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Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Fluconazole (FLZ) has been widely used in the treatment of infection caused by Candida albicans, including the treatment o...
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of...
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alt...
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Lyophilization also known as freeze-drying is a technique that has been employed to enhance the long-term durability of na...
Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: Pharmacokinetic and efficacy study in animal model
Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: Pharmacokinetic and efficacy study in animal model
This research work is to evaluate spanlastic-loaded raloxifene (RLX) nanogel administration via the transdermal route to a...
3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases
3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases
The peritoneal cavity offers an attractive administration route for challenging-to-treat diseases, such as peritoneal carc...
Progress of nanomaterials in the treatment of thrombus
Progress of nanomaterials in the treatment of thrombus
Thrombus has long been the major contributor of death and disability because it can cause adverse effects to varying degre...
Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
The field of nasal drug delivery gained enormously on interest over the past decade. Performing nasal in vivo studies is e...
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstra...
The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability
The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability
Licorice flavonoids (LFs) are derived from perennial herb licorice and have been attaining a considerable interest in cosm...
Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis
Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis
In an effort to overcome the nasal mucus barrier and epithelial barrier, as well as reduce entry into the bloodstream, we ...
Unmet technological demands in orodispersible films for age-appropriate paediatric drug delivery
Unmet technological demands in orodispersible films for age-appropriate paediatric drug delivery
Age-appropriateness of a formulation is the ability to deliver variable but accurate doses to the paediatric population in...
Preparation, characterization, pharmacokinetics and ulcerative colitis treatment of hyperoside-loaded mixed micelles
Preparation, characterization, pharmacokinetics and ulcerative colitis treatment of hyperoside-loaded mixed micelles
At present, ulcerative colitis (UC) has become a global disease due to its high incidence. Hyperoside (HYP) is a naturally...
Tunable polymeric micelles for taxane and corticosteroid co-delivery
Tunable polymeric micelles for taxane and corticosteroid co-delivery
Nanomedicine holds promise for potentiating drug combination therapies. Increasing (pre)clinical evidence is available exe...
A comparative study on the preparation and evaluation of solubilizing systems for silymarin
A comparative study on the preparation and evaluation of solubilizing systems for silymarin
Silymarin (SM) exhibits clinical efficacy in treating liver injuries, cirrhosis, and chronic hepatitis. However, its limit...
Kinetic assessment of iontophoretic delivery efficiency of niosomal tetracycline hydrochloride incorporated in electroconductive gel
Kinetic assessment of iontophoretic delivery efficiency of niosomal tetracycline hydrochloride incorporated in electroconductive gel
The purpose of this study was to conduct the kinetic assessment of iontophoretic delivery of niosomal tetracycline-HCl for...
Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration
Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration
A major clinical challenge today is the large number of bone defects caused by diseases or trauma. The development of thre...
Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study
Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study
Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus both Type 1 and Type 2 Diabetes m...
Guar gum as a microbially degradable component for an oral colon delivery system based on a combination strategy: formulation and in vitro evaluation
Guar gum as a microbially degradable component for an oral colon delivery system based on a combination strategy: formulation and in vitro evaluation
Oral colon delivery has widely been pursued exploiting naturally occurring polysaccharides degraded by the resident microb...
Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
Novel tumor-on-a-chip approaches are increasingly used to investigate tumor progression and potential treatment options. T...
Polycaprolactone microparticles for the subcutaneous administration of cannabidiol: in vitro and in vivo release
Polycaprolactone microparticles for the subcutaneous administration of cannabidiol: in vitro and in vivo release
Cannabidiol (CBD) has become a highly attractive entity in therapeutics. However, its low aqueous solubility, instability ...
Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption
Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption
Understanding the interactions between nanocarriers and plasma proteins is essential for controlling their biological fate...
Cubosomal functionalized block copolymer platform for dual delivery of linagliptin and empagliflozin: Recent advances in synergistic strategies for maximizing control of high-risk type II diabetes
Cubosomal functionalized block copolymer platform for dual delivery of linagliptin and empagliflozin: Recent advances in synergistic strategies for maximizing control of high-risk type II diabetes
A well-made chitosan-PVP block copolymer platform was equipped with highly ordered and uniform nano-channels. This highly ...
Correction: Combination of micelles and liposomes as a promising drug delivery system: a review
Correction: Combination of micelles and liposomes as a promising drug delivery system: a review
Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaJiecheng Qian, Youfa Xu, Xinyu Wan...
Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation
Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation
This study aimed to enhance the oral absorption of Panax notoginseng saponins (PNS) via nanoparticles modified with thiola...
Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy
Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy
Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (D...
Zein nanoparticles as oral carrier for mometasone furoate delivery
Zein nanoparticles as oral carrier for mometasone furoate delivery
Mometasone furoate (MF) is a synthetic glucocorticoid used clinically to treat specific inflammatory disorders including s...
A topical thermosensitive hydrogel system with cyclosporine A PEG-PCL micelles alleviates ulcerative colitis induced by TNBS in mice
A topical thermosensitive hydrogel system with cyclosporine A PEG-PCL micelles alleviates ulcerative colitis induced by TNBS in mice
Ulcerative colitis (UC) is an idiopathic, chronic, relapsing disease. In most cases, only the distal colon is affected, an...
Study on the regulation mechanism of effective glass transition temperature on the crystallization of crystalline solid dispersion
Study on the regulation mechanism of effective glass transition temperature on the crystallization of crystalline solid dispersion
The focus of this investigation was to determine the mechanism of effective glass transition temperature (TgE) on the crys...
Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route
Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route
Glioma refers to the most atypical variant of the malignant central nervous system tumors posturing massive challenge to t...
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