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Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Age-related macular degeneration (AMD) is a complex progressive eye disease, resulting in loss of central vision in the ag...
Peculiar Relations of Life Expectancy with Economics according to the Preston Curve and with Cultural Values according to the Hofstede Dimensions in Former Soviet Union and Yugoslavia Countries
Peculiar Relations of Life Expectancy with Economics according to the Preston Curve and with Cultural Values according to the Hofstede Dimensions in Former Soviet Union and Yugoslavia Countries
We checked whether national cultural differences according to Hofstede dimensions (HD) contribute to differences in life e...
Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1
Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1
Multiple sclerosis (MS) is among the most common diseases of the central nervous system. The disease leads to pathological...
Validation of the Portuguese Version of the Adult Carers Quality of Life Questionnaire (AC-QoL) among Informal Carers of Stroke Survivors
Validation of the Portuguese Version of the Adult Carers Quality of Life Questionnaire (AC-QoL) among Informal Carers of Stroke Survivors
Stroke is a leading cause of disability worldwide, significantly affecting not only the health and quality of life of surv...
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
We have studied the concentration of vitamins A (retinol) and E (α-tocopherol) in the tissues of the bank vole (Myode...
Should We Consider Water and Antibiotics to Be Geroprotectors?
Should We Consider Water and Antibiotics to Be Geroprotectors?
The authors try to consider the current situation with experimental gerontological research aimed at finding means to slow...
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
In modern conditions of constant adverse effects on living organisms, such as environmental pollution or global climate ch...
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Studying the mechanisms of age-related changes in vascular reactions and applying the acquired knowledge in clinics can he...
Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells
Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells
Many organs undergo negative changes during aging that affect their functions and ability to regenerate. In particular, th...
Demographic Indicators of Probability Models
Demographic Indicators of Probability Models
Describing mortality dynamics using average indicators without considering variability can yield average results, impeding...
Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts
Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts
Background: The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity and act...
Association between Telomere Length and Geriatric Status in Centenarians
Association between Telomere Length and Geriatric Status in Centenarians
Aim: To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. M...
Senolytic Drugs: Implications for Clinical Practice
Senolytic Drugs: Implications for Clinical Practice
Studying the mechanisms of aging is one of the most important goals of modern science. A significant amount of data on the...
Brain Aging
Brain Aging
Brain aging is part of the aging of the whole body, largely determining the success of general aging and the quality of li...
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
Despite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of g...
Mechanisms of Neurocognitive Adaptation during Aging Process
Mechanisms of Neurocognitive Adaptation during Aging Process
Human aging is associated with an increased risk of various geriatric syndromes, cognitive impairment being among the most...
Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats
Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats
Numerous studies have shown that mitochondria-targeted antioxidant SkQ1 can increase the lifespan of many species and supp...
Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
Genotoxic and cytotoxic drugs, widely used in anticancer therapy, target proliferating cells and induce cell death through...
Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues
Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues
The study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To t...
New Frailty Index Approach Predicts COVID-19 Mortality Risk
New Frailty Index Approach Predicts COVID-19 Mortality Risk
The relationships between blood biomarkers, frailty, and the risk of death of people diagnosed with COVID-19 is unclear. I...
Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease
Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease
In spite of numerous studies, pathogenesis of the sporadic (not inherited) form of Alzheimer’s disease (AD) still re...
Erratum to: Transport and Possible Outcome of Lipofuscin in Mouse Myocardium
Erratum to: Transport and Possible Outcome of Lipofuscin in Mouse Myocardium
An Erratum to this paper has been published: https://doi.org/10.1134/S2079057022310010
Effect of Physical Activity on Sleep Outcomes among Iranian Older Adults: A Cross-Sectional Study
Effect of Physical Activity on Sleep Outcomes among Iranian Older Adults: A Cross-Sectional Study
Sleep disorders have a significant impact on physical and mental health. This study was aimed to determine the effect of p...
On a New Paradigm of the Development of Neurodegenerative Diseases by the Example of Alzheimer’s Disease and Parkinson’s Disease
On a New Paradigm of the Development of Neurodegenerative Diseases by the Example of Alzheimer’s Disease and Parkinson’s Disease
The role of neuronal inflammation developing during the formation of amyloid plaques and Lewy bodies is investigated. The ...
Multidisciplinary Approach in the Treatment of Elderly and Senile Patients with Complications of Colon Cancer
Multidisciplinary Approach in the Treatment of Elderly and Senile Patients with Complications of Colon Cancer
The article presents the results of the treatment of elderly and senile patients with complications of colon cancer, in th...
Neurological Aspects of Systemic Lupus Erythematosus in Individuals with Late Ontogenetic Debut
Neurological Aspects of Systemic Lupus Erythematosus in Individuals with Late Ontogenetic Debut
The review presents the analysis of publications about the peculiarities of the manifestation of systemic lupus erythemato...
Age-Related Menopause and Carbonyl Stress
Age-Related Menopause and Carbonyl Stress
The review analyzes the published data of some studies on redox homeostasis in women with age-related physiological menopa...
Determinants of Subjective Loneliness and Quality of Life among Community-Dwelling Older Adults in Gorgan, Iran
Determinants of Subjective Loneliness and Quality of Life among Community-Dwelling Older Adults in Gorgan, Iran
The purpose of this study was to identify the determinants of, and relationship between, subjective loneliness, general he...
Neurological Complications and Consequences of the Novel Coronavirus COVID-19 Infection in Elderly and Senile Patients (Literature Review)
Neurological Complications and Consequences of the Novel Coronavirus COVID-19 Infection in Elderly and Senile Patients (Literature Review)
Based on available publications, the article systematizes information about some forms of lesions of the central nervous s...
Healthy Life Expectancy of People Over Age 65: Results of the Russian Epidemiological Study EVCALIPT
Healthy Life Expectancy of People Over Age 65: Results of the Russian Epidemiological Study EVCALIPT
The health of a population is an important indicator of the general well-being of the population, and it has its practical...
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