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Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
Multiple SARS-CoV-2 vaccine candidates have been approved for use and have had a major impact on the COVID-19 pandemic. Th...
Intestinal epithelium in early life
Intestinal epithelium in early life
Rapid development of the fetal and neonatal intestine is required to meet the growth requirements of early life and form a...
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease
Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal epithelial barrier leading to breach of bar...
Severity of neonatal influenza infection is driven by type I interferon and oxidative stress
Severity of neonatal influenza infection is driven by type I interferon and oxidative stress
Neonates exhibit increased susceptibility to respiratory viral infections, attributed to inflammation at the developing pu...
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution
In the beginning it was simple: we injected a protein antigen and studied the immune responses against the purified protei...
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn’s...
A new age for (mucosal) NeuroImmunology
A new age for (mucosal) NeuroImmunology
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W. & Kelley, K. W. From inflammation to sickness and depressi...
John Bienenstock Obituary
John Bienenstock Obituary
On the 25th of July, disheartening news of the untimely demise of our distinguished colleague and dear fr...
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant vaccine, accumulating sterylglucos...
The urothelium: a multi-faceted barrier against a harsh environment
The urothelium: a multi-faceted barrier against a harsh environment
All mucosal surfaces must deal with the challenge of exposure to the outside world. The urothelium is a highly specialized...
Role of the humoral immune response during COVID-19: guilty or not guilty?
Role of the humoral immune response during COVID-19: guilty or not guilty?
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral infections in the current pandemic of...
Microbiome-based interventions to modulate gut ecology and the immune system
Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the ability to modify host response...
Food for thought – ILC metabolism in the context of helminth infections
Food for thought – ILC metabolism in the context of helminth infections
Helminths are multicellular ancient organisms residing as parasites at mucosal surfaces of their host. Through adaptation ...
Trained immunity in type 2 immune responses
Trained immunity in type 2 immune responses
Immunological memory of innate immune cells, also termed “trained immunity”, allows for cross-protection again...
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy development, but the mechanisms cont...
Correction to: Trained immunity in type 2 immune responses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II...
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear whic...
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions ex...
Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections
Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections
The bladder supports a diversity of macrophage populations with functional roles related to homeostasis and host defense, ...
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations
Immune responses that result in asthma exacerbation are associated with allergen or viral exposure. Identification of comm...
Microbial antigen in human milk: a natural vaccine?
Microbial antigen in human milk: a natural vaccine?
A few studies shed light on the possible ways breast milk vaccination may work and provide the optimal route to activate t...
IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies
IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies
Control of gut microbes is crucial for not only local defense in the intestine but also proper systemic immune responses. ...
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Microbiota promotes or inhibits the pathogenesis of a range of immune-mediated disorders. Although recent studies have elu...
Lessons from helminths: what worms have taught us about mucosal immunology
Lessons from helminths: what worms have taught us about mucosal immunology
Ogilvie, B. M. Reagin-like antibodies in animals immune to helminth parasites. Nature 204, 91–92 (1964).CAS  Article  ...
Mucosal immunology of the ocular surface
Mucosal immunology of the ocular surface
The eye is a sensory organ exposed to the environment and protected by a mucosal tissue barrier. While it shares a number ...
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes
Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a br...
The rise to power of the microbiome: power and sample size calculation for microbiome studies
The rise to power of the microbiome: power and sample size calculation for microbiome studies
A priori power and sample size calculations are crucial to appropriately test null hypotheses and obtain valid conclusions...
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Intestinal epithelial barrier function is compromised in inflammatory bowel disease and barrier dysfunction contributes to...
The impact of biological sex on diseases of the urinary tract
The impact of biological sex on diseases of the urinary tract
Biological sex, being female or male, broadly influences diverse immune phenotypes, including immune responses to diseases...
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