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A gel-forming α-MSH analog promotes lasting melanogenesis
A gel-forming α-MSH analog promotes lasting melanogenesis
Human α-melanocyte stimulating hormone (α-MSH) is derived from the precursor proopiomelanocortin (POMC) peptide that is cr...
Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF
Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF
Acute-on-chronic liver failure (ACLF) is a distinct entity characterized by acutely worsening liver and multi-organ dysfun...
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis
IPF (idiopathic pulmonary fibrosis) is the most common form of idiopathic interstitial pneumonia. IPF is a progressive, ir...
Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice
Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice
Non-alcoholic fatty liver disease (NAFLD) is a common condition that can progress to the more severe conditions like non-a...
Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer
Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer
Behind breast cancer, colon cancer, and lung cancer, cervical cancer is one of the most common causes of cancer and the as...
N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype
N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype
N-palmitoylethanolamide (PEA), an analogue of the classical endocannabinoid N-arachidonylethanolamine (AEA) belonging to t...
Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats
Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats
Ischemic heart diseases are major threats to human health worldwide. Prompt reperfusion is the primary objective in saving...
A synopsis of multitarget therapeutic effects of anesthetics on depression
A synopsis of multitarget therapeutic effects of anesthetics on depression
Depression is a profound mental disorder that dampens the mood and undermines volition. The main symptoms of depression ar...
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Atherosclerotic cardiovascular diseases and their thrombotic complications are prevalent worldwide and are associated with...
Intranasal EP4 agonist and arginase-1 therapy in a murine model of asthma
Intranasal EP4 agonist and arginase-1 therapy in a murine model of asthma
Asthma is one of the most common chronic lung diseases affecting an estimated 358 million people worldwide (Soriano et al....
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways
Cardiovascular diseases seriously endanger human health because of their high mortality and morbidity (Aissaoui et al., 20...
Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway
Nonalcoholic fatty liver disease (NAFLD), the clinical hepatic manifestation of the metabolic syndrome, is marked by ectop...
Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway
Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway
Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in the adolescent, with an incidence of abou...
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Lung cancer is the primary cause of cancer-related deaths, affecting over 2 million people globally (Brody, 2020). Unfortu...
Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways
Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways
Serotonergic hallucinogens can induce profound alterations in human perception, emotion, cognition, and sense of self (Hol...
Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases
Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases
The ionotropic P2X7 receptor, primarily known as P2Z, is certainly the most emblematic of all purinergic receptors and has...