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Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis
Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis
Purpose: Creatinine clearance (CCr) and pharmacokinetic parameters are markedly affected by patho
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Background: Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints.
Pharmacodynamic Model-Based Safety Management of Eribulin-Induced Myelosuppression in Patients With Breast Cancer
Pharmacodynamic Model-Based Safety Management of Eribulin-Induced Myelosuppression in Patients With Breast Cancer
Background: Neutropenia is a major dose-limiting toxicity of cancer chemotherapy. Semimechanistic
Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children
Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children
Background: Cisplatin, widely used in the treatment of solid tumors, causes permanent hearing los
Application of User-Centered Codesign Principles to Address Barriers in Therapeutic Drug Monitoring
Application of User-Centered Codesign Principles to Address Barriers in Therapeutic Drug Monitoring
Background: Different software applications have been developed to support health care profession
Associations among Plasma Concentrations of Edoxaban and M-4, Prothrombin Time, and the SLCO1B1*15 Haplotype in Patients With Nonvalvular Atrial Fibrillation
Associations among Plasma Concentrations of Edoxaban and M-4, Prothrombin Time, and the SLCO1B1*15 Haplotype in Patients With Nonvalvular Atrial Fibrillation
Introduction: The authors aimed to examine the impact of single nucleotide polymorphisms in P-gly
Modeling Approach with Therapeutic Drug Monitoring Data to Describe Time Course of Clozapine Exposure and Positive and Negative Syndrome Scale Scores
Modeling Approach with Therapeutic Drug Monitoring Data to Describe Time Course of Clozapine Exposure and Positive and Negative Syndrome Scale Scores
Objective: The Positive and Negative Syndrome Scale (PANSS) is commonly used to assess the severi
Measuring Serum Vedolizumab and Vedolizumab Antibodies: Comparison of Commercial Assays with the Vedolizumab Clinical Development Assay
Measuring Serum Vedolizumab and Vedolizumab Antibodies: Comparison of Commercial Assays with the Vedolizumab Clinical Development Assay
Background: Vedolizumab (VDZ) is an anti-α4β7 integrin monoclonal antibody approved for inflammat
A Survey of Therapeutic Drug Monitoring Status in China
A Survey of Therapeutic Drug Monitoring Status in China
Objective: To understand the status of therapeutic drug monitoring (TDM) in China Mainland, and t
Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve–Guided Vancomycin Dosing: A Short Communication
Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve–Guided Vancomycin Dosing: A Short Communication
Background: The area under the concentration-time curve (AUC)–guided dosing of vancomycin has bee
Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Tacrolimus in Korean Adult Transplant Recipients: Erratum
Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Tacrolimus in Korean Adult Transplant Recipients: Erratum
In the December 2022 issue of Therapeutic Drug Monitoring, in the article “Pharmacokinetic Model Based on Stochastic Simul...
Generic Medicinal Products in Immunosuppressive Therapy—Should It be a Challenge for Therapeutic Drug Monitoring?
Generic Medicinal Products in Immunosuppressive Therapy—Should It be a Challenge for Therapeutic Drug Monitoring?
Abstract: Immunosuppressants have a narrow therapeutic index (NTIDs). Indisputably cyclosporine,
Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19
Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19
Abstract: Nirmatrelvir/ritonavir (Paxlovid) consists of a peptidomimetic inhibitor (nirmatrelvir)
Why Product Information Should not be Set in Stone: Lessons from a Decade of Linezolid Therapeutic Drug Monitoring: An Opinion Paper
Why Product Information Should not be Set in Stone: Lessons from a Decade of Linezolid Therapeutic Drug Monitoring: An Opinion Paper
*Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, Australia; and †...
