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Food for thought – ILC metabolism in the context of helminth infections
Food for thought – ILC metabolism in the context of helminth infections
Helminths are multicellular ancient organisms residing as parasites at mucosal surfaces of their host. Through adaptation ...
Trained immunity in type 2 immune responses
Trained immunity in type 2 immune responses
Immunological memory of innate immune cells, also termed “trained immunity”, allows for cross-protection again...
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy development, but the mechanisms cont...
Correction to: Trained immunity in type 2 immune responses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II...
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear whic...
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions ex...
Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections
Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections
The bladder supports a diversity of macrophage populations with functional roles related to homeostasis and host defense, ...
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations
Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations
Immune responses that result in asthma exacerbation are associated with allergen or viral exposure. Identification of comm...
Microbial antigen in human milk: a natural vaccine?
Microbial antigen in human milk: a natural vaccine?
A few studies shed light on the possible ways breast milk vaccination may work and provide the optimal route to activate t...
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Microbiota promotes or inhibits the pathogenesis of a range of immune-mediated disorders. Although recent studies have elu...
Lessons from helminths: what worms have taught us about mucosal immunology
Lessons from helminths: what worms have taught us about mucosal immunology
Ogilvie, B. M. Reagin-like antibodies in animals immune to helminth parasites. Nature 204, 91–92 (1964).CAS  Article  ...
Mucosal immunology of the ocular surface
Mucosal immunology of the ocular surface
The eye is a sensory organ exposed to the environment and protected by a mucosal tissue barrier. While it shares a number ...
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes
Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a br...
The rise to power of the microbiome: power and sample size calculation for microbiome studies
The rise to power of the microbiome: power and sample size calculation for microbiome studies
A priori power and sample size calculations are crucial to appropriately test null hypotheses and obtain valid conclusions...
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Intestinal epithelial barrier function is compromised in inflammatory bowel disease and barrier dysfunction contributes to...
The impact of biological sex on diseases of the urinary tract
The impact of biological sex on diseases of the urinary tract
Biological sex, being female or male, broadly influences diverse immune phenotypes, including immune responses to diseases...
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
Environmental microbial triggers shape the development and functionality of the immune system. Alveolar macrophages (AMs),...
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine
Cytokines are immunomodulatory proteins that orchestrate cellular networks in health and disease. Among these, interleukin...
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen
Antibiotics, among the most used medications in children, affect gut microbiome communities and metabolic functions. These...
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
Children are less likely than adults to suffer severe symptoms when infected with severe acute respiratory syndrome corona...
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues
Regulatory T cells (Tregs) mediate immune homeostasis, yet also facilitate nuanced immune responses during infection, bala...
Regulation of intestinal immunity by dietary fatty acids
Regulation of intestinal immunity by dietary fatty acids
Dietary fatty acids are absorbed through the intestine and are fundamental for cellular energy provision and structural fo...
Neuromedin U promotes human type 2 immune responses
Neuromedin U promotes human type 2 immune responses
Type 2 immunity mediates the immune responses against parasites and allergic stimuli. Evidence from studies of cell lines ...
Lung microbial-host interface through the lens of multi-omics
Lung microbial-host interface through the lens of multi-omics
In recent years, our understanding of the microbial world within us has been revolutionized by the use of culture-independ...
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut
The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in t...
Immunosurveillance of Candida albicans commensalism by the adaptive immune system
Immunosurveillance of Candida albicans commensalism by the adaptive immune system
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is invol...
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination
Breastfeeding protects against mucosal infections in infants. The underlying mechanisms through which immunity develops in...
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice
The lack of clinically applicable mucosal adjuvants is a major hurdle in designing effective mucosal vaccines. We hereby r...