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A neural pathway integrating stress and feeding
The prevalence of eating disorders has increased drastically worldwide [1]. While the etiology of neuropsychiatric eating ...
Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial
Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial
Preclinical research with rodents suggests that the L-type calcium channel blocker isradipine can enhance long-term extinc...
Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
Mitochondrial diseases, notably Leigh syndrome (LS), stand as significant concerns in inherited metabolic disorders, prima...
Ginsenoside RG3-loaded microneedles for in situ treatment of ovarian cancer
Ginsenoside RG3-loaded microneedles for in situ treatment of ovarian cancer
Ovarian cancer (OC) is one of the most common malignant tumors of the reproductive tract in women, with the third morbidit...
Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation
Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation
Sepsis encompasses the complicated syndrome of systemic inflammation triggered by infection. It is characterized by an imb...
Licochalcone D ameliorates lipid metabolism in hepatocytes by modulating lipogenesis and autophagy
Licochalcone D ameliorates lipid metabolism in hepatocytes by modulating lipogenesis and autophagy
Metabolic dysfunction-associated fatty liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD) ...
On the rheological and sensory properties of a novel natural salivary substitute
On the rheological and sensory properties of a novel natural salivary substitute
Volume 199, 1 August 2024, 106802Author links open overlay panel, , , , , , AbstractThe prevalence of xerostomia, the sens...
Nanomaterials-incorporated polymeric microneedles for wound healing applications
Nanomaterials-incorporated polymeric microneedles for wound healing applications
As a physical barrier, the skin is the organ most affected by a range of external factors. Wound is defined as a structura...
Ensitrelvir Fumaric Acid: First Approval
Ensitrelvir Fumaric Acid: First Approval
Ensitrelvir fumaric acid (Xocova®) is an oral SARS-CoV-2 main protease inhibitor developed by Shionogi for the treatm...
Geometric deep learning methods and applications in 3D structure-based drug design
Geometric deep learning methods and applications in 3D structure-based drug design
Geometric deep learning, which is one of 15 important research directions of artificial intelligence (AI),(p1) can learn h...
Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact
Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact
Rodrigo Vidaurre is a hydrogeologist and senior fellow at the Ecologic Institute, a nonprofit institute for environmental ...
Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
In March 2020, the World Health Organization (WHO) declared a global pandemic of the novel coronavirus-related pneumonia, ...
An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome
An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome
Marfan syndrome (MFS, OMIM #154700) is an autosomal dominant connective tissue disorder, with an estimated prevalence of a...
All-in-one nanotheranostic platform based on tumor microenvironment: new strategies in multimodal imaging and therapeutic protocol
All-in-one nanotheranostic platform based on tumor microenvironment: new strategies in multimodal imaging and therapeutic protocol
The progression of tumorigenesis, metastasis, and immune escape are closely related to the tumor microenvironment (TME) to...