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Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and...
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRN...
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
The combination of shikonin (SKN) and gefitinib (GFB) can reverse the drug resistance of lung cancer cells by affecting en...
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Nanoscale preparations, such as nanoparticles, micelles, and liposomes, are increasingly recognized in pharmaceutical tech...
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
In this technical note we show with two simple experiments how Perfluorodecalin (PFD), an injectable perfluorocarbon, can ...
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytok...
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
Doxorubicin is a key treatment for breast cancer, but its effectiveness often comes with significant side effects. Its act...
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Rheumatoid arthritis (RA) is a systemic immune disease with severe implications for joint health. The issue of non-specifi...
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Poly(lactide-co-glycolide) and poly(lactic-co-glycolic acids) (PLGAs) play a critical role in the development of commercia...
Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model
Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model
Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, for the manag...
Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature
Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature
Nanoparticles used for drug delivery often require intravenous administration exposing them to fluid forces within the vas...
Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma
Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma
Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders and arise from residual GBM cells ...
Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes
Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes
Besides enhancing osseo- and soft tissue integration, modulating inflammation at the implant site is also crucial for dent...
Formulation of protein-loaded nanoparticles via freeze-drying
Formulation of protein-loaded nanoparticles via freeze-drying
Several nanotechnology-based formulation strategies have been reported for the oral administration of biological drugs. Ho...
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Co-delivery of different protein-encoding polynucleotide species with varying expression kinetics of their therapeutic pro...
Enhanced antichemobrain activity of amino acid assisted ferulic acid solid dispersion in adult zebrafish (Danio rerio)
Enhanced antichemobrain activity of amino acid assisted ferulic acid solid dispersion in adult zebrafish (Danio rerio)
Chemotherapy-induced cognitive impairment (CICI), also known as “chemobrain,” is a common side effect of breas...
Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment
Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment
Glioblastoma (GBM) is the deadliest adult brain cancer. The current standard-of-care chemotherapy using orally administere...
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Skin cancer is a widespread type of cancer representing 30% of all cancer types worldwide. Resveratrol (RSV) is an antican...
Niacinamide: a review on dermal delivery strategies and clinical evidence
Niacinamide: a review on dermal delivery strategies and clinical evidence
Niacinamide, an active form of vitamin B3, is recognised for its significant dermal benefits including skin brightening, a...
Discerning computational, in vitro and in vivo investigations of self-assembling empagliflozin polymeric micelles in type-2 diabetes
Discerning computational, in vitro and in vivo investigations of self-assembling empagliflozin polymeric micelles in type-2 diabetes
Empagliflozin (EMPA) is an SGLT2 inhibitor, a new class of anti-diabetic medication, indicated for treating type-2 diabete...
Study on ultrasound-enhanced molecular transport in articular cartilage
Study on ultrasound-enhanced molecular transport in articular cartilage
Local intra-articular administration with minimal side effects and rapid efficacy is a promising strategy for treating ost...
Immunomodulatory potential of rapamycin-loaded mesoporous silica nanoparticles: pore size-dependent drug loading, release, and in vitro cellular responses
Immunomodulatory potential of rapamycin-loaded mesoporous silica nanoparticles: pore size-dependent drug loading, release, and in vitro cellular responses
Rapamycin is a potent immunosuppressive drug that has been recently proposed for a wide range of applications beyond its c...
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conven...
Microfluidic-based systems for the management of diabetes
Microfluidic-based systems for the management of diabetes
Diabetes currently affects approximately 500 million people worldwide and is one of the most common causes of mor...
Cell-mediated nanoparticle delivery systems: towards precision nanomedicine
Cell-mediated nanoparticle delivery systems: towards precision nanomedicine
Cell-mediated nanoparticle delivery systems (CMNDDs) utilize cells as carriers to deliver the drug-loaded nanoparticles. U...
Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination
Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination
Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS) in need of a curat...
Ti3C2 (MXene), an advanced carrier system: role in photothermal, photoacoustic, enhanced drugs delivery and biological activity in cancer therapy
Ti3C2 (MXene), an advanced carrier system: role in photothermal, photoacoustic, enhanced drugs delivery and biological activity in cancer therapy
In the realm of healthcare and the advancing field of medical sciences, the development of efficient drug delivery systems...
Inhaled delivery of cetuximab-conjugated immunoliposomes loaded with afatinib: A promising strategy for enhanced non-small cell lung cancer treatment
Inhaled delivery of cetuximab-conjugated immunoliposomes loaded with afatinib: A promising strategy for enhanced non-small cell lung cancer treatment
Afatinib (AT), an FDA-approved aniline-quinazoline derivative, is a first-line treatment for metastatic non-small cell lun...
Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood plasma and plasma membranes
Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood plasma and plasma membranes
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to des...
Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate: A promising strategy for managing glaucoma
Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate: A promising strategy for managing glaucoma
To improve drug bioavailability, eye drops can be replaced by drug-eluting contact lenses. However, issues of drug leachin...
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