SCI时时刷

search
+
RIP2 inhibition alleviates lipopolysaccharide-induced septic cardiomyopathy via regulating TAK1 signaling
PurposeRIP2 is a member of the receptor-interacting protein family that has been associated with various pathophysiologica...
Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-κB/NLRP3 signaling pathways
Sepsis is a lethal syndrome featured by a strong inflammatory response coinciding with multiple-organ functional impairmen...
Intradermal miR-16–5p targets Akt3 and reduces RTX-induced postherpetic neuralgia-mimic pain in mice
Postherpetic neuralgia (PHN) is the most common sequela of herpes zoster (HZ), which can be diagnosed if the neuralgia las...
AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery
Pulmonary hypertension (PH) is a fatal and incurable disease defined by an elevated resting mean pulmonary artery pressure...
Nicaraven protects against endotoxemia-induced inflammation and organ injury through modulation of AMPK/Sirt1 signaling in macrophages
At present, endotoxemia and sepsis are still causes of death in intensive care units, and the mortality of sepsis remains ...
Perspective insights of small molecules, phytoconstituents and biologics in the management of psoriasis: A focus on targeting major inflammatory cytokine pathways
Psoriasis is an inveterate, lasting and recurrent autoimmune ailment facilitated by deregulated immunologic responses from...
Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease with a significant impact on quality of life (...
Ribavirin extends the lifespan of Caenorhabditis elegans through AMPK-TOR Signaling
To explore the anti-aging effects of chlorogenic acid (CGA) and the underlying mechanisms based on a Caenorhabditis elegan...
Role of 5-HT1A receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice
3,4-methylenedioxymethamphetamine (MDMA) is a recreational drug abused worldwide and is known to induce unique prosocial e...
The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation
Airway inflammation is an important component of various airway diseases with a significant mortality and morbidity ratio....
NEP010, a novel compound with minor structural modification from afatinib, exhibited significantly improved antitumor activity
Non-small-cell lung cancer (NSCLC) has advanced in many areas, including classification, diagnosis, and therapy. After ext...
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells
Angiogenesis is a pathological phenomenon contribute to the development of chronic liver diseases, and anti-angiogenic the...
Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis
Obesity is a risk factor for various neurological diseases and can affect behavior, cognition, and mood. In 2020, the Worl...
ACE2/ANG-(1-7)/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, accounting for 60–80% of all worldwide dementia case...
Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy
Hypertension is the most important risk factor involved in the development of left ventricular hypertrophy (LVH) as a resp...
Immune-related interstitial lung disease induced by different immune checkpoint inhibitors regimens: A real-world study from 2014 to 2022 based on FAERS databases
The term idiopathic pleuroparenchymal fibroelastosis refers to a rare interstitial lung disease that predominantly involve...
Erratum to “Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone induced neurotoxicity in rats: Insights from an insilico & in vivo anti-Parkinson's disease study” [Eur. J. Pharmacol. 932 (2022) 175204]
Volume 945, 15 April 2023, 175534Author links open overlay panelRana E. Kamal a, Esther Menze b, Amgad Albohy c d, Hebatal...
Mollugin ameliorates murine allergic airway inflammation by inhibiting Th2 response and M2 macrophage activation
Asthma is one of the most common inflammatory lung diseases, affecting approximately 300 million people worldwide (Fortesc...
Modulation of transcription factors by small molecules in β-cell development and differentiation
To uncover novel candidate metabolomic and lipidomic biomarkers in newly-diagnosed type 1 diabetes (T1DM) after achieving ...
The significance of N6-methyladenosine-modified non-coding RNAs in different disorders
N6-methyladenosine (m6A) is a methylation mark that occurs in the N6-position of adenosine. As the most widespread interna...
Corrigendum to “Exenatide ameliorates hydrogen peroxide-induced pancreatic β-cell apoptosis through regulation of METTL3-mediated m6A methylation” [Eur. J. Pharmacol. 924 (2022) 174960]
Volume 946, 5 May 2023, 175652Author links open overlay panelSimin Zhou a b 1, Yue Sun a b 1, Yujie Xing a b, Zhi Wang b d...
Regulation of human endothelial cell migration by oral contraceptive estrogen receptor ligands
Ethinylestradiol (EE) and estetrol (E4) are the two main estrogenic agents used in combined oral contraceptives. These com...
Experimental study of EGFR-TKI aumolertinib combined with ionizing radiation in EGFR mutated NSCLC brain metastases tumor
Aumolertinib is an irreversible third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), al...
A focus on Rho/ROCK signaling pathway: An emerging therapeutic target in depression
Depression is a severe life-threatening psychiatric disorder that is characterized by a lack of interest, loss of pleasure...
Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919)
Major depression is the most common mental disorder that negatively affects the social, occupational, and educational aspe...
GABAergic neurons in the nucleus accumbens core mediate the antidepressant effects of sevoflurane
Major depressive disorder has emerged as one of the most prevalent mental disorders, however, a poor understanding of the ...
Curcumin analogue C66 ameliorates mouse cardiac dysfunction and structural disorders after acute myocardial infarction via suppressing JNK activation
Cardiovascular disease is one of leading causes of health hazards around the world, with acute myocardial infarction (AMI)...
Losartan attenuates acetic acid enema-induced visceral hypersensitivity by inhibiting the ACE1/Ang II/AT1 receptor axis in enteric glial cells
Visceral hypersensitivity is the main driver of abdominal pain in relation to irritable bowel syndrome (IBS), which may be...
The inhibitory effect of oral administration of lentinan on DSS-induced inflammation is exerted by the migration of T cells activated in the ileum to the colon
Inflammatory bowel disease (IBD) is a chronic inflammatory state in the intestinal tract that is related to abnormal immun...
Adjuvants approved for human use: What do we know and what do we need to know for designing good adjuvants?
Adjuvants represent one of the most significant biotechnological solutions regarding vaccine development, thereby broadeni...
阅读更多
format_indent_increase