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The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
The circadian system influences many different biological processes, including memory performance. While the suprachiasmat...
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
Vancomycin is commonly used in the prevention and treatment of intracranial infections in postoperative neurosurgical pati...
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Tacrolimus (TAC) has been increasingly used in patients with non-transplant settings. Because of its large between-subject...
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis
Patients with rheumatoid arthritis (RA) have a much higher incidence of cardiac dysfunction, which contributes to the high...
Anti-melanoma Effects of Resiquimod (RSQ) In Vitro and in Combination with Immune Checkpoint Blockade In Vivo
Anti-melanoma Effects of Resiquimod (RSQ) In Vitro and in Combination with Immune Checkpoint Blockade In Vivo
Melanoma is the deadliest form of skin cancer and surgery is currently the most effective treatment. However, there are si...
Including African data in drug discovery and development
The low number of clinical trials in Africa and biomedical datasets that disproportionately represent populations of Europ...
Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control
Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control
Baphicacanthis Cusiae Rhizoma et Radix, commonly known as Nan-Ban-Lan-Gen (NBLG), is an essential traditional Chinese medi...
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early non-response is a well-established prognostic marker but evidence-based and consistent recommendations to manage it ...
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Phantom limb pain (PLP) refers to pain perceived in a part of the body removed by amputation or trauma. Despite the high p...
Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing ev...
Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective ther...
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury
Acute kidney injury (AKI) is a commonly encountered comorbidity in critically ill children. The coexistence of AKI disturb...
Synthesis of biologically active sulfonamide-based indole analogs: a review
Synthesis of biologically active sulfonamide-based indole analogs: a review
The class of heterocyclic compounds exhibits a variety of pharmacological actions, long employed as an active ingredient i...