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Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field
Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field
Almost three decades have passed since the first posttraumatic stress disorder (PTSD) neuroimaging study was published. Si...
Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus
Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus
Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been a...
Dentate gyrus is needed for memory retrieval
Dentate gyrus is needed for memory retrieval
The hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactiv...
Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
A major genetic risk factor for psychosis is 22q11.2 deletion (22q11.2DS). However, robust and replicable functional brain...
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under...
Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study
Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study
Psychiatric comorbidity can be accounted for by a latent general psychopathology factor (p factor), which quantifies the v...
Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
Multiscale neuroscience conceptualizes mental illness as arising from aberrant interactions across and within multiple bio...
Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography...
Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits
Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits
Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using ...
Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and...
Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression
Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression
The dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vuln...
Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?
Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patient...
Social experience in adolescence shapes prefrontal cortex structure and function in adulthood
Social experience in adolescence shapes prefrontal cortex structure and function in adulthood
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influence...
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor
The intricate involvement of the serotonin 5-HT2A receptor (5-HT2AR) both in schizophrenia and in the activity of antipsyc...
Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study
Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study
Epigenetic age acceleration (EAA), defined as the difference between chronological age and epigenetically predicted age, w...
Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome
Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome
A microdeletion including the SNORD116 gene (SNORD116 MD) has been shown to drive the Prader-Willi syndrome (PWS) features...
Substance use and spine density: a systematic review and meta-analysis of preclinical studies
Substance use and spine density: a systematic review and meta-analysis of preclinical studies
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance u...
Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders
Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders
Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disea...
Correction: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The relationship between prefrontal cortex gray matter volume and subcortical dopamine release - an addendum
The relationship between prefrontal cortex gray matter volume and subcortical dopamine release - an addendum
Rogeau A, Nordio G, Veronese M, Brown K, Nour MM, Osugo M, et al. The relationship between glutamate, dopamine, and cortic...
Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data
Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data
Bipolar disorder is a chronic and complex polygenic disease with high rates of comorbidity. However, the independent contr...
Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders
Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of relea...
Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls
Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls
Recurrences of depressive episodes in major depressive disorder (MDD) can be explained by the diathesis-stress model, sugg...
Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
About one-third of patients with depression do not achieve adequate response to current treatment options. Although intrav...
Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We in...
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic varian...
Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of both innate and adaptive immune ...
Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects
Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with a specific conn...
Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression
Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression
Depression’s link to serotonin dysregulation is well-known. The monoamine theory posits that depression results from...
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor
Recent studies have consistently demonstrated that the regulation of chromatin and gene transcription plays a pivotal role...
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