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Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Available online 8 December 2023Author links open overlay panel, , , Highlights•Alginate oligosaccharide-mediated gut-skin...
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Melanoma is the most aggressive skin cancer and tends to metastasize to other tissues; therefore appropriate treatment in ...
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
One of the most common causes of irreversible blindness worldwide is glaucoma, which is characterized by cupping or excava...
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Used as a pharmaceutical-grade purified low dose preparation, botulinum neurotoxin serotype A (BoNT-A) is employed in vari...
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
Myocardial infarction with a pathogenic basis of thrombosis or vascular occlusion remains a global medical concern charact...
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term representing two subtypes: non-alcoholic fatty liver and non...
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
The peptidyl-prolyl cis/trans isomerase Pin1 positively regulates numerous cancer-driving pathways, and it is overexpresse...
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Microneedles (MNs) have emerged as a simple technology that overcame several obstacles of the conventional drug delivery s...
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
Ischemic heart disease is a serious threat to human health and one of the leading causes of death worldwide (Nowbar et al....
Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
N-(E)-p-Coumaroyl tyrosine is a phenolic amino acid derivative extracted from the Abrus mollis Hance, Syn of Abrus melanos...
Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis
Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis
Gastritis has recently been reported to be associated with nivolumab, and the clinical characteristics of nivolumab induce...
L-Borneol promotes skin flap survival by regulating HIF-1α/NF-κB pathway
L-Borneol promotes skin flap survival by regulating HIF-1α/NF-κB pathway
A skin flap is a dynamic tissue made up of skin tissue with underlying blood vessels. Skin flaps are used for wound healin...