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Neurotransmitter receptor-related gene signature as potential prognostic and therapeutic biomarkers in colorectal cancer
Neurotransmitter receptor-related gene signature as potential prognostic and therapeutic biomarkers in colorectal cancer
Background: Colorectal cancer is one of the most common malignant tumors worldwide. A various of neurotransmitter receptor...
Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells
Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells
Patients with digenic S100A3 and S100A13 mutations exhibited an atypical and progressive interstitial pulmonary fibrosis, ...
Crosstalk of nervous and immune systems in pancreatic cancer
Crosstalk of nervous and immune systems in pancreatic cancer
Pancreatic cancer is a highly malignant tumor known for its extremely low survival rate. The combination of genetic disord...
CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs
CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs
Pluripotent stem cells are characterized by their differentiation potential toward endoderm, mesoderm, and ectoderm. Howev...
Morphology-based deep learning approach for predicting adipogenic and osteogenic differentiation of human mesenchymal stem cells (hMSCs)
Morphology-based deep learning approach for predicting adipogenic and osteogenic differentiation of human mesenchymal stem cells (hMSCs)
Human mesenchymal stem cells (hMSCs) are multipotent progenitor cells with the potential to differentiate into various cel...
Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage
Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage
D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and car...
Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells
Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells
Breast cancer (BC) is a heterogeneous disease characterized by several molecular subtypes that differ in clinical behavior...
Analyzing the cellular plasma membrane by fast and efficient correlative STED and platinum replica EM
Analyzing the cellular plasma membrane by fast and efficient correlative STED and platinum replica EM
The plasma membrane of mammalian cells links transmembrane receptors, various structural components, and membrane-binding ...
Identification of heel bone mineral density as a risk factor of Alzheimer’s disease by analyzing large-scale genome-wide association studies datasets
Identification of heel bone mineral density as a risk factor of Alzheimer’s disease by analyzing large-scale genome-wide association studies datasets
Introduction: Both low bone mineral density (BMD) and Alzheimer’s disease (AD) commonly co_occur in the older adult. Until...
Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways
Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways
Cell adhesion and migration depend on the assembly and disassembly of adhesive structures known as focal adhesions. Cells ...
Varicocele and testicular cord torsion: immune testicular microenvironment imbalance
Varicocele and testicular cord torsion: immune testicular microenvironment imbalance
The main functions of the testis, steroidogenesis and spermatogenesis, depend on the endocrine axis and systemic and local...
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains
Neurons project long axons that contact other distant neurons. Neurons in the medial prefrontal cortex project into the li...
Methoxychlor induces oxidative stress and impairs early embryonic development in pigs
Methoxychlor induces oxidative stress and impairs early embryonic development in pigs
Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly used worldwide as an insecticide a...
Homemade: building the structure of the neurogenic niche
Homemade: building the structure of the neurogenic niche
Neural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their functio...
Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review
Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review
Alcohol-associated liver disease (ALD) is a condition that develops due to prolonged and excessive alcohol consumption. It...
Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface
Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface
The septin family of eukaryotic proteins comprises distinct classes of sequence-related monomers that associate in a defin...
Deciphering the age-dependent changes of pulmonary fibroblasts in mice by single-cell transcriptomics
Deciphering the age-dependent changes of pulmonary fibroblasts in mice by single-cell transcriptomics
Background and objectives: The heterogeneity of pulmonary fibroblasts, a critical aspect of both murine and human models u...
Biology of melanocytes in mammals
Biology of melanocytes in mammals
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessi...
Size-correlated polymorphisms in phyllotaxis-like periodic and symmetric tentacle arrangements in hydrozoan Coryne uchidai
Size-correlated polymorphisms in phyllotaxis-like periodic and symmetric tentacle arrangements in hydrozoan Coryne uchidai
Introduction: Periodic organ arrangements occur during growth and development and are widespread in animals and plants. In...
Heparanase contributes to pancreatic carcinoma progression through insulin-dependent glucose uptake
Heparanase contributes to pancreatic carcinoma progression through insulin-dependent glucose uptake
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor, which is highly resistant to existing therapies and charac...
Poly I:C-priming of adipose-derived mesenchymal stromal cells promotes a pro-tumorigenic phenotype in an immunocompetent mouse model of prostate cancer
Poly I:C-priming of adipose-derived mesenchymal stromal cells promotes a pro-tumorigenic phenotype in an immunocompetent mouse model of prostate cancer
Introduction: Mesenchymal stromal cells (MSC) are envisioned as a potential cellular vehicle for targeted cancer therapies...
Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
It is clear from an evolutionary perspective that some species are endowed with extreme regenerative capacity, while other...
The effects of semaphorin 3A in bone and cartilage metabolism: fundamental mechanism and clinical potential
The effects of semaphorin 3A in bone and cartilage metabolism: fundamental mechanism and clinical potential
Semaphorin 3A (Sema3A) is a neuroinformatic protein molecule with widespread expression across various tissues and organs....
Unveiling the pathogenic mechanisms of NPR2 missense variants: insights into the genotype-associated severity in acromesomelic dysplasia and short stature
Unveiling the pathogenic mechanisms of NPR2 missense variants: insights into the genotype-associated severity in acromesomelic dysplasia and short stature
Introduction: Natriuretic peptide receptor 2 (NPR2 or NPR-B) plays a central role in growth development and bone morphogen...
Quercetin improves and protects Calu-3 airway epithelial barrier function
Quercetin improves and protects Calu-3 airway epithelial barrier function
Introduction: In light of the impact of airway barrier leaks in COVID-19 and the significance of vitamin D in COVID-19 out...
Circular RNAs: emerging players in asthma and COPD
Circular RNAs: emerging players in asthma and COPD
Circular RNAs (circRNAs) belong to a unique class of endogenously expressed non-protein-coding RNAs with a distinct circul...
Editorial: Cuproptosis and tumor
Editorial: Cuproptosis and tumor
As a trace element, copper is widely involved in the physiological activities of cells and plays an 26 important role. Due...
How the latent geometry of a biological network provides information on its dynamics: the case of the gene network of chronic myeloid leukaemia
How the latent geometry of a biological network provides information on its dynamics: the case of the gene network of chronic myeloid leukaemia
Background: The concept of the latent geometry of a network that can be represented as a graph has emerged from the classr...
Envisioning a role for nuclear actin in prophase I spermatocytes
Envisioning a role for nuclear actin in prophase I spermatocytes
Actin is a multi-functional protein that is involved in numerous cellular processes including cytoskeleton regulation, cel...
Harnessing mechanobiology for kidney organoid research
Harnessing mechanobiology for kidney organoid research
Recently, organoids have emerged as revolutionizing tools with the unprecedented potential to recreate organ-specific micr...
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