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Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials
Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials
Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets in current pharmacological res...
Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder
Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder
Bipolar disorder (BD) is a global medical issue, afflicting around 1% of the population with manic and depressive episodes...
Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults
Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults
Marijuana is a widely used psychoactive substance in the US and medical and recreational legalization has risen over the p...
Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features
Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features
The effect of antipsychotic medication on resting state functional connectivity in major depressive disorder (MDD) is curr...
Expression of TCF7L2 in midbrain Vglut2-positive neurons
Expression of TCF7L2 in midbrain Vglut2-positive neurons
Authors and AffiliationsTsinghua- Peking Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaHuihui...
Correction to: Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder
Correction to: Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Genetic predisposition to macronutrient preference and workplace food choices
Genetic predisposition to macronutrient preference and workplace food choices
Prior research identified genetic variants influencing macronutrient preference, but whether genetic differences underlyin...
Alternative splicing in mouse brains affected by psychological stress is enriched in the signaling, neural transmission and blood-brain barrier pathways
Alternative splicing in mouse brains affected by psychological stress is enriched in the signaling, neural transmission and blood-brain barrier pathways
Psychological stress increases the risk of major psychiatric disorders. Psychological stress on mice was reported to induc...
Brain-based gene expression of putative risk genes for anorexia nervosa
Brain-based gene expression of putative risk genes for anorexia nervosa
The etiology of anorexia nervosa (AN) remains elusive. Recent genome-wide association studies identified the first genes l...
RNA alternative splicing impacts the risk for alcohol use disorder
RNA alternative splicing impacts the risk for alcohol use disorder
Alcohol use disorder (AUD) is a complex genetic disorder characterized by problems arising from excessive alcohol consumpt...
Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills
Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills
The proper maturation of emotional and sensory circuits requires fine-tuning of serotonin (5-HT) level during early postna...
Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Depression is a mental illness frequently accompanied by disordered energy metabolism. A dysregulated hypothalamus pituita...
Integrating subjective and objective—spatiotemporal approach to psychiatric disorders
Integrating subjective and objective—spatiotemporal approach to psychiatric disorders
Kyzar, E. J., & Denfield, G. H. Taking subjectivity seriously: towards a unification of phenomenology, psychiatry, and...
Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala
Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala
Females are more likely than males to develop post-traumatic stress disorder (PTSD). However, the neurobiological mechanis...
Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging
Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging
Obsessive-compulsive disorder (OCD) is an impairing psychiatric condition, which often onsets in childhood. Growing resear...
Microbial modulation via cross-fostering prevents the effects of pervasive environmental stressors on microglia and social behavior, but not the dopamine system
Microbial modulation via cross-fostering prevents the effects of pervasive environmental stressors on microglia and social behavior, but not the dopamine system
Environmental toxicant exposure, including air pollution, is increasing worldwide. However, toxicant exposures are not equ...
Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury
Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury
Alzheimer’s disease (AD), the leading cause of dementia in older adults, is a double proteinopathy characterized by ...
Investigating the shared genetic architecture between schizophrenia and body mass index
Investigating the shared genetic architecture between schizophrenia and body mass index
Evidence for reciprocal comorbidity of schizophrenia (SCZ) and body mass index (BMI) has grown in recent years. However, l...
Post-stroke depression: epigenetic and epitranscriptomic modifications and their interplay with gut microbiota
Post-stroke depression: epigenetic and epitranscriptomic modifications and their interplay with gut microbiota
Epigenetic and epitranscriptomic modifications that regulate physiological processes of an organism at the DNA and RNA lev...
Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence
Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence
Cross-sectional neuroimaging studies show that bipolar disorder is associated with structural brain abnormalities, predomi...
Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium
Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium
Using machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover ...
Coordination of RNA modifications in the brain and beyond
Coordination of RNA modifications in the brain and beyond
Gene expression regulation is a critical process throughout the body, especially in the nervous system. One mechanism by w...
Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis
Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis
In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most ...
CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory
CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory
The late 1990s were banner years in molecular neuroscience; seminal studies demonstrated that local protein synthesis, at ...
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects of homeostasis, including t...
School achievement in adolescence and the risk of mental disorders in early adulthood: a Finnish nationwide register study
School achievement in adolescence and the risk of mental disorders in early adulthood: a Finnish nationwide register study
School grades in adolescence have been linked to later psychiatric outcomes, but large-scale nationwide studies across the...
The interplay between sexual abuse and inflammation, oxidative stress, and DNA damage in drug-naïve panic disorder patients
The interplay between sexual abuse and inflammation, oxidative stress, and DNA damage in drug-naïve panic disorder patients
Although accumulating evidence suggests an interplay between child abuse and inflammatory processes and the pathophysiolog...
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is...
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, li...
Step by step: towards a better understanding of the genetic architecture of Alzheimer’s disease
Step by step: towards a better understanding of the genetic architecture of Alzheimer’s disease
Alzheimer’s disease (AD) is considered to have a large genetic component. Our knowledge of this component has progre...
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