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A comprehensive investigation of the interactions of human serum albumin with polymeric and hybrid nanoparticles
A comprehensive investigation of the interactions of human serum albumin with polymeric and hybrid nanoparticles
Nanoparticles (NPs) engineered as drug delivery systems continue to make breakthroughs as they offer numerous advantages o...
Fluorinated GlycoNucleoLipid-based hydrogels as new spatiotemporal stimulable DDS
Fluorinated GlycoNucleoLipid-based hydrogels as new spatiotemporal stimulable DDS
Achieving a controlled release of several active pharmaceutical ingredients (APIs) remains a challenge for improving their...
Nanoscaled metal-organic frameworks: charting a transformative path for cancer therapeutics and beyond
Nanoscaled metal-organic frameworks: charting a transformative path for cancer therapeutics and beyond
Through this inspirational note, we would like to highlight the potential of nanoscaled metal-organic frameworks within th...
Nanomedicines via the pulmonary route: a promising strategy to reach the target?
Nanomedicines via the pulmonary route: a promising strategy to reach the target?
Over the past decades, research on nanomedicines as innovative tools in combating complex pathologies has increased tenfol...
Drug delivery to and through the skin
Drug delivery to and through the skin
Drug delivery technology has advanced significantly over >50 years, and has produced remarkable innovation, c...
Evaluation of mAb 2C5-modified dendrimer-based micelles for the co-delivery of siRNA and chemotherapeutic drug in xenograft mice model
Evaluation of mAb 2C5-modified dendrimer-based micelles for the co-delivery of siRNA and chemotherapeutic drug in xenograft mice model
Combination therapy with small interfering RNA (siRNA) and chemotherapeutic drug is proven to be effective in downregulati...
Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?
Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?
Pain, a complex and debilitating condition affecting millions globally, is a significant concern, especially in the contex...
Targeting pentamidine towards CD44-overexpressing cells using hyaluronated lipid-polymer hybrid nanoparticles
Targeting pentamidine towards CD44-overexpressing cells using hyaluronated lipid-polymer hybrid nanoparticles
Biodegradable nanocarriers possess enormous potential for use as drug delivery systems that can accomplish controlled and ...
Biosafety evaluation of etoposide lipid nanomedicines in C. elegans
Biosafety evaluation of etoposide lipid nanomedicines in C. elegans
Neuroblastoma is a pediatric tumor that originates during embryonic development and progresses into aggressive tumors, pri...
An injectable, nanostructured implant for the delivery of adenosine triphosphate: towards long-acting formulations of small, hydrophilic drugs
An injectable, nanostructured implant for the delivery of adenosine triphosphate: towards long-acting formulations of small, hydrophilic drugs
While long-acting injectable treatments are gaining increasing interest in managing chronic diseases, the available drug d...
Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer: physicochemical characterization, in vitro dissolution, and in vivo evaluation
Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer: physicochemical characterization, in vitro dissolution, and in vivo evaluation
Febuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as a blood uric acid-reducing agent and has recently...
Antiretroviral action of Rosemary oil-based atazanavir formulation and the role of self-nanoemulsifying drug delivery system in the management of HIV-1 infection
Antiretroviral action of Rosemary oil-based atazanavir formulation and the role of self-nanoemulsifying drug delivery system in the management of HIV-1 infection
Atazanavir or ATV is an FDA-approved, HIV-1 protease inhibitor that belongs to the azapeptide group. Over time, it has bee...
Efficiency of PGK1 proteins delivered to the brain via a liposomal system through intranasal route administration for the treatment of spinocerebellar ataxia type 3
Efficiency of PGK1 proteins delivered to the brain via a liposomal system through intranasal route administration for the treatment of spinocerebellar ataxia type 3
A patient-friendly and efficient treatment method for patients with spinocerebellar ataxia type 3 (SCA3) was provided thro...
Metal organic framework–based variable-size nanoparticles for tumor microenvironment-responsive drug delivery
Metal organic framework–based variable-size nanoparticles for tumor microenvironment-responsive drug delivery
Nanoparticles (NPs) have been designed for the treatment of tumors increasingly. However, the drawbacks of single-size NPs...
Toward a solid microneedle patch for rapid and enhanced local analgesic action
Toward a solid microneedle patch for rapid and enhanced local analgesic action
Analgesic creams find widespread application as adjuncts for localized anesthesia prior to surgical procedures. Neverthele...
Chrono-tailored drug delivery systems: recent advances and future directions
Chrono-tailored drug delivery systems: recent advances and future directions
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nuc...
LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo
LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo
Long noncoding RNAs (lncRNAs) have been demonstrated to participate in neuroblastoma cisplatin resistance and tumorigenesi...
Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG
Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG
Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage degenerative damage and c...
Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study
Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study
Stigmasterol, a plant-derived sterol, sharing structural similarity with cholesterol, has demonstrated anti-osteoarthritis...
Porous silicon and silica carriers for delivery of peptide therapeutics
Porous silicon and silica carriers for delivery of peptide therapeutics
Peptides have gained tremendous popularity as biological therapeutic agents in recent years due to their favourable specif...
Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines
Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines
The global emergency of coronavirus disease 2019 (COVID-19) has spurred extensive worldwide efforts to develop vaccines fo...
Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors
Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors
This study explores the efficacy of human serum albumin (HSA)-based Drug-Free Macromolecular Therapeutics (DFMT) in treati...
A journey through the history of PEGylated drug delivery nanocarriers
A journey through the history of PEGylated drug delivery nanocarriers
This note aims to inspire through providing a personal view of the development and potential Drug Delivery Nanocarriers fu...
Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery
Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery
Fisetin (FS) is a flavonoid that possesses antioxidant and anti-inflammatory properties against ulcerative colitis. FS sho...
Oleogels for the ocular delivery of epalrestat: formulation, in vitro, in ovo, ex vivo and in vivo evaluation
Oleogels for the ocular delivery of epalrestat: formulation, in vitro, in ovo, ex vivo and in vivo evaluation
The ocular administration of lipophilic and labile drugs such as epalrestat, an aldose reductase inhibitor with potential ...
Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats
Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats
Emodin has been proven to have weight-reducing and lipid-lowering effects. In order to make emodin play a better anti-obes...
Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy
Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy
Conventional drugs have been facing various drug delivery obstacles, including first-pass metabolism for oral medications,...
Nanocomposite alginate hydrogel loaded with propranolol hydrochloride kolliphor® based cerosomes as a repurposed platform for Methicillin-Resistant Staphylococcus aureus-(MRSA)-induced skin infection; in-vitro, ex-vivo, in-silico, and in-vivo evaluation
Nanocomposite alginate hydrogel loaded with propranolol hydrochloride kolliphor® based cerosomes as a repurposed platform for Methicillin-Resistant Staphylococcus aureus-(MRSA)-induced skin infection; in-vitro, ex-vivo, in-silico, and in-vivo evaluation
Nanocomposite alginate hydrogel containing Propranolol hydrochloride (PNL) cerosomes (CERs) was prepared as a repurposed r...
Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for magnetic targeting to the blood–brain barrier
Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for magnetic targeting to the blood–brain barrier
Brain drug delivery is severely hindered by the presence of the blood–brain barrier (BBB). Its functionality relies ...
Investigation of long-term pressure on primary packaging materials and a biologic drug product for injection with a novel autoinjector concept
Investigation of long-term pressure on primary packaging materials and a biologic drug product for injection with a novel autoinjector concept
Gerresheimer and Midas Pharma have developed a novel cartridge-based autoinjector concept in which the cartridge as primar...
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