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MicroRNAs in pancreatic cancer drug resistance: mechanisms and therapeutic potential
1 IntroductionPC, the most common type being pancreatic adenocarcinoma (PDAC), remains one of the deadliest malignancies, ...
Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse
Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse
1 IntroductionExtracellular ATP is a ubiquitous mediator of local intercellular signaling within the body (Burnstock and D...
Ferroptosis and its relationship with cancer
1 IntroductionA strong correlation exists between regulatory cell death (RCD) and the onset, advancement, and management o...
Achieving myoblast engraftment into intact skeletal muscle via extracellular matrix
1 IntroductionAge-related skeletal muscle atrophy and weakness, known as sarcopenia, is a major problem, especially in dev...
Stem cell status and prognostic applications of cuproptosis-associated lncRNAs in acute myeloid leukemia
IntroductionAcute myeloid leukemia (AML), the most common form of acute leukemia in adults, is a highly aggressive and het...
A stumbling block in pancreatic cancer treatment: drug resistance signaling networks
1 IntroductionWith a five-year survival rate of approximately 12%, pancreatic cancer (PC) is one of the deadliest and wors...
Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials
1 IntroductionTelocytes, a previously unappreciated population of mesenchymal cells characterized by their distinctive lon...
CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies
1 IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid tumors and are already integr...
Oral microbiota: the overlooked catalyst in cancer initiation and progression
1 IntroductionCancer is the second greatest cause of mortality worldwide. According to estimates from the World Health Org...
Color fundus photograph-based diabetic retinopathy grading via label relaxed collaborative learning on deep features and radiomics features
1 IntroductionDiabetes Mellitus (DM) is a chronic metabolic disorder typically characterized by insufficient insulin produ...
HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms
1 IntroductionIn 2024, roughly two million people are estimated to be diagnosed with cancer, with 611,720 cancer-related d...
Editorial: Fertilization and early embryogenesis: from research to clinical practice
The fusion of an egg and a sperm triggers a complex plethora of events that will ultimately lead to the formation of a new...
Exosomes: new targets for understanding axon guidance in the developing central nervous system
1 IntroductionThe complexity and correct connectivity of neural circuits ensures that the brain operates correctly. During...
Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress
IntroductionIn vitro oocyte maturation (IVM), in vitro fertilization (IVF), and in vitro embryo culture (IVC) techniques h...
The quagga mussel, Dreissena rostriformis: a novel model for EcoEvoDevo, environmental research, and the applied sciences
1 IntroductionThe phylum Mollusca boasts approximately 120.000 extant species, which makes it the second-most speciose phy...
Organoids and spheroids: advanced in vitro models for liver cancer research
IntroductionPrimary liver cancers, notably cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) encompass a heterog...
Molecular dynamics of chemotactic signalling orchestrates dental pulp stem cell fibrosis during aging
1 IntroductionAging is an inevitable and gradual biological process that progressively affects the structural and function...
E3 Siah ubiquitin ligase regulates dichotomous spermatogenesis in Sitotroga cerealella
IntroductionThe ubiquitin proteasome system (UPS) is a crucial protein degradation pathway in eukaryotes, responsible for ...
Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells
1 IntroductionBeta-herpesviruses (BHVs) infect a large proportion of the human population and are associated with a variet...
A framework for the simulation of individual glycan coordinates to analyze spatial relationships within the glycocalyx
1 IntroductionThe glycocalyx is a dynamic, complex and dense layer of sugar structures that covers every human cell (Varki...
A scATAC-seq atlas of stasis zone in rat skin burn injury wound process
Burns are a significant global health issue that not only affect patients' physiological functions but also lead t...
Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues
1 IntroductionRecent advances in single-cell RNA sequencing (scRNA-seq) have dramatically expanded our understanding of th...
Involvement of RBP-J interacting and tubulin-associated protein in the distribution of protein regulator of cytokinesis 1 in mitotic spindles
1 IntroductionMicrotubules (MTs) mediate various cellular activities, such as chromosome congression in metaphase and segr...
Relevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver disease
1 IntroductionCurrently, more than 70% of grafts are obtained from donors after brain death (DBDs) (Kwong et al., 2021). B...
New insight in immunotherapy and combine therapy in colorectal cancer
1 IntroductionColorectal cancer is a prevalent gastrointestinal malignancy, ranking as the third most common cancer global...
Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions
IntroductionThe endoplasmic reticulum aminopeptidase 1 (ERAP1) and its paralog 2 (ERAP2), are members of the zinc metallop...
The role of Golgi complex proteins in cell division and consequences of their dysregulation
1 IntroductionIn vertebrate cells, the GC (Golgi complex) is composed of stacks of flattened cisternae that are laterally ...
A novel SEPT12 mutation, T96I, is associated with sperm head and annulus defects
1 IntroductionInfertility affects about 8%–12% of reproductive-aged couples worldwide and is recognized as a major health ...
Exploring the effect of gestational diabetes mellitus on retinal vascular morphology by PKSEA-Net
1 IntroductionDuring pregnancy, the immune system of women experiences a series of intricate alterations. A dynamic equili...
Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin
IntroductionThe development of metastases happens with most cancers and is the leading cause of cancer-associated death. I...
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