×
Close
註冊
登入
主页
用户
博客
照片
视频
医学图书S馆
医学图书M馆
医学图书D馆
医学术语
群组
活动
用户工具
用户指南
问答
谁看过我
反馈
语言
English
中文
推广
×
Close
CN1699 Our Business - Guide for Agents
分类
Pharmacology & Pharmacy
40953
Global Medical University
6074
Allergy
1886
Anatomy & Morphology
1685
Andrology
414
Anesthesia & Intensive Care
1408
Anesthesiology
6191
Audiology & Speech-Language Pathology
358
Behavioral Sciences
111
Biochemical Research Methods
8126
Biochemistry & Molecular Biology
33909
Biodiversity Conservation
366
Biology
9836
Biophysics
10790
Biotechnology & Applied Microbiology
9649
Cardiac & Cardiovascular Systems
35094
Cardiovascular & Respiratory Systems
1644
Cell & Tissue Engineering
766
Cell Biology
12161
Chemistry, Analytical
4649
Chemistry, Applied
12726
Chemistry, Medicinal
9574
Chemistry, Multidisciplinary
20857
Clinical Immunology & Infectious Disease
483
Clinical Medicine
9629
Clinical Neurology
18330
Clinical Psychology & Psychiatry
1679
Critical Care Medicine
3652
Dentistry, Oral Surgery & Medicine
15296
Dermatology
8009
Developmental Biology
7595
Ecology
655
Education, Scientific Disciplines
2191
Emergency Medicine
4689
Endocrinology, Metabolism & Nutrition
27884
Engineering, Biomedical
4156
Entomology
482
Environmental Medicine & Public Health
5403
Evolutionary Biology
288
Gastroenterology & Hepatology
13627
General & Internal Medicine
7955
Genetics & Heredity
17150
Geriatrics & Gerontology
5617
Gerontology
366
Health Care Sciences & Services
18058
Health Policy & Services
671
Hematology
5984
Immunology
28921
Infectious Diseases
15635
Integrative & Complementary Medicine
3230
Medical Ethics
1286
Medical Informatics
2681
Medical Laboratory Technology
433
Medicine, General & Internal
49689
Medicine, Legal
591
Medicine, Research & Experimental
20731
Microbiology
26879
Mycology
0
Nanoscience & Nanotechnology
5986
Neuroimaging
1495
Neurology
5251
Neurosciences
45690
Nursing
10572
Nutrition & Dietetics
8569
Obstetrics & Gynecology
9294
Oncology
59183
Ophthalmology
11231
Optics
5219
Orthopedics
12940
Orthopedics, Rehabilitation & Sports Medicine
2050
Otolaryngology
1697
Otorhinolaryngology
5409
Parasitology
1156
Pathology
5550
Pediatrics
24159
Peripheral Vascular Disease
5258
Pharmacology/Toxicology
14143
Physiology
9836
Polymer Science
686
Primary Health Care
907
Psychiatry
23074
Psychology
5697
Psychology, Applied
113
Psychology, Biological
393
Psychology, Clinical
896
Psychology, Developmental
235
Psychology, Educational
149
Psychology, Experimental
147
Psychology, Mathematical
0
Psychology, Multidisciplinary
1697
Psychology, Psychoanalysis
41
Psychology, Social
122
Public Health & Health Care Science
2416
Public, Environmental & Occupational Health
30698
Quantum Science & Technology
0
Radiology, Nuclear Medicine & Imaging
14064
Radiology, Nuclear Medicine & Medical Imaging
8814
Rehabilitation
3236
Remote Sensing
0
Reproductive Biology
3335
Reproductive Medicine
1340
Research/Laboratory Medicine & Medical Technology
4498
Respiratory System
8227
Rheumatology
6731
Social Sciences, Biomedical
1316
Substance Abuse
2990
Surgery
38474
Toxicology
4729
Transplantation
953
Tropical Medicine
314
Urology & Nephrology
14840
Veterinary Sciences
35
Virology
2655
Zoology
0
渠道
AAPS JOURNAL
330
Medrxiv - Pharmacology and Therapeutics
234
ACTA PHARMACOLOGICA SINICA
637
ADVANCED DRUG DELIVERY REVIEWS
0
ANTIVIRAL RESEARCH
0
CANCER CHEMOTHERAPY AND PHARMACOLOGY
410
CHEMICO-BIOLOGICAL INTERACTIONS
1112
CHEMMEDCHEM
274
CLINICAL PHARMACOKINETICS
377
CLINICAL PHARMACOLOGY & THERAPEUTICS
258
CNS DRUGS
216
CNS NEUROSCIENCE & THERAPEUTICS
116
DRUG DISCOVERY TODAY
279
DRUG METABOLISM AND DISPOSITION
464
DRUG RESISTANCE UPDATES
197
DRUG SAFETY
344
DRUGS
501
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
828
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
777
EUROPEAN JOURNAL OF PHARMACOLOGY
1811
INTERNATIONAL IMMUNOPHARMACOLOGY
3908
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2435
