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Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress
Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress
Exposure to trauma is a risk factor for the development of a number of mood disorders, and may enhance vulnerability to fu...
KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor
Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurol...
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of basal ganglia (BG) interneurons an...
Glutamatergic synapse in autism: a complex story for a complex disorder
Glutamatergic synapse in autism: a complex story for a complex disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathophysiological mechanisms are still unclear. Hyp...
Social isolation and the brain: effects and mechanisms
Social isolation and the brain: effects and mechanisms
An obvious consequence of the coronavirus disease (COVID-19) pandemic is the worldwide reduction in social interaction, wh...
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Progressive grey matter loss has been demonstrated among clinical high-risk (CHR) individuals who convert to psychosis, bu...
Neurodevelopmental disorders—high-resolution rethinking of disease modeling
Neurodevelopmental disorders—high-resolution rethinking of disease modeling
Neurodevelopmental disorders arise due to various risk factors that can perturb different stages of brain development, and...
Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway
Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway
Spatial learning and memory flexibility are known to require long-term potentiation (LTP) and long-term depression (LTD), ...
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Neuroinflammation has been implicated in multiple brain disorders but the extent and the magnitude of change in immune-rel...
Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling
Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling
The growth cone guides the axon or dendrite of striatal GABAergic projection neurons that protrude into the midbrain and c...
Clinical characteristics indexing genetic differences in schizophrenia: a systematic review
Clinical characteristics indexing genetic differences in schizophrenia: a systematic review
Genome-wide studies are among the best available tools for identifying etiologic processes underlying psychiatric disorder...
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic un...
Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study
Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study
Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder ...
War exposure, post-traumatic stress symptoms and hair cortisol concentrations in Syrian refugee children
War exposure, post-traumatic stress symptoms and hair cortisol concentrations in Syrian refugee children
Altered secretion of cortisol, the primary effector of the hypothalamus–pituitary–adrenal axis, has been propo...
Power and optimal study design in iPSC-based brain disease modelling
Power and optimal study design in iPSC-based brain disease modelling
Studies using induced pluripotent stem cells (iPSCs) are gaining momentum in brain disorder modelling, but optimal study d...
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia
Tandem repeat expansions (TREs) are associated with over 60 monogenic disorders and have recently been implicated in compl...
Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition
Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition
Missense and truncating variants in the X-chromosome-linked CLCN4 gene, resulting in reduced or complete loss-of-function ...
Impact of alcohol exposure on neural development and network formation in human cortical organoids
Impact of alcohol exposure on neural development and network formation in human cortical organoids
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and leads to a collection of dia...
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusi...
Obsessive-compulsive symptoms in two patients with strategic basal ganglia lesions
Obsessive-compulsive symptoms in two patients with strategic basal ganglia lesions
Obsessive-compulsive disorder (OCD) is a severe mental condition neuroanatomically characterized by cortico-striato-thalam...
Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex
Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex
Although large-scale genome-wide association studies (GWAS) have identified an association between MAD1L1 (Mitotic Arrest ...
Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use
Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use
Neuroimaging studies in substance use disorder have shown widespread impairments in white matter (WM) microstructure sugge...
Serotonin-releasing agents with reduced off-target effects
Serotonin-releasing agents with reduced off-target effects
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related di...
Arc controls alcohol cue relapse by a central amygdala mechanism
Arc controls alcohol cue relapse by a central amygdala mechanism
Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of...
Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation
Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation
Posttraumatic stress disorder (PTSD) after the pandemic has emerged as a major neuropsychiatric component of post-acute CO...
Overexpression of transmembrane TNFα in brain endothelial cells induces schizophrenia-relevant behaviors
Overexpression of transmembrane TNFα in brain endothelial cells induces schizophrenia-relevant behaviors
Upregulation of genes and coexpression networks related to immune function and inflammation have been repeatedly reported ...
Correction: An epigenetic mechanism for over-consolidation of fear memories
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate ...