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Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production
Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production
The activation of receptor-interacting protein kinase 1 (RIPK1) by death-inducing signaling complex (DISC) formation is es...
Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin
Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin
Horseshoe bats (Rhinolophus sinicus) might help maintain coronaviruses severely affecting human health, such as severe acu...
Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis
Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis
T helper (Th) 17 cells highly contribute to the immunopathology of rheumatoid arthritis. Morin, a natural flavonoid, owns ...
The role of microRNAs in neurodegenerative diseases: a review
The role of microRNAs in neurodegenerative diseases: a review
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene regulators in various neuronal degene...
Oxygen toxicity: cellular mechanisms in normobaric hyperoxia
Oxygen toxicity: cellular mechanisms in normobaric hyperoxia
In clinical settings, oxygen therapy is administered to preterm neonates and to adults with acute and chronic conditions s...
Single-cell transcriptomic analysis reveals the adverse effects of cadmium on the trajectory of neuronal maturation
Single-cell transcriptomic analysis reveals the adverse effects of cadmium on the trajectory of neuronal maturation
Cadmium (Cd) is an extensively existing environmental pollutant that has neurotoxic effects. However, the molecular mechan...
Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer
Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer
Colorectal cancer (CRC) is a common malignant cancer worldwide. Although the molecular mechanism of CRC carcinogenesis has...
Spatiotemporal role of muscarinic signaling in early chick development: exposure to cholinomimetic agents by a mathematical model
Spatiotemporal role of muscarinic signaling in early chick development: exposure to cholinomimetic agents by a mathematical model
Awareness is growing that, besides several neurotoxic effects, cholinomimetic drugs able to interfere the cholinergic neur...
The aryl hydrocarbon receptor directs the differentiation of murine progenitor blastomeres
The aryl hydrocarbon receptor directs the differentiation of murine progenitor blastomeres
Key regulatory decisions during cleavage divisions in mammalian embryogenesis determine the fate of preimplantation embryo...
Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM
Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM
With improvements in the survival rate of patients with cancer, fertility maintenance has become a major concern in terms ...
A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action
A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action
Aflatoxin B1 (AFB1), produced by fungi of the genus Aspergillus, is the most toxic and carcinogenic mycotoxin among the cl...
Neonatal rat ventricular myocytes interfacing conductive polymers and carbon nanotubes
Neonatal rat ventricular myocytes interfacing conductive polymers and carbon nanotubes
Carbon nanotubes (CNTs) have become promising advanced materials and a new tool to specifically interact with electrorespo...
WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice
WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice
Diabetic foot ulcer (DFU) is a devastating component of diabetes progression, leading to decreased quality of life and inc...
Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications
Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications
The current effective method for the treatment of myocardial infarction is timely restoration of the blood supply to the i...
CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway
CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway
Gemcitabine resistance is a frequently occurring and intractable obstacle in pancreatic cancer treatment. However, the und...
Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells
Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells
In dose-response and structure-activity studies, human hepatic HepG2 cells were exposed for 3 days to nano Cu, nano CuO or...
Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions
Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions
N-acetyltransferase 10 (NAT10), a nuclear acetyltransferase and a member of the GNAT family, plays critical roles in RNA s...
Circ_0004676 exacerbates triple-negative breast cancer progression through regulation of the miR-377-3p/E2F6/PNO1 axis
Circ_0004676 exacerbates triple-negative breast cancer progression through regulation of the miR-377-3p/E2F6/PNO1 axis
The significant roles of circular RNAs (circRNAs) in different cancers and diseases have been reported. We now focused on ...
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) hold great potential in the cardiovascular field fo...