JOURNAL OF CONTROLLED RELEASE
1666
JOURNAL OF ETHNOPHARMACOLOGY
3020
JOURNAL OF FOOD AND DRUG ANALYSIS
157
JOURNAL OF PHARMACEUTICAL ANALYSIS
480
NATURE REVIEWS DRUG DISCOVERY
729
NEUROPHARMACOLOGY
0
NEUROPSYCHOPHARMACOLOGY
837
NEUROTOXICOLOGY
0
PHARMACOGENOMICS
28
PHARMACOLOGY & THERAPEUTICS
384
PHARMACOTHERAPY
65
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
87
TOXICOLOGY AND APPLIED PHARMACOLOGY
1
TOXICOLOGY IN VITRO
524
VALUE IN HEALTH
20
VASCULAR PHARMACOLOGY
0
ANNALS OF PHARMACOTHERAPY
130
ANTIBIOTICS-BASEL
1984
BIOMEDICAL CHROMATOGRAPHY
243
BIOPHARMACEUTICS & DRUG DISPOSITION
20
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
0
CHEMOTHERAPY
81
CHINESE MEDICINE
495
CHIRALITY
73
CLINICAL NEUROPHARMACOLOGY
64
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
129
CLINICAL THERAPEUTICS
52
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
55
DOSE-RESPONSE
78
DRUG DEVELOPMENT RESEARCH
121
EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE
325
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
838
HUMAN & EXPERIMENTAL TOXICOLOGY
105
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
0
INTERNATIONAL JOURNAL OF TOXICOLOGY
36
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
172
JOURNAL OF ANTIBIOTICS
324
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
430
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
30
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
170
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
2335
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
505
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
176
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
0
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
0
JOURNAL OF PHARMACOLOGICAL SCIENCES
0
JOURNAL OF PHARMACY AND PHARMACOLOGY
18
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
805
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
121
PHARMACOGENOMICS & PERSONALIZED MEDICINE
300
PHARMACOLOGY
125
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
0
SKIN PHARMACOLOGY AND PHYSIOLOGY
70
THERAPEUTIC ADVANCES IN DRUG SAFETY
22
THERAPEUTIC DRUG MONITORING
181
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
51
INDIAN JOURNAL OF PHARMACOLOGY
16
JOURNAL OF APPLIED BIOMEDICINE
44
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
47
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
381
THERAPIE
368
SCIENTIA PHARMACEUTICA
108
ADMET AND DMPK
96
ADVANCED THERAPEUTICS
95
ADVANCES IN PHARMACOLOGY AND PHARMACY
115
ADVANCES IN TRADITIONAL MEDICINE
19
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE
26
ASIAN JOURNAL OF PHARMACEUTICS
190
CANADIAN JOURNAL OF HOSPITAL PHARMACY
223
CURRENT DRUG THERAPY
28
EGYPTIAN PHARMACEUTICAL JOURNAL
42
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
361
GABI JOURNAL-GENERICS AND BIOSIMILARS INITIATIVE JOURNAL
67
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
212
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH
164
JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY
29
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
150
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
302
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
44
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
39
JOURNAL OF PHARMACY PRACTICE
98
JOURNAL OF RESEARCH IN PHARMACY PRACTICE
40
RESEARCH JOURNAL OF PHARMACOGNOSY
111
PHARMACEUTICAL MEDICINE
62
PHARMACIA
154
PHARMACOECONOMICS-OPEN
254
PHARMACY
176
PHARMACY PRACTICE-GRANADA
31
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
126
DRUGS & AGING
256
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
561
INVESTIGATIONAL NEW DRUGS
325
JOURNAL OF PHARMACEUTICAL INNOVATION
359
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
165
NEUROTHERAPEUTICS
355
PEDIATRIC DRUGS
192
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
352
SCI时时刷
search
全部
推荐
+
Nanosimilars: A Scientific or A Regulatory Debate?
