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Probing the mechanism of release process from metal coordination-based acrylic pressure-sensitive adhesives: Synergistic effect of coordination and hydrogen bonding for controlled drug release
Probing the mechanism of release process from metal coordination-based acrylic pressure-sensitive adhesives: Synergistic effect of coordination and hydrogen bonding for controlled drug release
The transdermal drug delivery system (TDDS) is a sought-after route of drug administration (Wiedersberg and Guy, 2014). In...
An extension of biorelevant fed-state dissolution tests to clinical pharmacokinetics – A study on gastrointestinal factors influencing rivaroxaban exposure and efficacy in atrial fibrillation patients
An extension of biorelevant fed-state dissolution tests to clinical pharmacokinetics – A study on gastrointestinal factors influencing rivaroxaban exposure and efficacy in atrial fibrillation patients
Rivaroxaban is a direct factor Xa inhibitor which is used for the prevention of thromboembolic events in patients with non...
Enhanced intracellular accumulation and cytotoxicity of bortezomib against liver cancer cells using N-stearyl lactobionamide surface modified solid lipid nanoparticles
Enhanced intracellular accumulation and cytotoxicity of bortezomib against liver cancer cells using N-stearyl lactobionamide surface modified solid lipid nanoparticles
Hepatocellular carcinoma (HCC) is the most common type of liver cancer (“Cancer Research UK, 2002.about cancer”). Accordin...
Development of a PAT platform for the prediction of granule tableting properties
Development of a PAT platform for the prediction of granule tableting properties
In this work, the feasibility of implementing a process analytical technology (PAT) platform consisting of Near Infrared S...
The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted API–polymer compatibility
The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted API–polymer compatibility
The majority of new chemical entities and a considerable percentage of currently marketed active pharmaceutical ingredient...
Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia
Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia
Androgenetic alopecia is one of the most frequent nonscarring hair loss and is a heritable, androgen- and age-dependent pr...
Synergism and attenuation of triptolide through prodrug engineering combined with liposomal scaffold strategy to enhance inhibition in pancreatic cancer
Synergism and attenuation of triptolide through prodrug engineering combined with liposomal scaffold strategy to enhance inhibition in pancreatic cancer
The prognosis of pancreatic cancer (PCa) is extremely poor because of its resistance to conventional therapies. Many previ...
Novel strategies enhancing endodontic disinfection: Antibacterial biodegradable calcium hydroxide nanoparticles in an ex vivo model
Novel strategies enhancing endodontic disinfection: Antibacterial biodegradable calcium hydroxide nanoparticles in an ex vivo model
KeywordsAnti-bacterial agentsCalcium hydroxideDisinfectionEndodonticsEnterococcus faecalisNanoparticlesIn vitro antibacter...
A novel theoretical strategy for predicting dissolution kinetics and mechanisms of pharmaceuticals in complex biorelevant media
A novel theoretical strategy for predicting dissolution kinetics and mechanisms of pharmaceuticals in complex biorelevant media
In vitro dissolution testing is a key tool for evaluating pharmaceutical formulations, which can be used to predict in viv...
Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid
Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid
There is growing interest in the colon-targeted delivery of oral medications for treating local and systemic conditions. T...
Large volume subcutaneous delivery using multi-orifice jet injection
Large volume subcutaneous delivery using multi-orifice jet injection
Needle-free jet injection is an alternative drug delivery technique that uses the liquid drug itself to penetrate through ...
Incorporation of doxorubicin and CoFe2O4 nanoparticles into the cellulose acetate phthalate / polyvinyl alcohol (core)/ polyurethane (shell) nanofibers against A549 human lung cancer during chemotherapy/hyperthermia combined method
Incorporation of doxorubicin and CoFe2O4 nanoparticles into the cellulose acetate phthalate / polyvinyl alcohol (core)/ polyurethane (shell) nanofibers against A549 human lung cancer during chemotherapy/hyperthermia combined method
Now that we are writing the results of the anticancer activity of the cellulose acetate phthalate /polyvinyl alcohol-doxor...
Clickable polyethyleneimine incorporated into triblock copolymeric micelles as an efficient platform in the delivery of siRNA to NSCLC cells
Clickable polyethyleneimine incorporated into triblock copolymeric micelles as an efficient platform in the delivery of siRNA to NSCLC cells
The efficacy of transfection vectors to cross the endosomal membrane into the cytosol is a central aspect in the developme...
3D human foreskin model for testing topical formulations of sildenafil citrate
3D human foreskin model for testing topical formulations of sildenafil citrate
Sildenafil citrate is an approved drug used for the treatment of erectile dysfunction and premature ejaculation. Despite a...
