SCI时时刷

search
+
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
The circadian system influences many different biological processes, including memory performance. While the suprachiasmat...
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
Vancomycin is commonly used in the prevention and treatment of intracranial infections in postoperative neurosurgical pati...
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Tacrolimus (TAC) has been increasingly used in patients with non-transplant settings. Because of its large between-subject...
Nitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
Nitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
The aim of this study is to determine nitrofurantoin exposure in female patients with different age and renal function wit...
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis
Patients with rheumatoid arthritis (RA) have a much higher incidence of cardiac dysfunction, which contributes to the high...
Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development
Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development
A survey conducted by the Therapeutic Product Immunogenicity (TPI) community within the American Association of Pharmaceut...
Population-Based Pharmacodynamic Modeling of Omalizumab in Pediatric Patients with Moderate to Severe Persistent Inadequately Controlled Allergic Asthma
Population-Based Pharmacodynamic Modeling of Omalizumab in Pediatric Patients with Moderate to Severe Persistent Inadequately Controlled Allergic Asthma
Omalizumab is the first approved anti-immunoglobulin E (IgE) agent for the treatment of moderate to severe persistent inad...
Anti-melanoma Effects of Resiquimod (RSQ) In Vitro and in Combination with Immune Checkpoint Blockade In Vivo
Anti-melanoma Effects of Resiquimod (RSQ) In Vitro and in Combination with Immune Checkpoint Blockade In Vivo
Melanoma is the deadliest form of skin cancer and surgery is currently the most effective treatment. However, there are si...
Including African data in drug discovery and development
The low number of clinical trials in Africa and biomedical datasets that disproportionately represent populations of Europ...
PD1 agonist antibody passes first phase II trial for autoimmune disease
Discover the world’s best science and medicine | Nature.com
Docking on SERT reveals new inhibitors
Docking on SERT reveals new inhibitors
Discover the world’s best science and medicine | Nature.com
Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control
Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control
Baphicacanthis Cusiae Rhizoma et Radix, commonly known as Nan-Ban-Lan-Gen (NBLG), is an essential traditional Chinese medi...
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early non-response is a well-established prognostic marker but evidence-based and consistent recommendations to manage it ...
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Phantom limb pain (PLP) refers to pain perceived in a part of the body removed by amputation or trauma. Despite the high p...
Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions
Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions
An important barrier to HIV prevention among transgender women (TGW) is the concern that oral pre-exposure prophylaxis (Pr...
USING MACHINE LEARNING OR DEEP LEARNING MODELS IN A HOSPITAL SETTING TO DETECT INAPPROPRIATE PRESCRIPTIONS: A SYSTEMATIC REVIEW
USING MACHINE LEARNING OR DEEP LEARNING MODELS IN A HOSPITAL SETTING TO DETECT INAPPROPRIATE PRESCRIPTIONS: A SYSTEMATIC REVIEW
medRxiv - The Preprint Server for Health Sciences
Investigation of the biochemical and histopathological effects of vitamin C, selenium, and therapeutic ultrasound on muscle damage in rats
Investigation of the biochemical and histopathological effects of vitamin C, selenium, and therapeutic ultrasound on muscle damage in rats
Muscle injury is a common type of soft tissue injury. Increased oxidative damage has been reported after muscle injuries. ...
Correction to: Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia–reperfusion injury
Correction to: Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia–reperfusion injury
Correction to: Naunyn-Schmiedeberg’s Archives of Pharmacology (2020) 393...
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma
Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more than 1.9 million cases each ...
Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide. Upper and lower respiratory tract ...
Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing ev...
Triphenylphosphonium-functionalized N-heterocyclic carbene platinum complexes [(NHC-TPP+)Pt] induce cell death of human glioblastoma cancer stem cells
Glioblastoma is a highly aggressive brain cancer commonly found in adults. The current treatment includes surgical resecti...
ATB0,+-targeted nanoparticles initiate autophagy suppression to overcome chemoresistance for enhanced colorectal cancer therapy
Colorectal cancer (CRC) is the third most common type of malignancies and the leading cause of tumor death worldwide (Sieg...
Size-dependence of the skin penetration of andrographolide nanosuspensions: In vitro release-ex vivo permeation correlation and visualization of the delivery pathway
The opportunity of delivering drugs by penetration into or across the skin has enormous implications for the local treatme...
Characterization of Calea ternifolia and its Adulterant Chromolaena odorata Using Macro-Microscopy, HPTLC and UHPLC-UV–MS
Characterization of Calea ternifolia and its Adulterant Chromolaena odorata Using Macro-Microscopy, HPTLC and UHPLC-UV–MS
Calea ternifolia Kunth (syn. C. zacatechichi Schltdl.), Asteraceae, commonly known in English as dream herb, bitter-grass,...
Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective ther...
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury
Acute kidney injury (AKI) is a commonly encountered comorbidity in critically ill children. The coexistence of AKI disturb...
Development and validation of a stability-indicating RP-HPLC method for estimation of Lefamulin in pure and pharmaceutical drug products
Development and validation of a stability-indicating RP-HPLC method for estimation of Lefamulin in pure and pharmaceutical drug products
Commonly occurring serious lung parenchymal infection is community-acquired bacterial pneumonia (CABP). Lefamulin acetate ...
Synthesis of biologically active sulfonamide-based indole analogs: a review
Synthesis of biologically active sulfonamide-based indole analogs: a review
The class of heterocyclic compounds exhibits a variety of pharmacological actions, long employed as an active ingredient i...
Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, lung disease associated with the irreversible development o...
阅读更多
format_indent_increase