The paper highlights the necessity for a robust regulatory framework for assessing nanomedicines and their off-patent coun...
Aaps Journal
comment
0
thumb_up
0
Sample Size Determination and Study Design Impact on Dose-Scale Pharmacodynamic Bioequivalence: a Case Study Using Orlistat
Dose-scale pharmacodynamic bioequivalence is recommended for evaluating the consistency of generic and innovator formulati...
Aaps Journal
comment
0
thumb_up
0
Intact NMR Approach Quickly Reveals Synchronized Microstructural Changes in Oil-in-Water Nanoemulsion Formulations
A soft-core oil-in-water (o/w) nanoemulsion (NE) is composed of nanometer (nm) sized oil droplets, stabilized by a surfact...
Aaps Journal
comment
0
thumb_up
0
Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux tr...
Aaps Journal
comment
0
thumb_up
0
Kinetic Modeling for BT200 to Predict the Level of Plasma-Derived Coagulation Factor VIII in Humans
Lack of Factor VIII (FVIII) concentrates is one of limiting factors for Hemophilia A prophylaxis in resource-limited count...
Aaps Journal
comment
0
thumb_up
0
Neutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of...
Aaps Journal
comment
0
thumb_up
0
Establishing Virtual Bioequivalence and Clinically Relevant Specifications for Omeprazole Enteric-Coated Capsules by Incorporating Dissolution Data in PBPK Modeling
Currently, Biopharmaceutics Classification System (BCS) classes I and III are the only biological exemptions of immediate-...
Aaps Journal
comment
0
thumb_up
0
Effect of Physicochemical Properties on the Basic Drug-Acid-Polymer Interactions and Miscibility in PVA Based Orodispersible Films
Salts of weakly basic drugs can partially dissociate in formulations, to give basic drugs and counter acids. The aim of th...
Aaps Journal
comment
0
thumb_up
0
Immunogenicity of Atezolizumab: Influence of Testing Method and Sampling Frequency on Reported Anti-drug Antibody Incidence Rates
Measurement of anti-drug antibodies (ADA) to assess the incidence of ADA in a clinical trial is a critical step in immunog...
Aaps Journal
comment
0
thumb_up
0
The Influence of Various Freezing–thawing Methods of Skin on Drug Permeation and Skin Barrier Function
The selection of skin is crucial for the in vitro permeation test (IVPT). The purpose of this study was to investigate the...
Aaps Journal
comment
0
thumb_up
0
Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals
Blood microsampling has increasingly attracted interest in the past decades as a more patient-centric sampling approach, o...
Aaps Journal
comment
0
thumb_up
0
Doses Evaluated in Clinical Pharmacology Studies Investigating the Effect of Intrinsic and Extrinsic Factors on PK and Safety: Case Examples from Approved Drug Development Programs
Dose selection for investigations of intrinsic and extrinsic factors of pharmacokinetic variability as well as safety is a...
Aaps Journal
comment
0
thumb_up
0
Principal Features of Industry-Funded Trials that Posted Informed Consent Forms on ClinicalTrials.gov: a Cross-Sectional Analysis
We aim to characterize industry-funded trials that have posted the informed consent forms (ICFs), and to assess whether th...
Aaps Journal
comment
0
thumb_up
0
3-CMC, 4-CMC, and 4-BMC Human Metabolic Profiling: New Major Pathways to Document Consumption of Methcathinone Analogues?
Synthetic cathinones represent one of the largest and most abused new psychoactive substance classes, and have been involv...
Aaps Journal
comment
0
thumb_up
0
Playing Hide-and-Seek with Tyrosine Kinase Inhibitors: Can We Overcome Administration Challenges?
