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Issues and Events
Issues and Events
Updates to the Standards of Medical Care in Diabetes—2021The American Diabetes Association issued important updates to the...
The Tetracycline-Controlled Transactivator (Tet-On/Off) System in {beta}-Cells Reduces Insulin Expression and Secretion in Mice
The Tetracycline-Controlled Transactivator (Tet-On/Off) System in {beta}-Cells Reduces Insulin Expression and Secretion in Mice
AbstractControllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cel...
Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
IntroductionMetabolites, the products of cellular activity and the environment, can be considered as intermediates between...
Syntaxin 4 Enrichment in {beta}-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
Syntaxin 4 Enrichment in {beta}-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
AbstractSyntaxin 4 (STX4), a plasma membrane–localized SNARE protein, regulates human islet β-cell insulin secretion and p...
Diabetes and the Risk of Long-term Post-COVID Symptoms
Diabetes and the Risk of Long-term Post-COVID Symptoms
AbstractThis study investigated the association of diabetes in patients who recovered from severe acute respiratory syndro...
Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9
Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9
AbstractCyclic nucleotides cAMP and cGMP are important second messengers for the regulation of adaptive thermogenesis. The...
Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study
Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study
AbstractPatients with type 2 diabetes mellitus (T2DM) are at increased risk of severe coronavirus disease 2019 (COVID-19) ...
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
IntroductionThe outbreak of the novel β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function
AbstractReactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydroge...
Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner
Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner
AbstractWe previously demonstrated that male, but not female, Swiss Webster mice are susceptible to diabetes, with inciden...
Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1
Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1
AbstractThe two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4, both substrates for AMPK, play ...
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS)
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS)
AbstractLifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes...
The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes
The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes
AbstractEnd points that provide an early identification of treatment effects are needed to implement type 1 diabetes preve...
Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes
Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes
AbstractSodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of major adverse cardiovascular (CV) events and ...
COVID-19-Induced New-Onset Diabetes: Trends and Technologies
COVID-19-Induced New-Onset Diabetes: Trends and Technologies
IntroductionCoronavirus disease 2019 (COVID-19) is a global pandemic responsible for approximately 216 million confirmed c...
Novel Human Insulin Isoforms and C{alpha}-Peptide Product in Islets of Langerhans and Choroid Plexus
Novel Human Insulin Isoforms and C{alpha}-Peptide Product in Islets of Langerhans and Choroid Plexus
AbstractHuman insulin (INS) gene diverged from the ancestral genes of invertebrate and mammalian species millions of years...
Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect
Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect
AbstractEnteroviruses, including the Coxsackievirus Bs (CVB), have been implicated as causal agents in human type 1 diabet...
Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms
Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms
AbstractRecognition of β-cell antigens by autoreactive T cells is a critical step in the initiation of autoimmune type1 di...
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
AbstractIn the attempt to understand the origin of autoantibody (AAb) production in patients with and at risk for type 1 d...
CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
AbstractIn type 1 diabetes, autoimmune β-cell destruction may be favored by neoantigens harboring posttranslational modifi...
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation
AbstractDuring pancreas development, endocrine progenitors differentiate into the islet cell subtypes, which undergo furth...
Mineralocorticoid Receptor Pathway and Its Antagonism in a Model of Diabetic Retinopathy
Mineralocorticoid Receptor Pathway and Its Antagonism in a Model of Diabetic Retinopathy
AbstractDiabetic retinopathy remains a major cause of vision loss worldwide. Mineralocorticoid receptor (MR) pathway activ...
ENTPD3 Marks Mature Stem Cell-Derived {beta}-Cells Formed by Self-Aggregation In Vitro
ENTPD3 Marks Mature Stem Cell-Derived {beta}-Cells Formed by Self-Aggregation In Vitro
AbstractStem cell–derived β-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells ...
Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation
Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation
AbstractFrequencies of circulating immune cells are altered in those with type 1 and type 2 diabetes compared with healthy...
GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models
GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models
AbstractGlucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity an...
VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy
VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy
AbstractFoot process effacement is an important feature of early diabetic nephropathy (DN), which is closely related to th...
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
AbstractAdipose tissues are not homogeneous and show site-specific properties. An elusive and understudied adipose tissue ...
Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture
Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture
The incretin effect, i.e., the amplification of insulin secretion observed when glucose is administered orally as opposed ...
Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH
Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH
AbstractRegulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic f...
Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4{alpha}
Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4{alpha}
AbstractActivating transcription factor 3 (ATF3) has been shown to play an important role in HDL metabolism; yet, the role...
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