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Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Fibrillation of the amyloid beta (Aβ) peptide has often been associated with neurodegenerative pathologies such as Al...
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
To investigate the role of silent information regulator 6 (SIRT6) in regulating podocyte injury in diabetic nephropathy (D...
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Cholestasis caused by impaired bile secretion in the liver is associated with the accumulation of primary bile acids (BA):...
Acute CCl4-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
Acute CCl4-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
The main therapeutic strategy for the treatment of patients with toxic liver failure is the elimination of the toxic agent...
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Oxidative stress-induced lens epithelial cells (LECs) death plays a pivotal role in pathogenesis of age-related cataract (...
LncRNA UCA1 enhances NRF2 expression through the m6A pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
LncRNA UCA1 enhances NRF2 expression through the m6A pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
To explore the regulatory mechanism of lncRNA UCA1 and NRF2 in cardiomyocyte aging. In this study, we explored how lncRNA ...
TRIM46 accelerates H1N1 influenza virus-induced ferroptosis and inflammatory response by regulating SLC7A11 ubiquitination
TRIM46 accelerates H1N1 influenza virus-induced ferroptosis and inflammatory response by regulating SLC7A11 ubiquitination
Influenza A (H1N1) virus is an acute respiratory infection responsible for enormous morbidity and mortality worldwide. The...
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Bacillus licheniformis can use cyanide as a nitrogen source for its growth. However, it can also carry out aerobic respira...
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer
PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer
High IQ motif-containing GTPase activating protein 3 (IQGAP3) expression is considered to be associated with poor prognosi...
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alteratio...
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
Cysteine desulfurase (NFS1) is highly expressed in a variety of tumors, which is closely related to ferroptosis of tumor c...
METTL14 inhibits Aβ1-42-induced neuronal injury through regulating the stability of CBLN4 mRNA in Alzheimer’s disease
METTL14 inhibits Aβ1-42-induced neuronal injury through regulating the stability of CBLN4 mRNA in Alzheimer’s disease
Previous studies have suggested that N6-methyladenosine (mA) modification of RNA affects fundamental aspects of RNA metabo...
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
Rheumatoid arthritis (RA) is a chronic condition characterized by inflammation and an abnormal immune response. N6-methyla...
Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine (DEX) has been confirmed to exert neuroprotective effects in various nerve injury models by regulating fer...
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
This study investigated Cerium oxide nanoparticles (CeONPs) effect on central neuropathic pain (CNP). The compressive meth...
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
Diabetic nephropathy (DN) is one of microvascular complication associated with diabetes. Circular RNAs (circRNAs) have bee...
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The current study explored melatonin (MEL) and its receptors, including MEL type 1 receptor (MT1) receptor and MEL type 2 ...
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
Natural products are a great resource for physiologically active substances. It is widely recognized that a major percenta...
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by auto...
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associat...
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the...
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Miltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various ty...
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Ferritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg ...
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes ...
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Calcium serves as a widespread second messenger in almost every human and animal cell. The regulation of various cellular ...
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involve...
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an on...
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Inward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several dec...
CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis
CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis
Acute myocardial infarction (AMI) is one of the most prevalent cardiovascular diseases, accounting for a high incidence ra...
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