Tyrosine kinase inhibitors (TKIs) have demonstrated significant efficacy against various types of cancers through molecula...
Aaps Journal
comment
0
thumb_up
0
Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents
Bispecific and multispecific agents have become increasingly utilized in cancer treatment and immunotherapy, yet their com...
Aaps Journal
comment
0
thumb_up
0
Physiologically Based Biopharmaceutics Modeling for Gefapixant IR Formulation Development and Defining the Bioequivalence Dissolution Safe Space
Gefapixant is a weakly basic drug which has been formulated as an immediate release tablet for oral administration. A phys...
Aaps Journal
comment
0
thumb_up
0
Simulating Healthy Participant Pharmacokinetics for Renal and Hepatic Impairment Studies: Retrospective Assessment of the Approach
The recruitment of a parallel, healthy participants (HPs) arm in renal and hepatic impairment (RI and HI) studies is a com...
Aaps Journal
comment
0
thumb_up
0
Machine-Learning Assisted Screening of Correlated Covariates: Application to Clinical Data of Desipramine
Stepwise covariate modeling (SCM) has a high computational burden and can select the wrong covariates. Machine learning (M...
Aaps Journal
comment
0
thumb_up
0
Impact on Quality during In-Use Preparation of an Antibody Drug Conjugate with Eight Different Closed System Transfer Device Brands
The aim of this study was to investigate the in-use compatibility of eight commercially available closed system transfer d...
Aaps Journal
comment
0
thumb_up
0
Impact of Obesity on Hepatic Drug Clearance: What are the Influential Variables?
Drug clearance in obese subjects varies widely among different drugs and across subjects with different severity of obesit...
Aaps Journal
comment
0
thumb_up
0
Anti-Drug Antibody Incidence Comparison of Therapeutic Proteins Administered Via Subcutaneous vs. Intravenous Route
Subcutaneous (SC) administration of therapeutic proteins is perceived to pose higher risk of immunogenicity when compared ...
Aaps Journal
comment
0
thumb_up
0
Uncertainty Computation at Finite Distance in Nonlinear Mixed Effects Models—a New Method Based on Metropolis-Hastings Algorithm
The standard errors (SE) of the maximum likelihood estimates (MLE) of the population parameter vector in nonlinear mixed e...
Aaps Journal
comment
0
thumb_up
0
Prediction of Individual Disease Progression Including Parameter Uncertainty in Rare Neurodegenerative Diseases: The Example of Autosomal-Recessive Spastic Ataxia Charlevoix Saguenay (ARSACS)
The aim of this study was to develop a model to predict individual subject disease trajectories including parameter uncert...
Aaps Journal
comment
0
thumb_up
0
Pharmacokinetic Models for Inhaled Fluticasone Propionate and Salmeterol Xinafoate to Quantify Batch-to-Batch Variability
Advair Diskus is an essential treatment for asthma and chronic obstructive pulmonary disease. It is a dry powder inhaler w...
Aaps Journal
comment
0
thumb_up
0
Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling
This work shows the utilization of a physiologically based biopharmaceutics model (PBBM) to mechanistically explain the im...
Aaps Journal
comment
0
thumb_up
0
Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
The long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-t...
Aaps Journal
comment
0
thumb_up
0
Implementation of a Three-Way Comparability Assessment for a Bioanalytical Anti-Drug Antibody Method
Immunogenicity evaluation is a critical part of drug development. Regulatory guidelines from multiple health agencies prov...
Aaps Journal
comment
0
thumb_up
0
Group-by-Treatment Interaction Effects in Comparative Bioavailability Studies
Comparative bioavailability studies often involve multiple groups of subjects for a variety of reasons, such as clinical c...
Aaps Journal
comment
0
thumb_up
0
Preliminary Investigation of a Rapid and Feasible Therapeutic Drug Monitoring Method for the Real-Time Estimation of Blood Pazopanib Concentrations
Pazopanib is a multi-kinase inhibitor used to treat advanced/metastatic renal cell carcinoma and advanced soft tissue tumo...
Aaps Journal
comment
0
thumb_up
0
阅读更多
Modal title
×
Modal title
×
分享
登入
Global News and Health Forum
Join Now!
馬上登入
記住我
忘記密碼?
或者使用
Linkedin