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Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex
Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex
Human epidermal growth factor receptor 2 (HER2 or ErbB2) plays a critical role in cell signaling and its deregulation is i...
Cell-induced collagen alignment in a 3D in vitro culture during extracellular matrix production
Cell-induced collagen alignment in a 3D in vitro culture during extracellular matrix production
KeywordsOsteogenic differentiationCollagen alignment3D cell cultureVolume electron microscopy3D FIB/SEMAbbreviationshMSCsh...
Synthesis, in vitro Anti-HIV-1RT evaluation, molecular modeling, DFT and acute oral toxicity studies of some benzotriazole derivatives
Synthesis, in vitro Anti-HIV-1RT evaluation, molecular modeling, DFT and acute oral toxicity studies of some benzotriazole derivatives
Efforts to control HIV/AIDS since the late 1980 s have resulted in a global decline in new infections and deaths (De Clerc...
Dual pattern of cholesterol-induced decoupling of residue-residue interactions of Kir2.2
Dual pattern of cholesterol-induced decoupling of residue-residue interactions of Kir2.2
Numerous ion channels are sensitive to the quantity of cholesterol in the membrane (Fantini and Barrantes, 2013, Levitan e...
An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy
An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy
Cerebral vascular pathologies including cerebral amyloid angiopathy (CAA) are a major contributor to the progression of ne...
Cryo-EM structure of bacterial nitrilase reveals insight into oligomerization, substrate recognition, and catalysis
Cryo-EM structure of bacterial nitrilase reveals insight into oligomerization, substrate recognition, and catalysis
Many enzymes can self-assemble into higher-order structures with helical symmetry. A particularly noteworthy example is th...
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1
Staphylococcus aureus, an ESKAPE pathogen, is a major clinical concern due to its pathogenicity and manifold antimicrobial...
Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751
Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751
Tuberculosis (TB) persists as one of the world's deadliest infectious diseases, claiming the lives of 1.6 million people i...
Unveiling success determinants for AMB-assisted phase expansion of fusion proteins in ARP/wARP
Unveiling success determinants for AMB-assisted phase expansion of fusion proteins in ARP/wARP
Fusion proteins (FP) are a group of proteins in which two or more protein domains are integrated into a single-chain molec...
Molecular insights into the binding interactions and energetics of the omicron spike variant with hACE2 and a neutralizing antibody
Molecular insights into the binding interactions and energetics of the omicron spike variant with hACE2 and a neutralizing antibody
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) originated in the Wuhan province of China in December 201...
Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines
Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines
Sea urchins have a spherical outer shell and spines that extend from their shell composed of calcium carbonate (CaCO3). Th...
Optimal 3D angular sampling with applications to cryo-EM problems
Optimal 3D angular sampling with applications to cryo-EM problems
The goal of cryo-EM experiments in the biological sciences is to determine the atomic structure of a molecule and deduce i...
Magnesium-containing calcite synthesis by tropomyosin determined from sea urchin spines
Magnesium-containing calcite synthesis by tropomyosin determined from sea urchin spines
Sea urchins have a spherical outer shell and spines that extend from their shell composed of calcium carbonate (CaCO3). Th...
Deep Generative Priors for Biomolecular 3D Heterogeneous Reconstruction from Cryo-EM Projections
Deep Generative Priors for Biomolecular 3D Heterogeneous Reconstruction from Cryo-EM Projections
KeywordsSingle-particle analysisCryogenic electron microscopyProtein conformational variationDeep generative modelsData av...
Effects of Xylanase A double mutation on substrate specificity and structural dynamics
Effects of Xylanase A double mutation on substrate specificity and structural dynamics
Enzyme activity is traditionally studied with a major focus on the active site and how its structure contributes to the en...
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information
Single particle cryo-electron microscopy (cryo-EM) is a technique that can provide detailed structural information on the ...
Comprehensive structural overview of the C-terminal ligand-binding domains of the TetR family regulators
Comprehensive structural overview of the C-terminal ligand-binding domains of the TetR family regulators
TetR family regulators (TFRs) represent a large group of one-component bacterial signal transduction systems which recogni...
The structural biology of type III CRISPR-Cas systems
The structural biology of type III CRISPR-Cas systems
The CRISPR-Cas system is a widespread RNA-guided adaptive immune system found in both bacteria (50 %) and archaea (90 %) (...
Obituary Luis Bachmann An early pioneer of cryo-electron microscopy
Obituary Luis Bachmann An early pioneer of cryo-electron microscopy
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
ColabSeg: An interactive tool for editing, processing, and visualizing membrane segmentations from cryo-ET data
ColabSeg: An interactive tool for editing, processing, and visualizing membrane segmentations from cryo-ET data
KeywordsCryo-electron tomography (CryoET)electron microscopysegmentationlipid membranesimage analysisData availabilityThe ...
A strategic approach for efficient cryo-EM grid optimization using design of experiments
A strategic approach for efficient cryo-EM grid optimization using design of experiments
Cryo-electron microscopy (cryo-EM) is capable of producing high-resolution structures which are not practical to obtain vi...
Control of crystal growth during coccolith formation by the coccolithophore Gephyrocapsa oceanica
Control of crystal growth during coccolith formation by the coccolithophore Gephyrocapsa oceanica
KeywordsCoccolithophores, biomineralization, cryo-transmission electron microscopyFocused-ion beam scanning electron micro...
Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis
Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis
AbbreviationsFabHβ-Ketoacyl-ACP synthase IIIFASIIbacterial fatty acid synthesisKeywordsBacillus subtilisFabHAFabHBCrystal ...
Characterization of a new extra-axonemal structure in the Giardia intestinalis flagella
Characterization of a new extra-axonemal structure in the Giardia intestinalis flagella
Giardia intestinalis is a parasite that causes giardiasis, a diarrheal disease in humans and animals. It is one of the mos...
A strained N-capping motif in α-helices of βαβ-units
A strained N-capping motif in α-helices of βαβ-units
The N-cap and C-cap are amino acid residues that form the first and last hydrogen bonds between the α-helix backbone amide...
Focused Ion Beam-SEM 3D study of osteodentin in the teeth of the Atlantic wolfish Anarhichas lupus
Focused Ion Beam-SEM 3D study of osteodentin in the teeth of the Atlantic wolfish Anarhichas lupus
The evolutionary histories of dentin and bone are closely intertwined and must be considered together(Sire and Kawasaki, 2...
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite
Available online 5 January 2024, 108061Author links open overlay panel, , , , , , , AbstractThe low sensitivity of nuclear...