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DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
Natural products are a great resource for physiologically active substances. It is widely recognized that a major percenta...
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by auto...
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associat...
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the...
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Miltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various ty...
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Ferritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg ...
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes ...
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Calcium serves as a widespread second messenger in almost every human and animal cell. The regulation of various cellular ...
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involve...
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an on...
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Inward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several dec...
CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis
CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis
Acute myocardial infarction (AMI) is one of the most prevalent cardiovascular diseases, accounting for a high incidence ra...
Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells
Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells
Ferroptosis of the retinal pigment epithelial (RPE) cells leads to retinal neuron injury and even visual loss. Our study a...
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are s...
The effect of cytochrome c on Na,K-ATPase
The effect of cytochrome c on Na,K-ATPase
Na,K-ATPase is a crucial enzyme responsible for maintaining Na+, K+-gradients across the cell membrane, which is essential...
Interference with MTHFD2 induces ferroptosis in ovarian cancer cells through ERK signaling to suppress tumor malignant progression
Interference with MTHFD2 induces ferroptosis in ovarian cancer cells through ERK signaling to suppress tumor malignant progression
Ovarian cancer (OC) is a deadliest gynecological cancer with the highest mortality rate. Methylenetetrahydrofolate dehydro...
Fragment-based drug design of novel inhibitors targeting lipoprotein (a) kringle domain KIV-10-mediated cardiovascular disease
Fragment-based drug design of novel inhibitors targeting lipoprotein (a) kringle domain KIV-10-mediated cardiovascular disease
Cardiovascular diseases (CVDs) are the leading cause of death globally, attributed to a complex etiology involving metabol...
The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is an aggressive and rapidly expanding lung cancer. Abnormal upregulation or knockdown ...
Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway
Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway
Blood-brain barrier breakdown and ROS overproduction are important events during the progression of ischemic stroke aggrav...
Analysis of cholesterol-recognition motifs of the plasma membrane Ca2+-ATPase
Analysis of cholesterol-recognition motifs of the plasma membrane Ca2+-ATPase
The plasma membrane Ca2+-ATPase (PMCA) is crucial for the fine tuning of intracellular calcium levels in eukaryotic cells....
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Downregulation of circ_0044226 has been demonstrated to reduce pulmonary fibrosis, but the role of circ_0044226 in liver f...
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
Background: Diabetic retinopathy is one of the complications of diabetes mellitus. The aim of this study was to explore th...
CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury
CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury
Tetramethylpyrazine (TMP) is one of the active ingredients of Chuan Xiong that has been reported to have effects on numero...
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
Lung adenocarcinoma (LUAD) is one of the most lethal and common malignancies. The energy metabolism of LUAD is a critical ...
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effec...
Silencing of METTL3 suppressed ferroptosis of myocardial cells by m6A modification of SLC7A11 in a YTHDF2 manner
Silencing of METTL3 suppressed ferroptosis of myocardial cells by m6A modification of SLC7A11 in a YTHDF2 manner
Myocardial infarction (MI) is the main cause of heart failure (HF). N6-methyladenosine (m6A) methylation is associated wit...
Changes in ATPase activity, antioxidant enzymes and proline biosynthesis in yeast Candida guilliermondii NP-4 under X-irradiation
Changes in ATPase activity, antioxidant enzymes and proline biosynthesis in yeast Candida guilliermondii NP-4 under X-irradiation
This study investigates the effects of X-radiation on ATPase activity and antioxidant enzyme activity, particularly enzyme...
Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription
Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription
To verify the protective effect of circDNAJB6 on Bronchopulmonary dysplasia (BPD) cell and animal models and to explore th...
The branched mitochondrial respiratory chain from the jellyfish Stomolophus sp2 as a probable adaptive response to environmental changes
The branched mitochondrial respiratory chain from the jellyfish Stomolophus sp2 as a probable adaptive response to environmental changes
During their long evolutionary history, jellyfish have faced changes in multiple environmental factors, to which they may ...
Knockdown of circSlc8a1 inhibited the ferroptosis in the angiotensin II treated H9c2 cells via miR-673-5p/TFRC axis
Knockdown of circSlc8a1 inhibited the ferroptosis in the angiotensin II treated H9c2 cells via miR-673-5p/TFRC axis
This study aimed to investigate the role of circSlc8a1 in cardiac hypertrophy (CH), a pathological change in various cardi...
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