Ophthalmic wild olive (ACEBUCHE) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension
Ophthalmic wild olive (ACEBUCHE) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension
Oxidative stress plays a key role in several systemic and ocular diseases, including hypertensive eye diseases. In this co...
Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size
Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size
Nanomedicines can significantly impact human health for the prevention, diagnosis, and treatment of diseases (mainly cance...
Negative effects of cancellation during nanosecond range High-Frequency calcium based electrochemotherapy in vitro
Negative effects of cancellation during nanosecond range High-Frequency calcium based electrochemotherapy in vitro
Electrochemotherapy (ECT) is a pulsed electric field (PEF) mediated technique of targeted drug delivery for the treatment ...
Thermo- and pH-responsive targeted lipid-coated mesoporous nano silica platform for dual delivery of paclitaxel and gemcitabine to overcome HER2-positive breast cancer
Thermo- and pH-responsive targeted lipid-coated mesoporous nano silica platform for dual delivery of paclitaxel and gemcitabine to overcome HER2-positive breast cancer
In 2022, global cancer (GLOBOCAN) statistics showed that about 2.3 million new cases of invasive and non-invasive breast c...
Tumor-specific targeting of polymer drug delivery systems with recombinant proteins bound via tris(nitrilotriacetic acid)
Tumor-specific targeting of polymer drug delivery systems with recombinant proteins bound via tris(nitrilotriacetic acid)
The combination of synthetic polymers and natural proteins provides hybrid materials with unique properties. These materia...
Polymersomes for protein drug delivery across intestinal mucosa
Polymersomes for protein drug delivery across intestinal mucosa
The oral route of drug administration offers several advantages such as low cost, safety and higher patient acceptability ...
Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats
Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats
KeywordsOral drug deliveryLipid-based formulationsLipid-based drug delivery systemsSelf-nanoemulsifying drug delivery syst...
Injectable thermogel incorporating reactive oxygen species scavenger and nitric oxide donor to accelerate the healing process of diabetic wounds
Injectable thermogel incorporating reactive oxygen species scavenger and nitric oxide donor to accelerate the healing process of diabetic wounds
The healing process of skin wounds is intricate, lengthy and systematic, involving stages like blood clotting, inflammatio...
Impact of miconazole nitrate ferrying cationic and anionic nanoemulsion and gels on permeation profiles of across EpiDerm, artificial membrane, and skin: Instrumental evidences
Impact of miconazole nitrate ferrying cationic and anionic nanoemulsion and gels on permeation profiles of across EpiDerm, artificial membrane, and skin: Instrumental evidences
Progressive cases of global fungal infections are the major public health concern. Skin fungal diseases were the most conc...
A polyglutamic acid/tannic acid-based nano drug delivery system: Antibacterial, immunoregulation and sustained therapeutic strategies for oral ulcers
A polyglutamic acid/tannic acid-based nano drug delivery system: Antibacterial, immunoregulation and sustained therapeutic strategies for oral ulcers
Oral ulcers are a common oral mucosal lesion that manifests as a break in the surface of the oral mucosa. It is commonly f...
Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations
Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations
The compression of powders into tablets involves the generation of heat. Besides the elastic and plastic deformation of ma...
Reversible protein complexes as a promising avenue for the development of high concentration formulations of biologics
Reversible protein complexes as a promising avenue for the development of high concentration formulations of biologics
Over the last couple of decades, biological drugs have been gradually taking over small molecules in terms of the number o...
A mucoadhesive nanolipo gel containing Aegle marmelos gum to enhance transdermal effectiveness of linezolid for vaginal infection: In vitro evaluation, in vitro-ex vivo correlation, pharmacokinetic studies
A mucoadhesive nanolipo gel containing Aegle marmelos gum to enhance transdermal effectiveness of linezolid for vaginal infection: In vitro evaluation, in vitro-ex vivo correlation, pharmacokinetic studies
Efficient delivery of drugs at vaginal area remains a tough task owing to its perplexing internal environment including hi...
Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease
Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease
It is estimated that nearly a half of the world’s population over 30 years old suffer from some kind of periodontal diseas...
Supercritical antisolvent-fluidized bed for the preparation of dry powder inhaler for pulmonary delivery of nanomedicine
Supercritical antisolvent-fluidized bed for the preparation of dry powder inhaler for pulmonary delivery of nanomedicine
Over the past few years, nanotechnology has gained notable importance within the medical field. Nanomedicine presents mult...
Enhanced topical paromomycin delivery for cutaneous leishmaniasis treatment: Passive and iontophoretic approaches
Enhanced topical paromomycin delivery for cutaneous leishmaniasis treatment: Passive and iontophoretic approaches
Cutaneous leishmaniasis (CL) is a neglected vector-borne disease caused by protozoans of the Leishmania genus. The World H...
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