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Journal of Structural Biology – Paper of the Year 2022
Journal of Structural Biology – Paper of the Year 2022
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Local defocus estimation in Single Particle Analysis in Cryo-Electron Microscopy
Local defocus estimation in Single Particle Analysis in Cryo-Electron Microscopy
Single Particle analysis (SPA) aims to determine the three-dimensional structure of proteins and macromolecular complexes....
Contribution of a surface salt bridge to the protein stability of deep-sea Shewanella benthica cytochrome c'
Contribution of a surface salt bridge to the protein stability of deep-sea Shewanella benthica cytochrome c'
To comprehensively understand the relationship between organisms and natural environment at the molecular level, multidisc...
Insight into Structural Biophysics from Solution X-ray Scattering
Insight into Structural Biophysics from Solution X-ray Scattering
The challenge of structural biophysics is determining the structure of large self-assembled complexes made of many, often ...
Focused classifications and refinements in high-resolution single particle cryo-EM analysis
Focused classifications and refinements in high-resolution single particle cryo-EM analysis
Structural disorder is a characteristic feature of most macromolecular complexes in biology. This can occur in different w...
Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase
Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase
Escherichia coli’s dodecameric NADPH-dependent assimilatory sulfite reductase (SiR) is both asymmetric and highly flexible...
A new algorithm for particle weighted subtraction to decrease signals from unwanted components in Single Particle Analysis
A new algorithm for particle weighted subtraction to decrease signals from unwanted components in Single Particle Analysis
Single particle analysis (SPA) in cryo-electron microscopy (cryo-EM) is highly used to obtain the near-atomic structure of...
Selective Labeling of Phosphatidylserine for Cryo-TEM by a Two-Step Immunogold Method
Selective Labeling of Phosphatidylserine for Cryo-TEM by a Two-Step Immunogold Method
Cells and sub-cellular organelles of living organisms are enclosed and separated from the environment by membranes, compos...
Structure and heterogeneity of a highly cargo-loaded encapsulin shell
Structure and heterogeneity of a highly cargo-loaded encapsulin shell
Encapsulins are cargo-loaded protein nanocompartments found in a wide variety of prokaryotes (Giessen, 2022). Encapsulin s...
A STRP-ed definition of Structured Tandem Repeats in Proteins
A STRP-ed definition of Structured Tandem Repeats in Proteins
Tandem Repeat Proteins (TRPs) are a class of proteins with repetitive amino acid sequences that have been studied extensiv...
Lipid composition modulates interactions of p7 viroporin during membrane insertion
Lipid composition modulates interactions of p7 viroporin during membrane insertion
In recent years, lipids have received renewed attention as active players in illnesses due to their participation in patho...
Structure and dynamics of the mitochondrial DNA-compaction factor Abf2 from S. cerevisiae
Structure and dynamics of the mitochondrial DNA-compaction factor Abf2 from S. cerevisiae
Mitochondria are essential organelles that produce most of the energy via the oxidative phosphorylation (OXPHOS) system in...
Why does the first protein repeat often become the only one?
Why does the first protein repeat often become the only one?
Proteins contain a large portion of sequences with arrays of repeats that are directly adjacent to each other (Heringa, 19...
Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation
Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation
Titin is the largest protein found in nature and spans half a sarcomere in vertebrate striated muscle. The protein has mul...
Correlating cryo-super resolution radial fluctuations and dual-axis cryo-scanning transmission electron tomography to bridge the light-electron resolution gap
Correlating cryo-super resolution radial fluctuations and dual-axis cryo-scanning transmission electron tomography to bridge the light-electron resolution gap
Cryo-transmission electron tomography (cryo-ET, Frank (2006)), cryo-scanning transmission electron tomography (CSTET, Wolf...
New protein families with hendecad coiled coils in the proteome of life
Volume 215, Issue 3, September 2023, 108007Author links open overlay panel, Highlights•Hendecad coiled coils are widesprea...
Locating cellular contents during cryoFIB milling using cellular secondary-electron imaging
Cryo-electron tomography (cryoET) is a popular technology that allows the in situ observation of the molecular structure o...
Binding of human Cdc123 to eIF2γ
The heterotrimeric initiation factor 2 (e/aIF2) has a central role in eukaryotic and archaeal translation initiation (Hinn...
Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity
NAD biosynthesis has emerged as a highly active and vital process for cell homeostasis. It was originally believed that NA...
The role of tandem repeats in bacterial functional amyloids
Across different domains of life, we observe symmetry and modularity. This common phenomenon guarantees the optimization o...
Towards in situ high-resolution imaging of viruses and macromolecular complexes using cryo-electron tomography
Structural biology plays a central role in our understanding of life. The past few decades have witnessed the development ...
Towards in situ high-resolution imaging of viruses and macromolecular complexes using cryo-electron tomography
Structural biology plays a central role in our understanding of life. The past few decades have witnessed the development ...
The repetitive structure of DNA clamps: an overlooked protein tandem repeat
Structured tandem repeats proteins (STRPs) are a specific kind of tandem repeat proteins characterized by a modular and re...
Building alternative splicing and evolution-aware sequence-structure maps for protein repeats
Repetitive elements are a pervasive feature of proteins, ranging from simple tandem repeats to complex repeat architecture...
A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate
While recent advances in cryo-EM, coupled with single particle analysis, have the potential to allow structure determinati...
Cell recognition based on atomic force microscopy and modified residual neural network
Cell identification and recognition methods have been widely applied in various biomedical applications, such as subcellul...
Robust ab initio solution of the cryo-EM reconstruction problem at low resolution with small data sets
Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to ac...
Three dimensional structures of the inner and outer pig petrous bone using FIB-SEM: Implications for development and ancient DNA preservation
The petrous bone surrounds the inner ear cavities that house the cochlea and the vestibule organs responsible for hearing ...
Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes
New mutants have continued to emerge since the SARS-CoV-2 outbreak in 2019 (Cosar et al., 2022, Li et al., 2020, Mengist e...
4Three dimensional structures of the inner and outer pig petrous bone using FIB-SEM: implications for development and ancient DNA preservation
The petrous bone surrounds the inner ear cavities that house the cochlea and the vestibule organs responsible for hearing ...
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