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New insights into the effect of mutations on Affibody-Fc interaction, a molecular dynamics simulation approach
Staphylococcal protein A (SpA) domain B (the basis of affibody) has been widely used in affinity chromatography and found ...
Proton irradiation induced reactive oxygen species promote morphological and functional changes in HepG2 cells
The increased use of proton therapy has led to the need of better understanding the cellular mechanisms involved. The aim ...
The crystal structure of the H116Q mutant of NDM-1: An enzyme devoid of zinc ions
New Delhi metallo-β-lactamase 1 (NDM-1) is an important causative factor of antimicrobial resistance due to its efficient ...
Structure and dynamics of the von Willebrand Factor C6 domain
Von Willebrand disease (VWD) is a bleeding disorder with different levels of severity. VWD-associated mutations are locate...
Structural basis for cell type specific DNA binding of C/EBPβ: The case of cell cycle inhibitor p15INK4b promoter
C/EBPβ is a key regulator of numerous cellular processes, but it can also contribute to tumorigenesis and viral diseases. ...
Characterization of heterogeneity in nanodisc samples using Feret signatures
Nanodiscs have become a popular tool in structure determination of membrane proteins using cryogenic electron microscopy a...
BACTERIAL NADQ (COG4111) IS A NUDIX-LIKE, ATP-RESPONSIVE REGULATOR OF NAD BIOSYNTHESIS
Nicotinamide-adenine dinucleotide (NAD) is centrally important to metabolic reactions that involve redox chemistry. In bac...
Smart Data Collection for CryoEM
This report provides an overview of the discussions, presentations, and consensus thinking from the Workshop on Smart Data...
Automatic determination of the handedness of Single-Particle maps of macromolecules solved by CryoEM
Available online 29 October 2022, 107915Highlights•HaPi (Handedness Pipeline) can automatically determine the hand of cyro...
SAM1 domain of SASH1 harbors distinctive structural heterogeneity
The sterile alpha motif (SAM) domains are among the most versatile protein domains in biology, and the variety of the olig...
Sub-micrometric spatial distribution of amorphous and crystalline carbonates in biogenic crystals using coherent Raman microscopy
In living organisms, calcium carbonate biomineralization combines complex bio-controlled physical and chemical processes t...
Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodeling by Hfq master regulator
The bacterial chromosomic DNA is packed within a membrane-less structure, the nucleoid, due to the association of DNA with...
Statistical proofs of the interdependence between nearest neighbor effects on polypeptide backbone conformations
Available online 19 October 2022, 107907Highlights•Rigorous investigation of distributions of polypeptide backbone dihedra...
Age-associated thin hair displays molecular, structural and mechanical characteristic changes
Hair thinning occurs during normal chronological aging in women and in men leading to an increased level of thinner hair s...
Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8
Fatty acid kinase is necessary for the incorporation of exogenous fatty acids into membrane phospholipids. Fatty acid kina...
High-resolution cryo-EM performance comparison of two latest-generation cryo electron microscopes on the human ribosome
Recent technological advances in cryo electron microscopy (cryo-EM) have led to new opportunities in the structural biolog...
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM
Available online 3 October 2022, 107902Highlights•Universal problem of incorrect absolute magnification in nearly all cryo...
Crystal structure of the Phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain
Phospholipase A and Acyltransferase 4 (PLAAT4) is a class II tumor suppressor, that also plays a role as a restrictor of i...
Journal of Structural Biology – Paper of the Year 2021
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Conformational ensemble of amyloid-forming semenogelin 1 peptide SEM1(68–107) by NMR spectroscopy and MD simulations
SEM1(68–107) is a peptide corresponding to the region of semenogelin 1 protein from 68 to 107 amino acid position. SEM1(68...
Metallic Support Films Reduce Optical Heating in Cryogenic Correlative Light and Electron Tomography
Available online 1 October 2022, 107901Highlights:•Super-resolved cryoCLEM is limited by sample heating due to optical exc...
Paper of the year
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Paper of the year draft
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Multi-curve fitting and tubulin-lattice signal removal for structure determination of large microtubule-based motors
Available online 8 September 2022, 107897AbstractRevealing high-resolution structures of microtubule-associated proteins (...
MlaC belongs to a unique class of non-canonical substrate-binding proteins and follows a novel phospholipid-binding mechanism
Available online 7 September 2022, 107896Highlights•MlaC comprises two domains viz. NTF2-like and PBP.•Each domain can be ...
Electron-counting MicroED data with the K2 and K3 direct electron detectors
Available online 28 August 2022, 107886Highlights•Gatan K2/K3 direct electron detector used for MicroED in counting mode.•...