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Retinal degeneration in rpgra mutant zebrafish
Retinal degeneration in rpgra mutant zebrafish
Introduction: Pathogenic mutations in RPGRORF15, one of two major human RPGR isoforms, were responsible for most X-linked ...
Defining the ligand-dependent proximatome of the sigma 1 receptor
Defining the ligand-dependent proximatome of the sigma 1 receptor
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerati...
Characterization of cuproptosis in gastric cancer and relationship with clinical and drug reactions
Characterization of cuproptosis in gastric cancer and relationship with clinical and drug reactions
Gastric cancer (GC) is the fifth most common cancer worldwide. Cuproptosis is associated with cell growth and death as wel...
Epigenetic modification in Parkinson’s disease
Epigenetic modification in Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. ...
Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection
Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection
Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, bu...
Role of Wnt signaling pathway in joint development and cartilage degeneration
Role of Wnt signaling pathway in joint development and cartilage degeneration
Osteoarthritis (OA) is a prevalent musculoskeletal disease that affects approximately 500 million people worldwide. Unfort...
IFT46 gene promoter-driven ciliopathy disease model in zebrafish
IFT46 gene promoter-driven ciliopathy disease model in zebrafish
Ciliopathies are human genetic disorders caused by abnormal formation and dysfunction of cellular cilia. Cilia are microtu...
Evolution and function of calponin and transgelin
Evolution and function of calponin and transgelin
Calponin and transgelin (originally named SM22) are homologous cytoskeleton proteins that regulate actin-activated myosin ...
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation
Introduction: The mitochondrial uniporter (MCU) Ca2+ ion channel represents the primary means for Ca2+ uptake by mitochond...
In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility
In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility
Ovastacin (ASTL), a zinc metalloprotease, is released from a fertilized egg during exocytosis of cortical granules which o...
Inherent differences of small airway contraction and Ca2+ oscillations in airway smooth muscle cells between BALB/c and C57BL/6 mouse strains
Inherent differences of small airway contraction and Ca2+ oscillations in airway smooth muscle cells between BALB/c and C57BL/6 mouse strains
BALB/c and C57BL/6 mouse strains are widely used as animal model in studies of respiratory diseases, such as asthma. Asthm...
Reproducibility and FAIR principles: the case of a segment polarity network model
Reproducibility and FAIR principles: the case of a segment polarity network model
The issue of reproducibility of computational models and the related FAIR principles (findable, accessible, interoperable,...
Aberrant protein targeting activates quality control on the ribosome
Aberrant protein targeting activates quality control on the ribosome
Cells synthesize thousands of different proteins that should be delivered to different cellular compartments, integrated i...
Sevoflurane inhibited reproductive function in male mice by reducing oxidative phosphorylation through inducing iron deficiency
Sevoflurane inhibited reproductive function in male mice by reducing oxidative phosphorylation through inducing iron deficiency
Sevoflurane (Sev) is one of the commonly used inhalation anesthetic chemicals in clinics. It has great impact on spermatog...
Live cell imaging of DNA and RNA with fluorescent signal amplification and background reduction techniques
Live cell imaging of DNA and RNA with fluorescent signal amplification and background reduction techniques
Illuminating DNA and RNA dynamics in live cell can elucidate their life cycle and related biochemical activities. Various ...
Comprehensive analysis of REST corepressors (RCORs) in pan-cancer
Comprehensive analysis of REST corepressors (RCORs) in pan-cancer
REST corepressors (RCORs) are the core component of the LSD1/CoREST/HDACs transcriptional repressor complex, which have be...
Whole-Genome Doubling as a source of cancer: how, when, where, and why?
Whole-Genome Doubling as a source of cancer: how, when, where, and why?
Chromosome instability is a well-known hallmark of cancer, leading to increased genetic plasticity of tumoral cells, which...
Term alpaca placenta glycosylation profile and its correlation with pregnancy maintenance and fetal survival
Term alpaca placenta glycosylation profile and its correlation with pregnancy maintenance and fetal survival
Alpaca is a South American camelid, particularly present in Peruvian highlands, where oxygen concentration and atmospheric...
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length
Hereditary fibrosing poikiloderma (HFP) is a rare human dominant negative disorder caused by mutations in the FAM111B gene...
Regulation of erythroid differentiation in K562 cells by the EPAS1-IRS2 axis under hypoxic conditions
Regulation of erythroid differentiation in K562 cells by the EPAS1-IRS2 axis under hypoxic conditions
Red blood cells (RBCs) produced in vitro have the potential to alleviate the worldwide demand for blood transfusion. Hemat...
Toeing the line between regeneration and fibrosis
Toeing the line between regeneration and fibrosis
Understanding the remarkable capacity of vertebrates to naturally regenerate injured body parts has great importance for p...
Current progress on in vitro differentiation of ovarian follicles from pluripotent stem cells
Current progress on in vitro differentiation of ovarian follicles from pluripotent stem cells
Mammalian female reproduction requires a functional ovary. Competence of the ovary is determined by the quality of its bas...
FGF signaling in cranial suture development and related diseases
FGF signaling in cranial suture development and related diseases
Suture mesenchymal stem cells (SMSCs) are a heterogeneous stem cell population with the ability to self-renew and differen...
RDA coupled with deep sequencing detects somatic SVA-retrotranspositions and mosaicism in the human brain
RDA coupled with deep sequencing detects somatic SVA-retrotranspositions and mosaicism in the human brain
Cells of the developing human brain are affected by the progressive acquisition of genetic and epigenetic alterations that...
Advances in molecular characterization of pediatric acute megakaryoblastic leukemia not associated with Down syndrome; impact on therapy development
Advances in molecular characterization of pediatric acute megakaryoblastic leukemia not associated with Down syndrome; impact on therapy development
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) in which leukemic blasts have meg...
Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella
Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella
Introduction: Tracing the genetic causes for male infertility due to asthenoteratozoospermia has revealed at least 40 caus...
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
Cadmium (Cd) is a toxic heavy metal found throughout the environment and one of the top ten toxicants of major public heal...
A novel glycolysis-related gene signature for predicting the prognosis of multiple myeloma
A novel glycolysis-related gene signature for predicting the prognosis of multiple myeloma
Background: Metabolic reprogramming is an important hallmark of cancer. Glycolysis provides the conditions on which multip...
Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma
Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is among the deadliest cancers worldwide, and advanced HCC is difficult to trea...
Role of microRNA carried by small extracellular vesicles in urological tumors
Role of microRNA carried by small extracellular vesicles in urological tumors
Small extracellular vesicles (sEVs) are minute vesicles secreted by various cells that are capable of transporting cargo, ...
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