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Corrigendum: Characterizing the neutrophilic inflammation in chronic rhinosinusitis with nasal polyps
Corrigendum: Characterizing the neutrophilic inflammation in chronic rhinosinusitis with nasal polyps
Jian-Wen RuanJie-Fang ZhaoXue-Li LiBo LiaoLi PanKe-Zhang ZhuQi-Miao FengJin-Xin LiuZi-E. YuJia SongHai Wang*Zheng Liu*Depa...
Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity
Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity
Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardi...
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release
Background: Cancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ...
VMP1: a multifaceted regulator of cellular homeostasis with implications in disease pathology
VMP1: a multifaceted regulator of cellular homeostasis with implications in disease pathology
Vacuole membrane protein 1 (VMP1) is an integral membrane protein that plays a pivotal role in cellular processes, particu...
Functional determination of site-mutations in rdxA involved in metronidazole resistance of Helicobacter pylori
Functional determination of site-mutations in rdxA involved in metronidazole resistance of Helicobacter pylori
BackgroundMetronidazole (MTZ) is among the first-line drugs against the human gastric pathogen Helicobacter pylori (H. pyl...
Editorial: Deregulated signaling pathways in inflammation and cancer
Signaling pathways govern how cells survive, proliferate, communicate and respond to their environment. Alterations in sig...
Corrigendum: Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation
P. P. S. J. Khedoe1*W. A. A. M. van Schadewijk1M. Schwiening2J. P. Ng-Blichfeldt3,4S. J. Marciniak2J. Stolk1R. Gosens3P. S...
Role of actin-binding proteins in prostate cancer
Role of actin-binding proteins in prostate cancer
The molecular mechanisms driving the onset and metastasis of prostate cancer remain poorly understood. Actin, under the co...
Piloting a scale-up platform for high-quality human T-cells production
Piloting a scale-up platform for high-quality human T-cells production
Cell and gene therapies are an innovative solution to various severe diseases and unfulfilled needs. Adoptive cell therapy...
A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control
A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control
Introduction: Mouse embryonic stem cell (ESC) self-renewal can be maintained through dual inhibition of GSK3 and MEK kinas...
Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability
Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability
In Alzheimer’s Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau, may act as alarmins/damage-asso...
Transcriptional profiling sheds light on the fibrotic aspects of idiopathic subglottic tracheal stenosis
Transcriptional profiling sheds light on the fibrotic aspects of idiopathic subglottic tracheal stenosis
Idiopathic subglottic stenosis (ISGS) is a rare fibrotic disease of the upper trachea with an unknown pathomechanism. It t...
Disease-associated gut microbiome and metabolome changes in rats with chronic hypoxia-induced pulmonary hypertension
Disease-associated gut microbiome and metabolome changes in rats with chronic hypoxia-induced pulmonary hypertension
BackgroundPulmonary hypertension (PH) is a progressive disease affecting the lung vasculature that is characterized by sus...
The synergy of morphokinetic parameters and sHLA-G in cleavage embryo enhancing implantation rates
The synergy of morphokinetic parameters and sHLA-G in cleavage embryo enhancing implantation rates
Objective: This study aimed to assess the relationship between implantation and soluble HLA-G (sHLA-G) expression in cleav...
The multifaceted role of insulin-like growth factor binding protein 7
The multifaceted role of insulin-like growth factor binding protein 7
Insulin-like growth factor binding protein 7 (IGFBP7) serves as a crucial extracellular matrix protein, exerting pivotal r...
High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension
High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant mod...
Ribosome heterogeneity in development and disease
Ribosome heterogeneity in development and disease
Traditionally viewed as a fixed and homogeneous machinery for protein synthesis, the ribosome is increasingly recognized f...
RhoGDI1 regulates cell-cell junctions in polarized epithelial cells
RhoGDI1 regulates cell-cell junctions in polarized epithelial cells
Cell-cell contact formation of polarized epithelial cells is a multi-step process that involves the co-ordinated activitie...
The role of autophagy in the progression of HIV infected cardiomyopathy
The role of autophagy in the progression of HIV infected cardiomyopathy
Although highly active antiretroviral therapy (HAART) has changed infection with human immunodeficiency virus (HIV) from a...
Differential Talin cleavage in transformed and non-transformed cells and its consequences
Differential Talin cleavage in transformed and non-transformed cells and its consequences
This study investigates differences in focal adhesion (FA) morphology and Talin cleavage levels between transformed and no...
Editorial: The molecular regulation of microbial metabolism
Microorganisms are integral to ecosystems, serving as key producers of natural products with broad implications for pharma...
Inter-kingdom communication and the sympoietic way of life
Organisms are now seen as holobionts, consortia of several species that interact metabolically such that they sustain and ...