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Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Available online 8 December 2023Author links open overlay panel, , , Highlights•Alginate oligosaccharide-mediated gut-skin...
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Melanoma is the most aggressive skin cancer and tends to metastasize to other tissues; therefore appropriate treatment in ...
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
One of the most common causes of irreversible blindness worldwide is glaucoma, which is characterized by cupping or excava...
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Used as a pharmaceutical-grade purified low dose preparation, botulinum neurotoxin serotype A (BoNT-A) is employed in vari...
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Alzheimer's disease (AD), a common neurodegenerative disease, is characterized by a progressive decline in both cognitive ...
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R) and Mu-Opioid Receptor 1 (MOR1) ...
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Myocardial remodeling, which is a widely recognized independent risk factor for cardiac events (Xie et al., 2022; Yin et a...
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
Myocardial infarction with a pathogenic basis of thrombosis or vascular occlusion remains a global medical concern charact...
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term representing two subtypes: non-alcoholic fatty liver and non...
Gellan gum-based bi-polymeric hydrogel scaffolds loaded with Rosuvastatin calcium: A useful tool for tendon tissue regeneration
Gellan gum-based bi-polymeric hydrogel scaffolds loaded with Rosuvastatin calcium: A useful tool for tendon tissue regeneration
Volume 192, 1 January 2024, 106659Author links open overlay panel, , , AbstractStatins have been long used in tissue engin...
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
The two anti-epidermal growth factor receptor monoclonal antibodies (mAbs) cetuximab and panitumumab are the pillars for t...
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
The design of nanocapsules with a controlled architecture remains a major scientific and technological objective to this d...
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
The interactions of oral drugs with the complex environment of the gastrointestinal tract (GIT) may cause issues with drug...
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
The peptidyl-prolyl cis/trans isomerase Pin1 positively regulates numerous cancer-driving pathways, and it is overexpresse...
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Microneedles (MNs) have emerged as a simple technology that overcame several obstacles of the conventional drug delivery s...
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
Ischemic heart disease is a serious threat to human health and one of the leading causes of death worldwide (Nowbar et al....
Analysis of Artabotrys hexapetalus Stem Bark and Leaf Ethanol Extracts as α-Glucosidase Inhibitors: In Vitro Analysis, LC-MS/MS, Machine Learning, and Molecular Docking
Analysis of Artabotrys hexapetalus Stem Bark and Leaf Ethanol Extracts as α-Glucosidase Inhibitors: In Vitro Analysis, LC-MS/MS, Machine Learning, and Molecular Docking
Artabotrys hexapetalus (L.f.) Bhandari, Annonaceae, is one of Artabotrys species found in Asia, such as Sri Lanka, India, ...
Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice
Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice
Type 2 diabetes mellitus is accompanied by hyperglycaemia, liver dysfunction and intestinal dysbiosis. Bioactive peptides,...
Anti-inflammatory Response and Detection of Pharmacologically Active Components in Serum of Rats with Carrageenan-Induced Paw Swelling Treated with Phellodendron chinense
Anti-inflammatory Response and Detection of Pharmacologically Active Components in Serum of Rats with Carrageenan-Induced Paw Swelling Treated with Phellodendron chinense
Phellodendron chinense C.K.Schneid., Rutaceae, is a traditional Chinese medicine that is considered to have heat-clearing ...
Hygrophila auriculata Improves Insulin Resistance by Reducing Oxidative Stress, Membrane Stabilization and Increasing Hepatic Heat Shock Protein 70 (Hsp70) Expression
Hygrophila auriculata Improves Insulin Resistance by Reducing Oxidative Stress, Membrane Stabilization and Increasing Hepatic Heat Shock Protein 70 (Hsp70) Expression
The present study aimed to evaluate the effect of the methanolic extract of Hygrophila auriculata (Schumach.) Heine, Acant...
Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
N-(E)-p-Coumaroyl tyrosine is a phenolic amino acid derivative extracted from the Abrus mollis Hance, Syn of Abrus melanos...
Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Long-term care issues, specifically metabolic bone disorders, are a concern for people living with human immunodeficiency ...
Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis
Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis
Gastritis has recently been reported to be associated with nivolumab, and the clinical characteristics of nivolumab induce...
United States Value Set for the Functional Assessment of Cancer Therapy-General Eight Dimensions (FACT-8D), a Cancer-Specific Preference-Based Quality of Life Instrument
United States Value Set for the Functional Assessment of Cancer Therapy-General Eight Dimensions (FACT-8D), a Cancer-Specific Preference-Based Quality of Life Instrument
To develop a value set reflecting the United States (US) general population’s preferences for health states describe...
Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death
Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death
Liver fibrosis (LF) is the massive deposition of intrahepatic extracellular matrix (ECM) that occurs in most chronic hepat...
Molecular mechanism of Gan-song Yin inhibiting the proliferation of renal tubular epithelial cells by regulating miR-21-5p in adipocyte exosomes
Molecular mechanism of Gan-song Yin inhibiting the proliferation of renal tubular epithelial cells by regulating miR-21-5p in adipocyte exosomes
Ethnopharmacological relevanceGan-song Yin is derived from the classic ancient prescription " Gan-song pill " for the trea...
Integrating network pharmacology and experimental verification to explore the mucosal protective effect of Chimonanthus nitens Oliv. Leaf Granule on ulcerative colitis
Integrating network pharmacology and experimental verification to explore the mucosal protective effect of Chimonanthus nitens Oliv. Leaf Granule on ulcerative colitis
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease mainly located in the rectum and colon. The ex...
L-Borneol promotes skin flap survival by regulating HIF-1α/NF-κB pathway
L-Borneol promotes skin flap survival by regulating HIF-1α/NF-κB pathway
A skin flap is a dynamic tissue made up of skin tissue with underlying blood vessels. Skin flaps are used for wound healin...
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