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Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability
Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability
This study explores the genetic and epidemiologic correlates of long-term photoplethysmography-derived pulse rate variabil...
Hippocampal neurogenesis in adult primates: a systematic review
Hippocampal neurogenesis in adult primates: a systematic review
It had long been considered that no new neurons are generated in the primate brain beyond birth, but recent studies have i...
The pathogenic APP N-terminal Val225Ala mutation alters tau protein liquid-liquid phase separation and exacerbates synaptic damage
The pathogenic APP N-terminal Val225Ala mutation alters tau protein liquid-liquid phase separation and exacerbates synaptic damage
Amyloid precursor protein (APP) is predominantly located in synapses of neurons and its mutations have been well recognize...
Cognitive functioning in people with psychotic experiences: a systematic review and meta-analysis study
Cognitive functioning in people with psychotic experiences: a systematic review and meta-analysis study
Earlier research suggested that psychotic experiences (PEs), the extended-psychosis phenotype, are associated with cogniti...
Large-scale proteomic analyses of incident Alzheimer’s disease reveal new pathophysiological insights and potential therapeutic targets
Large-scale proteomic analyses of incident Alzheimer’s disease reveal new pathophysiological insights and potential therapeutic targets
Pathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 ...
Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction
Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction
Schizophrenia (SCZ) is a severe mental disorder affecting around 1% of individuals worldwide. The variability in response ...
Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure
Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure
Clinical and preclinical studies have identified somatostatin (SST)-positive interneurons as critical elements that regula...
Gene–dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer’s mice
Gene–dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer’s mice
High post-menopausal levels of the pituitary gonadotropin follicle-stimulating hormone (FSH) are strongly associated with ...
Hippocampal area CA2 activity supports social investigation following an acute social stress
Hippocampal area CA2 activity supports social investigation following an acute social stress
Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an anim...
Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure
Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure
Analyses of postmortem human brains and preclinical studies of rodents have identified somatostatin (SST)-positive, dendri...
Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs
Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs
Preservation of dendritic spines is a putative mechanism of protection against cognitive impairment despite development of...
Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis
Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis
People with bipolar disorder (BD) have an increased risk of premature mortality and the respiratory mortality rate is high...
The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder
The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder
Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-defic...
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome
Repetitive stereotyped behaviors are core symptoms of autism spectrum disorders (ASD) and fragile X syndrome (FXS), the pr...
Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion
Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion
Adult neural stem and progenitor cells (NSPCs) reside in the dentate gyrus (DG) of the hippocampus throughout the lifespan...
Genome-wide copy number variation association study in anorexia nervosa
Genome-wide copy number variation association study in anorexia nervosa
This study represents the first large-scale investigation of rare (<1% population frequency) copy number variants (...
The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach
The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach
Working memory (WM), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophre...
Gene expression profiles of endothelium, microglia and oligodendrocytes in hippocampus of post-stroke depression rat at single cell resolution
Gene expression profiles of endothelium, microglia and oligodendrocytes in hippocampus of post-stroke depression rat at single cell resolution
Post-stroke depression (PSD) is a common but severe mental complication after stroke. However, the cellular and molecular ...
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring, although the unde...
Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition
Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition
Retrosplenial cortex (RSC) is a brain region involved in neuropsychiatric and neurodegenerative disorders. It has reciproc...
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
The C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-t...
Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis
Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis
Neuroactive steroids including allopregnanolone are implicated in the pathophysiology of peripartum depressive symptoms (P...
Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies
Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies
This study was conducted to clarify patterns of cortico-limbic volume abnormalities in late life depression (LLD) relative...
Evidence of altered monoamine oxidase B, an astroglia marker, in early psychosis and high-risk state
Evidence of altered monoamine oxidase B, an astroglia marker, in early psychosis and high-risk state
A novel radiotracer, [11C]SL25.1188, targets monoamine oxidase-B (MAO-B) enzyme, found primarily in astrocytes, which meta...
Neuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity
Neuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity
Neuroimaging-based subtyping is increasingly used to explain heterogeneity in psychiatric disorders. However, the clinical...
Comment on “Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study.” by Gifuni et al.
Gifuni AJ, Pereira F, Chakravarty MM, Lepage M, Chase HW, Geoffroy MC, et al. Perception of social inclusion/exclusion and...
Causal and common risk pathways linking childhood maltreatment to later intimate partner violence victimization
Causal and common risk pathways linking childhood maltreatment to later intimate partner violence victimization
Childhood maltreatment and intimate partner violence (IPV) victimization are major psychiatric risk factors. Maltreatment ...
Attention and executive delays in early childhood: a meta-analysis of neurodevelopmental conditions
Attention and executive delays in early childhood: a meta-analysis of neurodevelopmental conditions
The objective of this review was to evaluate attention and executive function performance in children with neurodevelopmen...
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
Although specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the ...
A burden of rare copy number variants in obsessive-compulsive disorder
A burden of rare copy number variants in obsessive-compulsive disorder
Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common si...
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