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Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and bloo...
Cardiac fibroblasts in heart failure and regeneration
Cardiac fibroblasts in heart failure and regeneration
In heart disease patients, myocyte loss or malfunction invariably leads to fibrosis, involving the activation and accumula...
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Protein kinases play roles in diverse cellular functions, with approximately 2% of the human genome dedicated to encoding ...
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Low back pain (LBP) is a prevalent musculoskeletal disorder, affecting approximately 70% of individuals at some point in t...
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice
The pivotal role of FGF18 in the regulation of craniofacial and skeletal development has been well established. Previous s...
The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages
The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages
Radiation-induced lung injury (RILI) is a common complication of anti-cancer treatments for thoracic and hematologic malig...
TRIF-dependent signaling and its role in liver diseases
TRIF-dependent signaling and its role in liver diseases
TIR domain-containing adaptor inducing IFN-β (TRIF) is a crucial adaptor molecule downstream of toll-like receptors 3 (TLR...
Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking
Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking
Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitor...
Chimeric antigen receptor (CAR) modified T Cells in acute myeloid leukemia: limitations and expectations
Chimeric antigen receptor (CAR) modified T Cells in acute myeloid leukemia: limitations and expectations
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a poor prognosis despite the advent of novel the...
The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy
The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy
Cancer-associated fibroblasts (CAFs), a class of stromal cells in the tumor microenvironment (TME), play a key role in con...
Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
The generation of iPSC-derived hepatocyte-like cells (HLCs) is a powerful tool for studying liver diseases, their therapy ...
Editorial: Glioma: from genetic to cellular heterogeneity
Editorial: Glioma: from genetic to cellular heterogeneity
Gliomas are primary tumors of the central nervous system that affect individuals of all ages. Staggering 5-year 13 surviva...
Mesenchymal cell migration on one-dimensional micropatterns
Mesenchymal cell migration on one-dimensional micropatterns
Quantitative studies of mesenchymal cell motion are important to elucidate cytoskeleton function and mechanisms of cell mi...
NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics
NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics
Extracellular vesicles (EVs) are a type of cytoplasmic vesicles secreted by a variety of cells. EVs originating from cells...
Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease
Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease
Genesis of skeletal muscle relies on the differentiation and fusion of mono-nucleated muscle progenitor cells into the mul...
Mitochondrial stress response and myogenic differentiation
Mitochondrial stress response and myogenic differentiation
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands,...
Editorial: New trends in cardiovascular development, evolution and disease
Editorial: New trends in cardiovascular development, evolution and disease
The heart represents the main conduit of the circulatory system, with the primary role of pumping the blood through the pu...
“Next top” mouse models advancing CTCL research
“Next top” mouse models advancing CTCL research
This review systematically describes the application of in vivo mouse models in studying cutaneous T-cell lymphoma (CTCL),...
Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions
Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions
Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione (GSH) depletion, glutathione pe...
Shaping Oncogenic Microenvironments: Contribution of Fibronectin
Shaping Oncogenic Microenvironments: Contribution of Fibronectin
The extracellular matrix (ECM) is a complex network of proteins and glycans, dynamically remodeled and specifically tailor...
Corrigendum: Editorial: Metabolic modulation of cellular function
Corrigendum: Editorial: Metabolic modulation of cellular function
Corrigendum: Editorial: Metabolic modulation of cellular functionOr Kakhlon 1, 2∗, Ann Saada 2, 3 and Pablo V Escriba 4, 5...
Cancer spreading patterns based on epithelial-mesenchymal plasticity
Cancer spreading patterns based on epithelial-mesenchymal plasticity
Introduction: Metastasis is a major cause of cancer-related deaths, underscoring the necessity to discern the rules and pa...
Editorial: Non-cadherin based cell adhesion in tissue remodeling
Editorial: Non-cadherin based cell adhesion in tissue remodeling
Cell junctions play central roles in regulating cell-cell interactions, tissue architecture and collective cellular behavi...
Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma
Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma
BackgroundGlioma is the most common cancer of the central nervous system with poor therapeutic response and clinical progn...
Transcriptomic profile of premature ovarian insufficiency with RNA-sequencing
Transcriptomic profile of premature ovarian insufficiency with RNA-sequencing
IntroductionThis study aimed to explore the transcriptomic profile of premature ovarian insufficiency (POI) by investigati...
Corrigendum: Mutation of Gemin5 causes defective hematopoietic stem/progenitor cells proliferation in zebrafish embryonic hematopoiesis
Corrigendum: Mutation of Gemin5 causes defective hematopoietic stem/progenitor cells proliferation in zebrafish embryonic hematopoiesis
Incorrect Funding In the published article, there were two errors in the Funding statement. Firstly, we inadvertently fail...
Editorial: Reviews and advances in inflammatory diseases and the tumor necrosis factor
Editorial: Reviews and advances in inflammatory diseases and the tumor necrosis factor
a docking platform for the assembly of the IKK complex leading to activation of NF-κB and MAPK signaling pathways. These s...
Exosomes: efficient macrophage-related immunomodulators in chronic lung diseases
Exosomes: efficient macrophage-related immunomodulators in chronic lung diseases
Macrophages, the predominant immune cells in the lungs, play a pivotal role in maintaining the delicate balance of the pul...
Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice
Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice
Chronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hype...
Characterization of polyamine metabolism predicts prognosis, immune profile, and therapeutic efficacy in lung adenocarcinoma patients
Characterization of polyamine metabolism predicts prognosis, immune profile, and therapeutic efficacy in lung adenocarcinoma patients
BackgroundPolyamine modification patterns in lung adenocarcinoma (LUAD) and their impact on prognosis, immune infiltration...
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