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PEGylated and functionalized polylactide-based nanocapsules: An overview
Polymeric nanocapsules (NC) are versatile mixed vesicular nanocarriers, generally containing a lipid core with a polymeric...
Cosmeceutical formulations of pro-vitamin E phosphate: In-vitro release testing and dermal penetration into excised human skin
Long-term exposure to solar radiation can lead to skin damage such as photoageing, and photocarcinogenesis. This can be pr...
CDX-modified chitosan nanoparticles remarkably reduce therapeutic dose of fingolimod in the EAE model of mice
Fingolimod (Fin), an FDA-approved drug, is used to control relapsing-remitting multiple sclerosis (MS). This therapeutic a...
Antidiabetic potential of Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) on Streptozotocin-induced diabetic rats-An implication on in vivo approach
Gymnemic acid is glycosides of triterpene with recognized and valuable applications for several chronic diseases, mainly d...
Local delivery of artesunate dimer liposomes incorporated injectable hydrogel for H2O2 and pH-independent chemodynamic therapy
Chemodynamic therapy (CDT) has emerged as a powerful tumor treatment option by inducing the imbalance of redox homeostasis...
Co-delivery of gemcitabine and Triapine by calcium carbonate nanoparticles against chemoresistant pancreatic cancer
Pancreatic cancer is a malignant disease with high mortality, and its systemic treatment strategy mainly focuses on chemot...
Novel bilayer coating on gentamicin-loaded titanium nanotube for orthopedic implants applications
Fabricating a multifunctional orthopedic implant which prevents post-surgery infection is highly desirable in advanced mat...
Clindamycin phosphate and bone morphogenetic protein-7 loaded combined nanoparticle-graft and nanoparticle-film formulations for alveolar bone regeneration – An in vitro and in vivo evaluation
Commonly utilized techniques for healing alveolar bone destruction such as the use of growth factors, suffering from short...
Tumor targeted combination therapeutic system for the effective treatment of drug resistant triple negative breast cancer
Breast cancer has become the malignant tumor with the largest incidence, especially the drug resistant triple negative bre...
Fabrication and characterization of anti-rosacea 3D nanofibrous customized sheet masks as a novel scaffold for repurposed use of spironolactone with pre-clinical studies
The repurposed oral use of spironolactone (SP) as an anti-rosacea drug faces many challenges that hinder its efficacy and ...
Improved infectious burn wound healing by applying lyophilized particles containing probiotics and prebiotics
Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers, with the final compos...
Preoperative administration of a biomimetic platelet nanodrug enhances postoperative drug delivery by bypassing thrombus
The postoperative thrombus attached to the damaged blood vessels severely obstructs drugs from crossing the damaged blood–...
Freezing process influences cake appearance of a lyophilized amorphous protein formulation with low solid content and high fill configuration
Low solid content and high fill drug product configuration pose special challenges for achieving elegant cake appearance a...
Formulation optimization of sterilized xanthones-loaded nanoemulgels and evaluation of their wound healing activities
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Carbosilane ruthenium metallodendrimer as alternative anti-cancer drug carrier in triple negative breast cancer mouse model: A preliminary study
The carbosilane metallodendrimer G1-[[NCPh(o-N)Ru(η6- p-cymene)Cl]Cl]4 (CRD13), based on an arene Ru(II) complex coordinat...
Delivering mRNA to a human NK cell line, NK-92 cells, by lipid nanoparticles
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Unconventional and conventional Pickering emulsions: Perspectives and challenges in skin applications
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Machine learning in additive manufacturing & Microfluidics for smarter and safer drug delivery systems
3PNN3D Printing and Neural Network co-modellingAIArtificial IntelligenceANNsArtificial Neural NetworksAPIsActive Pharmaceu...
Nanofiber-coated implants: Development and safety after intravitreal application in rabbits
Intravitreal injections are the preferred choice for drug administration to the posterior segment of the eye. However, the...
Pharmacokinetic evaluation of poorly soluble compounds formulated as nano- or microcrystals after intraperitoneal injection to mice
KeywordsDrug deliveryLymphaticsParenteralPreformulationSuspensionIntraperitoneal administrationMicroparticlesNanoparticles...
Control of API release with matrix polymorphism in tristearin microspheres
Glycerides are widely employed as solid matrices in a range of pharmaceutical intermediates and dosage forms. Diffusion-ba...
Preclinical modeling of intravitreal suspensions
There are a number of obstacles that complicate the development of intravitreal delivered small molecules therapies. One s...
Transport and deposition of beclomethasone dipropionate drug aerosols with varying ethanol concentration in severe asthmatic subjects
This study aims to assess the effects of varying an ethanol co-solvent on the deposition of drug particles in severe asthm...
A multiple controlled-release hydrophilicity minocycline hydrochloride delivery system for the efficient treatment of periodontitis
The complexity of periodontitis, including the complex formation mechanisms and the complex periodontium physiological env...
In situ rearranged multifunctional lipid nanoparticles via synergistic potentiation for oral insulin delivery
Oral administration of therapeutic peptides/proteins (TPPs) is confronted with multiple gastrointestinal (GI) barriers suc...
Cuprous oxide nanoparticles incorporated into a polymeric matrix embedded in fabrics to prevent spread of SARS-CoV-2
This paper describes the development of a coating for cotton and polypropylene (PP) fabrics based on a polymeric matrix em...
Fabrication of a new photoluminescent and pH-responsive nanocomposite based on a hyperbranched polymer prepared from amino acid for targeted drug delivery applications
In this study, the Fe3O4 nanoparticles were encapsulated in the hyperbranched poly L-lysine citramid (HBPLC). The Fe3O4-HB...
Anionic polysaccharides for stabilization and sustained release of antimicrobial peptides
Chemical and enzymatic in vivo degradation of antimicrobial peptides represents a major challenge for their therapeutic us...
Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy
Two of the most promising techniques in terms of ex vivo skin imaging and quantifying are confocal Raman microscopy and MA...
Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment
KeywordsCelecoxibNanosuspensionsParticle size-dependent pharmacokineticsLong-actingAnalgesic effectsAbbreviationsAUCArea u...
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