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The important role of the histone acetyltransferases p300/CBP in cancer and the promising anticancer effects of p300/CBP inhibitors
The important role of the histone acetyltransferases p300/CBP in cancer and the promising anticancer effects of p300/CBP inhibitors
Histone acetyltransferases p300 (E1A-associated protein p300) and CBP (CREB binding protein), collectively known as p300/C...
Deciphering SPP1-related macrophage signaling in the pathogenesis of intervertebral disc degeneration
Deciphering SPP1-related macrophage signaling in the pathogenesis of intervertebral disc degeneration
This study delved into the molecular mechanisms underlying mechanical stress-induced intervertebral disc degeneration (msi...
Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin
Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin
Utilizing single-cell transcriptome sequencing (scRNA-seq) technology, this study explores the viability of employing mese...
Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer
Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadil...
SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation
SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation
Alzheimer’s disease (AD), the most prevalent form of dementia in the elderly, involves critical changes such as redu...
Proteomic patterns associated with ketamine response in major depressive disorders
Proteomic patterns associated with ketamine response in major depressive disorders
Major depressive disorder (MDD) is characterized by persistent feelings of sadness and loss of interest. Ketamine has been...
ANXA10 sensitizes microsatellite instability-high colorectal cancer to anti-PD-1 immunotherapy via assembly of HLA-DR dimers by regulating CD74
ANXA10 sensitizes microsatellite instability-high colorectal cancer to anti-PD-1 immunotherapy via assembly of HLA-DR dimers by regulating CD74
Microsatellite instability-high (MSI-H) metastatic colorectal cancer (CRC) patients are the dominant population in immune ...
Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19
Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19
The underlying mechanisms explaining the differential course of SARS-CoV-2 infection and the potential clinical consequenc...
NFKB1 as a key player in Tumor biology: from mechanisms to therapeutic implications
NFKB1 as a key player in Tumor biology: from mechanisms to therapeutic implications
NFKB1, a core transcription factor critical in various biological process (BP), is increasingly studied for its role in tu...
A novel SIRT1 activator attenuates neuropathic pain by inhibiting spinal neuronal activation via the SIRT1-mGluR1/5 pathway
A novel SIRT1 activator attenuates neuropathic pain by inhibiting spinal neuronal activation via the SIRT1-mGluR1/5 pathway
Neuropathic pain is a type of pain caused by an injury or disease of the somatosensory nervous system. Currently, there is...
Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ
Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ
Vascular endothelial cell-derived exosomes are thought to mediate disease progression by regulating macrophage polarizatio...
RNF112, whose transcription is regulated by KLF4, inhibits colorectal cancer growth via promoting ubiquitin-dependent degradation of NAA40
RNF112, whose transcription is regulated by KLF4, inhibits colorectal cancer growth via promoting ubiquitin-dependent degradation of NAA40
RING finger protein 112 (RNF112) exerts a key role in human tumors. However, its biological function in colorectal cancer ...
Identification of cancer-associated fibroblast subtypes and prognostic model development in breast cancer: role of the RUNX1/SDC1 axis in promoting invasion and metastasis
Identification of cancer-associated fibroblast subtypes and prognostic model development in breast cancer: role of the RUNX1/SDC1 axis in promoting invasion and metastasis
In this study, we identified cancer-associated fibroblast (CAF) molecular subtypes and developed a CAF-based prognostic mo...
DNAJB4/HLJ1 deficiency sensitizes diethylnitrosamine-induced hepatocarcinogenesis with peritumoral STAT3 activation
DNAJB4/HLJ1 deficiency sensitizes diethylnitrosamine-induced hepatocarcinogenesis with peritumoral STAT3 activation
Environmental chemicals and toxins are known to impact human health and contribute to cancer developments. Among these, ge...
RBM19 promotes the progression of prostate cancer under docetaxel treatment via SNHG21/PIM1 axis
RBM19 promotes the progression of prostate cancer under docetaxel treatment via SNHG21/PIM1 axis
RBM family proteins plays the critical role in the progression of numerous tumors. However, whether RBM family proteins in...
AP-1 activates KCNN4-mediated Ca2+ signaling to induce the Th1/Th17 differentiation of CD4+ cells in chronic non-bacterial prostatitis
AP-1 activates KCNN4-mediated Ca2+ signaling to induce the Th1/Th17 differentiation of CD4+ cells in chronic non-bacterial prostatitis
The intraprostatic inflammatory infiltrate is characterized by Th1 CD4+ T cells, and its molecular mechanism is not well d...
Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase
Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase
N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related N-acetyltransferase (GNAT) family and it plays a crucial ro...
Targeting CDK1 and copper homeostasis in breast cancer via a nanopolymer drug delivery system
Targeting CDK1 and copper homeostasis in breast cancer via a nanopolymer drug delivery system
The prevalence of breast cancer (BRCA) is notable in the female population, being a commonly diagnosed malignancy, where t...
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates both oxidative stress and mitochondrial biogenesis. Our previ...
miR-21-loaded bone marrow mesenchymal stem cell-derived exosomes inhibit pyroptosis by targeting MALT1 to repair chemotherapy-induced premature ovarian insufficiency
miR-21-loaded bone marrow mesenchymal stem cell-derived exosomes inhibit pyroptosis by targeting MALT1 to repair chemotherapy-induced premature ovarian insufficiency
Chemotherapy is essential for treating malignant tumors, but it can cause premature ovarian insufficiency (POI). Recent st...
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway
Herpes simplex keratitis (HSK), an ocular disease resulted from herpes simplex virus type 1 (HSV-1) infection, leads to th...
eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction
eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction
Doxorubicin-induced cardiotoxicity (DIC) poses a threat to the health and prognosis of cancer patients. It is important to...
E2F1-driven CENPM expression promotes glycolytic reprogramming and tumorigenicity in glioblastoma
E2F1-driven CENPM expression promotes glycolytic reprogramming and tumorigenicity in glioblastoma
Centromere protein M (CENPM), traditionally associated with chromosome segregation, is now recognized for its significant ...
SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression
SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression
Synovial sarcoma (SS) is a rare soft tissue sarcoma characterized by high-grade malignancy and poor prognosis. Preliminary...
HMGA1 influence on iron-induced cell death in Tfh cells of SLE patients
HMGA1 influence on iron-induced cell death in Tfh cells of SLE patients
The autoimmune disorder known as Systemic Lupus Erythematosus (SLE) exhibits intricate features with abnormal immune respo...
Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia
Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid pr...
METTL3, m6A modification, and EGR1: interplay affecting myocardial I/R injury outcomes
METTL3, m6A modification, and EGR1: interplay affecting myocardial I/R injury outcomes
The occurrence of severe myocardial ischemia/reperfusion (I/R) injury is associated with the clinical application of reest...
Identification of gastric cancer stem cells with CD44 and Lgr5 double labelling and their initial roles on gastric cancer malignancy and chemotherapy resistance
Identification of gastric cancer stem cells with CD44 and Lgr5 double labelling and their initial roles on gastric cancer malignancy and chemotherapy resistance
Accumulating evidences have indicated that cancer stem cells (CSCs) can initiate tumor progression and cause recurrence af...
NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes
NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes
Globally, pre-eclampsia (PE) poses a major threat to the health and survival of pregnant women and fetuses, contributing s...
Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury
Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury
Toxicant exposure can lead to acute liver injury, characterized by hepatic reprogramming and wound healing. Hepatic stella...
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