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Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human ...
TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. ...
HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding prot...
Delivery of miR-15b-5p via magnetic nanoparticle-enhanced bone marrow mesenchymal stem cell-derived extracellular vesicles mitigates diabetic osteoporosis by targeting GFAP
Delivery of miR-15b-5p via magnetic nanoparticle-enhanced bone marrow mesenchymal stem cell-derived extracellular vesicles mitigates diabetic osteoporosis by targeting GFAP
Diabetic osteoporosis (DO) presents significant clinical challenges. This study aimed to investigate the potential of magn...
Mechanistic and therapeutic perspectives of non-coding RNA-modulated apoptotic signaling in diabetic retinopathy
Mechanistic and therapeutic perspectives of non-coding RNA-modulated apoptotic signaling in diabetic retinopathy
Diabetic retinopathy (DR), a significant and vision-endangering complication associated with diabetes mellitus, constitute...
SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics
SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics
The primary objective of this investigation is to delve into the involvement of the long noncoding RNA (lncRNA) SPACA6P-AS...
Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity
Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity
Structural cardiotoxicity (SCT) presents a high-impact risk that is poorly tolerated in drug discovery unless significant ...
Endosome mediated nucleocytoplasmic trafficking and endomembrane allocation is crucial to polyglutamine toxicity
Endosome mediated nucleocytoplasmic trafficking and endomembrane allocation is crucial to polyglutamine toxicity
Aggregation of aberrant proteins is a common pathological hallmark in neurodegeneration such as polyglutamine (polyQ) and ...
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway
MALT1 has been implicated as an upstream regulator of NF-κB signaling in immune cells and tumors. This study determin...
Correction to: Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury
Correction to: Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy
LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy
Long noncoding RNAs play an important role in several pathogenic processes in diabetic nephropathy, but the relationship w...
HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells
HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells
Vasculogenic mimicry (VM) is an enigmatic physiological feature that influences blood supply within glioblastoma (GBM) tum...
Deoxynivalenol induces m6A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro
Deoxynivalenol induces m6A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro
Hippocampal neurons maintain the ability of proliferation throughout life to support neurogenesis. Deoxynivalenol (DON) is...
The microRNA Let-7 and its exosomal form: Epigenetic regulators of gynecological cancers
The microRNA Let-7 and its exosomal form: Epigenetic regulators of gynecological cancers
Many types of gynecological cancer (GC) are often silent until they reach an advanced stage, and are therefore often diagn...
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy
MYBL1 is a strong transcriptional activator involved in the cell signaling. However, there is no systematic study on the r...
Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP
Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP
Ensartinib, an approved ALK inhibitor, is used as a first-line therapy for advanced ALK-positive non-small cell lung cance...
Exosomes derived from adipose tissue-derived stem cells alleviated H2O2-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway
Exosomes derived from adipose tissue-derived stem cells alleviated H2O2-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway
Hypertrophic scar (HS) is characterized by excessive collagen deposition and myofibroblasts activation. Endothelial-to-mes...
Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish
Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish
Purinergic receptor P2Y11, a G protein-coupled receptor that is stimulated by extracellular ATP, has been demonstrated to ...
Activation of lipophagy ameliorates cadmium-induced neural tube defects via reducing low density lipoprotein cholesterol levels in mouse placentas
Activation of lipophagy ameliorates cadmium-induced neural tube defects via reducing low density lipoprotein cholesterol levels in mouse placentas
Neural tube defects (NTDs) represent a prevalent and severe category of congenital anomalies in humans. Cadmium (Cd) is an...
Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A
Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A
Bisphenol A (BPA) is a common component in the manufacture of daily plastic consumer goods. Recent studies have suggested ...
SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury
SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury
Mitochondrial dysfunction contributes to cerebral ischemia–reperfusion (CI/R) injury, which can be ameliorated by Si...
Exosomes enriched by miR-429-3p derived from ITGB1 modified Telocytes alleviates hypoxia-induced pulmonary arterial hypertension through regulating Rac1 expression
Exosomes enriched by miR-429-3p derived from ITGB1 modified Telocytes alleviates hypoxia-induced pulmonary arterial hypertension through regulating Rac1 expression
Recent studies have emphasized the critical role of Telocytes (TCs)-derived exosomes in organ tissue injury and repair. Ou...
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Fumonisin B1 (FB1), a water-soluble mycotoxin released by Fusarium moniliforme Sheld, is widely present in corn and its de...
Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation
Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation
Anorectal malformation (ARM) is a prevalent early pregnancy digestive tract anomaly. The intricate anatomy of the embryoni...
MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1α through miR-185-5p/TEAD1 pathway
MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1α through miR-185-5p/TEAD1 pathway
In pancreatic ductal adenocarcinomas (PDAC), profound hypoxia plays key roles in regulating cancer cell behavior, includin...
Function and regulation of Rab GTPases in cancers
Function and regulation of Rab GTPases in cancers
The Rab small GTPases are characterized by the distinct intracellular localization and modulate various endocytic, transcy...
Exosomal YB-1 facilitates ovarian restoration by MALAT1/miR-211-5p/FOXO3 axis
Exosomal YB-1 facilitates ovarian restoration by MALAT1/miR-211-5p/FOXO3 axis
Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mese...
Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer
Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer
Lung cancer is a common malignancy that is frequently associated with systemic metabolic disorders. Early detection is piv...
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms
Copper ionophore NSC319726 has attracted researchers' attention in treating diseases, particularly cancers. However, i...
Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review
Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review
Small membranes known as exosomes surround them and are released by several cell types both in vitro and in vivo. These me...
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