Analytical Performance of the New Siemens Affinity Chrome-Mediated Immunoassay Everolimus Assay and Its Interchangeability With the Thermo Quantitative Microsphere System for Routine Therapeutic Drug Monitoring of Patients After Solid Organ Transplantation
Analytical Performance of the New Siemens Affinity Chrome-Mediated Immunoassay Everolimus Assay and Its Interchangeability With the Thermo Quantitative Microsphere System for Routine Therapeutic Drug Monitoring of Patients After Solid Organ Transplantation
Background: A new homogeneous affinity chrome-mediated immunoassay (ACMIA) “EVRO” from Siemens He
Volumetric Absorptive Microsampling for the Therapeutic Drug Monitoring of Everolimus in Patients Who Have Undergone Liver Transplant
Volumetric Absorptive Microsampling for the Therapeutic Drug Monitoring of Everolimus in Patients Who Have Undergone Liver Transplant
Background: Therapeutic drug monitoring (TDM) of everolimus is required to prevent organ rejectio
Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
Background: After heart transplantation, calcineurin inhibitors (CNI) (cyclosporin A and tacrolim
Effect of Therapeutic Plasma Exchange on Itraconazole Pharmacokinetics: A Case Study
Effect of Therapeutic Plasma Exchange on Itraconazole Pharmacokinetics: A Case Study
Abstract: The authors present the case of a 34-year-old male patient who underwent therapeutic pl
New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis
New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis
Background: Acute pulmonary exacerbations (APEs) in patients with adult cystic fibrosis (CF) are
Development and Evaluation of a Height-Based Tobramycin Initial Dosing Nomogram for the Treatment of Adult Cystic Fibrosis Pulmonary Exacerbations
Development and Evaluation of a Height-Based Tobramycin Initial Dosing Nomogram for the Treatment of Adult Cystic Fibrosis Pulmonary Exacerbations
Abstract: Tobramycin is widely used to treat pulmonary exacerbations of cystic fibrosis. Height h
Clearance of Piperacillin–Tazobactam and Vancomycin During Continuous Renal Replacement With Regional Citrate Anticoagulation
Clearance of Piperacillin–Tazobactam and Vancomycin During Continuous Renal Replacement With Regional Citrate Anticoagulation
Background: The use of regional citrate anticoagulation during continuous venovenous hemodiafiltr
Failure of Risk Assessment After Paracetamol Overdose—A Short Communication
Failure of Risk Assessment After Paracetamol Overdose—A Short Communication
Background: The accepted treatment for patients with acetaminophen/paracetamol overdose includes
Acute Sodium Oxybate Intoxication: A Case Report and Review of the Literature
Acute Sodium Oxybate Intoxication: A Case Report and Review of the Literature
Purpose: Despite a better safety profile than illicit γ-hydroxybutyric acid (GHB) and other GHB a
Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs
Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs
Background: The general population widely uses herbal medicines, as they are regarded as effectiv
About an Acute Ethanol Intoxication Case of an Infant
About an Acute Ethanol Intoxication Case of an Infant
*CHU Lille, Unité Fonctionnelle de Toxicologie, Lille, France †Univ. Lille, ULR 4483—IMPECS—IMPact de l’Envir...
Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts Varies as a Function of Screening Criterion Used
Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts Varies as a Function of Screening Criterion Used
*Department of Psychological Science, University of Arkansas, Fayetteville, Arkansas †Department of Psychiatr...
TDM Is Alive and Kicking!
TDM Is Alive and Kicking!
*Univ Rennes, CHU Rennes, Inserm, EHESP; †INSERM, Centre d'Investigation Clinique 1414, Rennes, France; and ...
The Appropriately Designed TDM Clinical Trial: Endpoints, Pitfalls, and Perspectives
The Appropriately Designed TDM Clinical Trial: Endpoints, Pitfalls, and Perspectives
Background: Appropriately designed clinical trials can provide the evidence needed to broadly imp
New Immunoassays in Therapeutic Drug Monitoring: Where is the Journey Heading?
New Immunoassays in Therapeutic Drug Monitoring: Where is the Journey Heading?
*Saladax Biomedical, Inc., Bethlehem, Pennsylvania; and †Department of Pathology, Johns Hopkins University Sc...
Immunosuppressant Monitoring—Performance of the First Mass Spectrometry–Based Automated Clinical Analyzer Cascadion
Immunosuppressant Monitoring—Performance of the First Mass Spectrometry–Based Automated Clinical Analyzer Cascadion
Background: Automatic analyzers simplify processes and may help improve standardization. The firs
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