, activated microglia release chemokines t...
Light dampens metabolism
Light dampens metabolism
A study in mice reveals the neural pathway through which light regulates glucose metabolism.
Flexible and generalizable representations of touch
The representational geometry of neural population activity in the somatosensory cortex of mice allows for high flexibilit...
Mitochondrial complex I deficiency and Parkinson disease
In this Journal Club, Janelle Drouin-Ouellet describes the 1989 paper that provided the first evidence for mitochondrial d...
Spectrins: molecular organizers and targets of neurological disorders
Spectrins: molecular organizers and targets of neurological disorders
Spectrins are cytoskeletal proteins that are expressed ubiquitously in the mammalian nervous system. Pathogenic v...
Neurophysiological mechanisms of error monitoring in human and non-human primates
Neurophysiological mechanisms of error monitoring in human and non-human primates
Performance monitoring is an important executive function that allows us to gain insight into our own behaviour. This rema...
Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With sweeping advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell ty...
Development, wiring and function of dopamine neuron subtypes
Development, wiring and function of dopamine neuron subtypes
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate speci...
Switching into a dissociated state
Ketamine-induced dissociated states in mice result from the suppression and activation of cortical pyramidal neuron popula...
Neurotoxic effects of air pollution: an urgent public health concern
A growing body of epidemiological evidence linking air pollution to multiple brain disorders suggests that these adverse e...
The plasticitome of cortical interneurons
The plasticitome of cortical interneurons
Hebb postulated that, to store information in the brain, assemblies of excitatory neurons coding for a percept are bound t...
Two-way communication
Deletion of Gabrb3, which encodes the β3 subunit of the GABAA receptor selectively in pyramidal neurons of developing...
Avoiding social interactions
Avoiding social interactions
Hyperactivity in a subset of lateral septum neurons inhibits social reward processing and drives social avoidance followin...
Revealing silent synapses in the adult brain
Revealing silent synapses in the adult brain
Evidence for the presence of silent synapses in the visual cortex of adult mice is uncovered.
Less is more: a critical role of synapse pruning in neural circuit wiring
In this Journal Club, Xiang Yu describes a 1986 study that provided crucial evidence for synaptic pruning in cortical deve...
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