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Dose Monitoring of Lamotrigine Monotherapy in Pregnancy: Are Pregnant Women with Epilepsy Currently Optimally Managed? A Systematic Review
Dose Monitoring of Lamotrigine Monotherapy in Pregnancy: Are Pregnant Women with Epilepsy Currently Optimally Managed? A Systematic Review
Background: Lamotrigine monotherapy is the first-line treatment for epilepsy in pregnant women. H
Establishing and Extending the Use of Therapeutic Drug Monitoring in Neuropsychopharmacology
Establishing and Extending the Use of Therapeutic Drug Monitoring in Neuropsychopharmacology
Compared with that in previous decades, a prolonged phase of marked stagnation in the development of novel neuropsychophar...
Validation of Population Pharmacokinetic Models for Clozapine Dosage Prediction
Validation of Population Pharmacokinetic Models for Clozapine Dosage Prediction
Background: Clozapine is unique in its capacity to ameliorate severe schizophrenia but at high ri
Delayed Lithium Reintoxication in a Case of Severe Multidrug Intoxication: A Case Study
Delayed Lithium Reintoxication in a Case of Severe Multidrug Intoxication: A Case Study
Abstract: The authors present a case of severe multidrug intoxication following massive ingestion
Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions
Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions
Background: Recently, several studies have assessed the effects of therapeutic drug monitoring of
Enantiomer Plasma Concentrations of Tranylcypromine as a Test for Peripheral Monoamine Oxidase Inhibition
Enantiomer Plasma Concentrations of Tranylcypromine as a Test for Peripheral Monoamine Oxidase Inhibition
*Aristo Pharma GmbH, Medical-Scientific Department, Berlin, Germany; †Department of Psychiatry and Psychother...
Phenytoin Intoxication in a Patient Receiving a Therapeutic Dose for Postoperative Seizure Prophylaxis: A Case Study
Phenytoin Intoxication in a Patient Receiving a Therapeutic Dose for Postoperative Seizure Prophylaxis: A Case Study
Objective: Phenytoin is commonly prescribed to prevent postoperative seizures. Despite the rarity
Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?
Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?
Background: Gentamicin is used to treat severe infections and has a small therapeutic window. Thi
Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: A Scoping Review and Future Perspective
Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: A Scoping Review and Future Perspective
Background: Trazodone hydrochloride is an antidepressant used in clinical practice. As a substrat
Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients With Solid Organ Transplants and Its Correlation to Efficacy and Toxicity
Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients With Solid Organ Transplants and Its Correlation to Efficacy and Toxicity
Background: Cytomegalovirus causes morbidity and mortality, especially in immunocompromised patie
A Survey of Therapeutic Drug Monitoring Status in China: Erratum
A Survey of Therapeutic Drug Monitoring Status in China: Erratum
In the April 2023 issue of Therapeutic Drug Monitoring, in the article “A Survey of Therapeutic Drug Monitoring Status in ...
Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis
Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis
Purpose: Creatinine clearance (CCr) and pharmacokinetic parameters are markedly affected by patho
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Background: Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints.
