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A gel-forming α-MSH analog promotes lasting melanogenesis
A gel-forming α-MSH analog promotes lasting melanogenesis
Human α-melanocyte stimulating hormone (α-MSH) is derived from the precursor proopiomelanocortin (POMC) peptide that is cr...
Impaired vascular β-adrenergic relaxation in spontaneously hypertensive rats: The differences between conduit and resistance arteries
Impaired vascular β-adrenergic relaxation in spontaneously hypertensive rats: The differences between conduit and resistance arteries
It was suggested that impaired β-adrenergic relaxation in spontaneously hypertensive rats (SHR) might contribute to their ...
Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model
Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model
Alzheimer's disease (AD) is the most common cause of amnesia in old age. Clinical signs in Alzheimer's patients include lo...
Sulforaphane ameliorated podocyte injury according to regulation of the Nrf2/PINK1 pathway for mitophagy in diabetic kidney disease
Sulforaphane ameliorated podocyte injury according to regulation of the Nrf2/PINK1 pathway for mitophagy in diabetic kidney disease
Diabetic kidney disease (DKD) , also called diabetic nephropathy, one of the most common complication of diabetes mellitus...
Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF
Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF
Acute-on-chronic liver failure (ACLF) is a distinct entity characterized by acutely worsening liver and multi-organ dysfun...
SCH 644343 alleviates ischemic stroke-induced neuroinflammation by promoting microglial polarization via the IL-4/SREBP-1 signaling pathway
SCH 644343 alleviates ischemic stroke-induced neuroinflammation by promoting microglial polarization via the IL-4/SREBP-1 signaling pathway
Ischemic stroke (IS) is an acute cerebrovascular disease, and according to its etiology, it can be divided into ischemic a...
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling
Chromofungin (CHR) is a biologically active peptide derived from chromogranin A that exhibits anti-inflammatory effects. H...
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis
IPF (idiopathic pulmonary fibrosis) is the most common form of idiopathic interstitial pneumonia. IPF is a progressive, ir...
Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice
Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice
Non-alcoholic fatty liver disease (NAFLD) is a common condition that can progress to the more severe conditions like non-a...
Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer
Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer
Behind breast cancer, colon cancer, and lung cancer, cervical cancer is one of the most common causes of cancer and the as...
N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype
N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype
N-palmitoylethanolamide (PEA), an analogue of the classical endocannabinoid N-arachidonylethanolamine (AEA) belonging to t...
Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats
Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats
Ischemic heart diseases are major threats to human health worldwide. Prompt reperfusion is the primary objective in saving...
A synopsis of multitarget therapeutic effects of anesthetics on depression
A synopsis of multitarget therapeutic effects of anesthetics on depression
Depression is a profound mental disorder that dampens the mood and undermines volition. The main symptoms of depression ar...
Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-κB pathway through AHR and promoting microglial polarization towards the M2 phenotype in mice with bilateral carotid artery stenosis (BCAS)
Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-κB pathway through AHR and promoting microglial polarization towards the M2 phenotype in mice with bilateral carotid artery stenosis (BCAS)
Cerebral small vessel disease (CSVD) is considered to be one of most common causes of stroke and vascular dementia with hi...
5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice
5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice
Social animals form dominance hierarchies, which can considerably influence their daily activities and general health (Dwo...
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Atherosclerotic cardiovascular diseases and their thrombotic complications are prevalent worldwide and are associated with...
Intranasal EP4 agonist and arginase-1 therapy in a murine model of asthma
Intranasal EP4 agonist and arginase-1 therapy in a murine model of asthma
Asthma is one of the most common chronic lung diseases affecting an estimated 358 million people worldwide (Soriano et al....
Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease
Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder characterized by inevitable loss of memor...
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways
Cardiovascular diseases seriously endanger human health because of their high mortality and morbidity (Aissaoui et al., 20...
High urea induces anxiety disorders associated with chronic kidney disease by promoting abnormal proliferation of OPC in amygdala
High urea induces anxiety disorders associated with chronic kidney disease by promoting abnormal proliferation of OPC in amygdala
Chronic kidney disease (CKD) with anxiety disorder is of a great concern due to its high morbidity and mortality. Urea, as...
Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Nonalcoholic fatty liver disease (NAFLD), the clinical hepatic manifestation of the metabolic syndrome, is marked by ectop...
Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway
Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway
Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in the adolescent, with an incidence of abou...
Synergism of small molecules targeting VDAC with sorafenib, regorafenib or lenvatinib on hepatocarcinoma cell proliferation and survival
Synergism of small molecules targeting VDAC with sorafenib, regorafenib or lenvatinib on hepatocarcinoma cell proliferation and survival
A dynamic balance between oxidative metabolism and aerobic glycolysis supports tumor growth (Alam et al., 2016; Cassim et ...
Etoricoxib nanostructured lipid carriers attenuate inflammation by modulating Cyclooxygenase-2 signaling and activation of nuclear factor-κB-p65 pathways in radiation-induced acute cardiotoxicity in rats
Etoricoxib nanostructured lipid carriers attenuate inflammation by modulating Cyclooxygenase-2 signaling and activation of nuclear factor-κB-p65 pathways in radiation-induced acute cardiotoxicity in rats
One of the most important disorders following radiotherapy is cardiovascular disease (Little et al., 2023; Yi et al., 2023...
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Lung cancer is the primary cause of cancer-related deaths, affecting over 2 million people globally (Brody, 2020). Unfortu...
Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways
Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways
Serotonergic hallucinogens can induce profound alterations in human perception, emotion, cognition, and sense of self (Hol...
Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential
Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential
Apoptosis is the predominant form of cellular suicide crucial to innumerable physiological processes and for the preservat...
A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus
A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus
The sensing of self RNA by the endosomal Toll-like receptors (TLRs) 7 and 8 initiates pathogenic mechanisms underlying the...
Geniposide ameliorates acute kidney injury via enhancing the phagocytic ability of macrophages towards neutrophil extracellular traps
Geniposide ameliorates acute kidney injury via enhancing the phagocytic ability of macrophages towards neutrophil extracellular traps
Acute kidney injury (AKI) is a common clinical critical illness, with sudden decline in renal function caused by various r...
Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases
Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases
The ionotropic P2X7 receptor, primarily known as P2Z, is certainly the most emblematic of all purinergic receptors and has...
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