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Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis
Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis
Wnt signaling is a principal pathway regulating the essential activities of cell proliferation. Here, we investigated the ...
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis
Radioresistance is the primary reason for radiotherapy failure in non-small cell lung cancer (NSCLC) patients. Glycosylati...
Correction to: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway
Correction to: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway
Department of Thyroid and Breast Surgery, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, 518000, Guangdong Prov...
Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells
Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells
Infertility has attracted global concern, and disruption of testosterone is a common cause of male infertility. Exploring ...
USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer
USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer
Cancer stem cells (CSCs) encompass a subset of highly aggressive tumor cells that are involved in tumor initiation and pro...
Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells
Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells
Hyperhomocysteinemia (HHcy) plays a salient role in male infertility. However, whether HHcy interferes with testosterone p...
Pyroptosis in neurodegenerative diseases: from bench to bedside
Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to t...
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Gasdermin (GSDM) family, the key executioners of pyroptosis, play crucial roles in anti-pathogen and anti-tumor immunities...
Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization
Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization
Tungsten is widely used in medical, industrial, and military applications. The environmental exposure to tungsten has incr...
Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells
Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells
Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compo...
Targeting epigenetic deregulations for the management of esophageal carcinoma: recent advances and emerging approaches
Targeting epigenetic deregulations for the management of esophageal carcinoma: recent advances and emerging approaches
Ranking from seventh in incidence to sixth in mortality, esophageal carcinoma is considered a severe malignancy of food pi...
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells
Overcoming multidrug resistance (MDR) represents a major obstacle in cancer chemotherapy. Cardiac glycosides (CGs) are eff...
Brain pericytes in culture display diverse morphological and functional phenotypes
Brain pericytes in culture display diverse morphological and functional phenotypes
Pericytes play several important functions in the neurovascular unit including contractile control of capillaries, mainten...
Extracellular vesicles derived from paclitaxel-sensitive nasopharyngeal carcinoma cells deliver miR-183-5p and impart paclitaxel sensitivity through a mechanism involving P-gp
Extracellular vesicles derived from paclitaxel-sensitive nasopharyngeal carcinoma cells deliver miR-183-5p and impart paclitaxel sensitivity through a mechanism involving P-gp
Paclitaxel treatment has been applied for late-stage nasopharyngeal carcinoma (NPC), but therapy failure usually occurs du...
T-cell senescence induced by peripheral phospholipids
T-cell senescence induced by peripheral phospholipids
We present an integrated analysis of the clinical measurements, immune cells, and plasma lipidomics of 2000 individuals re...
GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4
GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4
The disease sepsis is caused by an infection that damages organs. Liver injury, with ferroptosis playing a key role, is an...
Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis
Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis
Endothelial-to-mesenchymal transition (EndMT), the process by which endothelial cells lose their characteristics and acqui...
Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells
Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells
Mesenchymal stem cells (MSCs) are emerging crucial regulators in the tumor microenvironment (TME), which contributes to tu...
A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
Cell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for imp...
Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial fibrosis
Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial fibrosis
The development of diabetic nephropathy (DN) could be promoted by the occurrence of tubulointerstitial fibrosis (TIF), whi...
Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia
Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia
RNA-binding proteins (RBPs), long non-coding RNAs (lncRNAs), and small nucleolar RNAs (snoRNAs) were found to play crucial...
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach
GABAA receptors, members of the pentameric ligand-gated ion channel superfamily, are widely expressed in the central nervo...
P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway
P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway
Purinergic signaling-mediated mitochondria dysfunction and innate immune-mediated inflammation act as triggers during acet...
Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal
Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal
Prolonged exposure to toxic heavy metals leads to deleterious health outcomes including kidney injury. Metal exposure occu...
SNORD17-mediated KAT6B mRNA 2’-O-methylation regulates vasculogenic mimicry in glioblastoma cells
SNORD17-mediated KAT6B mRNA 2’-O-methylation regulates vasculogenic mimicry in glioblastoma cells
Glioblastoma (GBM) is a primary tumor in the intracranial compartment. Vasculogenic mimicry (VM) is a process in which a p...
Therapeutic values of engineered immune cells: a precision-guided weapon
Therapeutic values of engineered immune cells: a precision-guided weapon
Immune cell genetic engineering mainly includes cellular receptor engineering with high safet...
The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death
The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death
Targeting BCL2 family proteins to induce cancer cell death has been successful in the treatment of cancer. BH3 mimetics su...
RETRACTED ARTICLE: Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway
RETRACTED ARTICLE: Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway
Department of Oncology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, ChinaFeng Xue & Cai...
Cellular signaling crosstalk between Wnt signaling and gap junctions inbenzo[a]pyrene toxicity
Cellular signaling crosstalk between Wnt signaling and gap junctions inbenzo[a]pyrene toxicity
Gap junctional intercellular communication (GJIC) is considered a key biological mechanism to maintain homeostasis in cell...
Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay
Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay
DNA repair is an essential agent in cancer development, progression, prognosis, and response to therapy. We have adapted a...
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