Pharmacodynamic Model-Based Safety Management of Eribulin-Induced Myelosuppression in Patients With Breast Cancer
Pharmacodynamic Model-Based Safety Management of Eribulin-Induced Myelosuppression in Patients With Breast Cancer
Background: Neutropenia is a major dose-limiting toxicity of cancer chemotherapy. Semimechanistic
Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children
Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children
Background: Cisplatin, widely used in the treatment of solid tumors, causes permanent hearing los
Application of User-Centered Codesign Principles to Address Barriers in Therapeutic Drug Monitoring
Application of User-Centered Codesign Principles to Address Barriers in Therapeutic Drug Monitoring
Background: Different software applications have been developed to support health care profession
Associations among Plasma Concentrations of Edoxaban and M-4, Prothrombin Time, and the SLCO1B1*15 Haplotype in Patients With Nonvalvular Atrial Fibrillation
Associations among Plasma Concentrations of Edoxaban and M-4, Prothrombin Time, and the SLCO1B1*15 Haplotype in Patients With Nonvalvular Atrial Fibrillation
Introduction: The authors aimed to examine the impact of single nucleotide polymorphisms in P-gly
Modeling Approach with Therapeutic Drug Monitoring Data to Describe Time Course of Clozapine Exposure and Positive and Negative Syndrome Scale Scores
Modeling Approach with Therapeutic Drug Monitoring Data to Describe Time Course of Clozapine Exposure and Positive and Negative Syndrome Scale Scores
Objective: The Positive and Negative Syndrome Scale (PANSS) is commonly used to assess the severi
Measuring Serum Vedolizumab and Vedolizumab Antibodies: Comparison of Commercial Assays with the Vedolizumab Clinical Development Assay
Measuring Serum Vedolizumab and Vedolizumab Antibodies: Comparison of Commercial Assays with the Vedolizumab Clinical Development Assay
Background: Vedolizumab (VDZ) is an anti-α4β7 integrin monoclonal antibody approved for inflammat
A Survey of Therapeutic Drug Monitoring Status in China
A Survey of Therapeutic Drug Monitoring Status in China
Objective: To understand the status of therapeutic drug monitoring (TDM) in China Mainland, and t
Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve–Guided Vancomycin Dosing: A Short Communication
Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve–Guided Vancomycin Dosing: A Short Communication
Background: The area under the concentration-time curve (AUC)–guided dosing of vancomycin has bee
Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Tacrolimus in Korean Adult Transplant Recipients: Erratum
Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Tacrolimus in Korean Adult Transplant Recipients: Erratum
In the December 2022 issue of Therapeutic Drug Monitoring, in the article “Pharmacokinetic Model Based on Stochastic Simul...
Generic Medicinal Products in Immunosuppressive Therapy—Should It be a Challenge for Therapeutic Drug Monitoring?
Generic Medicinal Products in Immunosuppressive Therapy—Should It be a Challenge for Therapeutic Drug Monitoring?
Abstract: Immunosuppressants have a narrow therapeutic index (NTIDs). Indisputably cyclosporine,
Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19
Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19
Abstract: Nirmatrelvir/ritonavir (Paxlovid) consists of a peptidomimetic inhibitor (nirmatrelvir)
Why Product Information Should not be Set in Stone: Lessons from a Decade of Linezolid Therapeutic Drug Monitoring: An Opinion Paper
Why Product Information Should not be Set in Stone: Lessons from a Decade of Linezolid Therapeutic Drug Monitoring: An Opinion Paper
*Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, Australia; and †...
Analytical Performance of the New Siemens Affinity Chrome-Mediated Immunoassay Everolimus Assay and Its Interchangeability With the Thermo Quantitative Microsphere System for Routine Therapeutic Drug Monitoring of Patients After Solid Organ Transplantation
Analytical Performance of the New Siemens Affinity Chrome-Mediated Immunoassay Everolimus Assay and Its Interchangeability With the Thermo Quantitative Microsphere System for Routine Therapeutic Drug Monitoring of Patients After Solid Organ Transplantation
Background: A new homogeneous affinity chrome-mediated immunoassay (ACMIA) “EVRO” from Siemens He
Volumetric Absorptive Microsampling for the Therapeutic Drug Monitoring of Everolimus in Patients Who Have Undergone Liver Transplant
Volumetric Absorptive Microsampling for the Therapeutic Drug Monitoring of Everolimus in Patients Who Have Undergone Liver Transplant
Background: Therapeutic drug monitoring (TDM) of everolimus is required to prevent organ rejectio
Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
Background: After heart transplantation, calcineurin inhibitors (CNI) (cyclosporin A and tacrolim
Effect of Therapeutic Plasma Exchange on Itraconazole Pharmacokinetics: A Case Study
Effect of Therapeutic Plasma Exchange on Itraconazole Pharmacokinetics: A Case Study
Abstract: The authors present the case of a 34-year-old male patient who underwent therapeutic pl
New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis
New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis
Background: Acute pulmonary exacerbations (APEs) in patients with adult cystic fibrosis (CF) are
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