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The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases
Volume 88, December 2022, 101143AbstractToll-like receptors (TLRs) are pattern recognition receptors (PRRs) that respond t...
Data structuring may prevent ambiguity and improve personalized medical prognosis
Topics expected to influence personalized medicine (PM), where medical decisions, practices, and treatments are tailored t...
Roles of Siglecs in neurodegenerative diseases
Available online 9 September 2022, 101141AbstractMicroglia are resident myeloid cells in the central nervous system (CNS) ...
Impact of Siglecs on autoimmune diseases
Available online 30 August 2022, 101140AbstractAutoimmune diseases affect tens of millions of people just in the United St...
Measuring the intake of dietary bioactives: Pitfalls and how to avoid them
Available online 26 August 2022, 101139AbstractBioactives are food constituents that, while not essential to human life, c...
Discovery, classification, evolution and diversity of Siglecs
Available online 18 August 2022, 101117AbstractImmunoglobulin (Ig) superfamily proteins play diverse roles in vertebrates,...
Role of Siglecs in viral infections: A double-edged sword interaction
Available online 16 August 2022, 101113AbstractSialic-acid-binding immunoglobulin-like lectins are cell surface immune rec...
Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health
Available online 11 August 2022, 101116AbstractOur food supply contains a range of essential and non-essential food compon...
Human sialoglycan ligands for immune inhibitory Siglecs
Available online 11 August 2022, 101110Highlights•Immune inhibitory Siglecs on the surface of human immune cells engage Si...
Siglec receptors as new immune checkpoints in cancer
Available online 7 August 2022, 101112AbstractCancer immunotherapy in the form of immune checkpoint inhibitors and cellula...
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe
Available online 5 August 2022, 101111AbstractAlzheimer's disease (AD) is the most common form of neurodegenerative diseas...
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but extensively metabolized by the human...
Human colonic catabolism of dietary flavan-3-ol bioactives
Available online 2 August 2022, 101107AbstractUnderstanding the fate of ingested polyphenols is crucial in elucidating the...
Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential
Volume 88, December 2022, 101106AbstractAmongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) h...
Have safety and efficacy assessments of bioactives come of age?
Available online 17 July 2022, 101103AbstractThis article describes why the safety and efficacy assessment of non-nutrient...
Siglecs in allergy and asthma
Available online 11 July 2022, 101104AbstractThe term “allergic diseases” encompasses several common, IgE-mediated conditi...
Molecular aspects of exposome and metabolic diseases
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The human inflammasomes
Volume 88, December 2022, 101100AbstractTwo decades of inflammasome research has led to a vast body of knowledge on the co...
Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad
Volume 87, October 2022, 100944AbstractThe biological role of two key vitamins, folic acid and vitamin D is so fundamental...
Impact of the exposome on the development and function of pancreatic β-cells
David Hill, DPhil, FCAHS is Scientific Director of the Lawson Health Research Institute, London, Ontario, Canada and is a ...
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system
Volume 87, October 2022, 100955AbstractDuring pregnancy, there is an intense crosstalk between mother and placenta. During...
Cathepsin V: Molecular characteristics and significance in health and disease
Human cysteine cathepsins form a family of eleven proteases (B, C, F, H, K, L, O, S, V, W, X/Z) that play important roles ...
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health
Available online 18 April 2022, 101095AbstractThe placental exposome represents the sum of all placental exposures, and th...
Pathological implication of protein post-translational modifications in cancer
Available online 7 April 2022, 101097AbstractProtein post-translational modifications (PTMs) profoundly influence protein ...
The influence of the dietary exposome on oxidative stress in pregnancy complications
Jelmer R Prins is an obstetrician-scientist and works at the University Medical Center Groningen. His research focuses on ...
Molecular aspects of asthma
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Caspase mechanisms in the regulation of inflammation
Available online 2 March 2022, 101085AbstractRegulated cell death is defined as genetically encoded pathways that lead tow...
Avenues for post-translational protein modification prevention and therapy
Available online 25 February 2022, 101083AbstractNon-enzymatic post-translational modifications (nPTMs) of proteins have e...
Glucose-derived posttranslational modification in cardiovascular disease
Available online 24 February 2022, 101084AbstractGlucose and its metabolites provide building blocks for cellular structur...