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Frataxin is essential for zebrafish embryogenesis and pronephros formation
1 IntroductionFriedreich’s Ataxia (FRDA, OMIM #229300) is an autosomal recessive neurodegenerative disease and the most co...
The pro-fibrotic role of autophagy in renal intrinsic cells: mechanisms and therapeutic potential in chronic kidney disease
1 IntroductionChronic kidney disease (CKD) is a progressive disorder characterized by chronic structural and functional da...
Cell therapy in kidney diseases: advancing treatments for renal regeneration
1 IntroductionKidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), represent a significa...
Anticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models
1 IntroductionPancreatic adenocarcinoma (PDAC) is one of the most malignant neoplastic disease due to its invasiveness, fr...
Multi-omics in exploring the pathophysiology of diabetic retinopathy
1 IntroductionDiabetic retinopathy (DR) is a leading cause of vision impairment and blindness among the working-age popula...
The role of sphingolipid rheostat in the adult-type diffuse glioma pathogenesis
1 IntroductionGliomas, the most prevalent and aggressive form of intracranial cancer, account for over 80% of malignant br...
Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis
IntroductionSepsis is a dysregulated host response to infection that can lead to life-threatening organ failure. Cardiac d...
Progress in the pathogenic mechanism, histological characteristics of hereditary dentine disorders and clinical management strategies
1 IntroductionHereditary dentine disorders are rare genetic dental developmental disorders characterized by abnormalities ...
Deciphering hematopoietic stem cell development: key signaling pathways and mechanisms
IntroductionVarious types of blood cells, such as lymphoid and myeloid cells, are produced from hematopoietic stem cells (...
Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease
Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease
1 Introduction1.1 PIWI proteins and piRNAsPIWI-interacting RNAs, called piRNAs, are single-stranded small RNAs with a size...
An improved method for whole-mount in situ hybridization in regenerating tails of Xenopus laevis tadpoles
1 IntroductionOne of the most frequently used methods in the concept of “seeing is believing” is in situ hybridization, wh...
Editorial: Genetic and cellular heterogeneity in tumors
occupying 10%-20% of invasive breast cancer cases, is the subtype with the worst prognosis caused by the absence of target...
The role of ferroptosis-related non-coding RNA in liver fibrosis
1 IntroductionLiver fibrosis is typified by the persistent accumulation and aberrant distribution of extracellular matrix ...
T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions
1 IntroductionAdipose tissue, a subtype of connective tissue, encompasses a diverse array of cell types, including stem/pr...
Editorial: Epigenetic regulation of genome integrity and its implications in human diseases
environment, including methylation, acetylation, phosphorylation, etc (Bannister et al., 2011;Millán-Zambrano et ...
Comprehensive study of SNAREs involved in the post-Golgi transport in Drosophila photoreceptors
1 IntroductionMany in situ cells, such as epithelial cells and neurons, show polarity and have more than two types of well...
Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review
1 IntroductionChronic atrophic gastritis (CAG) is one of the most prevalent gastrointestinal diseases, characterized by ga...
Protein “purity,” proteoforms, and the albuminome: critical observations on proteome and systems complexity
1 IntroductionBiomarkers and therapeutics are meant to be highly selective agents. Regrettably, this has, over decades, no...
Applications of artificial intelligence in regenerative dentistry: promoting stem cell therapy and the scaffold development
1 IntroductionRecently, AI has grown in a number of ways thanks to developments in needs of computer hardware, software, a...
Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling
1 IntroductionCalcium is viewed as a vital signaling molecule that regulates many important physiological processes includ...
Impact of galectin-3 on neurotrophic factor expression by PCR array: potential implications for the human cornea
The cornea is densely innervated to maintain the integrity of the ocular surface, facilitating functions such as sensation...
Paternal impact on the developmental programming of sexual dimorphism
IntroductionSexual dimorphism (SDM) refers to the phenotypic variations between males and females within the same species....
Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
Highlights• Passaging promotes the activation of fibroblasts to myofibroblasts.• TGFβ1 treatment activates the fibroblasts...
Factors, mechanisms and improvement methods of muscle strength loss
1 IntroductionThe decline in organ function is an inevitable part of aging. The global population aged 65 and older is pro...
The protective role of gamma zone peripapillary atrophy in diabetic retinopathy: insights from deep learning and SS-OCT angiography
1 IntroductionDiabetes mellitus is a major public health issue that projected to affect 693 million adults by 2045 (Cho et...
miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells
IntroductionDuring the development of the vertebrate central nervous system (CNS), multipotent neural stem/progenitor cell...
Advances and prospects of precision nanomedicine in personalized tumor theranostics
1 IntroductionTumor, or cancer, is a disease characterized by abnormal proliferation and growth of cells, which can occur ...
Erratum: Embryonic temperature has long-term effects on muscle circRNA expression and somatic growth in Nile tilapia
An erratum on: Rbbani G, Murshed R, Siriyappagouder P, Sharko F, Nedoluzhko A, Joshi R, Galindo-Villegas J, Raeymaekers JA...
Editorial: Proceedings of the 9th international symposium on the biology of vertebrate sex determination 2023
al., 2021). In most mammals, sex determination is genetically dictated, initiated by the expression of the testis-promotin...
Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration
Approaches to regenerate vocal fold in glottic insufficiency remains to be a focus for exploration. This is attributed to ...
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