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BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
Clinical trials are currently exploring combinations of PARP inhibitors and immunotherapies for the treatment of ovarian c...
Anethole supplementation during in vitro maturation increases in vitro goat embryo production in a concentration-dependent manner
Anethole supplementation during in vitro maturation increases in vitro goat embryo production in a concentration-dependent manner
In vitro maturation (IVM) process aims to provide oocytes with the necessary conditions to complete a set of processes in ...
Bovine nucleoprotein transitions genes and protein abundance as valuable markers of sperm motility and the correlation with fertility
Bovine nucleoprotein transitions genes and protein abundance as valuable markers of sperm motility and the correlation with fertility
The widespread use of artificial insemination (AI) in bovine breeding is indicative of the need to select bull based on th...
Proteomic analysis of boar sperm with differential ability of liquid preservation at 17 °C
Proteomic analysis of boar sperm with differential ability of liquid preservation at 17 °C
Artificial insemination (AI) is an effective tool in promoting genetic progress and reducing reproductive populations in t...
Pyruvate enhances stallion sperm function in high glucose media improving overall metabolic efficiency
Pyruvate enhances stallion sperm function in high glucose media improving overall metabolic efficiency
Volume 215, February 2024, Pages 113-124Author links open overlay panel, , , , , , , , , Highlights•10 mM pyruvate in a 67...
L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus
L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus
AbbreviationsASCapoptosis-associated speck-like protein containing a CARDCARDcaspase activation and recruitment domainCf-m...
Preservation of fertility in female and male prepubertal patients diagnosed with cancer
Preservation of fertility in female and male prepubertal patients diagnosed with cancer
Over the past two decades, the importance of fertility preservation has grown not only in the realm of medical and clinica...
Attenuated AKT signaling by miR-146a-5p interferes with chicken granulosa cell proliferation, lipid deposition and progesterone biosynthesis
Attenuated AKT signaling by miR-146a-5p interferes with chicken granulosa cell proliferation, lipid deposition and progesterone biosynthesis
The economic benefits of commercial chickens depend primarily on their egg-laying ability, with the most critical factor b...
Differential transcript usage across mammalian oocytes at the germinal vesicle and metaphase II stages
Differential transcript usage across mammalian oocytes at the germinal vesicle and metaphase II stages
High-quality oocytes are essential for the newborn generation in all mammalian species. An aberrant process during oocyte ...
BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways
BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways
Mouse and human embryonic stem cell (ESC) lines were isolated from preimplantation embryos in the 1980s and 1998 respectiv...
l-valine supplementation disturbs vital molecular pathways and induces apoptosis in mouse testes
l-valine supplementation disturbs vital molecular pathways and induces apoptosis in mouse testes
The branched-chain amino acids (BCAAs: leucine, isoleucine and valine) are essential for animal growth [1,2], since animal...
Quantitative trait loci exploration and characterization of gestation length in Holstein cattle
Quantitative trait loci exploration and characterization of gestation length in Holstein cattle
Traits related to fertility have received increasing interest in the last decades, after realizing that intense selection ...
Clonally derived chicken primordial germ cell lines maintain biological characteristics and proliferative potential in long-term culture
Clonally derived chicken primordial germ cell lines maintain biological characteristics and proliferative potential in long-term culture
Primordial germ cells (PGCs) are responsible for the production of gametes and originate during embryonic development. Whi...
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) may contribute to polycystic ovarian syndrome (PCOS) since it plays important roles in ...
Progress of the application clinical prediction model in polycystic ovary syndrome
Progress of the application clinical prediction model in polycystic ovary syndrome
Clinical prediction models play an important role in the field of medicine. These can help predict the probability of an i...
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
The genotype-phenotype relationships between TUBB8 variants and female infertility are difficult to clearly define due to ...
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
Inflammation and immunity are two main characteristics of tumor microenvironment (TME). Interferon-gamma (IFN-γ) is g...
PGT-A mosaicism based on NGS intermediate copy numbers: is it time to stop reporting them?
PGT-A mosaicism based on NGS intermediate copy numbers: is it time to stop reporting them?
Mosaicism represents a genuine real phenomenon, but its high prevalence and undisclosed clinical significance, stress the ...
Glucose and redox metabolism in meiotically blocked in vitro grown mouse antral follicles
Glucose and redox metabolism in meiotically blocked in vitro grown mouse antral follicles
Glucose and redox metabolism characterization in mouse antral follicles with meiotically blocked oocytes, after in vitro f...