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IL-37 improves mice myocardial infarction via inhibiting YAP-NLRP3 signaling mediated macrophage programming
ObjectiveMyocardial infarction is the highest cause of cardiovascular death. Previous studies found that patients with myo...
NLRP3 inflammasomes: A potential target to improve mitochondrial biogenesis in Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative condition for which no approved treatment exists to prevent collect...
Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc− to deplete GSH
Ferroptosis is a non-apoptotic cell death characterized by iron-mediated ROS accumulation and increasing lipid peroxidatio...
Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway
Being at the important pathological stage and the critical treatment period of non-alcoholic fatty liver disease (NAFLD), ...
ASIC1a induces mitochondrial apoptotic responses in acute lung injury
AimThis study aimed to investigate the promoting effect of acid-sensing ion channel 1a (ASIC1a) on lipopolysaccharide (LPS...
Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor
BackgroundCysteinyl-maresins, also known as maresin-conjugates in tissue regeneration (MCTRs), are recently discovered lip...
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway
Puerarin (Pue) has been widely used in the treatment of hypertension and cardiovascular diseases, but the basic mechanism ...
Hydrogen sulfide donor GYY4137 attenuates vascular complications in mesenteric bed of streptozotocin-induced diabetic rats
Hydrogen sulfide (H2S) has been reported to have beneficial effects in different pathological conditions. Objectives: the ...
Transcription factor EB protects against endoplasmic reticulum stress in human coronary artery endothelial cells
Oxidative stress and endoplasmic reticulum (ER) stress promote atherogenesis while transcription factor EB (TFEB) inhibits...
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice
Imbalance of macrophage polarization plays a critical role in the progression of rheumatoid arthritis (RA). Geniposide (GE...
Immunomodulatory role of Nanocurcumin in COVID-19 patients with dropped natural killer cells frequency and function
The ongoing COVID-19 pandemic is still a challenging problem in the case of infection treatment. The immunomodulatory effe...
Serum cholesterol increase in statin users associated with antibiotic use: Case-crossover study
Purpose3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (“statins”) reduce risk of atherosclerotic di...
The role of kappa opioid receptors in immune system – An overview
Opioids are one of the most effective anti-nociceptive agents used in patients with cancer pain or after serious surgery i...
Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats
The purpose of the present study was to investigate the effects of ERK1/2 inhibition on both the amygdala and hippocampal ...
Methylglyoxal impairs ATP- and UTP-induced relaxation in the rat carotid arteries
Although methylglyoxal (MGO), a highly reactive dicarbonyl compound, influences the functioning of the vasculature, modula...