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Biomarkers of frailty
Biomarkers of frailty
Frailty is a biological syndrome which has offered since its inception great opportunities to provide explanations to many...
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan
“Ageing defies easy definition, at least in biological terms. It is not merely the passage of time. It is the manifestatio...
Obesity and male fertility disorders
Obesity and male fertility disorders
Volume 97, June 2024, 101273Author links open overlay panel, , , , , AbstractOften associated with obesity, male infertili...
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
The onset of sarcopenia is intimately linked with aging, posing significant implications not only for individual patient q...
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics
Extracellular vesicles are shed by every cell type and can be found in any biofluid. They contain different molecules that...
DNA melting analysis
DNA melting analysis
Separation of the two strands of DNA is necessary for semiconservative replication and cell division (Meselson and Stahl, ...
Cancer-associated muscle weakness - From triggers to molecular mechanisms
Cancer-associated muscle weakness - From triggers to molecular mechanisms
Skeletal muscle weakness is a debilitating consequence of many malignancies. Muscle weakness has a negative impact on both...
E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases
E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases
Protein ubiquitination is a dynamic multifaceted post-translational modification in which ubiquitin (Ub), a small 76 amino...
Organ Fibrosis: Emerging diagnostic and therapeutic strategies
Organ Fibrosis: Emerging diagnostic and therapeutic strategies
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Circulating tumor cells as liquid biopsy markers in cancer patients
Circulating tumor cells as liquid biopsy markers in cancer patients
Volume 96, April 2024, 101258Author links open overlay panel, Highlights•CTCs are tumor cells circulating in the blood.•CT...
Principles of digital sequencing using unique molecular identifiers
Principles of digital sequencing using unique molecular identifiers
Massively parallel sequencing technologies have long been used in both basic research and clinical routine. The recent int...
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing
Volume 96, April 2024, 101255Author links open overlay panel, , AbstractSingle-cell technologies have transformed biomedic...
Recent advances in intestinal fibrosis
Recent advances in intestinal fibrosis
Intestinal fibrosis is characterised by the accumulation of extracellular matrix (ECM) within the intestinal walls (Lenti ...
Digital PCR for the characterization of reference materials
Digital PCR for the characterization of reference materials
Volume 96, April 2024, 101256Author links open overlay panel, , , , , AbstractWell-characterized reference materials suppo...
Are we getting closer to a successful neoantigen cancer vaccine?
Are we getting closer to a successful neoantigen cancer vaccine?
Over the past decade, significant advances in immunotherapy, such as already approved by regulatory agencies several immun...
Current and emerging sequencing-based tools for precision cancer medicine
Current and emerging sequencing-based tools for precision cancer medicine
Cancer is caused by a vast number of recurrent genetic alterations important for disease initiation, progression and relap...
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis
Systemic sclerosis (also called scleroderma, SSc) is a chronic autoimmune disorder characterized by excessive collagen dep...
Improving the quality of quantitative polymerase chain reaction experiments: 15 years of MIQE
Improving the quality of quantitative polymerase chain reaction experiments: 15 years of MIQE
In 1998 The Lancet published a study insinuating a possible link between the MMR vaccine administered to children and auti...
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation
Glaucoma is the leading cause of irreversible blindness and affects more than 60 million people worldwide, of which nearly...
Corrigendum to “The changing epidemiology of fungal infections” [Mol. Aspect. Med. 94 (2023) 101215]
Corrigendum to “The changing epidemiology of fungal infections” [Mol. Aspect. Med. 94 (2023) 101215]
Volume 95, February 2024, 101240Author links open overlay panelCornelia Lass-Flörl, Stephan SteixnerShow morePrevious arti...
Reviewing the significance of dendritic cell vaccines in interrupting breast cancer development
Reviewing the significance of dendritic cell vaccines in interrupting breast cancer development
In 2020, the World Health Organisation (WHO) reported more than 2.26 million new cases of breast cancer (BC) and almost 68...
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Volume 95, February 2024, 101231Author links open overlay panel, Highlights•Concepts and mechanisms responsible for liver ...
Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies
Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies
Volume 95, February 2024, 101231Author links open overlay panel, Highlights•Concepts and mechanisms responsible for liver ...
Rodent genetically modified models of glaucoma
Rodent genetically modified models of glaucoma
Glaucoma, a progressive optic neuropathy characterised by the loss of retinal ganglion cells (RGC), is one of the leading ...
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis
Glaucoma, a group of ocular diseases, is characterized by apoptotic loss of retinal ganglion cells (RGCs) and optic nerve ...
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects
Neurodegeneration is characterized by a progressive loss of neurons and their processes (axons, dendrites, synapses) in de...
Practical issues related to non-Aspergillus invasive mold infections
Practical issues related to non-Aspergillus invasive mold infections
Invasive fungal disease (IFD) is a major complication in modern medicine, affecting predominantly individuals with impaire...
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies
Pulmonary fibrosis is considered to be one of the most irreversible forms of fibrosis across different organs, despite the...
Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma
Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma
Volume 94, December 2023, 101218Author links open overlay panelAbstractMore than 76 million people worldwide are afflicted...
Computational methods in glaucoma research: Current status and future outlook
Computational methods in glaucoma research: Current status and future outlook
Primary open-angle glaucoma (POAG) is a significant cause of blindness worldwide (Kwon et al., 2009). It is characterized ...
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