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KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood
KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood
KRAS mutants are common in many cancers and wild-type KRAS is essential in development as its absence causes embryonic let...
Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo
During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migratio...
Egr1 plays a major role in the transcriptional response of white adipocytes to insulin and environmental cues
Egr1 plays a major role in the transcriptional response of white adipocytes to insulin and environmental cues
It is believed that insulin regulates metabolic functions of white adipose tissue primarily at the post-translational leve...
Meis2 controls skeletal formation in the hyoid region
Meis2 controls skeletal formation in the hyoid region
A vertebrate skull is composed of many skeletal elements which display enormous diversity of shapes. Cranial bone formatio...
Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology
Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology
Genomic DNA in all cell types is exposed to insults from endogenous sources, such as oxidative stress, as well as exogenou...
Electrochemically induced in vitro focal hypoxia in human neurons
Electrochemically induced in vitro focal hypoxia in human neurons
Focalised hypoxia is widely prevalent in diseases such as stroke, cardiac arrest, and dementia. While in some cases hypoxi...
The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma
The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma
Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell carcinoma (OSCC) that is inoperabl...
Pathobiological functions and clinical implications of annexin dysregulation in human cancers
Pathobiological functions and clinical implications of annexin dysregulation in human cancers
Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserve...
Genetically encoded fluorescent biosensors for GPCR research
Genetically encoded fluorescent biosensors for GPCR research
G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus...
Recent updates on anticancer mechanisms of polyphenols
Recent updates on anticancer mechanisms of polyphenols
In today’s scenario, when cancer cases are increasing rapidly, anticancer herbal compounds become imperative. Studies on t...
Fibronectin-1 is a dominant mechanism for rheumatoid arthritis via the mediation of synovial fibroblasts activity
Fibronectin-1 is a dominant mechanism for rheumatoid arthritis via the mediation of synovial fibroblasts activity
Rheumatoid arthritis (RA) has a high incidence and adverse effects on patients, thus posing a serious threat to people’s l...
Epigenetic disorders: Lessons from the animals–animal models in chromatinopathies
Epigenetic disorders: Lessons from the animals–animal models in chromatinopathies
Chromatinopathies are defined as genetic disorders caused by mutations in genes coding for protein involved in the chromat...
Revealing phosphorylation regulatory networks during embryogenesis of honey bee worker and drone (Apis mellifera)
Revealing phosphorylation regulatory networks during embryogenesis of honey bee worker and drone (Apis mellifera)
Protein phosphorylation is known to regulate a comprehensive scenario of critical cellular processes. However, phosphoryla...
Resetting the epigenome: Methylation dynamics in cancer stem cells
Resetting the epigenome: Methylation dynamics in cancer stem cells
The molecular mechanisms that regulate stem cell pluripotency and differentiation has shown the crucial role that methylat...
Extracellular cell-free RNA profile in human large follicles and small follicles
Extracellular cell-free RNA profile in human large follicles and small follicles
Background: Previous studies have shown that a large number of valuable and functional cell-free RNAs (cfRNAs) were found ...
Sharing the wealth: The versatility of proteins targeted to peroxisomes and other organelles
Sharing the wealth: The versatility of proteins targeted to peroxisomes and other organelles
Peroxisomes are eukaryotic organelles with critical functions in cellular energy and lipid metabolism. Depending on the or...
Biological benefits of collective swimming of sperm in a viscoelastic fluid
Biological benefits of collective swimming of sperm in a viscoelastic fluid
Collective swimming is evident in the sperm of several mammalian species. In bull (Bos taurus) sperm, high viscoelasticity...
Control of actin polymerization via reactive oxygen species generation using light or radiation
Control of actin polymerization via reactive oxygen species generation using light or radiation
Actin is one of the most prevalent proteins in cells, and its amino acid sequence is remarkably conserved from protozoa to...
A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
Nuclear positioning is important for the functionality of many cell types and is mediated by interactions of cytoskeletal ...