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Frailty and biological age. Which best describes our aging and longevity?
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Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy
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Hippo signaling modulation and its biological implications in urological malignancies
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The uniqueness of on-demand male contraception
The uniqueness of on-demand male contraception
Because nearly half of pregnancies worldwide are unintended, available contraceptive methods are inadequate. Moreover, due...
Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis
Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis
Volume 97, June 2024, 101282Author links open overlay panelAbstractMeiosis is a critical step for spermatogenesis and ooge...
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling
Excessive accumulation of intermuscular adipose tissue (IMAT) is a common pathological feature in various metabolic and he...
Modern methods of molecular diagnostics
Modern methods of molecular diagnostics
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
A practical guide to spatial transcriptomics
A practical guide to spatial transcriptomics
Spatial transcriptomics represents a cutting-edge technique in molecular biology that allows mapping the gene expression p...
Ensuring accuracy in the development and application of nucleic acid amplification tests (NAATs) for infectious disease
Ensuring accuracy in the development and application of nucleic acid amplification tests (NAATs) for infectious disease
Nucleic acid amplification tests (NAATs) and advanced sequencing have been increasingly applied to support clinical diagno...
NRF2-mediated regulation of lipid pathways in viral infection
NRF2-mediated regulation of lipid pathways in viral infection
In a cell, lipids are thought to perform three main functions. Some lipids may also be involved in forming lipid rafts, wh...
RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention
RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention
Despite the development of therapeutics and advancements for the treatment of cardiovascular diseases, cardiovascular dise...
Biomarkers of frailty
Biomarkers of frailty
Frailty is a biological syndrome which has offered since its inception great opportunities to provide explanations to many...
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan
“Ageing defies easy definition, at least in biological terms. It is not merely the passage of time. It is the manifestatio...
Obesity and male fertility disorders
Obesity and male fertility disorders
Volume 97, June 2024, 101273Author links open overlay panel, , , , , AbstractOften associated with obesity, male infertili...
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
The onset of sarcopenia is intimately linked with aging, posing significant implications not only for individual patient q...
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics
Extracellular vesicles are shed by every cell type and can be found in any biofluid. They contain different molecules that...
DNA melting analysis
DNA melting analysis
Separation of the two strands of DNA is necessary for semiconservative replication and cell division (Meselson and Stahl, ...
Cancer-associated muscle weakness - From triggers to molecular mechanisms
Cancer-associated muscle weakness - From triggers to molecular mechanisms
Skeletal muscle weakness is a debilitating consequence of many malignancies. Muscle weakness has a negative impact on both...
E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases
E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases
Protein ubiquitination is a dynamic multifaceted post-translational modification in which ubiquitin (Ub), a small 76 amino...
Organ Fibrosis: Emerging diagnostic and therapeutic strategies
Organ Fibrosis: Emerging diagnostic and therapeutic strategies
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Circulating tumor cells as liquid biopsy markers in cancer patients
Circulating tumor cells as liquid biopsy markers in cancer patients
Volume 96, April 2024, 101258Author links open overlay panel, Highlights•CTCs are tumor cells circulating in the blood.•CT...
Principles of digital sequencing using unique molecular identifiers
Principles of digital sequencing using unique molecular identifiers
Massively parallel sequencing technologies have long been used in both basic research and clinical routine. The recent int...
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing
Volume 96, April 2024, 101255Author links open overlay panel, , AbstractSingle-cell technologies have transformed biomedic...
Recent advances in intestinal fibrosis
Recent advances in intestinal fibrosis
Intestinal fibrosis is characterised by the accumulation of extracellular matrix (ECM) within the intestinal walls (Lenti ...
Digital PCR for the characterization of reference materials
Digital PCR for the characterization of reference materials
Volume 96, April 2024, 101256Author links open overlay panel, , , , , AbstractWell-characterized reference materials suppo...
Are we getting closer to a successful neoantigen cancer vaccine?
Are we getting closer to a successful neoantigen cancer vaccine?
Over the past decade, significant advances in immunotherapy, such as already approved by regulatory agencies several immun...
Current and emerging sequencing-based tools for precision cancer medicine
Current and emerging sequencing-based tools for precision cancer medicine
Cancer is caused by a vast number of recurrent genetic alterations important for disease initiation, progression and relap...
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis
Systemic sclerosis (also called scleroderma, SSc) is a chronic autoimmune disorder characterized by excessive collagen dep...
Improving the quality of quantitative polymerase chain reaction experiments: 15 years of MIQE
Improving the quality of quantitative polymerase chain reaction experiments: 15 years of MIQE
In 1998 The Lancet published a study insinuating a possible link between the MMR vaccine administered to children and auti...