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Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Cytosolic thiouridylase 2 (CTU2) is an enzyme modifying transfer RNAs post-transcriptionally, which has been implicated in...
The transcriptomic signature of respiratory sensitizers using an alveolar model
The transcriptomic signature of respiratory sensitizers using an alveolar model
Environmental contaminants are ubiquitous in the air we breathe and can potentially cause adverse immunological outcomes s...
YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus
YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus
RNA-binding proteins (RBPs) make vital impacts on tumor progression and are important potential targets for tumor treatmen...
Administration of Gas6 attenuates lung fibrosis via inhibition of the epithelial-mesenchymal transition and fibroblast activation
Administration of Gas6 attenuates lung fibrosis via inhibition of the epithelial-mesenchymal transition and fibroblast activation
The epithelial-mesenchymal transition (EMT) and fibroblast activation are major events in idiopathic pulmonary fibrosis pa...
Establishment and characterization of cytochrome P450 1A1 CRISPR/Cas9 Knockout Bovine Foetal Hepatocyte Cell Line (BFH12)
Establishment and characterization of cytochrome P450 1A1 CRISPR/Cas9 Knockout Bovine Foetal Hepatocyte Cell Line (BFH12)
The cytochrome P450 1A (CYP1A) subfamily of xenobiotic metabolizing enzymes (XMEs) consists of two different isoforms, nam...
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future
Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and their risk factors contribute to high...
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy
Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic ...
Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction (FGR) is a common complication of pregnancy and can have significant impact on obstetric and neon...
RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma
RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma
RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our investiga...
Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension
Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension
Nuclear protein 1 (Nupr1) is a multifunctional stress-induced protein involved in the regulation of tumorigenesis, apoptos...
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulat...
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
Lung cancer is the most common cause of cancer-related deaths worldwide and is caused by multiple factors, including high-...
Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation
Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation
Neutrophils play a crucial role in the immune system within tumor microenvironment. At present, numerous studies have expl...
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their inve...
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
Stroke is a major medical problem, and novel therapeutic targets are urgently needed. This study investigates the protecti...
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells. G...
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are m...
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure ...
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury (DILI), and limited options are av...
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The ...
SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway
SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway
Human malignant gliomas are the most common and aggressive primary malignant tumors of the human central nervous system. V...
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipu...
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
Iron overload enhances osteoclastic bone resorption and induces osteoporosis. Excess iron is highly toxic. The modulation ...
GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy
GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy
Chimeric antigen receptor (CAR)-T-cell therapy is a revolutionary treatment that has become a mainstay of advanced cancer ...