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Unlocking the potential of beta-glucans: a comprehensive review from synthesis to drug delivery carrier potency
Unlocking the potential of beta-glucans: a comprehensive review from synthesis to drug delivery carrier potency
Modernization and lifestyle changes have resulted in a number of diseases, including cancer, that require complicated and ...
3D printed microneedles: revamping transdermal drug delivery systems
3D printed microneedles: revamping transdermal drug delivery systems
One of the advancements of the transdermal drug delivery system (TDDS) is the development of microneedles (MNs). These mic...
F127/chlorin e6-nanomicelles to enhance Ce6 solubility and PDT-efficacy mitigating lung metastasis in melanoma
F127/chlorin e6-nanomicelles to enhance Ce6 solubility and PDT-efficacy mitigating lung metastasis in melanoma
Photodynamic Therapy (PDT) is a promising paradigm for treating cancer, especially superficial cancers, including skin and...
Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures
Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures
Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuropr...
Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation
Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation
Breast cancer (BC) is the most commonly diagnosed cancer among women. Chemo-, immune- and photothermal therapies are emplo...
Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery
Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery
Cataract surgery is followed by post-operative eye drops for a duration of 4–6 weeks. The multitude of ocular barrie...
Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion
Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion
(20 S)-Ginsenoside Rh2 is a natural saponin derived from Panax ginseng Meyer (P. ginseng), which showed significa...
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded amorphous solid dispersion
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded amorphous solid dispersion
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonrespons...
Comparative study of iontophoresis-assisted transdermal delivery of bupivacaine and lidocaine as anesthetic drugs
Comparative study of iontophoresis-assisted transdermal delivery of bupivacaine and lidocaine as anesthetic drugs
Postoperative pain management is an important aspect of the overall surgical care process. Effective pain management not o...
Unravelling the role of tumor microenvironment responsive nanobiomaterials in spatiotemporal controlled drug delivery for lung cancer therapy
Unravelling the role of tumor microenvironment responsive nanobiomaterials in spatiotemporal controlled drug delivery for lung cancer therapy
Design and development of efficient drug delivery technologies that impart site-specificity is the need of the hour for th...
Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice
Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice
Due to the unique physiological barriers within the lungs, there are considerable challenges in developing drug delivery s...
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and...
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRN...
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
The combination of shikonin (SKN) and gefitinib (GFB) can reverse the drug resistance of lung cancer cells by affecting en...
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Nanoscale preparations, such as nanoparticles, micelles, and liposomes, are increasingly recognized in pharmaceutical tech...
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
In this technical note we show with two simple experiments how Perfluorodecalin (PFD), an injectable perfluorocarbon, can ...
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytok...
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
Doxorubicin is a key treatment for breast cancer, but its effectiveness often comes with significant side effects. Its act...
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Rheumatoid arthritis (RA) is a systemic immune disease with severe implications for joint health. The issue of non-specifi...
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Poly(lactide-co-glycolide) and poly(lactic-co-glycolic acids) (PLGAs) play a critical role in the development of commercia...
Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model
Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model
Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, for the manag...
Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature
Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature
Nanoparticles used for drug delivery often require intravenous administration exposing them to fluid forces within the vas...
Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma
Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma
Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders and arise from residual GBM cells ...
Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes
Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes
Besides enhancing osseo- and soft tissue integration, modulating inflammation at the implant site is also crucial for dent...
Formulation of protein-loaded nanoparticles via freeze-drying
Formulation of protein-loaded nanoparticles via freeze-drying
Several nanotechnology-based formulation strategies have been reported for the oral administration of biological drugs. Ho...
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Co-delivery of different protein-encoding polynucleotide species with varying expression kinetics of their therapeutic pro...
Enhanced antichemobrain activity of amino acid assisted ferulic acid solid dispersion in adult zebrafish (Danio rerio)
Enhanced antichemobrain activity of amino acid assisted ferulic acid solid dispersion in adult zebrafish (Danio rerio)
Chemotherapy-induced cognitive impairment (CICI), also known as “chemobrain,” is a common side effect of breas...
Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment
Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment
Glioblastoma (GBM) is the deadliest adult brain cancer. The current standard-of-care chemotherapy using orally administere...
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Skin cancer is a widespread type of cancer representing 30% of all cancer types worldwide. Resveratrol (RSV) is an antican...
Niacinamide: a review on dermal delivery strategies and clinical evidence
Niacinamide: a review on dermal delivery strategies and clinical evidence
Niacinamide, an active form of vitamin B3, is recognised for its significant dermal benefits including skin brightening, a...
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