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RIP2 inhibition alleviates lipopolysaccharide-induced septic cardiomyopathy via regulating TAK1 signaling
PurposeRIP2 is a member of the receptor-interacting protein family that has been associated with various pathophysiologica...
Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-κB/NLRP3 signaling pathways
Sepsis is a lethal syndrome featured by a strong inflammatory response coinciding with multiple-organ functional impairmen...
Intradermal miR-16–5p targets Akt3 and reduces RTX-induced postherpetic neuralgia-mimic pain in mice
Postherpetic neuralgia (PHN) is the most common sequela of herpes zoster (HZ), which can be diagnosed if the neuralgia las...
AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery
Pulmonary hypertension (PH) is a fatal and incurable disease defined by an elevated resting mean pulmonary artery pressure...
Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease with a significant impact on quality of life (...
Ribavirin extends the lifespan of Caenorhabditis elegans through AMPK-TOR Signaling
To explore the anti-aging effects of chlorogenic acid (CGA) and the underlying mechanisms based on a Caenorhabditis elegan...
Role of 5-HT1A receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice
3,4-methylenedioxymethamphetamine (MDMA) is a recreational drug abused worldwide and is known to induce unique prosocial e...
The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation
Airway inflammation is an important component of various airway diseases with a significant mortality and morbidity ratio....
NEP010, a novel compound with minor structural modification from afatinib, exhibited significantly improved antitumor activity
Non-small-cell lung cancer (NSCLC) has advanced in many areas, including classification, diagnosis, and therapy. After ext...
Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis
Obesity is a risk factor for various neurological diseases and can affect behavior, cognition, and mood. In 2020, the Worl...
Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy
Hypertension is the most important risk factor involved in the development of left ventricular hypertrophy (LVH) as a resp...
Mollugin ameliorates murine allergic airway inflammation by inhibiting Th2 response and M2 macrophage activation
Asthma is one of the most common inflammatory lung diseases, affecting approximately 300 million people worldwide (Fortesc...
Modulation of transcription factors by small molecules in β-cell development and differentiation
To uncover novel candidate metabolomic and lipidomic biomarkers in newly-diagnosed type 1 diabetes (T1DM) after achieving ...
The significance of N6-methyladenosine-modified non-coding RNAs in different disorders
N6-methyladenosine (m6A) is a methylation mark that occurs in the N6-position of adenosine. As the most widespread interna...
Regulation of human endothelial cell migration by oral contraceptive estrogen receptor ligands
Ethinylestradiol (EE) and estetrol (E4) are the two main estrogenic agents used in combined oral contraceptives. These com...
Experimental study of EGFR-TKI aumolertinib combined with ionizing radiation in EGFR mutated NSCLC brain metastases tumor
Aumolertinib is an irreversible third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), al...
A focus on Rho/ROCK signaling pathway: An emerging therapeutic target in depression
Depression is a severe life-threatening psychiatric disorder that is characterized by a lack of interest, loss of pleasure...
Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919)
Major depression is the most common mental disorder that negatively affects the social, occupational, and educational aspe...
GABAergic neurons in the nucleus accumbens core mediate the antidepressant effects of sevoflurane
Major depressive disorder has emerged as one of the most prevalent mental disorders, however, a poor understanding of the ...
Adjuvants approved for human use: What do we know and what do we need to know for designing good adjuvants?
Adjuvants represent one of the most significant biotechnological solutions regarding vaccine development, thereby broadeni...