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Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice
Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice
Bipolar disorder (BD) and major depressive disorder (MDD) are the most prevalent mood disorders and cause considerable bur...
The dopaminergic effects of esketamine are mediated by a dual mechanism involving glutamate and opioid receptors
The dopaminergic effects of esketamine are mediated by a dual mechanism involving glutamate and opioid receptors
Esketamine represents a new class of drugs for treating mood disorders. Unlike traditional monoaminergic-based therapies, ...
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure
Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, y...
Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood
Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood
Childhood maltreatment is increasingly recognized as a pivotal risk factor for adverse health outcomes. However, comprehen...
Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain
Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain
Chronic stress is a causal antecedent condition for major depressive disorder and associates with altered patterns of neur...
YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs
YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs
Germline mutations of YY1 cause Gabriele-de Vries syndrome (GADEVS), a neurodevelopmental disorder featuring intellectual ...
Characterizing metabolomic and proteomic changes in depression: a systematic analysis
Characterizing metabolomic and proteomic changes in depression: a systematic analysis
Despite the widespread use of metabolomics and proteomics to explore the molecular landscape of depression, there is a lac...
Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study
Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study
Deficits in mediodorsal thalamus-dorsolateral prefrontal cortex (MDT-DLPFC) resting-state functional magnetic resonance im...
Transthyretin, a novel prognostic marker of POCD revealed by time-series RNA-sequencing analysis
Transthyretin, a novel prognostic marker of POCD revealed by time-series RNA-sequencing analysis
Postoperative cognitive dysfunction (POCD) is defined as a declined cognition, measured by neuropsychological tests, that ...
Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes
Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes
Clozapine is the only approved pharmacotherapy for treatment-resistant schizophrenia. However, widespread utilization of c...
Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section
Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section
Recently published large-scale randomised controlled trials (RCTs) have questioned the efficacy of preventive intervention...
Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes
Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes
Phosphatase and Tensin Homolog (PTEN) is a dual-specific protein and lipid phosphatase that regulates AKT and downstream s...
Gestational autoantibody exposure impacts early brain development in a rat model of MAR autism
Gestational autoantibody exposure impacts early brain development in a rat model of MAR autism
Maternal autoantibody-related autism (MARA) is a subtype of autism characterized by the maternal production of specific pa...
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia
Schizophrenia (SCZ) is a complex psychiatric disorder with unclear biological mechanisms. Spectrins, cytoskeletal proteins...
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
Late-life depression (LLD) has been linked to increased likelihood of dementia, although mechanisms responsible for this a...
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
Alterations induced by maternal immune activation (MIA) during gestation impact the subsequent neurodevelopment of progeny...
Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex
Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex
Regulation of interpersonal distance or “personal space” (PS; the space near the body into which others cannot...
Correction: Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder
Authors and AffiliationsDepartamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de...
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models
Most of the fear literature on humans and animals tests healthy individuals. However, fear memories can differ between hea...
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Both post-mortem and in vivo data argue for dopamine dysfunction in patients with Alzheimer’s Disease (AD). However,...
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence
Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links ...
The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure
The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure
In this perspective we draw together the data from the genome wide association studies for Alzheimer’s disease, Park...
Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use
The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has b...
Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Cognitive and neural mechanisms underlying bipolar disorder (BD) and its treatment are still poorly understood. Here we ex...
Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits
Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits
Alzheimer’s disease (AD) is characterized by memory loss and neuropsychiatric symptoms associated with cerebral amyl...
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Helmholtz Pioneer Campus, Helmholtz Munich, Neuherberg, GermanyNa CaiComputational Health Centre, Helmholtz Munich, Neuher...
Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain
Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain
Age-related dopamine (DA) neuron loss is a primary feature of Parkinson’s disease. However, whether similar biologic...
D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders
D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders
Lysosomal storage disorders characterized by defective heparan sulfate (HS) degradation, such as Mucopolysaccharidosis typ...
Reply to “Concerns regarding the interpretation of Shank3 protein isoforms expressed in Shank3B−/− mice: potential off-target effects by a neomycin resistance cassette”
Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN. Neuron type-specific proteomics reveals distinct Shank3 pro...
Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study
Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study
Mental disorders are associated with an increased risk of premature death, including suicide. This study aimed to examine ...
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